{"id":"https://openalex.org/W3152480366","doi":null,"title":"Polycyclic aromatic hydrocarbons influence naive CD4+ T cell differentiation","display_name":"Polycyclic aromatic hydrocarbons influence naive CD4+ T cell differentiation","publication_year":2019,"publication_date":"2019-12-31","ids":{"openalex":"https://openalex.org/W3152480366","mag":"3152480366"},"language":"en","primary_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/31485","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/31485","pdf_url":"http://hdl.handle.net/1808/31485","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1808/31485","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060284209","display_name":"Amanda J. Dunbar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Amanda Jo Dunbar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060284209"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.218299999833107,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0957999974489212,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.9940000176429749},{"id":"https://openalex.org/keywords/naive-cd4-t-cells","display_name":"naive CD4+ T cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/t-cell-costimulation","display_name":"T cell costimulation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.9160000085830688},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":0.8840000033378601},{"id":"https://openalex.org/keywords/pyrene","display_name":"pyrene","score":0.9980000257492065},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cd25","display_name":"CD25","score":0.6909999847412109},{"id":"https://openalex.org/keywords/magnetic-bead-separation","display_name":"magnetic bead separation","score":0.5049999952316284},{"id":"https://openalex.org/keywords/t-cell-viability","display_name":"T cell viability","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46807584166526794}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kuscholarworks.ku.edu:1808/31485","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/31485","pdf_url":"http://hdl.handle.net/1808/31485","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:3152480366","doi":null,"is_oa":false,"landing_page_url":"https://kuscholarworks.ku.edu/handle/1808/31485","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/31485","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1808/31485","pdf_url":"http://hdl.handle.net/1808/31485","source":{"id":"https://openalex.org/S4306400421","display_name":"KU ScholarWorks (The University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3152480366.pdf","grobid_xml":"https://content.openalex.org/works/W3152480366.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W104029063","https://openalex.org/W1559250314","https://openalex.org/W2001632450","https://openalex.org/W2002624692","https://openalex.org/W2002729535","https://openalex.org/W2070690965","https://openalex.org/W2080664482","https://openalex.org/W2084550635","https://openalex.org/W2093794158","https://openalex.org/W2099635702","https://openalex.org/W2126408606","https://openalex.org/W2134450176","https://openalex.org/W2148049431","https://openalex.org/W2188224444","https://openalex.org/W2331531679","https://openalex.org/W2426509981","https://openalex.org/W2464720069","https://openalex.org/W2489481562","https://openalex.org/W2894439500"],"related_works":["https://openalex.org/W1607733107","https://openalex.org/W2001632450","https://openalex.org/W2093794158","https://openalex.org/W2041367589","https://openalex.org/W826156230","https://openalex.org/W2262430915","https://openalex.org/W1565814966","https://openalex.org/W2027229755","https://openalex.org/W1969931271","https://openalex.org/W2085294848"],"abstract_inverted_index":{"CD4+":[0,265],"T":[1,17,32,64,79,99,128,176,196,232,257,266,294,304,374,389],"cells":[2,18,33,233,258,305,390,396],"are":[3,138],"essential":[4],"for":[5,132,345,362,383],"the":[6,13,41,63,71,78,86,93,97,158,162,167,253,275,278,336,346,354,384,392,395,404],"effective":[7],"functioning":[8],"and":[9,26,30,39,103,112,116,185,207,212,237,240,243,262,322,351,367],"appropriate":[10],"regulation":[11],"of":[12,73,169,187,222,225,230,255,277,287,319,332,349,369,387,394],"immune":[14,42,159],"system.":[15,160],"Antigen-na\u00efve":[16],"require":[19],"two":[20,172],"distinct":[21],"costimulatory":[22,75,94,101],"signals":[23],"to":[24,37,62,150,171,192,291,311,365,397],"activate":[25],"differentiate":[27,308,366],"into":[28],"effector":[29,211,242],"memory":[31,213,244],"which":[34,142,297,399],"can":[35,124],"respond":[36],"antigen":[38,50],"direct":[40],"response.":[43],"The":[44,67],"first":[45],"signal":[46,69,131],"is":[47,70,400],"through":[48,313],"cognate":[49],"presented":[51],"in":[52,110,204,216,234,247,285,309,335,371,391,401],"major":[53],"histocompatibility":[54],"class":[55],"II":[56],"on":[57,77,85,92,154],"an":[58,380],"antigen-presenting":[59,87],"cell":[60,65,80,100,129,177,197,214,245,267,326],"binding":[61],"receptor.":[66],"second":[68,130],"interaction":[72],"a":[74,82,127,181,220],"receptor":[76],"with":[81,296,403],"counter-receptor":[83],"expressed":[84],"cell.":[88],"This":[89,376],"work":[90],"focuses":[91],"receptors":[95],"CD28,":[96],"classic":[98],"molecule,":[102],"intercellular":[104],"adhesion":[105,111],"molecule-1":[106],"(ICAM-1).":[107],"ICAM-1":[108,123,200,236,314],"functions":[109],"extravasation":[113],"during":[114,174,199],"inflammation,":[115],"our":[117],"lab":[118],"has":[119],"previously":[120],"published":[121,300,405],"that":[122,280,330],"function":[125],"as":[126],"activation.":[133],"Polycyclic":[134],"aromatic":[135],"hydrocarbons":[136],"(PAHs)":[137],"ubiquitous":[139],"environmental":[140],"contaminants":[141],"have":[143,151,299],"been":[144],"shown":[145],"by":[146,273],"many":[147],"other":[148],"investigators":[149],"diverse":[152],"effects":[153],"human":[155],"health":[156],"including":[157],"In":[161,289],"present":[163],"work,":[164],"we":[165,298],"examined":[166],"consequences":[168],"exposure":[170],"PAHs":[173],"na\u00efve":[175,195,231,256,264,293,303,373,388],"costimulation.":[178,218],"Bisphenol":[179],"A,":[180],"widely":[182],"used":[183],"plasticizer":[184],"component":[186],"epoxy":[188],"resins,":[189],"was":[190,282,342],"found":[191],"weakly":[193],"promote":[194],"proliferation":[198,229],"costimulation":[201,206,312],"but":[202],"not":[203,209,307],"CD28":[205,238,316],"did":[208,306],"perturb":[210],"differentiation":[215,246,254,350],"either":[217],"Pyrene,":[219],"product":[221],"incomplete":[223],"combustion":[224],"organic":[226],"materials,":[227],"enhanced":[228],"both":[235,248],"costimulations":[239],"inhibited":[241],"costimulations.":[249],"We":[250,328],"also":[251,378],"compared":[252],"isolated":[259],"using":[260],"StemSep":[261,281,292],"EasySep":[263,337,355,372],"isolation":[268],"kits":[269],"upon":[270],"being":[271,283],"informed":[272],"StemCell,":[274],"manufacturer":[276],"kits,":[279],"discontinued":[284],"favor":[286],"EasySep.":[288],"contrast":[290],"cells,":[295],"previously,":[301],"EasySep-purified":[302],"response":[310],"or":[315],"without":[317],"addition":[318],"exogenous":[320],"cytokines":[321],"had":[323],"dramatically":[324],"increased":[325],"death.":[327],"showed":[329],"inclusion":[331],"CD25":[333],"antibody":[334,340],"negative":[338],"selection":[339],"cocktail":[341],"partially":[343,359],"responsible":[344],"observed":[347,363],"loss":[348,368],"viability.":[352],"Likewise,":[353],"magnetic":[356],"beads":[357],"were":[358],"at":[360],"fault":[361],"failure":[364],"viability":[370],"cells.":[375],"result":[377],"suggested":[379],"important":[381],"role":[382],"CD25lo":[385],"population":[386],"ability":[393],"differentiate,":[398],"keeping":[402],"literature.":[406]},"counts_by_year":[],"updated_date":"2026-09-19T00:03:45.406941","created_date":"2021-04-13T00:00:00"}