{"id":"https://openalex.org/W3149847267","doi":"https://doi.org/10.1055/s-2004-823098","title":"Nonalcoholic Steatohepatitis","display_name":"Nonalcoholic Steatohepatitis","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W3149847267","doi":"https://doi.org/10.1055/s-2004-823098","mag":"3149847267","pmid":"https://pubmed.ncbi.nlm.nih.gov/15085483"},"language":"es","primary_location":{"id":"doi:10.1055/s-2004-823098","doi":"https://doi.org/10.1055/s-2004-823098","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2004-823098","pdf_url":null,"source":{"id":"https://openalex.org/S176130430","display_name":"Seminars in Liver Disease","issn_l":"0272-8087","issn":["0272-8087","1098-8971"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Liver Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072014736","display_name":"Elizabeth M. Brunt","orcid":"https://orcid.org/0000-0003-1862-325X","observed_orcids":["https://orcid.org/0000-0003-1862-325X"]},"institutions":[{"id":"https://openalex.org/I2802034949","display_name":"Saint Louis University Hospital","ror":"https://ror.org/01v49sd11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801580383","https://openalex.org/I2802034949"]},{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth\u00a0M.\u00a0Brunt","raw_affiliation_strings":["Saint Louis University Liver Center, Saint Louis University Health Sciences Center, Department of Pathology, St. Louis, Missouri 63110, USA. bruntem@slu.edu","Associate Professor of Pathology, Saint Louis University Liver Center, Saint Louis University Health Sciences Center, Department of Pathology, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Louis University Liver Center, Saint Louis University Health Sciences Center, Department of Pathology, St. Louis, Missouri 63110, USA. bruntem@slu.edu","institution_ids":["https://openalex.org/I2802034949","https://openalex.org/I47838141"]},{"raw_affiliation_string":"Associate Professor of Pathology, Saint Louis University Liver Center, Saint Louis University Health Sciences Center, Department of Pathology, St. Louis, Missouri","institution_ids":["https://openalex.org/I47838141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072014736"],"corresponding_institution_ids":["https://openalex.org/I2802034949","https://openalex.org/I47838141"],"apc_list":null,"apc_paid":null,"fwci":24.1813,"has_fulltext":false,"cited_by_count":486,"citation_normalized_percentile":{"value":0.99769585,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"24","issue":"1","first_page":"3","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.875},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.7820000052452087},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.7689999938011169},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.5460000038146973},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7480000257492065},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.8008748292922974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7867633104324341},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.7142754793167114},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.5789015889167786},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5501563549041748},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5203932523727417},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.5150863528251648},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5142857432365417},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5097202658653259},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5080358982086182},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.48203930258750916},{"id":"https://openalex.org/C3018708256","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic steatohepatitis","level":5,"score":0.42092615365982056},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41426533460617065},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4139007031917572},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37230348587036133},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.2488497793674469},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09928062558174133}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005235","descriptor_name":"Fatty Liver, Alcoholic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1055/s-2004-823098","doi":"https://doi.org/10.1055/s-2004-823098","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2004-823098","pdf_url":null,"source":{"id":"https://openalex.org/S176130430","display_name":"Seminars in Liver Disease","issn_l":"0272-8087","issn":["0272-8087","1098-8971"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Liver Disease","raw_type":"journal-article"},{"id":"pmid:15085483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15085483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in liver disease","raw_type":"Journal Article"},{"id":"pmid:2491061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2491061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anales de medicina interna (Madrid, Spain : 1984)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1976137269","https://openalex.org/W3144776074","https://openalex.org/W1479724872","https://openalex.org/W2124284531","https://openalex.org/W4243183216","https://openalex.org/W2893426090","https://openalex.org/W1479998951","https://openalex.org/W2339139416","https://openalex.org/W2426341519","https://openalex.org/W2057164540"],"abstract_inverted_index":{"Nonalcoholic":[0,40],"fatty":[1],"liver":[2,12,48,60],"disease":[3],"(NAFLD)":[4],"is":[5,43,65],"being":[6],"increasingly":[7],"recognized":[8],"as":[9,71],"a":[10,23,52,66],"common":[11],"disorder":[13],"that":[14,50],"represents":[15],"the":[16,20,44,89,113,124,128,133],"hepatic":[17],"manifestation":[18],"of":[19,27,47,75,77,82,91,115,130,135],"metabolic":[21],"syndrome,":[22],"variably":[24],"defined":[25],"aggregate":[26],"disorders":[28],"related":[29,122],"to":[30,123],"obesity,":[31],"insulin":[32],"resistance,":[33],"type":[34],"II":[35],"diabetes,":[36],"hypertension":[37],"and":[38,58,94,112,117,138],"hyperlipidemia.":[39],"steatohepatitis":[41,84],"(NASH)":[42],"progressive":[45,55],"form":[46],"injury":[49,93],"carries":[51],"risk":[53],"for":[54],"fibrosis,":[56],"cirrhosis,":[57],"end-stage":[59],"disease.":[61],"Hepatocellular":[62],"carcinoma":[63],"(HCC)":[64],"documented":[67],"complication":[68],"in":[69,127],"an":[70],"yet":[72],"unknown":[73],"percentage":[74],"cases":[76],"NASH":[78,137],"cirrhosis.":[79,140],"The":[80],"diagnosis":[81],"nonalcoholic":[83],"requires":[85],"histopathologic":[86],"evaluation":[87],"because":[88],"lesions":[90,126],"parenchymal":[92],"fibrosis":[95],"cannot":[96],"be":[97],"detected":[98],"by":[99],"imaging":[100],"studies":[101,111],"or":[102],"laboratory":[103],"tests.":[104],"This":[105],"article":[106],"will":[107],"briefly":[108],"discuss":[109],"prevalence":[110],"pathophysiology":[114],"NAFLD":[116],"focus":[118],"on":[119],"current":[120],"discussions":[121],"specific":[125],"pathology":[129],"NASH,":[131],"including":[132],"challenges":[134],"pediatric":[136],"NASH-related":[139]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":32}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-04-13T00:00:00"}