{"id":"https://openalex.org/W3149735005","doi":"https://doi.org/10.3390/cells10040819","title":"Quantification of Circulating Cell Free Mitochondrial DNA in Extracellular Vesicles with PicoGreen\u2122 in Liquid Biopsies: Fast Assessment of Disease/Trauma Severity","display_name":"Quantification of Circulating Cell Free Mitochondrial DNA in Extracellular Vesicles with PicoGreen\u2122 in Liquid Biopsies: Fast Assessment of Disease/Trauma Severity","publication_year":2021,"publication_date":"2021-04-06","ids":{"openalex":"https://openalex.org/W3149735005","doi":"https://doi.org/10.3390/cells10040819","mag":"3149735005","pmid":"https://pubmed.ncbi.nlm.nih.gov/33917426","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8067453"},"language":"en","primary_location":{"id":"doi:10.3390/cells10040819","doi":"https://doi.org/10.3390/cells10040819","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells10040819","pdf_url":"https://www.mdpi.com/2073-4409/10/4/819/pdf?version=1617940734","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4409/10/4/819/pdf?version=1617940734","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022998040","display_name":"Michela Marcatti","orcid":"https://orcid.org/0000-0003-1921-4626","observed_orcids":["https://orcid.org/0000-0003-1921-4626"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michela Marcatti","raw_affiliation_strings":["Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA"],"raw_orcid":"https://orcid.org/0000-0003-1921-4626","affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008810604","display_name":"Jamal I. Saada","orcid":"https://orcid.org/0000-0001-9550-9704","observed_orcids":["https://orcid.org/0000-0001-9550-9704"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamal Saada","raw_affiliation_strings":["Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065074421","display_name":"Ikenna C Okereke","orcid":"https://orcid.org/0000-0001-5652-985X","observed_orcids":["https://orcid.org/0000-0001-5652-985X"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ikenna Okereke","raw_affiliation_strings":["Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA"],"raw_orcid":"https://orcid.org/0000-0001-5652-985X","affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056060130","display_name":"Charles E. Wade","orcid":"https://orcid.org/0000-0003-0055-5885","observed_orcids":["https://orcid.org/0000-0003-0055-5885"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles E. Wade","raw_affiliation_strings":["Department of Surgery, University of Texas Health Science Center in Houston, Houston, TX 77003, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Texas Health Science Center in Houston, Houston, TX 77003, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048246567","display_name":"Stefan H. Bossmann","orcid":"https://orcid.org/0000-0002-0058-0127","observed_orcids":["https://orcid.org/0000-0002-0058-0127"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan H. Bossmann","raw_affiliation_strings":["Department of Cancer Biology, The University of Kansas Medical Center, Kansas City, KS 66160, USA"],"raw_orcid":"https://orcid.org/0000-0002-0058-0127","affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, The University of Kansas Medical Center, Kansas City, KS 66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014674134","display_name":"Massoud Motamedi","orcid":"https://orcid.org/0000-0003-0733-2588","observed_orcids":["https://orcid.org/0000-0003-0733-2588"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Massoud Motamedi","raw_affiliation_strings":["Departments of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA"],"raw_orcid":"https://orcid.org/0000-0003-0733-2588","affiliations":[{"raw_affiliation_string":"Departments of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090643968","display_name":"Bartosz Szcz\u0119sny","orcid":"https://orcid.org/0000-0002-6196-3981","observed_orcids":["https://orcid.org/0000-0002-6196-3981"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bartosz Szczesny","raw_affiliation_strings":["Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA","Departments of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA"],"raw_orcid":"https://orcid.org/0000-0002-6196-3981","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Departments of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5090643968"],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":1.9601,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.87750112,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"10","issue":"4","first_page":"819","last_page":"819"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8134999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.1468999981880188,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.9390000104904175},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.8510000109672546},{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.8349999785423279},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.8320000171661377},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":1.0},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.8019999861717224},{"id":"https://openalex.org/keywords/qpcr-comparison","display_name":"qPCR comparison","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6241232752799988},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.6209092140197754},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.5581886768341064},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.551092267036438},{"id":"https://openalex.org/C152110520","wikidata":"https://www.wikidata.org/wiki/Q14225730","display_name":"Cell-free fetal DNA","level":5,"score":0.4806141257286072},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.47176745533943176},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.4461529850959778},{"id":"https://openalex.org/C2777527632","wikidata":"https://www.wikidata.org/wiki/Q238382","display_name":"DAPI","level":3,"score":0.44406723976135254},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.4321857690811157},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41095829010009766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40340664982795715},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3594170808792114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34460151195526123},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31395378708839417},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24999776482582092},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1906348466873169},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18046537041664124},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1646953523159027},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09786483645439148},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08999454975128174},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000070642","descriptor_name":"Brain Injuries, Traumatic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000070642","descriptor_name":"Brain Injuries, Traumatic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000073890","descriptor_name":"Liquid Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009930","descriptor_name":"Organic Chemicals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/cells10040819","doi":"https://doi.org/10.3390/cells10040819","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells10040819","pdf_url":"https://www.mdpi.com/2073-4409/10/4/819/pdf?version=1617940734","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8067453","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8067453","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmid:33917426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33917426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e6cd8a66509c421eb95411d2fb73315f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e6cd8a66509c421eb95411d2fb73315f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 10, Iss 4, p 819 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cells10040819","doi":"https://doi.org/10.3390/cells10040819","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells10040819","pdf_url":"https://www.mdpi.com/2073-4409/10/4/819/pdf?version=1617940734","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Decent work and economic growth","id":"https://metadata.un.org/sdg/8","score":0.6800000071525574}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G7402732623","display_name":"Collaborative Research:  A Point-of-Care Device for Diagnosis and Management of Pulmonary Diseases","funder_award_id":"1804422","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3149735005.pdf","grobid_xml":"https://content.openalex.org/works/W3149735005.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1488562032","https://openalex.org/W1663606074","https://openalex.org/W1995933703","https://openalex.org/W2028107828","https://openalex.org/W2030307914","https://openalex.org/W2035232303","https://openalex.org/W2037849505","https://openalex.org/W2049381885","https://openalex.org/W2060050187","https://openalex.org/W2068538439","https://openalex.org/W2104183007","https://openalex.org/W2106449742","https://openalex.org/W2109130949","https://openalex.org/W2129899300","https://openalex.org/W2136474306","https://openalex.org/W2164320986","https://openalex.org/W2171497162","https://openalex.org/W2198964395","https://openalex.org/W2294395959","https://openalex.org/W2398080083","https://openalex.org/W2414639590","https://openalex.org/W2467136872","https://openalex.org/W2554880605","https://openalex.org/W2594835795","https://openalex.org/W2751319692","https://openalex.org/W2781505076","https://openalex.org/W2783228241","https://openalex.org/W2786514708","https://openalex.org/W2809795782","https://openalex.org/W2884918777","https://openalex.org/W2887997888","https://openalex.org/W2896518198","https://openalex.org/W2896791112","https://openalex.org/W2900822956","https://openalex.org/W2911278071","https://openalex.org/W2913075317","https://openalex.org/W2920848372","https://openalex.org/W2922144466","https://openalex.org/W2937257353","https://openalex.org/W2946298500","https://openalex.org/W2956865263","https://openalex.org/W2971827065","https://openalex.org/W2987234948","https://openalex.org/W2991532494","https://openalex.org/W2997832213","https://openalex.org/W3010739138","https://openalex.org/W3011557809","https://openalex.org/W3012821961","https://openalex.org/W3025346034","https://openalex.org/W3125322167","https://openalex.org/W4248178819"],"related_works":["https://openalex.org/W2159136239","https://openalex.org/W3047205374","https://openalex.org/W7097109469","https://openalex.org/W4310082951","https://openalex.org/W7160924564","https://openalex.org/W2761606129","https://openalex.org/W2583541072","https://openalex.org/W2598418636","https://openalex.org/W2036635697","https://openalex.org/W7154647257"],"abstract_inverted_index":{"The":[0],"analysis":[1,137,179],"of":[2,18,29,60,64,73,78,92,107,138,141,147,153,172,180,187,200,210,219],"circulating":[3],"cell":[4],"free":[5],"DNA":[6,131,148,181],"(ccf-DNA)":[7],"is":[8,36,44,149,158],"an":[9],"emerging":[10],"diagnostic":[11,190],"tool":[12],"for":[13],"the":[14,58,105,118,139,145,170,176,178,185],"detection":[15],"and":[16,23,33,46,50,67,76,84,97,124,157,197,217],"monitoring":[17],"tissue":[19,32],"injury,":[20],"disease":[21],"progression,":[22],"potential":[24,186],"treatment":[25,218],"effects.":[26],"Currently,":[27],"most":[28],"ccf-DNA":[30,61,93,142,201],"in":[31,62,94,102,175],"liquid":[34],"biopsies":[35],"analysed":[37],"with":[38,70,161,202],"real-time":[39],"quantitative":[40,85],"PCR":[41],"(qPCR)":[42],"that":[43,144,167,195],"primer-":[45],"template-specific,":[47],"labour":[48],"intensive":[49],"cost-inefficient.":[51],"In":[52],"this":[53],"report":[54],"we":[55,193],"directly":[56],"compare":[57],"amounts":[59],"serum":[63],"healthy":[65,108],"volunteers,":[66],"subjects":[68],"presenting":[69],"various":[71],"stages":[72],"lung":[74,95],"adenocarcinoma,":[75],"survivors":[77],"traumatic":[79,98],"brain":[80,99],"injury":[81,100],"using":[82,113],"qPCR":[83,125],"PicoGreen\u2122":[86,122,203],"fluorescence":[87,123],"assay.":[88],"A":[89],"significant":[90],"increase":[91],"adenocarcinoma":[96],"patients,":[101],"comparison":[103],"to":[104,169],"group":[106],"human":[109],"subjects,":[110],"was":[111,126],"found":[112,127],"both":[114],"analytical":[115],"methods.":[116],"However,":[117],"direct":[119],"correlation":[120],"between":[121],"only":[128],"when":[129],"mitochondrial":[130],"(mtDNA)-specific":[132],"primers":[133],"were":[134],"used.":[135],"Further":[136],"location":[140],"indicated":[143],"majority":[146],"located":[150],"within":[151,182],"lumen":[152],"extracellular":[154],"vesicles":[155],"(EVs)":[156],"easily":[159],"detected":[160],"mtDNA-specific":[162],"primers.":[163],"We":[164],"have":[165],"concluded":[166],"due":[168],"presence":[171],"active":[173],"DNases":[174],"blood,":[177],"EVs":[183],"has":[184],"providing":[188],"rapid":[189,198],"outcomes.":[191],"Moreover,":[192],"speculate":[194],"accurate":[196],"quantification":[199],"fluorescent":[204],"probe":[205],"used":[206],"as":[207],"a":[208],"point":[209],"care":[211],"approach":[212],"could":[213],"facilitate":[214],"immediate":[215],"assessment":[216],"critically":[220],"ill":[221],"patients.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-04-13T00:00:00"}
