{"id":"https://openalex.org/W3149563025","doi":null,"title":"Manejo das Hemorragias Relacionadas aos Anticoagulantes Orais de A\u00e7\u00e3o Direta: Manejo das Hemorragias Relacionadas aos Anticoagulantes Orais de A\u00e7\u00e3o Direta","display_name":"Manejo das Hemorragias Relacionadas aos Anticoagulantes Orais de A\u00e7\u00e3o Direta: Manejo das Hemorragias Relacionadas aos Anticoagulantes Orais de A\u00e7\u00e3o Direta","publication_year":2019,"publication_date":"2019-10-19","ids":{"openalex":"https://openalex.org/W3149563025","mag":"3149563025"},"language":"pt","primary_location":{"id":"pmh:oai:ojs3.jca.org.br:article/26","doi":null,"is_oa":true,"landing_page_url":"https://www.jca.org.br/jca/article/view/26","pdf_url":"https://www.jca.org.br/jca/article/download/26/28","source":{"id":"https://openalex.org/S4210195185","display_name":"Journal of Cardiac Arrhythmias","issn_l":"2674-7081","issn":["2674-7081","2674-7472"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2674-7472","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jca.org.br/jca/article/download/26/28","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032599565","display_name":"Isabela Ramos Ali Ganem","orcid":"https://orcid.org/0000-0001-6340-991X","observed_orcids":["https://orcid.org/0000-0001-6340-991X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabela Ramos Ali Ganem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101743858","display_name":"Luiz Claudio Behrmann Martins","orcid":"https://orcid.org/0000-0003-4969-857X","observed_orcids":["https://orcid.org/0000-0003-4969-857X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luiz Claudio Behrmann Martins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084776013","display_name":"Carlos Eduardo Mendon\u00e7a Tom\u00e9","orcid":"https://orcid.org/0000-0001-7260-7483","observed_orcids":["https://orcid.org/0000-0001-7260-7483"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Eduardo Mendon\u00e7a Tom\u00e9","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7260-7483","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"2","first_page":"89","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/direct-oral-anticoagulants","display_name":"direct oral anticoagulants","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anticoagulation-reversal","display_name":"anticoagulant reversal","score":0.6949999928474426},{"id":"https://openalex.org/keywords/idarucizumab","display_name":"idarucizumab","score":0.9649999737739563},{"id":"https://openalex.org/keywords/dabigatran","display_name":"dabigatran","score":0.9049999713897705},{"id":"https://openalex.org/keywords/andexanet-alfa","display_name":"andexanet alfa","score":0.9089999794960022},{"id":"https://openalex.org/keywords/factor-xa-inhibitors","display_name":"factor Xa inhibitors","score":0.7409999966621399},{"id":"https://openalex.org/keywords/thrombin-inhibitors","display_name":"thrombin inhibitors","score":0.6610000133514404},{"id":"https://openalex.org/keywords/intracranial-hemorrhage","display_name":"intracranial hemorrhage","score":0.9470000267028809},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/vitamin-k-antagonists","display_name":"vitamin K antagonists","score":0.6669999957084656},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9426325559616089},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5424315929412842},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.4507012367248535},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4421222507953644},{"id":"https://openalex.org/C3017811039","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Major bleeding","level":3,"score":0.4372923970222473},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.21173977851867676},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.18710365891456604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15616634488105774}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ojs3.jca.org.br:article/26","doi":null,"is_oa":true,"landing_page_url":"https://www.jca.org.br/jca/article/view/26","pdf_url":"https://www.jca.org.br/jca/article/download/26/28","source":{"id":"https://openalex.org/S4210195185","display_name":"Journal of Cardiac Arrhythmias","issn_l":"2674-7081","issn":["2674-7081","2674-7472"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2674-7472","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3149563025","doi":null,"is_oa":true,"landing_page_url":"https://jca.org.br/jca/article/download/26/28","pdf_url":null,"source":{"id":"https://openalex.org/S4210195185","display_name":"Journal of Cardiac Arrhythmias","issn_l":"2674-7081","issn":["2674-7081","2674-7472"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cardiac Arrhythmias","raw_type":null}],"best_oa_location":{"id":"pmh:oai:ojs3.jca.org.br:article/26","doi":null,"is_oa":true,"landing_page_url":"https://www.jca.org.br/jca/article/view/26","pdf_url":"https://www.jca.org.br/jca/article/download/26/28","source":{"id":"https://openalex.org/S4210195185","display_name":"Journal of Cardiac Arrhythmias","issn_l":"2674-7081","issn":["2674-7081","2674-7472"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2674-7472","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3149563025.pdf","grobid_xml":"https://content.openalex.org/works/W3149563025.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W826970266","https://openalex.org/W1547546593","https://openalex.org/W1555652492","https://openalex.org/W1965320794","https://openalex.org/W1971941179","https://openalex.org/W1974709342","https://openalex.org/W1980009210","https://openalex.org/W1997615758","https://openalex.org/W2010861397","https://openalex.org/W2015854890","https://openalex.org/W2017709949","https://openalex.org/W2052834849","https://openalex.org/W2057577245","https://openalex.org/W2059900810","https://openalex.org/W2065193471","https://openalex.org/W2084904145","https://openalex.org/W2113446992","https://openalex.org/W2126850212","https://openalex.org/W2132370419","https://openalex.org/W2160160759","https://openalex.org/W2166610266","https://openalex.org/W2174386486","https://openalex.org/W2191895465","https://openalex.org/W2196906371","https://openalex.org/W2203036336","https://openalex.org/W2329823765","https://openalex.org/W2413194881","https://openalex.org/W2478829584","https://openalex.org/W2514338974","https://openalex.org/W2515178430","https://openalex.org/W2530886467","https://openalex.org/W2531750597","https://openalex.org/W2792634476","https://openalex.org/W2808207445"],"related_works":["https://openalex.org/W2981443800","https://openalex.org/W2982127876","https://openalex.org/W2920759029","https://openalex.org/W2810513411","https://openalex.org/W3175277269","https://openalex.org/W3159211416","https://openalex.org/W2736458630","https://openalex.org/W2588613504","https://openalex.org/W2963524094","https://openalex.org/W2803093116"],"abstract_inverted_index":{"Introduction:":[0],"Direct":[1],"Oral":[2],"Anticoagulant":[3],"\u2013":[4],"DOACs)":[5],"are":[6,31,201],"a":[7,146,184],"new":[8],"class":[9],"of":[10,41,63,84,90,101,111,117,124,157,163,167,191,216,222,230],"anticoagulant":[11],"that":[12,169],"directly":[13],"inhibit":[14],"the":[15,26,37,61,82,99,109,131,137,152,155,161,202,213,217,220,228],"trombine":[16],"(dabigatrane)":[17],"or":[18,54],"Xa":[19,125],"factor":[20],"(rivaroxabane,":[21],"edoxabane":[22],"and":[23,39,98,119,133,140,179,189,199],"apixabane)":[24],"in":[25,45,50,67,70,77,81,136,145,187],"coagulation":[27],"cascade.":[28],"These":[29],"medications":[30],"being":[32,210],"more":[33],"frequently":[34],"used":[35,170],"for":[36],"treatment":[38,190],"prevention":[40],"thrombolytic":[42,192],"events,":[43],"mainly":[44],"patients":[46],"with":[47,88],"atrial":[48],"fibrillation,":[49],"substitute":[51],"to":[52,160,174,207],"varfrine":[53],"other":[55],"vitamin":[56],"K":[57],"antagonists":[58],"(VKAs).":[59],"Although":[60],"incidence":[62],"hemorrhage":[64,86,158],"is":[65],"higher":[66],"AVKs":[68],"than":[69],"DOACs,":[71],"these":[72],"events":[73,205],"may":[74,142,234],"also":[75],"occur":[76],"this":[78],"group,":[79],"even":[80],"form":[83],"intracranial":[85],"(ICH),":[87],"risk":[89],"death.":[91],"Nowadays,":[92],"DOACs":[93,182,223],"indications":[94],"have":[95,127],"progressively":[96],"enhanced":[97],"availability":[100],"their":[102,112,208],"specific":[103,224],"reverse":[104,115,122,215,225],"agents":[105,226],"certainly":[106],"will":[107],"enhance":[108],"safety":[110,229],"usage.":[113],"Idarucizumab,":[114],"agent":[116,123],"dabigatrane,":[118],"alpha":[120],"andexanet,":[121],"factor,":[126],"been":[128],"approved":[129,144],"by":[130],"Food":[132],"Drug":[134],"Administration":[135],"United":[138],"States":[139],"ciraparantag":[141],"be":[143,235],"near":[147],"future.":[148],"Objective:":[149],"To":[150],"review":[151],"literature":[153,168],"on":[154],"manage":[156],"related":[159,206],"use":[162],"DOACs.":[164],"Methods:":[165],"Review":[166],"articles":[171],"from":[172,176],"1998":[173],"2017,":[175],"several":[177],"platforms":[178],"journals.":[180],"Conclusion:":[181],"constitute":[183],"great":[185],"advance":[186],"prophylaxis":[188],"diseases,":[193],"which":[194],"presents":[195],"elevated":[196],"morbid":[197],"mortality,":[198],"hemorrhages":[200],"main":[203],"adverse":[204],"usage,":[209],"rarely":[211],"necessary":[212],"immediate":[214],"anticoagulation.":[218],"However,":[219],"existence":[221],"enhances":[227],"patients,":[231],"whose":[232],"anticoagulation":[233],"rapidly":[236],"reversed":[237],"if":[238],"necessary.":[239]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-04-13T00:00:00"}
