{"id":"https://openalex.org/W3149526092","doi":null,"title":"Lipids in Health and Disease","display_name":"Lipids in Health and Disease","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W3149526092","mag":"3149526092"},"language":"en","primary_location":{"id":"mag:3149526092","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1186/1476-511X-7-20.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023283860","display_name":"Wei-Tsung Kao","orcid":"https://orcid.org/0000-0003-2818-5337","observed_orcids":["https://orcid.org/0000-0003-2818-5337"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei-Tsung Kao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2818-5337","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049908925","display_name":"Yung\u2010Chieh Yen","orcid":"https://orcid.org/0000-0002-2174-2244","observed_orcids":["https://orcid.org/0000-0002-2174-2244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yung\u2010Chieh Yen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2174-2244","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008141197","display_name":"For\u2010Wey Lung","orcid":"https://orcid.org/0000-0002-4505-7583","observed_orcids":["https://orcid.org/0000-0002-4505-7583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"For\u2010Wey Lung","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4505-7583","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.448199987411499,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.448199987411499,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.2847000062465668,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.13050000369548798,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.8579999804496765},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/beta2-adrenergic-receptor","display_name":"beta2-adrenergic receptor","score":0.8820000290870667},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9570000171661377},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.7910000085830688},{"id":"https://openalex.org/keywords/chinese-older-adults","display_name":"Chinese older adults","score":0.41200000047683716},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.6639999747276306},{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.6759999990463257},{"id":"https://openalex.org/keywords/income","display_name":"income","score":0.4230000078678131},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.6899999976158142},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.953000009059906},{"id":"https://openalex.org/keywords/gene-gene-interaction","display_name":"gene-gene interaction","score":0.734000027179718},{"id":"https://openalex.org/keywords/lipoprotein-metabolism","display_name":"lipoprotein metabolism","score":0.703000009059906},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.9139999747276306},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.5170000195503235},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.35199999809265137},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.705703616142273},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7041571140289307},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6237066388130188},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.6161933541297913},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.5998958349227905},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.5681523680686951},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4833785891532898},{"id":"https://openalex.org/C2776551241","wikidata":"https://www.wikidata.org/wiki/Q24768001","display_name":"Phospholipase A2","level":3,"score":0.46898916363716125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4295578896999359},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4216734766960144},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.33157679438591003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3298496603965759},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31955236196517944},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30746424198150635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2129165530204773},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14144542813301086}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3149526092","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1186/1476-511X-7-20.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W82809700","https://openalex.org/W991373308","https://openalex.org/W1930168886","https://openalex.org/W1982145862","https://openalex.org/W1985908429","https://openalex.org/W1992530497","https://openalex.org/W2012901328","https://openalex.org/W2027093388","https://openalex.org/W2041106971","https://openalex.org/W2053905513","https://openalex.org/W2071654344","https://openalex.org/W2071697205","https://openalex.org/W2075826151","https://openalex.org/W2079992316","https://openalex.org/W2110755408","https://openalex.org/W2116404316","https://openalex.org/W2135870859","https://openalex.org/W2146467002","https://openalex.org/W2147351691","https://openalex.org/W2160859079","https://openalex.org/W2324258168","https://openalex.org/W2414292604"],"related_works":["https://openalex.org/W2161336980","https://openalex.org/W1982145862","https://openalex.org/W2361039989","https://openalex.org/W2357067972","https://openalex.org/W2362974169","https://openalex.org/W2357822131","https://openalex.org/W2359889411","https://openalex.org/W2037805667","https://openalex.org/W2042341394","https://openalex.org/W2114298106"],"abstract_inverted_index":{"Background:":[0],"Explore":[1],"the":[2,47,85,88,122,146,161,166,188,210,218,253,280,371,374,391],"interaction":[3],"between":[4,49],"apolipoprotein":[5],"E":[6,222],"(Apo":[7],"E),":[8],"phospholipase":[9],"A2":[10],"(PLA2)":[11],"and":[12,19,53,57,82,136,175,223,257,299,313,335,385],"\u03b22":[13],"adrenergic":[14],"receptor":[15],"(\u03b22-AR)":[16],"gene":[17,55,90,234],"polymorphisms":[18,56,235],"lipid":[20,58,226,240,268,324],"profiles":[21,227],"in":[22,42,80,84,143,158,185,213,230,264,279,333,387],"an":[23,365],"elderly":[24],"Chinese":[25],"population.":[26],"Methods:":[27],"Five":[28],"hundred":[29,61],"subjects":[30,115,126,144,159,186],"aged":[31],"65":[32],"to":[33,45,65,121],"74":[34],"years":[35],"were":[36,78,155,183,228,277],"randomly":[37],"selected":[38],"from":[39],"a":[40,102,200,272],"community":[41],"southern":[43],"Taiwan":[44],"assess":[46],"relationship":[48],"Apo":[50,221],"E,":[51],"PLA2":[52,224],"\u03b22-AR":[54,89],"profiles.":[59,241,269],"Two":[60,74],"sixty-seven":[62],"participants":[63],"agreed":[64],"have":[66],"venous":[67],"blood":[68,297],"drawn":[69],"for":[70,267],"DNA":[71],"studies.":[72],"Results:":[73],"statistically":[75],"significant":[76,237],"differences":[77],"noted":[79,157,184],"TC":[81,118,131,150],"LDL-C":[83,138],"Gln27Glu":[86,110,123],"of":[87,220,255,282,373],"polymorphism":[91,111,124],"(P":[92],"=":[93,96,107,128,134,141,153,173,181,206],"0.007,":[94],"P":[95],"0.022).":[97],"The":[98,109,192],"low-income":[99],"group":[100],"had":[101,116,199],"higher":[103,169,176],"HDL-C":[104,204],"level":[105],"(p":[106,127,133,140,152,172,180,205],"0.076).":[108],"Glu/Glu":[112],"or":[113],"Gln/Glu":[114],"lower":[117,137],"levels":[119,132,139,151,171,179],"compared":[120],"Gln/Gln":[125],"0.092).":[129],"Lower":[130,149],"0.082)":[135],"0.045)":[142],"with":[145,160,187,196],"Cys19Arg16Glu27":[147],"haplotype.":[148,164,191],"0.06)":[154],"also":[156],"Cys19Gly":[162,189],"16Glu27":[163],"On":[165],"other":[167],"hand,":[168],"VLDL-C":[170],"0.185)":[174],"triglyceride":[177],"(TG)":[178],"0.190)":[182],"16Gln27":[190],"e2":[193],"allele":[194],"combined":[195],"low":[197,243,314],"income":[198,211,244],"positive":[201],"effect":[202,238,246],"on":[203,225,239,247],"0.0011),":[207],"after":[208],"adding":[209],"factor":[212],"this":[214,231],"study.":[215],"Conclusion:":[216],"When":[217],"effects":[219],"included":[229],"study,":[232,274],"\u03b22AR":[233],"reduced":[236],"Similarly,":[242],"increased":[245],"HDL-C.":[248],"This":[249,348,363],"study":[250],"appeared":[251],"that":[252],"results":[254],"gene-gene":[256],"gene-environment":[258],"interaction,":[259],"it":[260],"should":[261],"be":[262],"considered":[263],"further":[265],"studies":[266],"Background":[270],"In":[271],"previous":[273],"endogenous":[275],"catecholamines":[276],"involved":[278],"regulation":[281],"adipose":[283],"tissue":[284],"lipolysis,":[285],"nonesterified":[286],"fatty":[287],"acid":[288],"distribution,":[289,384],"lipoprotein":[290,316],"metabolism,":[291],"obesity,":[292,309],"glucose":[293],"homeostasis,":[294],"diabetes":[295],"mellitus,":[296],"pressure":[298],"metabolic":[300],"syndrome":[301,304],"[1].":[302],"Metabolic":[303],"was":[305],"defined":[306],"as":[307],"abdominal":[308],"hyperglycemia,":[310],"hypertension,":[311],"hypertriglyceridemia":[312],"high-density":[315],"cholesterol":[317],"(HDL-C).":[318],"Adrenergic":[319],"receptors":[320],"(ARs)":[321],"can":[322],"regulate":[323],"mobilization,":[325],"energy":[326],"expenditure":[327],"Published:":[328],"21":[329,345],"May":[330,346],"2008":[331,343,347,355],"Lipids":[332],"Health":[334],"Disease":[336],"2008,":[337],"7:20":[338],"doi:10.1186/1476-511X-7-20":[339],"Received:":[340],"19":[341],"March":[342],"Accepted:":[344],"article":[349,368],"is":[350,364,394],"available":[351],"from:":[352],"http://www.lipidworld.com/content/7/1/20":[353],"\u00a9":[354],"Kao":[356],"et":[357],"al;":[358],"licensee":[359],"BioMed":[360],"Central":[361],"Ltd.":[362],"Open":[366],"Access":[367],"distributed":[369],"under":[370],"terms":[372],"Creative":[375],"Commons":[376],"Attribution":[377],"License":[378],"(http://creativecommons.org/licenses/by/2.0),":[379],"which":[380],"permits":[381],"unrestricted":[382],"use,":[383],"reproduction":[386],"any":[388],"medium,":[389],"provided":[390],"original":[392],"work":[393],"properly":[395],"cited.":[396]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2021-04-13T00:00:00"}