{"id":"https://openalex.org/W3149429338","doi":"https://doi.org/10.1177/20587384211008291","title":"Immuno-modulation by heat-killed Lacticaseibacillus paracasei MCC1849 and its application to food products","display_name":"Immuno-modulation by heat-killed Lacticaseibacillus paracasei MCC1849 and its application to food products","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3149429338","doi":"https://doi.org/10.1177/20587384211008291","mag":"3149429338","pmid":"https://pubmed.ncbi.nlm.nih.gov/33787390","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8020404"},"language":"en","primary_location":{"id":"doi:10.1177/20587384211008291","doi":"https://doi.org/10.1177/20587384211008291","is_oa":true,"landing_page_url":"https://doi.org/10.1177/20587384211008291","pdf_url":null,"source":{"id":"https://openalex.org/S199192407","display_name":"International Journal of Immunopathology and Pharmacology","issn_l":"0394-6320","issn":["0394-6320","2058-7384"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Immunopathology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/20587384211008291","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002458275","display_name":"Hazuki Maehata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272692","display_name":"Morinaga Milk Industry Co., Ltd. (Japan)","ror":"https://ror.org/04hy75g65","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405272692"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hazuki Maehata","raw_affiliation_strings":["Food Ingredients and Technology Institute, Research and Development Division, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Ingredients and Technology Institute, Research and Development Division, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405272692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084786002","display_name":"Satoshi Arai","orcid":"https://orcid.org/0000-0002-0700-6830","observed_orcids":["https://orcid.org/0000-0002-0700-6830"]},"institutions":[{"id":"https://openalex.org/I4405272692","display_name":"Morinaga Milk Industry Co., Ltd. (Japan)","ror":"https://ror.org/04hy75g65","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405272692"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Satoshi Arai","raw_affiliation_strings":["Food Ingredients and Technology Institute, Research and Development Division, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0700-6830","affiliations":[{"raw_affiliation_string":"Food Ingredients and Technology Institute, Research and Development Division, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405272692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074580847","display_name":"Noriyuki Iwabuchi","orcid":"https://orcid.org/0009-0009-1673-7414","observed_orcids":["https://orcid.org/0009-0009-1673-7414"]},"institutions":[{"id":"https://openalex.org/I4405272692","display_name":"Morinaga Milk Industry Co., Ltd. (Japan)","ror":"https://ror.org/04hy75g65","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405272692"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriyuki Iwabuchi","raw_affiliation_strings":["Food Ingredients and Technology Institute, Research and Development Division, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Ingredients and Technology Institute, Research and Development Division, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405272692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051696973","display_name":"Fumiaki Abe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272692","display_name":"Morinaga Milk Industry Co., Ltd. (Japan)","ror":"https://ror.org/04hy75g65","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405272692"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumiaki Abe","raw_affiliation_strings":["Food Ingredients and Technology Institute, Research and Development Division, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Ingredients and Technology Institute, Research and Development Division, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405272692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084786002"],"corresponding_institution_ids":["https://openalex.org/I4405272692"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":null,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":null,"first_page":"20587384211008291","last_page":"20587384211008291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heat-killed-probiotics","display_name":"heat-killed probiotics","score":0.9350000023841858},{"id":"https://openalex.org/keywords/postbiotics","display_name":"postbiotics","score":0.9309999942779541},{"id":"https://openalex.org/keywords/paraprobiotics","display_name":"paraprobiotics","score":0.9760000109672546},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/lactic-acid-bacteria","display_name":"lactic acid bacteria","score":0.8349999785423279},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.7480000257492065},{"id":"https://openalex.org/keywords/health-benefits","display_name":"health benefits","score":0.6909999847412109},{"id":"https://openalex.org/keywords/probiotic-foods","display_name":"probiotic foods","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C2779433226","wikidata":"https://www.wikidata.org/wiki/Q1799829","display_name":"Lactobacillus paracasei","level":4,"score":0.8807213306427002},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.7738101482391357},{"id":"https://openalex.org/C3018122547","wikidata":"https://www.wikidata.org/wiki/Q5690813","display_name":"Health benefits","level":2,"score":0.6392571926116943},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.5389071702957153},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.5317437052726746},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.42317959666252136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41857367753982544},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.41344061493873596},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3930102586746216},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3300606906414032},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.25874757766723633},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.09222128987312317},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.08267149329185486},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069980","descriptor_name":"Lacticaseibacillus paracasei","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005516","descriptor_name":"Food Microbiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1177/20587384211008291","doi":"https://doi.org/10.1177/20587384211008291","is_oa":true,"landing_page_url":"https://doi.org/10.1177/20587384211008291","pdf_url":null,"source":{"id":"https://openalex.org/S199192407","display_name":"International Journal of Immunopathology and Pharmacology","issn_l":"0394-6320","issn":["0394-6320","2058-7384"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Immunopathology and Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8020404","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8020404/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8020404/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Immunopathol Pharmacol","raw_type":"Text"},{"id":"pmid:33787390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33787390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of immunopathology and pharmacology","raw_type":"Editorial"},{"id":"pmh:oai:doaj.org/article:8c676c30cfc4446cb3c09826446fc763","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8c676c30cfc4446cb3c09826446fc763","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Immunopathology and Pharmacology, Vol 35 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/20587384211008291","doi":"https://doi.org/10.1177/20587384211008291","is_oa":true,"landing_page_url":"https://doi.org/10.1177/20587384211008291","pdf_url":null,"source":{"id":"https://openalex.org/S199192407","display_name":"International Journal of Immunopathology and Pharmacology","issn_l":"0394-6320","issn":["0394-6320","2058-7384"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Immunopathology and Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3149429338.pdf","grobid_xml":"https://content.openalex.org/works/W3149429338.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W94516324","https://openalex.org/W1977053325","https://openalex.org/W1977328678","https://openalex.org/W2002800047","https://openalex.org/W2009219530","https://openalex.org/W2036001773","https://openalex.org/W2060401427","https://openalex.org/W2069535448","https://openalex.org/W2073900522","https://openalex.org/W2099299955","https://openalex.org/W2114488493","https://openalex.org/W2125901952","https://openalex.org/W2129302556","https://openalex.org/W2141049630","https://openalex.org/W2163491850","https://openalex.org/W2173673029","https://openalex.org/W2210731378","https://openalex.org/W2279130505","https://openalex.org/W2406729335","https://openalex.org/W2471262218","https://openalex.org/W2554404348","https://openalex.org/W2558222672","https://openalex.org/W2594389980","https://openalex.org/W2600027756","https://openalex.org/W2757316484","https://openalex.org/W2762408398","https://openalex.org/W2793397992","https://openalex.org/W2801213637","https://openalex.org/W2807753813","https://openalex.org/W2886231451","https://openalex.org/W2891718001","https://openalex.org/W2892527163","https://openalex.org/W2912865065","https://openalex.org/W2939404371","https://openalex.org/W2946450286","https://openalex.org/W2946568639","https://openalex.org/W2950412262","https://openalex.org/W2953714808","https://openalex.org/W2960816097","https://openalex.org/W2989562712","https://openalex.org/W2995522736","https://openalex.org/W3013551363","https://openalex.org/W3038698648","https://openalex.org/W4211246989"],"related_works":["https://openalex.org/W4391635610","https://openalex.org/W2016564596","https://openalex.org/W7163050057","https://openalex.org/W4390702188","https://openalex.org/W3149773615","https://openalex.org/W4383377898","https://openalex.org/W4385578040","https://openalex.org/W4416301517","https://openalex.org/W3093521289","https://openalex.org/W2999022490"],"abstract_inverted_index":{"Probiotics":[0],"are":[1,63],"microorganisms":[2],"that":[3,59,99],"confer":[4],"health":[5,23,32,61,112],"benefits":[6,113],"to":[7],"host.":[8],"Well-known":[9],"examples":[10],"include":[11],"Bifidobacterium":[12],"and":[13,31,41,50,72,121],"Lactobacillus":[14],"species.":[15],"In":[16],"recent":[17],"years,":[18],"interest":[19],"in":[20,97,103,105,142],"promoting":[21],"our":[22],"with":[24,79],"probiotics":[25,139],"has":[26,34],"grown":[27],"as":[28],"life":[29],"expectancy":[30],"awareness":[33],"increased.":[35],"However,":[36],"some":[37],"concerns":[38],"for":[39,44,126,140],"safety":[40],"stability":[42],"exist":[43],"these":[45],"live":[46],"organisms.":[47],"Thus,":[48],"\u201cpostbiotics\u201d":[49],"\u201cparaprobiotics,\u201d":[51],"non-viable":[52,106],"heat-killed":[53,107,115,138],"microbial":[54],"cells":[55],"or":[56],"cell":[57],"fractions":[58],"retain":[60],"benefits,":[62],"increasingly":[64],"favored.":[65],"Unfortunately,":[66],"little":[67],"information":[68],"on":[69],"clinical":[70],"efficacy":[71],"mechanisms":[73,128],"of":[74,114,129,136],"action":[75],"is":[76,89],"available":[77,81],"compared":[78],"many":[80],"probiotics.":[82],"Lacticaseibacillus":[83],"(previous":[84],"name":[85],"Lactobacillus)":[86],"paracasei":[87,117],"MCC1849":[88,118],"a":[90,123],"commonly":[91],"used":[92],"lactic":[93],"acid":[94],"bacterial":[95],"strain":[96],"Japan":[98],"displays":[100],"immuno-modulatory":[101],"effects":[102],"humans":[104],"form.":[108],"This":[109],"review":[110],"discusses":[111],"L.":[116],"immune":[119],"modulation":[120],"offers":[122],"theoretical":[124],"basis":[125],"its":[127],"action.":[130],"We":[131],"also":[132],"discuss":[133],"the":[134],"feasibility":[135],"using":[137],"application":[141],"food":[143],"products.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-04-13T00:00:00"}
