{"id":"https://openalex.org/W3148901355","doi":"https://doi.org/10.1101/2021.04.02.438184","title":"The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects","display_name":"The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects","publication_year":2021,"publication_date":"2021-04-04","ids":{"openalex":"https://openalex.org/W3148901355","doi":"https://doi.org/10.1101/2021.04.02.438184","mag":"3148901355"},"language":"en","primary_location":{"id":"doi:10.1101/2021.04.02.438184","doi":"https://doi.org/10.1101/2021.04.02.438184","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.04.02.438184","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/06/23/2021.04.02.438184.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2021/06/23/2021.04.02.438184.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Erwan Lambert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4387154478","display_name":"Approches \u00e9pid\u00e9miologiques et mol\u00e9culaires int\u00e9gratives visant \u00e0 am\u00e9liorer la compr\u00e9hension des maladies chroniques li\u00e9es au vieillissement","ror":"https://ror.org/03rvrjk28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Erwan Lambert","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Orthis Saha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4387154478","display_name":"Approches \u00e9pid\u00e9miologiques et mol\u00e9culaires int\u00e9gratives visant \u00e0 am\u00e9liorer la compr\u00e9hension des maladies chroniques li\u00e9es au vieillissement","ror":"https://ror.org/03rvrjk28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Orthis Saha","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bruna Soares Landeira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4387154478","display_name":"Approches \u00e9pid\u00e9miologiques et mol\u00e9culaires int\u00e9gratives visant \u00e0 am\u00e9liorer la compr\u00e9hension des maladies chroniques li\u00e9es au vieillissement","ror":"https://ror.org/03rvrjk28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruna Soares Landeira","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ana Raquel Melo de Farias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]},{"id":"https://openalex.org/I4387154478","display_name":"Approches \u00e9pid\u00e9miologiques et mol\u00e9culaires int\u00e9gratives visant \u00e0 am\u00e9liorer la compr\u00e9hension des maladies chroniques li\u00e9es au vieillissement","ror":"https://ror.org/03rvrjk28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}],"countries":["BR","FR"],"is_corresponding":false,"raw_author_name":"Ana Raquel Melo de Farias","raw_affiliation_strings":["Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil","Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil","institution_ids":["https://openalex.org/I35046152"]},{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xavier Hermant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4387154478","display_name":"Approches \u00e9pid\u00e9miologiques et mol\u00e9culaires int\u00e9gratives visant \u00e0 am\u00e9liorer la compr\u00e9hension des maladies chroniques li\u00e9es au vieillissement","ror":"https://ror.org/03rvrjk28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Xavier Hermant","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004892020","display_name":"Arnaud Carrier","orcid":"https://orcid.org/0000-0002-9200-7685","observed_orcids":["https://orcid.org/0000-0002-9200-7685"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210167107","display_name":"European Genomic Institute for Diabetes","ror":"https://ror.org/05n2c8735","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210167107"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Arnaud Carrier","raw_affiliation_strings":["Univ. Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1283-UMR 8199 EGID, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1283-UMR 8199 EGID, Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210167107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076557600","display_name":"Alexandre Pelletier","orcid":"https://orcid.org/0000-0003-2979-2470","observed_orcids":["https://orcid.org/0000-0003-2979-2470"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210167107","display_name":"European Genomic Institute for Diabetes","ror":"https://ror.org/05n2c8735","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210167107"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandre Pelletier","raw_affiliation_strings":["Univ. Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1283-UMR 8199 EGID, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1283-UMR 8199 EGID, Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210167107"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lindsay Davoine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4387154478","display_name":"Approches \u00e9pid\u00e9miologiques et mol\u00e9culaires int\u00e9gratives visant \u00e0 am\u00e9liorer la compr\u00e9hension des maladies chroniques li\u00e9es au vieillissement","ror":"https://ror.org/03rvrjk28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lindsay Davoine","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Clo\u00e9 Dupont","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4387154478","display_name":"Approches \u00e9pid\u00e9miologiques et mol\u00e9culaires int\u00e9gratives visant \u00e0 am\u00e9liorer la compr\u00e9hension des maladies chroniques li\u00e9es au vieillissement","ror":"https://ror.org/03rvrjk28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Clo\u00e9 Dupont","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033321689","display_name":"Philippe Amouyel","orcid":"https://orcid.org/0000-0001-9088-234X","observed_orcids":["https://orcid.org/0000-0001-9088-234X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4387154478","display_name":"Approches \u00e9pid\u00e9miologiques et mol\u00e9culaires int\u00e9gratives visant \u00e0 am\u00e9liorer la compr\u00e9hension des maladies chroniques li\u00e9es au vieillissement","ror":"https://ror.org/03rvrjk28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Amouyel","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025636710","display_name":"Am\u00e9lie Bonnefond","orcid":"https://orcid.org/0000-0001-9976-3005","observed_orcids":["https://orcid.org/0000-0001-9976-3005"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210167107","display_name":"European Genomic Institute for Diabetes","ror":"https://ror.org/05n2c8735","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210167107"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Am\u00e9lie Bonnefond","raw_affiliation_strings":["Univ. Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1283-UMR 8199 EGID, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1283-UMR 8199 EGID, Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210167107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086994906","display_name":"Frank Lafont","orcid":"https://orcid.org/0000-0001-8668-2580","observed_orcids":["https://orcid.org/0000-0001-8668-2580"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210098529","display_name":"Center for Infection and Immunity of Lille","ror":"https://ror.org/00dyt5s15","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210096427","https://openalex.org/I4210098529"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Frank Lafont","raw_affiliation_strings":["Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210098529"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Farida Adelfettah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4387154478","display_name":"Approches \u00e9pid\u00e9miologiques et mol\u00e9culaires int\u00e9gratives visant \u00e0 am\u00e9liorer la compr\u00e9hension des maladies chroniques li\u00e9es au vieillissement","ror":"https://ror.org/03rvrjk28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Farida Adelfettah","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040983698","display_name":"Patrik Verstreken","orcid":"https://orcid.org/0000-0002-5073-5393","observed_orcids":["https://orcid.org/0000-0002-5073-5393"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Patrik Verstreken","raw_affiliation_strings":["Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium","VIB Center for Brain & Disease Research, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB Center for Brain & Disease Research, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I4210153928","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Julien Chapuis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4387154478","display_name":"Approches \u00e9pid\u00e9miologiques et mol\u00e9culaires int\u00e9gratives visant \u00e0 am\u00e9liorer la compr\u00e9hension des maladies chroniques li\u00e9es au vieillissement","ror":"https://ror.org/03rvrjk28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julien Chapuis","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010734363","display_name":"Nicolas Barois","orcid":"https://orcid.org/0000-0002-5057-1931","observed_orcids":["https://orcid.org/0000-0002-5057-1931"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210098529","display_name":"Center for Infection and Immunity of Lille","ror":"https://ror.org/00dyt5s15","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210096427","https://openalex.org/I4210098529"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Barois","raw_affiliation_strings":["Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France","Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US41-UMS2014-PLBS, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210098529"]},{"raw_affiliation_string":"Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US41-UMS2014-PLBS, Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052299722","display_name":"Fabien Delahaye","orcid":"https://orcid.org/0000-0002-9921-8653","observed_orcids":["https://orcid.org/0000-0002-9921-8653"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210167107","display_name":"European Genomic Institute for Diabetes","ror":"https://ror.org/05n2c8735","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210167107"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabien Delahaye","raw_affiliation_strings":["Univ. Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1283-UMR 8199 EGID, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CNRS, CHU Lille, Institut Pasteur de Lille, U1283-UMR 8199 EGID, Lille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4210167107"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bart Dermaut","orcid":"https://orcid.org/0000-0002-6968-0572","observed_orcids":["https://orcid.org/0000-0002-6968-0572"]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bart Dermaut","raw_affiliation_strings":["Centre for Medical Genetics, Ghent University Hospital, Ghent, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-6968-0572","affiliations":[{"raw_affiliation_string":"Centre for Medical Genetics, Ghent University Hospital, Ghent, Belgium","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004893591","display_name":"Jean\u2010Charles Lambert","orcid":"https://orcid.org/0000-0003-0829-7817","observed_orcids":["https://orcid.org/0000-0003-0829-7817"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4387154478","display_name":"Approches \u00e9pid\u00e9miologiques et mol\u00e9culaires int\u00e9gratives visant \u00e0 am\u00e9liorer la compr\u00e9hension des maladies chroniques li\u00e9es au vieillissement","ror":"https://ror.org/03rvrjk28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Charles Lambert","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France"],"raw_orcid":"https://orcid.org/0000-0003-0829-7817","affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marcos R. Costa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]},{"id":"https://openalex.org/I4387154478","display_name":"Approches \u00e9pid\u00e9miologiques et mol\u00e9culaires int\u00e9gratives visant \u00e0 am\u00e9liorer la compr\u00e9hension des maladies chroniques li\u00e9es au vieillissement","ror":"https://ror.org/03rvrjk28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}],"countries":["BR","FR"],"is_corresponding":true,"raw_author_name":"Marcos R. Costa","raw_affiliation_strings":["Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil","Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil","institution_ids":["https://openalex.org/I35046152"]},{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063922665","display_name":"Pierre Dourlen","orcid":"https://orcid.org/0000-0002-3562-1080","observed_orcids":["https://orcid.org/0000-0002-3562-1080"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I2800921988","display_name":"Institut Pasteur de Lille","ror":"https://ror.org/05k9skc85","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2800921988"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4387154478","display_name":"Approches \u00e9pid\u00e9miologiques et mol\u00e9culaires int\u00e9gratives visant \u00e0 am\u00e9liorer la compr\u00e9hension des maladies chroniques li\u00e9es au vieillissement","ror":"https://ror.org/03rvrjk28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Pierre Dourlen","raw_affiliation_strings":["Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE facteurs de risque et d\u00e9terminants mol\u00e9culaires des maladies li\u00e9es au vieillissement, DISTALZ, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I4387154478"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5063922665"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I2800921988","https://openalex.org/I3018718406","https://openalex.org/I35046152","https://openalex.org/I4387154478"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.052000001072883606,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bin1","display_name":"BIN1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8820000290870667},{"id":"https://openalex.org/keywords/early-endosomes","display_name":"early endosomes","score":0.6570000052452087},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9670000076293945},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7149999737739563},{"id":"https://openalex.org/keywords/brain-organoids","display_name":"brain organoids","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.9265000224113464},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.8705000281333923},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5853000283241272},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5683000087738037},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5597000122070312},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5343000292778015},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5224000215530396},{"id":"https://openalex.org/C2778264360","wikidata":"https://www.wikidata.org/wiki/Q675010","display_name":"Lysosomal storage disease","level":3,"score":0.40070000290870667},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.35679998993873596},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.3472999930381775},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34200000762939453},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.33250001072883606},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.2964000105857849},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2759000062942505},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2694999873638153},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.26010000705718994},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25609999895095825}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2021.04.02.438184","doi":"https://doi.org/10.1101/2021.04.02.438184","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.04.02.438184","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/06/23/2021.04.02.438184.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2021.04.02.438184","doi":"https://doi.org/10.1101/2021.04.02.438184","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.04.02.438184","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/06/23/2021.04.02.438184.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2589139458","display_name":null,"funder_award_id":"ALZ201906008477","funder_id":"https://openalex.org/F4320321589","funder_display_name":"Fondation pour la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G3479052434","display_name":null,"funder_award_id":"ANR\u201010\u2010EQPX\u201007\u201001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3510491964","display_name":null,"funder_award_id":"phs000424.v8.p2","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5112221070","display_name":null,"funder_award_id":"P40 OD018537","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G6091343702","display_name":null,"funder_award_id":"ALZ201912009628","funder_id":"https://openalex.org/F4320321589","funder_display_name":"Fondation pour la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G6099097669","display_name":null,"funder_award_id":"IA 52242","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7240651115","display_name":null,"funder_award_id":"ANR-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8510727784","display_name":null,"funder_award_id":"ANR-10-EQPX","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G9000095838","display_name":null,"funder_award_id":"NIH-P40OD018537","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000862742","display_name":"Bloomington Drosophila Stock Center at Indiana University","funder_award_id":"P40OD018537","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000879327","display_name":"DROSOPHILA GENOMICS RESOURCE CENTER","funder_award_id":"P40OD010949","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320315322","display_name":"Fondation Vaincre Alzheimer","ror":"https://ror.org/05hesyx60"},{"id":"https://openalex.org/F4320316132","display_name":"Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease","ror":"https://ror.org/05g2seg35"},{"id":"https://openalex.org/F4320316862","display_name":"Equipex","ror":null},{"id":"https://openalex.org/F4320317224","display_name":"European Genomic Institute for Diabetes","ror":"https://ror.org/05n2c8735"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320323712","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320338403","display_name":"Common Fund","ror":"https://ror.org/001d55x84"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3148901355.pdf","grobid_xml":"https://content.openalex.org/works/W3148901355.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1680905070","https://openalex.org/W1908692741","https://openalex.org/W1941934587","https://openalex.org/W1968344841","https://openalex.org/W1999922223","https://openalex.org/W2014588460","https://openalex.org/W2017009575","https://openalex.org/W2017886031","https://openalex.org/W2019422608","https://openalex.org/W2053365501","https://openalex.org/W2054357322","https://openalex.org/W2067937471","https://openalex.org/W2074958723","https://openalex.org/W2077904579","https://openalex.org/W2080684506","https://openalex.org/W2090375050","https://openalex.org/W2095715640","https://openalex.org/W2115779804","https://openalex.org/W2121312696","https://openalex.org/W2134159136","https://openalex.org/W2156016682","https://openalex.org/W2159367229","https://openalex.org/W2163777695","https://openalex.org/W2166336042","https://openalex.org/W2171753511","https://openalex.org/W2179438025","https://openalex.org/W2468488057","https://openalex.org/W2491615326","https://openalex.org/W2536136445","https://openalex.org/W2557653052","https://openalex.org/W2580395304","https://openalex.org/W2740332229","https://openalex.org/W2889898768","https://openalex.org/W2895305250","https://openalex.org/W2914475876","https://openalex.org/W2916749909","https://openalex.org/W2940322549","https://openalex.org/W2951997054","https://openalex.org/W2954072698","https://openalex.org/W2967807085","https://openalex.org/W2988958689","https://openalex.org/W3012061414","https://openalex.org/W3029808235","https://openalex.org/W3045809806","https://openalex.org/W3093674228","https://openalex.org/W3120777691","https://openalex.org/W4223591189","https://openalex.org/W4253610833"],"related_works":["https://openalex.org/W6977037055","https://openalex.org/W6939166847","https://openalex.org/W6920784042","https://openalex.org/W6977460921","https://openalex.org/W3112513279","https://openalex.org/W6901897296","https://openalex.org/W6902042747","https://openalex.org/W6977146991","https://openalex.org/W6902105356","https://openalex.org/W2766952739"],"abstract_inverted_index":{"SUMMARY":[0],"The":[1],"Bridging":[2],"Integrator":[3],"1":[4],"(":[5],"BIN1":[6,36,85,131],")":[7],"gene":[8,13,130],"is":[9,22,72,142],"a":[10,65],"major":[11],"susceptibility":[12,129],"for":[14,55,74],"Alzheimer\u2019s":[15],"disease":[16],"(AD).":[17],"Deciphering":[18],"its":[19,26],"pathophysiological":[20,145],"role":[21],"challenging":[23],"due":[24],"to":[25,41,59,109,137],"numerous":[27],"isoforms.":[28],"Here":[29],"we":[30],"observed":[31],"in":[32,88,112,120],"Drosophila":[33],"that":[34,64,126],"human":[35,78],"isoform1":[37],"(BIN1iso1)":[38],"overexpression,":[39],"contrary":[40],"BIN1iso8":[42],"and":[43,51,82,118,133],"BIN1iso9,":[44],"induced":[45,79],"an":[46,110,143],"accumulation":[47],"of":[48,91,115,147],"endosomal":[49],"vesicles":[50],"neurodegeneration.":[52,76],"Systematic":[53],"search":[54],"endosome":[56,70],"regulators":[57],"able":[58],"prevent":[60],"BIN1iso1-induced":[61],"neurodegeneration":[62,119],"indicated":[63],"defect":[66],"at":[67],"the":[68,75,89,113,127],"early":[69,92,116,144],"level":[71],"responsible":[73],"In":[77],"neurons":[80],"(hiNs)":[81],"cerebral":[83],"organoids,":[84],"knock-out":[86],"resulted":[87],"narrowing":[90],"endosomes.":[93],"This":[94],"phenotype":[95],"was":[96],"rescued":[97],"by":[98],"BIN1iso1":[99,105],"but":[100],"not":[101],"BIN1iso9":[102],"expression.":[103],"Finally,":[104],"overexpression":[106],"also":[107],"led":[108],"increase":[111],"size":[114,139],"endosomes":[117],"hiNs.":[121],"Altogether,":[122],"our":[123],"data":[124],"demonstrate":[125],"AD":[128,148],",":[132],"especially":[134],"BIN1iso1,":[135],"contributes":[136],"early-endosome":[138],"deregulation,":[140],"which":[141],"hallmark":[146],"pathology.":[149]},"counts_by_year":[{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-04-13T00:00:00"}
