{"id":"https://openalex.org/W31488915","doi":null,"title":"Role of the JNK Signal Transduction Pathway in Cell Survival: a Dissertation","display_name":"Role of the JNK Signal Transduction Pathway in Cell Survival: a Dissertation","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W31488915","mag":"31488915"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.umassmed.edu:gsbs_diss-1232","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/gsbs_diss/232","pdf_url":null,"source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Morningside Graduate School of Biomedical Sciences Dissertations and Theses","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003545841","display_name":"Jennifer A. Lamb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer Lamb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003545841"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00199646,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.35519999265670776,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.8199999928474426},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tnf-alpha-induced-apoptosis","display_name":"TNF-induced apoptosis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/jund","display_name":"JunD","score":0.746999979019165},{"id":"https://openalex.org/keywords/ap-1-transcription-factor","display_name":"AP-1 transcription factor","score":0.8939999938011169},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.6949999928474426},{"id":"https://openalex.org/keywords/junb","display_name":"JunB","score":0.7760000228881836},{"id":"https://openalex.org/keywords/jnk1","display_name":"JNK1","score":0.6460000276565552},{"id":"https://openalex.org/keywords/jnk2","display_name":"JNK2","score":0.9570000171661377},{"id":"https://openalex.org/keywords/premature-senescence","display_name":"premature senescence","score":0.8899999856948853},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.6140000224113464},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.7099999785423279},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7889999747276306},{"id":"https://openalex.org/keywords/serine-threonine-kinase","display_name":"serine/threonine kinase","score":0.722000002861023},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6175254583358765},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32439446449279785},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22504284977912903}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.umassmed.edu:gsbs_diss-1232","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/gsbs_diss/232","pdf_url":null,"source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Morningside Graduate School of Biomedical Sciences Dissertations and Theses","raw_type":"text"},{"id":"mag:31488915","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/gsbs_diss/232/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2804576535","https://openalex.org/W2035967893","https://openalex.org/W2063208932","https://openalex.org/W1996681941","https://openalex.org/W2013330018","https://openalex.org/W7097689998","https://openalex.org/W4297970368","https://openalex.org/W1503046511","https://openalex.org/W1976228247","https://openalex.org/W2096686003"],"abstract_inverted_index":{"The":[0,64,105,121,188,524,535],"c-Jun":[1,55],"NH2-terminal":[2],"kinases":[3,10,23],"(JNK)":[4],"are":[5,12,179],"evolutionarily":[6],"conserved":[7],"serine/threonine":[8],"protein":[9,418,483],"that":[11,107,298,376,386,401,468],"activated":[13,65],"by":[14,31,379,411,424],"proinflammatory":[15,138],"cytokines,":[16],"environmental":[17],"stress,":[18],"and":[19,56,81,97,117,146,165,229,306,315,441,455,530],"genotoxic":[20],"agents.":[21],"These":[22,255,465],"play":[24],"key":[25,384,450],"regulatory":[26],"roles":[27,99,451],"within":[28,529],"a":[29,219,271,506],"cell":[30,36,77,82,91,136,263],"coordinating":[32],"signals":[33,528],"from":[34],"the":[35,44,61,86,109,129,152,160,202,258,274,285,289,324,341,381,402,405,432,456,469,478,481,492,511,515,542,549],"surface":[37],"to":[38,71,103,113,127,143,157,172,182,193,222,240,318,352,388,476,508,518,540],"nuclear":[39],"transcription":[40,52,66,268,367],"factors.":[41],"JNK":[42,87,110,133,145,153,176,230,241,247,259,275,281,304,330,357,397,493,499,516],"phosphorylates":[43],"amino":[45],"terminal":[46],"domain":[47],"of":[48,60,85,123,131,162,196,267,273,288,345,348,383,404,420,431,480,498,514,527,544,551],"all":[49,58],"three":[50],"Jun":[51],"factors":[53,67,269,368],"(JunB,":[54],"JunD)":[57],"members":[59],"AP-1":[62,265,290,443,457],"family.":[63],"modulate":[68,369],"gene":[69,370,463],"expression":[70,195,287,382,403,419,479],"generate":[72],"appropriate":[73],"biological":[74],"responses,":[75],"including":[76],"migration,":[78],"proliferation,":[79],"differentiation":[80],"death.\\nThe":[83],"role":[84,130,344],"signaling":[88,111,154,260,343,500,503,546,552],"pathway":[89,112,155,261,471,475,494,517],"in":[90,201,226,246,262,329,413,426,460,485],"death/apoptosis":[92],"is":[93,119,126,141,244,270,282,326,350,373,533],"controversial,":[94],"both":[95,115,227,453],"pro-apoptotic":[96],"pro-survival":[98],"have":[100,296],"been":[101],"attributed":[102,192,239],"JNK.":[104],"mechanism":[106,221,507],"enables":[108],"mediate":[114,301,519],"apoptosis":[116,184],"survival":[118,225,342,406,521],"unclear.":[120],"aim":[122],"this":[124,234,490],"study":[125],"examine":[128],"TNF-stimulated":[132,390],"activation":[134,217],"on":[135],"survival.\\nThe":[137,264],"cytokine":[139],"TNF,":[140],"known":[142,207],"activate":[144],"induce":[147],"apoptosis.":[148,321,356,391,523],"To":[149],"test":[150],"whether":[151],"contributes":[156],"TNF-induced":[158,183,461],"apoptosis,":[159],"response":[161],"wild":[163],"type":[164],"Jnk1-/-":[166],"Jnk2-/-":[167],"(JNK":[168],"deficient":[169,177,231,248,305,331,358,398],"fibroblasts)":[170],"fibroblasts":[171,178,332,399],"TNF":[173,197,214,319,354,412,425,486],"was":[174,409,422],"examined.":[175],"more":[180],"sensitive":[181],"than":[185],"wild-type":[186,228,395,415,428],"fibroblasts.":[187,416,429],"TNF-sensitivity":[189,236,325],"cannot":[190],"be":[191,238,539],"altered":[194],"receptors":[198],"or":[199,204,522],"defects":[200],"NF-\u043aB":[203,216,438,454,474],"AKT":[205],"pathways,":[206],"anti-apoptotic":[208,482],"signal":[209,276],"transduction":[210,277],"pathways.":[211],"(In":[212],"fact,":[213,323],"stimulated":[215],"provides":[218],"major":[220],"account":[223,509],"for":[224,284,452,510],"cells.)":[232],"However":[233],"increased":[235,316],"can":[237,300,339],"deficiency.":[242],"Apoptosis":[243],"suppressed":[245,328],"cells":[249,309,359],"when":[250],"transduced":[251,333,360],"with":[252,334,361,396,473,501],"JNK1":[253],"retrovirus.":[254,336],"data":[256],"implicate":[257],"family":[266,291],"target":[272],"pathway.":[278],"In":[279,322],"addition":[280],"required":[283],"normal":[286],"member,":[292],"JunD.":[293],"Previous":[294],"studies":[295],"indicated":[297,449],"JunD":[299,307,335,338,349,363,377,459],"survival.":[302],"Interestingly,":[303],"null":[308],"display":[310],"similar":[311],"phenotypes:":[312],"premature":[313],"senescence":[314],"sensitivity":[317],"induced":[320,355,410,423],"also":[327],"Although":[337],"replace":[340],"JNK,":[346],"phosphorylation":[347],"essential":[351],"inhibit":[353,389],"phosphomutant":[362],"retrovirus":[364],"maintain":[365],"TNF-sensitivity.\\nActivated":[366],"expression.":[371,464],"It":[372],"most":[374],"likely":[375],"functions":[378],"regulating":[380],"molecules":[385],"act":[387],"Microarray":[392],"analysis":[393],"comparing":[394],"revealed":[400,435],"gene,":[407],"cIAP-2,":[408],"only":[414,427],"Furthermore,":[417],"cIAP-2":[421,433,462,484],"Analysis":[430],"promoter":[434],"two":[436],"critical":[437],"binding":[439,444],"sites":[440],"one":[442],"site.":[445],"Luciferase":[446],"reporter":[447],"assays":[448],"component,":[458],"experiments":[466],"establish":[467],"JNK/JunD":[470],"collaborates":[472],"increase":[477],"treated":[487],"cells.":[488],"Without":[489],"collaboration,":[491],"mediates":[495],"apoptosis.\\nThe":[496],"integration":[497],"other":[502],"pathways":[504,532,547],"represents":[505],"dual":[512],"ability":[513],"either":[520],"dynamic":[525],"coordination":[526],"between":[531],"critical.":[534],"future":[536],"challenge":[537],"will":[538],"fit":[541],"details":[543],"individual":[545],"into":[548],"context":[550],"networks.":[553]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}