{"id":"https://openalex.org/W3148738573","doi":null,"title":"Revista Brasileira de Psiquiatria","display_name":"Revista Brasileira de Psiquiatria","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W3148738573","mag":"3148738573"},"language":"es","primary_location":{"id":"mag:3148738573","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Marcel_Benadiba/publication/235883578_New_molecular_targets_for_PET_and_SPECT_imaging_in_neurodegenerative_diseases/links/00b4952792d9f32593000000.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059684426","display_name":"Marcel Benadiba","orcid":"https://orcid.org/0000-0001-5672-2334","observed_orcids":["https://orcid.org/0000-0001-5672-2334"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcel Benadiba","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5672-2334","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054322115","display_name":"Gert Luurtsema","orcid":"https://orcid.org/0000-0001-8599-8129","observed_orcids":["https://orcid.org/0000-0001-8599-8129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gert Luurtsema","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8599-8129","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072082551","display_name":"Lauro Wichert\u2010Ana","orcid":"https://orcid.org/0000-0003-2059-5120","observed_orcids":["https://orcid.org/0000-0003-2059-5120","https://orcid.org/0000-0002-3722-1099"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lauro Wichert\u2010Ana","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2059-5120","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055580205","display_name":"Carlos Alberto Buchpiguel","orcid":"https://orcid.org/0000-0003-0956-2790","observed_orcids":["https://orcid.org/0000-0003-0956-2790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Alberto Buchpigel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048182376","display_name":"Geraldo F. Busatto","orcid":"https://orcid.org/0000-0003-4749-4602","observed_orcids":["https://orcid.org/0000-0003-4749-4602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geraldo F. Busatto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4749-4602","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.19099999964237213,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9940000176429749},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9869999885559082},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.996999979019165},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":1.0},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.8650000095367432},{"id":"https://openalex.org/keywords/single-photon-emission-computed-tomography","display_name":"single photon emission computed tomography","score":0.996999979019165},{"id":"https://openalex.org/keywords/in-vivo-imaging","display_name":"in vivo imaging","score":0.4699999988079071},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.6660000085830688},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/disease-progression-monitoring","display_name":"disease progression monitoring","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.7739902138710022},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5585938692092896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48463186621665955},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47092145681381226},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2940148115158081},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2789520025253296}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3148738573","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Marcel_Benadiba/publication/235883578_New_molecular_targets_for_PET_and_SPECT_imaging_in_neurodegenerative_diseases/links/00b4952792d9f32593000000.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W412854271","https://openalex.org/W1510712843","https://openalex.org/W1647378451","https://openalex.org/W1796740069","https://openalex.org/W1907416804","https://openalex.org/W1965518966","https://openalex.org/W1967207691","https://openalex.org/W1967642097","https://openalex.org/W1973166472","https://openalex.org/W1976753010","https://openalex.org/W1983102835","https://openalex.org/W1983390737","https://openalex.org/W1984303697","https://openalex.org/W1986837175","https://openalex.org/W1991282216","https://openalex.org/W1995734607","https://openalex.org/W1999605604","https://openalex.org/W2000031872","https://openalex.org/W2001408101","https://openalex.org/W2003169732","https://openalex.org/W2012076586","https://openalex.org/W2016097851","https://openalex.org/W2018365681","https://openalex.org/W2018616136","https://openalex.org/W2018708829","https://openalex.org/W2019019161","https://openalex.org/W2019050557","https://openalex.org/W2019595740","https://openalex.org/W2021356347","https://openalex.org/W2021471758","https://openalex.org/W2022077813","https://openalex.org/W2022296972","https://openalex.org/W2022383347","https://openalex.org/W2023484964","https://openalex.org/W2024449044","https://openalex.org/W2028436804","https://openalex.org/W2029191095","https://openalex.org/W2032736331","https://openalex.org/W2033344011","https://openalex.org/W2033492638","https://openalex.org/W2033759470","https://openalex.org/W2034876350","https://openalex.org/W2035247886","https://openalex.org/W2040174321","https://openalex.org/W2040434160","https://openalex.org/W2041966991","https://openalex.org/W2042907121","https://openalex.org/W2043074324","https://openalex.org/W2043415277","https://openalex.org/W2045064847","https://openalex.org/W2051098162","https://openalex.org/W2051827059","https://openalex.org/W2052366303","https://openalex.org/W2053093036","https://openalex.org/W2053116497","https://openalex.org/W2056608230","https://openalex.org/W2059841300","https://openalex.org/W2060220993","https://openalex.org/W2067897311","https://openalex.org/W2069469473","https://openalex.org/W2071846689","https://openalex.org/W2072303926","https://openalex.org/W2073673434","https://openalex.org/W2074427084","https://openalex.org/W2077541192","https://openalex.org/W2079183773","https://openalex.org/W2079313884","https://openalex.org/W2084299658","https://openalex.org/W2084453905","https://openalex.org/W2084527638","https://openalex.org/W2087924155","https://openalex.org/W2090778626","https://openalex.org/W2093482942","https://openalex.org/W2094088619","https://openalex.org/W2094221501","https://openalex.org/W2097925533","https://openalex.org/W2100442068","https://openalex.org/W2103440561","https://openalex.org/W2112288163","https://openalex.org/W2112865233","https://openalex.org/W2115609442","https://openalex.org/W2116531960","https://openalex.org/W2116750341","https://openalex.org/W2118935127","https://openalex.org/W2119823987","https://openalex.org/W2120095464","https://openalex.org/W2127221119","https://openalex.org/W2130852003","https://openalex.org/W2132766843","https://openalex.org/W2133285177","https://openalex.org/W2133621398","https://openalex.org/W2133719476","https://openalex.org/W2135350966","https://openalex.org/W2139699215","https://openalex.org/W2145035318","https://openalex.org/W2146420070","https://openalex.org/W2146729934","https://openalex.org/W2148933151","https://openalex.org/W2149761960","https://openalex.org/W2149954869","https://openalex.org/W2152038045","https://openalex.org/W2153286749","https://openalex.org/W2153474045","https://openalex.org/W2154780300","https://openalex.org/W2158930854","https://openalex.org/W2159789463","https://openalex.org/W2162142674","https://openalex.org/W2163057869","https://openalex.org/W2163232985","https://openalex.org/W2163372429","https://openalex.org/W2166765896","https://openalex.org/W2167720733","https://openalex.org/W2168962112","https://openalex.org/W4249152566"],"related_works":["https://openalex.org/W2148160826","https://openalex.org/W4393278740","https://openalex.org/W1482949270","https://openalex.org/W3006765030","https://openalex.org/W4404566755","https://openalex.org/W4413107657","https://openalex.org/W3084145585","https://openalex.org/W4390719378","https://openalex.org/W2921565251","https://openalex.org/W2074341690"],"abstract_inverted_index":{"The":[0],"pathophysiology":[1],"of":[2,67,84,88,100,117,133,137],"neurodegenerative":[3],"diseases":[4],"(ND)":[5],"such":[6,50,85],"as":[7,51,122,124],"Alzheimer\u2019s":[8],"disease":[9,13,138],"(AD)":[10],"and":[11,47,58,72,102,109,135],"Parkinson\u2019s":[12],"(PD)":[14],"has":[15],"not":[16],"yet":[17],"been":[18,29],"completely":[19],"elucidated.":[20],"However,":[21],"in":[22,44,63,93,114,128],"the":[23,64,81,115],"past":[24],"few":[25],"years,":[26],"there":[27],"have":[28],"great":[30],"knowledge":[31],"advances":[32],"about":[33],"intra-and":[34],"extracellular":[35],"proteins":[36],"that":[37],"may":[38],"display":[39],"impaired":[40],"function":[41],"or":[42],"expression":[43],"AD,":[45],"PD":[46],"other":[48],"ND,":[49],"amyloid":[52],"beta":[53],"(A\u03b2),":[54],"\u03b1-synuclein,":[55],"tau":[56],"protein":[57],"neuroinflammatory":[59],"markers.":[60],"Recent":[61],"developments":[62],"imaging":[65],"techniques":[66],"positron":[68],"emission":[69,75],"tomography":[70,77],"(PET)":[71],"single":[73],"photon":[74],"computed":[76],"(SPECT)":[78],"now":[79],"allow":[80],"non-invasive":[82],"tracking":[83],"molecular":[86],"targets":[87],"known":[89],"relevance":[90],"to":[91,130],"ND":[92,121,134],"vivo.":[94],"This":[95],"article":[96],"summarizes":[97],"recent":[98],"findings":[99],"PET":[101],"SPECT":[103],"studies":[104],"using":[105],"these":[106],"novel":[107],"methods,":[108],"discusses":[110],"their":[111],"potential":[112],"role":[113],"field":[116],"drug":[118],"development":[119],"for":[120],"well":[123],"future":[125],"clinical":[126],"applications":[127],"regard":[129],"differential":[131],"diagnosis":[132],"monitoring":[136],"progression.":[139]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-04-13T00:00:00"}