{"id":"https://openalex.org/W3148523922","doi":"https://doi.org/10.21203/rs.3.rs-360686/v1","title":"Dual Targeting of Integrin \u03b1v\u03b23 and VEGF Receptor Improves PET Imaging of Breast Cancer","display_name":"Dual Targeting of Integrin \u03b1v\u03b23 and VEGF Receptor Improves PET Imaging of Breast Cancer","publication_year":2021,"publication_date":"2021-03-30","ids":{"openalex":"https://openalex.org/W3148523922","doi":"https://doi.org/10.21203/rs.3.rs-360686/v1","mag":"3148523922"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-360686/v1","doi":"https://doi.org/10.21203/rs.3.rs-360686/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-360686/v1","pdf_url":"https://www.researchsquare.com/article/rs-360686/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-360686/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043198278","display_name":"Lanlin Yao","orcid":"https://orcid.org/0000-0002-1801-6081","observed_orcids":["https://orcid.org/0000-0002-1801-6081"]},"institutions":[{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lanlin Yao","raw_affiliation_strings":["The First Affiliated Hospital of Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Xiamen University","institution_ids":["https://openalex.org/I4210087327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089041127","display_name":"Yesen Li","orcid":"https://orcid.org/0000-0002-7689-6363","observed_orcids":["https://orcid.org/0000-0002-7689-6363"]},"institutions":[{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yesen Li","raw_affiliation_strings":["The First Affiliated Hospital of Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Xiamen University","institution_ids":["https://openalex.org/I4210087327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031029049","display_name":"Haojun Chen","orcid":"https://orcid.org/0000-0002-9101-8884","observed_orcids":["https://orcid.org/0000-0002-9101-8884"]},"institutions":[{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haojun Chen","raw_affiliation_strings":["The First Affiliated Hospital of Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Xiamen University","institution_ids":["https://openalex.org/I4210087327"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xuejun Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272336","display_name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","ror":"https://ror.org/040qz4226","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272336"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuejun Wen","raw_affiliation_strings":["State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","institution_ids":["https://openalex.org/I4405272336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075562958","display_name":"Yizheng Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yizheng Pang","raw_affiliation_strings":["The First Affiliated Hospital of Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Xiamen University","institution_ids":["https://openalex.org/I4210087327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101609784","display_name":"Zijun Chen","orcid":"https://orcid.org/0000-0003-2051-2938","observed_orcids":["https://orcid.org/0000-0003-2051-2938"]},"institutions":[{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zijun Chen","raw_affiliation_strings":["The First Affiliated Hospital of Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Xiamen University","institution_ids":["https://openalex.org/I4210087327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003848809","display_name":"Zhide Guo","orcid":"https://orcid.org/0000-0002-9110-159X","observed_orcids":["https://orcid.org/0000-0002-9110-159X","https://orcid.org/0000-0002-3371-9295"]},"institutions":[{"id":"https://openalex.org/I4405272336","display_name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","ror":"https://ror.org/040qz4226","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272336"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhide Guo","raw_affiliation_strings":["State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","institution_ids":["https://openalex.org/I4405272336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068113724","display_name":"Xianzhong Zhang","orcid":"https://orcid.org/0000-0001-8591-8301","observed_orcids":["https://orcid.org/0000-0001-8591-8301"]},"institutions":[{"id":"https://openalex.org/I4405272336","display_name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","ror":"https://ror.org/040qz4226","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405272336"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianzhong Zhang","raw_affiliation_strings":["State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","institution_ids":["https://openalex.org/I4405272336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103271899","display_name":"Hua Wu","orcid":"https://orcid.org/0000-0002-5392-3234","observed_orcids":["https://orcid.org/0000-0002-5392-3234"]},"institutions":[{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Wu","raw_affiliation_strings":["The First Affiliated Hospital of Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Xiamen University","institution_ids":["https://openalex.org/I4210087327"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013391830","display_name":"Wei Guo","orcid":"https://orcid.org/0000-0002-7868-2684","observed_orcids":["https://orcid.org/0000-0002-7868-2684"]},"institutions":[{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Guo","raw_affiliation_strings":["The First Affiliated Hospital of Xiamen University"],"raw_orcid":"https://orcid.org/0000-0002-7868-2684","affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Xiamen University","institution_ids":["https://openalex.org/I4210087327"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-imaging","display_name":"breast cancer imaging","score":0.8700000047683716},{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":0.972000002861023},{"id":"https://openalex.org/keywords/neuropilin-1","display_name":"neuropilin-1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vegf-receptors","display_name":"VEGF receptors","score":0.8050000071525574},{"id":"https://openalex.org/keywords/rgd-peptide","display_name":"RGD peptide","score":0.7979999780654907},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.6140000224113464},{"id":"https://openalex.org/keywords/mcf-7-xenografts","display_name":"MCF-7 xenografts","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tumor-targeting-specificity","display_name":"tumor targeting specificity","score":0.5759999752044678},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6650299429893494},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.6410162448883057},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5368440747261047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4874846935272217},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47375327348709106},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45020759105682373},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39578330516815186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3816486895084381},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3366272449493408}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-360686/v1","doi":"https://doi.org/10.21203/rs.3.rs-360686/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-360686/v1","pdf_url":"https://www.researchsquare.com/article/rs-360686/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-360686/v1","doi":"https://doi.org/10.21203/rs.3.rs-360686/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-360686/v1","pdf_url":"https://www.researchsquare.com/article/rs-360686/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1978927977","display_name":null,"funder_award_id":"81471684","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7139432741","display_name":null,"funder_award_id":"81801735","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3148523922.pdf","grobid_xml":"https://content.openalex.org/works/W3148523922.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2029203386","https://openalex.org/W2073775185","https://openalex.org/W2198691414","https://openalex.org/W2507742464","https://openalex.org/W2526678081","https://openalex.org/W2637198528","https://openalex.org/W2749366950","https://openalex.org/W2805305511","https://openalex.org/W2806631624","https://openalex.org/W2891345952","https://openalex.org/W2909709257","https://openalex.org/W2971652399","https://openalex.org/W3019107393","https://openalex.org/W3027483951","https://openalex.org/W3119977236"],"related_works":["https://openalex.org/W4223449108","https://openalex.org/W2995755583","https://openalex.org/W7163986414","https://openalex.org/W2391026663","https://openalex.org/W1990531088","https://openalex.org/W1973914960","https://openalex.org/W4413140883","https://openalex.org/W3014772987","https://openalex.org/W2065246138","https://openalex.org/W2791321995"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Neuropilin-1":[2],"(NRP-1)":[3],"and":[4,17,26,35,61,65,74,82,88,112,139,143,155,163,173],"integrin":[5,33,80,156],"\u03b1v\u03b23":[6,34,81],"receptors":[7],"are":[8],"both":[9],"overexpressed":[10],"in":[11,47,51,72,75,85,97,134],"breast":[12,187],"cancer.":[13],"Methods:":[14],"We":[15,37,77],"developed":[16],"synthesized":[18],"a":[19],"heterodimeric":[20,45],"tracer":[21,151],"consisting":[22],"of":[23,43,68],"Arg\u2212Gly\u2212Asp":[24],"(RGD)":[25],"Ala-Thr-Trp-Leu-Pro-Pro-Arg":[27],"(ATWLPPR)":[28],"peptides":[29,46,55],"that":[30,104,149],"simultaneously":[31],"targets":[32,153],"NRP-1.":[36],"then":[38,57],"investigated":[39,71],"the":[40,62,119,150],"diagnostic":[41],"efficacy":[42,67],"RGD-ATWLPPR":[44,54],"MCF-7":[48,86,105],"xenograft":[49],"models":[50],"mice.":[52],"DOTA-conjugated":[53],"were":[56,70,107],"radiolabeled":[58],"with":[59,161],"68Ga,":[60],"receptor-binding":[63],"characteristics":[64],"tumor-targeting":[66],"68Ga-DOTA-RGD-ATWLPPR":[69,116,147,165],"vitro":[73],"vivo.":[76],"also":[78],"detected":[79],"NRP-1":[83,154],"expression":[84],"cells":[87],"tumor":[89,123,175],"tissues.":[90],"Results:":[91],"The":[92],"peptide":[93],"showed":[94,103,121,148],"high":[95],"stability":[96],"vitro.":[98],"Static":[99],"PET/CT":[100],"imaging":[101,184],"studies":[102,136,145],"tumors":[106],"clearly":[108],"visible":[109],"30":[110],"min":[111,114],"60":[113],"after":[115],"injection.":[117],"Further,":[118],"heterodimer":[120],"higher":[122,167],"uptake":[124],"than":[125],"68Ga-DOTA-RGD":[126,162],"or":[127],"68Ga-DOTA-ATWLPPR":[128],"alone.":[129],"High":[130],"specificity":[131],"was":[132],"shown":[133],"blocking":[135],"using":[137,146],"RGD":[138],"ATWLPPR":[140],"peptides.":[141],"MicroPET/CT":[142],"biodistribution":[144],"specifically":[152],"\u03b1\u03bd\u03b23":[157],"receptors.":[158],"Conclusions:":[159],"Compared":[160],"68Ga-DOTA-ATWLPPR,":[164],"has":[166,180],"binding":[168],"affinity,":[169],"better":[170],"targeting":[171],"efficiency,":[172],"longer":[174],"retention":[176],"time.":[177],"It":[178],"therefore":[179],"potential":[181],"as":[182],"an":[183],"probe":[185],"for":[186],"cancer":[188],"detection.":[189]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2021-04-13T00:00:00"}