{"id":"https://openalex.org/W3148049554","doi":"https://doi.org/10.1017/cts.2021.690","title":"00005 Urine tumor DNA detects minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy","display_name":"00005 Urine tumor DNA detects minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy","publication_year":2021,"publication_date":"2021-03-01","ids":{"openalex":"https://openalex.org/W3148049554","doi":"https://doi.org/10.1017/cts.2021.690","mag":"3148049554"},"language":"en","primary_location":{"id":"doi:10.1017/cts.2021.690","doi":"https://doi.org/10.1017/cts.2021.690","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2021.690","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/0A12D8BF0EF884576A0EDF0E1C7A5E5A/S2059866121006907a.pdf/div-class-title-00005-urine-tumor-dna-detects-minimal-residual-disease-in-muscle-invasive-bladder-cancer-treated-with-curative-intent-radical-cystectomy-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/0A12D8BF0EF884576A0EDF0E1C7A5E5A/S2059866121006907a.pdf/div-class-title-00005-urine-tumor-dna-detects-minimal-residual-disease-in-muscle-invasive-bladder-cancer-treated-with-curative-intent-radical-cystectomy-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100350905","display_name":"Kevin Yi Chen","orcid":"https://orcid.org/0009-0003-4223-7938","observed_orcids":["https://orcid.org/0009-0003-4223-7938","https://orcid.org/0000-0002-5421-1538"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Chen","raw_affiliation_strings":["Washington University School of Medicine in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087963216","display_name":"Pradeep S. Chauhan","orcid":"https://orcid.org/0000-0003-4304-011X","observed_orcids":["https://orcid.org/0000-0003-4304-011X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pradeep S. Chauhan","raw_affiliation_strings":["Washington University School of Medicine in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006165195","display_name":"Ramandeep K. Babbra","orcid":"https://orcid.org/0000-0002-6244-5107","observed_orcids":["https://orcid.org/0000-0002-6244-5107"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramandeep K. Babbra","raw_affiliation_strings":["Washington University School of Medicine in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037828313","display_name":"Wenjia Feng","orcid":"https://orcid.org/0000-0002-6320-3927","observed_orcids":["https://orcid.org/0000-0002-6320-3927"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenjia Feng","raw_affiliation_strings":["Washington University School of Medicine in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100779047","display_name":"Eric H. Kim","orcid":"https://orcid.org/0000-0002-0284-8342","observed_orcids":["https://orcid.org/0000-0002-0284-8342"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric H. Kim","raw_affiliation_strings":["Washington University School of Medicine in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058121721","display_name":"Zachary L. Smith","orcid":"https://orcid.org/0000-0002-5945-3288","observed_orcids":["https://orcid.org/0000-0002-5945-3288"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary L. Smith","raw_affiliation_strings":["Washington University School of Medicine in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071620573","display_name":"Vivek K. Arora","orcid":"https://orcid.org/0000-0003-1694-9109","observed_orcids":["https://orcid.org/0000-0003-1694-9109"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek K. Arora","raw_affiliation_strings":["Washington University School of Medicine in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070207276","display_name":"Aadel A. Chaudhuri","orcid":"https://orcid.org/0000-0003-3115-3061","observed_orcids":["https://orcid.org/0000-0003-3115-3061"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aadel A. Chaudhuri","raw_affiliation_strings":["Washington University School of Medicine in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":1750,"currency":"USD","value_usd":1750},"apc_paid":{"value":1750,"currency":"USD","value_usd":1750},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05681173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"s1","first_page":"113","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.4088999927043915,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.8140000104904175},{"id":"https://openalex.org/keywords/muscle-invasive-bladder-cancer","display_name":"muscle-invasive bladder cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/radical-cystectomy","display_name":"radical cystectomy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.7310000061988831},{"id":"https://openalex.org/keywords/bladder-sparing-therapy","display_name":"bladder-sparing treatment","score":0.8479999899864197},{"id":"https://openalex.org/keywords/adjuvant-immunotherapy","display_name":"adjuvant immunotherapy","score":0.8379999995231628},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.8650000095367432},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.8999999761581421},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9729999899864197},{"id":"https://openalex.org/keywords/variant-allele-frequency","display_name":"variant allele frequency","score":0.8130000233650208},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6710000038146973},{"id":"https://openalex.org/keywords/patient-selection-for-immunotherapy","display_name":"immunotherapy selection","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2775910329","wikidata":"https://www.wikidata.org/wiki/Q245995","display_name":"Cystectomy","level":4,"score":0.9141521453857422},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.8171166181564331},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6463609933853149},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.5427274107933044},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4820883572101593},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.46810221672058105},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.46716320514678955},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.433857798576355},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4154673218727112},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3968668580055237},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38217973709106445},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1017/cts.2021.690","doi":"https://doi.org/10.1017/cts.2021.690","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2021.690","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/0A12D8BF0EF884576A0EDF0E1C7A5E5A/S2059866121006907a.pdf/div-class-title-00005-urine-tumor-dna-detects-minimal-residual-disease-in-muscle-invasive-bladder-cancer-treated-with-curative-intent-radical-cystectomy-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8827992","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8827992","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Transl Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f94b2114ff41450a887fc12541e7fb63","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f94b2114ff41450a887fc12541e7fb63","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical and Translational Science, Vol 5, Pp 113-114 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1017/cts.2021.690","doi":"https://doi.org/10.1017/cts.2021.690","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2021.690","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/0A12D8BF0EF884576A0EDF0E1C7A5E5A/S2059866121006907a.pdf/div-class-title-00005-urine-tumor-dna-detects-minimal-residual-disease-in-muscle-invasive-bladder-cancer-treated-with-curative-intent-radical-cystectomy-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3148049554.pdf","grobid_xml":"https://content.openalex.org/works/W3148049554.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3196536233","https://openalex.org/W3182417193","https://openalex.org/W4324137070","https://openalex.org/W3173023590","https://openalex.org/W3208628758","https://openalex.org/W7162630763","https://openalex.org/W4394802210","https://openalex.org/W4400108782","https://openalex.org/W4410823007","https://openalex.org/W4212886718"],"abstract_inverted_index":{"ABSTRACT":[0],"IMPACT:":[1],"Urine":[2,144],"tumor":[3,12,77,118],"DNA":[4,78,96,168],"non-invasively":[5,59,115,320],"detects":[6],"minimal":[7,55],"residual":[8,56,194],"disease":[9,57,195],"and":[10,238,306],"infers":[11],"mutational":[13,119,153],"burden":[14,154],"in":[15,165,191,197,331],"locally":[16],"advanced":[17],"bladder":[18,45,109],"cancer":[19,46],"prior":[20,117,298],"to":[21,53,63,69,93,202,218,258,275,299],"radical":[22,49,103],"cystectomy,":[23],"which":[24,309,323],"may":[25,283,310],"potentially":[26],"enable":[27],"the":[28,100,131,135,159,227,332],"selection":[29],"of":[30,102,161,180,229,236,240],"patients":[31,107,192,277,313,330],"for":[32,43,90,125,287,314,329],"bladder-sparing":[33,65,315],"treatment":[34,42],"or":[35],"facilitate":[36,325],"personalized":[37,326],"adjuvant":[38,327],"immunotherapy.":[39],"OBJECTIVES/GOALS:":[40],"Standard-of-care":[41],"muscle-invasive":[44],"(MIBC)":[47],"is":[48],"cystectomy.":[50],"The":[51,121],"inability":[52],"assess":[54],"(MRD)":[58],"limits":[60],"our":[61],"ability":[62],"offer":[64],"treatment.":[66,316],"We":[67,83],"sought":[68],"develop":[70],"a":[71,86,171,206,234,265],"liquid":[72],"biopsy":[73],"solution":[74],"via":[75],"urine":[76,94,166],"(utDNA)":[79],"analysis.":[80],"METHODS/STUDY":[81],"POPULATION:":[82],"applied":[84,264],"uCAPP-Seq,":[85],"targeted":[87],"sequencing":[88,179],"method":[89],"detecting":[91],"utDNA,":[92],"cell-free":[95,167],"samples":[97],"acquired":[98],"on":[99],"day":[101],"cystectomy":[104],"from":[105,148,158,175],"42":[106],"with":[108,134,193,233,278,303],"cancer.":[110],"utDNA":[111,123,186,216,223,243,260,295,317],"variant-calling":[112],"was":[113,128,145,156],"performed":[114],"without":[116],"knowledge.":[120],"overall":[122],"level":[124],"each":[126],"patient":[127],"represented":[129],"by":[130,169],"non-silent":[132,162],"mutation":[133],"highest":[136],"variant":[137],"allele":[138],"fraction":[139],"after":[140],"removing":[141],"germline":[142],"variants.":[143],"similarly":[146],"analyzed":[147],"15":[149],"healthy":[150],"adults.":[151],"Tumor":[152],"(TMB)":[155],"inferred":[157,280],"number":[160],"mutations":[163],"detected":[164,196],"applying":[170],"linear":[172,266],"relationship":[173,267],"derived":[174],"TCGA":[176],"whole":[177],"exome":[178],"409":[181],"MIBC":[182],"tumors.":[183],"RESULTS/ANTICIPATED":[184],"RESULTS:":[185],"levels":[187],"were":[188],"significantly":[189,225,247,302],"higher":[190],"their":[198],"surgical":[199],"pathology":[200],"compared":[201,257],"those":[203],"who":[204,282],"achieved":[205],"pathologic":[207,230,304],"complete":[208,231],"response":[209,232,305],"(P":[210],"=":[211,252,255,270],"0.002).":[212],"Using":[213],"an":[214],"optimal":[215],"threshold":[217],"define":[219],"MRD":[220,224,244,296],"detection,":[221],"positive":[222],"predicted":[226],"absence":[228],"sensitivity":[235],"81%":[237],"specificity":[239],"81%.":[241],"Positive":[242],"also":[245,319],"portended":[246],"worse":[248],"progression-free":[249,307],"survival":[250],"(HR":[251],"7.4;":[253],"P":[254,272],"0.03)":[256],"negative":[259],"MRD.":[261],"Furthermore,":[262],"we":[263],"(Pearson":[268],"r":[269],"0.84;":[271],"<":[273],"0.0001)":[274],"identify":[276],"high":[279],"TMB":[281],"have":[284],"been":[285],"candidates":[286],"early":[288],"immune":[289],"checkpoint":[290],"blockade.":[291],"DISCUSSION/SIGNIFICANCE":[292],"OF":[293],"FINDINGS:":[294],"analysis":[297],"surgery":[300],"correlated":[301],"survival,":[308],"help":[311],"select":[312],"can":[318],"infer":[321],"TMB,":[322],"could":[324],"therapy":[328],"future.":[333]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2021-04-13T00:00:00"}
