{"id":"https://openalex.org/W314798373","doi":"https://doi.org/10.1016/j.coph.2015.04.003","title":"Cachexia and sarcopenia: mechanisms and potential targets for intervention","display_name":"Cachexia and sarcopenia: mechanisms and potential targets for intervention","publication_year":2015,"publication_date":"2015-05-14","ids":{"openalex":"https://openalex.org/W314798373","doi":"https://doi.org/10.1016/j.coph.2015.04.003","mag":"314798373","pmid":"https://pubmed.ncbi.nlm.nih.gov/25974750"},"language":"en","primary_location":{"id":"doi:10.1016/j.coph.2015.04.003","doi":"https://doi.org/10.1016/j.coph.2015.04.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coph.2015.04.003","pdf_url":null,"source":{"id":"https://openalex.org/S13215328","display_name":"Current Opinion in Pharmacology","issn_l":"1471-4892","issn":["1471-4892","1471-4973"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W314798373"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048204665","display_name":"Josep Mar\u00eda Adell Argil\u00e9s","orcid":"https://orcid.org/0000-0003-4683-5428","observed_orcids":["https://orcid.org/0000-0003-4683-5428"]},"institutions":[{"id":"https://openalex.org/I4388891874","display_name":"Institut de Biomedicina de la Universitat de Barcelona","ror":"https://ror.org/01y43zx14","country_code":"ES","type":"education","lineage":["https://openalex.org/I4388891874","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Josep M Argil\u00e9s","raw_affiliation_strings":["Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain","Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain","Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4388891874","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4388891874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005897976","display_name":"S\u00edlvia Busquets","orcid":"https://orcid.org/0000-0002-9319-3555","observed_orcids":["https://orcid.org/0000-0002-9319-3555","https://orcid.org/0000-0001-8177-8348"]},"institutions":[{"id":"https://openalex.org/I4388891874","display_name":"Institut de Biomedicina de la Universitat de Barcelona","ror":"https://ror.org/01y43zx14","country_code":"ES","type":"education","lineage":["https://openalex.org/I4388891874","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Silvia Busquets","raw_affiliation_strings":["Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain. Electronic address: silviabusquets@ub.edu","Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain","Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain. Electronic address: silviabusquets@ub.edu","institution_ids":["https://openalex.org/I4388891874","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4388891874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016102725","display_name":"Britta Stemmler","orcid":"https://orcid.org/0009-0006-1526-1790","observed_orcids":["https://orcid.org/0009-0006-1526-1790"]},"institutions":[{"id":"https://openalex.org/I4210112049","display_name":"Nutrition & Sant\u00e9 (Spain)","ror":"https://ror.org/02tx52885","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210112049"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Britta Stemmler","raw_affiliation_strings":["BSA Nutrition Centre, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BSA Nutrition Centre, Barcelona, Spain","institution_ids":["https://openalex.org/I4210112049"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067995365","display_name":"Francisco Javier L\u00f3pez-Soriano","orcid":"https://orcid.org/0000-0003-1493-3023","observed_orcids":["https://orcid.org/0000-0003-1493-3023"]},"institutions":[{"id":"https://openalex.org/I4388891874","display_name":"Institut de Biomedicina de la Universitat de Barcelona","ror":"https://ror.org/01y43zx14","country_code":"ES","type":"education","lineage":["https://openalex.org/I4388891874","https://openalex.org/I71999127"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco J L\u00f3pez-Soriano","raw_affiliation_strings":["Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain","Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain","Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4388891874","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Cancer Research Group, Departament de Bioqu\u00edmica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4388891874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005897976"],"corresponding_institution_ids":["https://openalex.org/I4388891874","https://openalex.org/I71999127"],"apc_list":{"value":3510,"currency":"USD","value_usd":3510},"apc_paid":null,"fwci":3.4595,"has_fulltext":false,"cited_by_count":333,"citation_normalized_percentile":{"value":0.96568627,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"22","issue":null,"first_page":"100","last_page":"106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.5595999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.5595999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.43630000948905945,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cachexia","display_name":"cachexia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":1.0},{"id":"https://openalex.org/keywords/skeletal-muscle-atrophy","display_name":"skeletal muscle atrophy","score":0.859000027179718},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/myocyte-apoptosis","display_name":"myocyte apoptosis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/muscle-regeneration","display_name":"muscle regeneration","score":0.6029999852180481},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.843999981880188},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9789999723434448},{"id":"https://openalex.org/keywords/protein-synthesis-and-degradation","display_name":"protein synthesis and degradation","score":0.5770000219345093},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/anorexia","display_name":"anorexia","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cancer-cachexia","display_name":"cancer cachexia","score":0.7039999961853027},{"id":"https://openalex.org/keywords/healthy-aging","display_name":"healthy aging","score":0.7139999866485596},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.878000020980835}],"concepts":[{"id":"https://openalex.org/C2777704314","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cachexia","level":3,"score":0.9109872579574585},{"id":"https://openalex.org/C2779764123","wikidata":"https://www.wikidata.org/wiki/Q7972881","display_name":"Wasting","level":2,"score":0.8886493444442749},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.8837860822677612},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7331132888793945},{"id":"https://openalex.org/C2778654693","wikidata":"https://www.wikidata.org/wiki/Q254327","display_name":"Anorexia","level":2,"score":0.6426924467086792},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5565431714057922},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5392467379570007},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5382205843925476},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48720210790634155},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.4572235941886902},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4546854496002197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4425390958786011},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.4218181371688843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3746168613433838},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2671735882759094},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.14071238040924072}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002100","descriptor_name":"Cachexia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055948","descriptor_name":"Sarcopenia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D055948","descriptor_name":"Sarcopenia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D055948","descriptor_name":"Sarcopenia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.coph.2015.04.003","doi":"https://doi.org/10.1016/j.coph.2015.04.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coph.2015.04.003","pdf_url":null,"source":{"id":"https://openalex.org/S13215328","display_name":"Current Opinion in Pharmacology","issn_l":"1471-4892","issn":["1471-4892","1471-4973"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Pharmacology","raw_type":"journal-article"},{"id":"pmid:25974750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25974750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G135111123","display_name":null,"funder_award_id":"SAF 26091-2011","funder_id":"https://openalex.org/F4320321739","funder_display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda"},{"id":"https://openalex.org/G4134995162","display_name":null,"funder_award_id":"SAF 26091 2011","funder_id":"https://openalex.org/F4320323737","funder_display_name":"Ministerio de Ciencia y Tecnolog\u00eda"}],"funders":[{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"},{"id":"https://openalex.org/F4320323737","display_name":"Ministerio de Ciencia y Tecnolog\u00eda","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W184703081","https://openalex.org/W196236367","https://openalex.org/W1560089387","https://openalex.org/W1920702573","https://openalex.org/W1968698003","https://openalex.org/W1968827777","https://openalex.org/W1970080134","https://openalex.org/W1975708365","https://openalex.org/W1985471058","https://openalex.org/W1996734072","https://openalex.org/W1997789055","https://openalex.org/W2003064100","https://openalex.org/W2019743110","https://openalex.org/W2020950228","https://openalex.org/W2022060563","https://openalex.org/W2024010226","https://openalex.org/W2030772730","https://openalex.org/W2034058585","https://openalex.org/W2035304443","https://openalex.org/W2043541438","https://openalex.org/W2048798480","https://openalex.org/W2058368576","https://openalex.org/W2062078253","https://openalex.org/W2063690006","https://openalex.org/W2066734635","https://openalex.org/W2085184858","https://openalex.org/W2086792627","https://openalex.org/W2088086126","https://openalex.org/W2088307238","https://openalex.org/W2091482618","https://openalex.org/W2093524310","https://openalex.org/W2102902846","https://openalex.org/W2104097983","https://openalex.org/W2109795229","https://openalex.org/W2116294028","https://openalex.org/W2117033249","https://openalex.org/W2127424726","https://openalex.org/W2131264254","https://openalex.org/W2137229109","https://openalex.org/W2142749323","https://openalex.org/W2145280166","https://openalex.org/W2147556188","https://openalex.org/W2148901052","https://openalex.org/W2149953626","https://openalex.org/W2150683917","https://openalex.org/W2152409376","https://openalex.org/W2157924103","https://openalex.org/W2170351370","https://openalex.org/W2324831040","https://openalex.org/W2415082419"],"related_works":["https://openalex.org/W2268548723","https://openalex.org/W2401761488","https://openalex.org/W2049274197","https://openalex.org/W1560089387","https://openalex.org/W2121603818","https://openalex.org/W3183472519","https://openalex.org/W4406112543","https://openalex.org/W2085548226","https://openalex.org/W2049572120","https://openalex.org/W2124477946"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":35},{"year":2024,"cited_by_count":33},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":32},{"year":2021,"cited_by_count":32},{"year":2020,"cited_by_count":35},{"year":2019,"cited_by_count":35},{"year":2018,"cited_by_count":37},{"year":2017,"cited_by_count":27},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":7}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}