{"id":"https://openalex.org/W3147728334","doi":null,"title":"CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment.","display_name":"CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment.","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3147728334","mag":"3147728334","pmid":"https://pubmed.ncbi.nlm.nih.gov/33791155","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7994168"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7994168","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7994168","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7994168","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076636659","display_name":"Wen\u2010Chieh Liao","orcid":"https://orcid.org/0000-0001-7848-2124","observed_orcids":["https://orcid.org/0000-0001-7848-2124"]},"institutions":[{"id":"https://openalex.org/I4210104362","display_name":"Chung Shan Medical University Hospital","ror":"https://ror.org/01abtsn51","country_code":"TW","type":"funder","lineage":["https://openalex.org/I4210104362"]},{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-Chieh Liao","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Chung Shan Medical University, Taichung, Taiwan","Department of Medical Education, Chung Shan Medical University Hospital Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Chung Shan Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]},{"raw_affiliation_string":"Department of Medical Education, Chung Shan Medical University Hospital Taichung, Taiwan","institution_ids":["https://openalex.org/I4210104362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030166913","display_name":"Hung\u2010Rong Yen","orcid":"https://orcid.org/0000-0002-0131-1658","observed_orcids":["https://orcid.org/0000-0002-0131-1658"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hung-Rong Yen","raw_affiliation_strings":["School of Chinese Medicine, China Medical University, Taichung. Taiwan","Department of Chinese Medicine, China Medical University Hospital Taichung, Taiwan","Chinese Medicine Research Center, China Medical University Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Medicine, China Medical University, Taichung. Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Department of Chinese Medicine, China Medical University Hospital Taichung, Taiwan","institution_ids":["https://openalex.org/I4210126829"]},{"raw_affiliation_string":"Chinese Medicine Research Center, China Medical University Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017671441","display_name":"Chia\u2010Hua Chen","orcid":"https://orcid.org/0000-0003-0536-8085","observed_orcids":["https://orcid.org/0000-0003-0536-8085"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Hua Chen","raw_affiliation_strings":["Molecular Medicine Research Center, Chang Gung University Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine Research Center, Chang Gung University Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102465589","display_name":"Yin-Hung Chu","orcid":"https://orcid.org/0009-0002-3641-1912","observed_orcids":["https://orcid.org/0009-0002-3641-1912"]},"institutions":[{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yin-Hung Chu","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Chung Shan Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Chung Shan Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088328453","display_name":"Ying Song","orcid":"https://orcid.org/0000-0003-0279-4652","observed_orcids":["https://orcid.org/0000-0003-0279-4652"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ying-Chyi Song","raw_affiliation_strings":["School of Chinese Medicine, China Medical University Taichung, Taiwan","Chinese Medicine Research Center, China Medical University Taichung, Taiwan","Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Medicine, China Medical University Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Chinese Medicine Research Center, China Medical University Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068124939","display_name":"To-Jung Tseng","orcid":"https://orcid.org/0000-0001-5837-2235","observed_orcids":["https://orcid.org/0000-0001-5837-2235"]},"institutions":[{"id":"https://openalex.org/I4210104362","display_name":"Chung Shan Medical University Hospital","ror":"https://ror.org/01abtsn51","country_code":"TW","type":"funder","lineage":["https://openalex.org/I4210104362"]},{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"To-Jung Tseng","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Chung Shan Medical University Taichung, Taiwan","Department of Medical Education, Chung Shan Medical University Hospital Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Chung Shan Medical University Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]},{"raw_affiliation_string":"Department of Medical Education, Chung Shan Medical University Hospital Taichung, Taiwan","institution_ids":["https://openalex.org/I4210104362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001618120","display_name":"Chiung\u2010Hui Liu","orcid":"https://orcid.org/0000-0002-2656-2576","observed_orcids":["https://orcid.org/0000-0002-2656-2576"]},"institutions":[{"id":"https://openalex.org/I4210104362","display_name":"Chung Shan Medical University Hospital","ror":"https://ror.org/01abtsn51","country_code":"TW","type":"funder","lineage":["https://openalex.org/I4210104362"]},{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chiung-Hui Liu","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Chung Shan Medical University Taichung, Taiwan","Department of Medical Education, Chung Shan Medical University Hospital Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Chung Shan Medical University Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]},{"raw_affiliation_string":"Department of Medical Education, Chung Shan Medical University Hospital Taichung, Taiwan","institution_ids":["https://openalex.org/I4210104362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0609,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.86911588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"11","issue":"3","first_page":"812","last_page":"826"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/syndecan-4","display_name":"syndecan-4","score":0.8899999856948853},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9380000233650208},{"id":"https://openalex.org/keywords/extracellular-matrix-modification","display_name":"extracellular matrix modification","score":0.4749999940395355},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7865031957626343},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6952834725379944},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6414660215377808},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6235588788986206},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5990992188453674},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5965532064437866},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5337881445884705},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4996182918548584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4659239947795868},{"id":"https://openalex.org/C118646709","wikidata":"https://www.wikidata.org/wiki/Q1657620","display_name":"CA15-3","level":4,"score":0.4316054880619049},{"id":"https://openalex.org/C65001120","wikidata":"https://www.wikidata.org/wiki/Q14912913","display_name":"Syndecan 1","level":3,"score":0.43075573444366455},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3424686789512634},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3404436707496643},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3234233260154724},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10519713163375854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:7994168","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7994168","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:33791155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33791155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"mag:3147728334","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/MED/33791155","pdf_url":null,"source":{"id":"https://openalex.org/S198195518","display_name":"American Journal of Cancer Research","issn_l":"2156-6976","issn":["2156-6976"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","norway-1","poland-100"],"host_organization":"https://openalex.org/P4310320994","host_organization_name":"e-Century Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310320994"],"host_organization_lineage_names":["e-Century Publishing Corporation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Cancer Research","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7994168","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7994168","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1531194977","https://openalex.org/W1889990950","https://openalex.org/W1898194260","https://openalex.org/W1964081206","https://openalex.org/W1968475366","https://openalex.org/W2000153205","https://openalex.org/W2006188134","https://openalex.org/W2019209583","https://openalex.org/W2023990383","https://openalex.org/W2035640198","https://openalex.org/W2051833330","https://openalex.org/W2061273916","https://openalex.org/W2064315259","https://openalex.org/W2097674841","https://openalex.org/W2100240574","https://openalex.org/W2111787323","https://openalex.org/W2139731402","https://openalex.org/W2149441684","https://openalex.org/W2150032631","https://openalex.org/W2154931831","https://openalex.org/W2157793046","https://openalex.org/W2166171496","https://openalex.org/W2167629024","https://openalex.org/W2215578332","https://openalex.org/W2265419075","https://openalex.org/W2266814182","https://openalex.org/W2274939643","https://openalex.org/W2290411490","https://openalex.org/W2303301650","https://openalex.org/W2399999257","https://openalex.org/W2511964116","https://openalex.org/W2577967191","https://openalex.org/W2656075814","https://openalex.org/W2743587567","https://openalex.org/W2766991138","https://openalex.org/W2767529657","https://openalex.org/W2781844803","https://openalex.org/W2783055842","https://openalex.org/W2886688163","https://openalex.org/W2887484375","https://openalex.org/W2889646458","https://openalex.org/W2942793545","https://openalex.org/W2945867085","https://openalex.org/W2948505287","https://openalex.org/W2954322358","https://openalex.org/W2960011166","https://openalex.org/W2980454391","https://openalex.org/W3005385755"],"related_works":["https://openalex.org/W4398183332","https://openalex.org/W4293579374","https://openalex.org/W3112198380","https://openalex.org/W4220861780","https://openalex.org/W6901935264","https://openalex.org/W6920981480","https://openalex.org/W6939418209","https://openalex.org/W6939491349","https://openalex.org/W6976973776","https://openalex.org/W6920970290"],"abstract_inverted_index":{"in":[0,21],"breast":[1,22],"cancer":[2,9,23],"contributes":[3],"to":[4],"the":[5,16],"malignant":[6],"behaviour":[7],"of":[8,18],"cells,":[10],"thereby":[11],"providing":[12],"novel":[13],"insights":[14],"on":[15],"significance":[17],"CHPF-modified":[19],"SDC4":[20],"pathogenesis.":[24]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-04-13T00:00:00"}