{"id":"https://openalex.org/W3147313296","doi":"https://doi.org/10.1126/sciadv.abe2261","title":"Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer","display_name":"Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer","publication_year":2021,"publication_date":"2021-04-07","ids":{"openalex":"https://openalex.org/W3147313296","doi":"https://doi.org/10.1126/sciadv.abe2261","mag":"3147313296","pmid":"https://pubmed.ncbi.nlm.nih.gov/33827814"},"language":"en","primary_location":{"id":"doi:10.1126/sciadv.abe2261","doi":"https://doi.org/10.1126/sciadv.abe2261","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.abe2261","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.abe2261?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.science.org/doi/pdf/10.1126/sciadv.abe2261?download=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021872221","display_name":"Su H. Park","orcid":"https://orcid.org/0000-0002-1070-4031","observed_orcids":["https://orcid.org/0000-0002-1070-4031"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Su H. Park","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"],"raw_orcid":"https://orcid.org/0000-0002-1070-4031","affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028592828","display_name":"Ka-wing Fong","orcid":"https://orcid.org/0000-0001-6995-0264","observed_orcids":["https://orcid.org/0000-0001-6995-0264"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ka-wing Fong","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100608891","display_name":"Jung Kim","orcid":"https://orcid.org/0000-0001-6274-2841","observed_orcids":["https://orcid.org/0000-0001-6274-2841"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":null,"type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jung Kim","raw_affiliation_strings":["Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"],"raw_orcid":"https://orcid.org/0000-0001-6274-2841","affiliations":[{"raw_affiliation_string":"Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4391012607"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321360","display_name":"Fang Wang","orcid":"https://orcid.org/0000-0001-7640-3584","observed_orcids":["https://orcid.org/0000-0001-7640-3584"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fang Wang","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008484454","display_name":"Xiaodong L\u00fc","orcid":"https://orcid.org/0000-0003-4731-0762","observed_orcids":["https://orcid.org/0000-0003-4731-0762"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaodong Lu","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"],"raw_orcid":"https://orcid.org/0000-0003-4731-0762","affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007748088","display_name":"Yongik Lee","orcid":"https://orcid.org/0000-0001-9129-1381","observed_orcids":["https://orcid.org/0000-0001-9129-1381"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongik Lee","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022244205","display_name":"Lourdes T. Brea","orcid":"https://orcid.org/0000-0001-9727-7185","observed_orcids":["https://orcid.org/0000-0001-9727-7185"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lourdes T. Brea","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"],"raw_orcid":"https://orcid.org/0000-0001-9727-7185","affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049631164","display_name":"Kristine M. Wadosky","orcid":"https://orcid.org/0000-0003-3952-9377","observed_orcids":["https://orcid.org/0000-0003-3952-9377"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristine Wadosky","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090478455","display_name":"Chunming Guo","orcid":"https://orcid.org/0009-0007-6141-0037","observed_orcids":["https://orcid.org/0009-0007-6141-0037"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunming Guo","raw_affiliation_strings":["Department of Urology and Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA","Department of Urology and Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology and Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Urology and Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066860794","display_name":"Sarki Abba Abdulkadir","orcid":"https://orcid.org/0000-0003-2963-2899","observed_orcids":["https://orcid.org/0000-0003-2963-2899"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarki A. Abdulkadir","raw_affiliation_strings":["Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA","Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]},{"raw_affiliation_string":"Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079900802","display_name":"John D. Crispino","orcid":"https://orcid.org/0000-0002-8182-8306","observed_orcids":["https://orcid.org/0000-0002-8182-8306"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D. Crispino","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","Division of Experimental Hematology, Department of Hematology, St. Jude Children\u2019s Hospital, Memphis, TN, USA","Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA","Division of Experimental Hematology, Department of Hematology, St. Jude Children's Hospital, Memphis, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Division of Experimental Hematology, Department of Hematology, St. Jude Children\u2019s Hospital, Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]},{"raw_affiliation_string":"Division of Experimental Hematology, Department of Hematology, St. Jude Children's Hospital, Memphis, TN, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043224088","display_name":"Deyu Fang","orcid":"https://orcid.org/0000-0002-4211-2751","observed_orcids":["https://orcid.org/0000-0002-4211-2751"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deyu Fang","raw_affiliation_strings":["Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014490969","display_name":"Panagiotis Ntziachristos","orcid":"https://orcid.org/0000-0001-6374-8954","observed_orcids":["https://orcid.org/0000-0001-6374-8954"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Panagiotis Ntziachristos","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA","Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]},{"raw_affiliation_string":"Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100352243","display_name":"Xin Liu","orcid":"https://orcid.org/0000-0002-5646-423X","observed_orcids":["https://orcid.org/0000-0002-5646-423X","https://orcid.org/0009-0003-4579-4289","https://orcid.org/0009-0008-8149-2858"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Liu","raw_affiliation_strings":["Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-5646-423X","affiliations":[{"raw_affiliation_string":"Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100372189","display_name":"Xue Li","orcid":"https://orcid.org/0000-0002-3072-0573","observed_orcids":["https://orcid.org/0000-0002-3072-0573"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue Li","raw_affiliation_strings":["Department of Urology and Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA","Department of Urology and Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3072-0573","affiliations":[{"raw_affiliation_string":"Department of Urology and Department of Surgery, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Urology and Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101559436","display_name":"Yong Wan","orcid":"https://orcid.org/0000-0001-9358-9392","observed_orcids":["https://orcid.org/0000-0001-9358-9392"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Wan","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine Chicago, IL, USA","Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006539902","display_name":"David W. Goodrich","orcid":"https://orcid.org/0000-0002-1021-1827","observed_orcids":["https://orcid.org/0000-0002-1021-1827"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David W. Goodrich","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-1021-1827","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036670708","display_name":"Jonathan C. Zhao","orcid":"https://orcid.org/0000-0002-3163-380X","observed_orcids":["https://orcid.org/0000-0002-3163-380X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan C. Zhao","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026756753","display_name":"Jindan Yu","orcid":"https://orcid.org/0000-0002-2326-0409","observed_orcids":["https://orcid.org/0000-0002-2326-0409","https://orcid.org/0009-0002-2082-5141"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jindan Yu","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA","Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"],"raw_orcid":"https://orcid.org/0000-0002-2326-0409","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]},{"raw_affiliation_string":"Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5026756753"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":7.3771,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.98018382,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"7","issue":"15","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.020600000396370888,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxa1","display_name":"FOXA1","score":1.0},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9449999928474426},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/lysine-methylation","display_name":"lysine methylation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/bub3","display_name":"Bub3","score":0.7870000004768372},{"id":"https://openalex.org/keywords/usp7","display_name":"USP7","score":0.9950000047683716},{"id":"https://openalex.org/keywords/deubiquitination","display_name":"deubiquitination","score":0.8690000176429749},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.9679999947547913},{"id":"https://openalex.org/keywords/post-translational-regulation","display_name":"post-translational regulation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/polycomb-group-proteins","display_name":"Polycomb group proteins","score":0.6359999775886536},{"id":"https://openalex.org/keywords/ezh2-inhibitors","display_name":"EZH2 inhibitors","score":0.9039999842643738},{"id":"https://openalex.org/keywords/usp7-inhibitors","display_name":"USP7 inhibitors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/androgen-dependent-cancer","display_name":"androgen-dependent cancer","score":0.753000020980835},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7432775497436523},{"id":"https://openalex.org/C154456304","wikidata":"https://www.wikidata.org/wiki/Q18027046","display_name":"FOXA1","level":4,"score":0.6176022291183472},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5015883445739746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39338070154190063},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33217841386795044},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2734643220901489},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1126/sciadv.abe2261","doi":"https://doi.org/10.1126/sciadv.abe2261","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.abe2261","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.abe2261?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},{"id":"pmid:33827814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33827814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science advances","raw_type":"Journal Article"},{"id":"pmh:oai:archive.ugent.be:01GWQ5ZTH3PYM0C8GV09BHHNKF","doi":null,"is_oa":true,"landing_page_url":"https://biblio.ugent.be/publication/01GWQ5ZTH3PYM0C8GV09BHHNKF","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 2375-2548","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8026124","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8026124","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Adv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1126/sciadv.abe2261","doi":"https://doi.org/10.1126/sciadv.abe2261","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.abe2261","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.abe2261?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1080240078","display_name":null,"funder_award_id":"P50CA180995","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1766022441","display_name":null,"funder_award_id":"R01CA248770","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1821827801","display_name":"Genomics and bioinformatics analysis to understand castration-resistant prostate cancer","funder_award_id":"R50CA211271","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1896109005","display_name":null,"funder_award_id":"R01-CA207757","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2314199764","display_name":"Interplay between ER and TGF-b in carcinogenesis","funder_award_id":"R01CA202948","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2489657203","display_name":null,"funder_award_id":"GM136308","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G27085544","display_name":"National Resource for Translational and Developmental Proteomics","funder_award_id":"P41GM108569","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2773359888","display_name":"NOTCH signaling controls transformation to androgen independent neuroendocrine prostate cancer","funder_award_id":"R01CA234162","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2878135161","display_name":null,"funder_award_id":"R50CA211271","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G3652182155","display_name":null,"funder_award_id":"P50CA180995","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G3997653435","display_name":null,"funder_award_id":"R01CA207757","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G4058752620","display_name":"Molecular Basis of Gene Regulation by Polycomb Repressive Complex 2","funder_award_id":"R35GM136308","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4428245006","display_name":null,"funder_award_id":"U24-CA274159","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5059139047","display_name":null,"funder_award_id":"R01CA227918","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G5270267321","display_name":null,"funder_award_id":"R01CA258765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5457008155","display_name":null,"funder_award_id":"R01GM121662","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5814058592","display_name":null,"funder_award_id":"R01CA258857","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5832509643","display_name":null,"funder_award_id":"R01 CA172384","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G590252499","display_name":null,"funder_award_id":"R01CA250110","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6202851986","display_name":null,"funder_award_id":"R01 DK110477","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G659005591","display_name":null,"funder_award_id":"R01 CA227918","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6826840480","display_name":null,"funder_award_id":"W81XWH-17-1-0578","funder_id":"https://openalex.org/F4320338485","funder_display_name":"DOD Prostate Cancer Research Program"},{"id":"https://openalex.org/G7229213997","display_name":null,"funder_award_id":"R01CA234162","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G7315267629","display_name":null,"funder_award_id":"R01CA172384","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G7448544785","display_name":null,"funder_award_id":"2017CHAL2008","funder_id":"https://openalex.org/F4320306163","funder_display_name":"Prostate Cancer Foundation"},{"id":"https://openalex.org/G764017491","display_name":null,"funder_award_id":"IRG-18-163-24","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G765418344","display_name":null,"funder_award_id":"W81XWH-17-1-0405","funder_id":"https://openalex.org/F4320338485","funder_display_name":"DOD Prostate Cancer Research Program"},{"id":"https://openalex.org/G8790056486","display_name":null,"funder_award_id":"T32CA09560","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G8935006416","display_name":null,"funder_award_id":"GM121662","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G9000891045","display_name":"The Robert H. Lurie Comprehensive Cancer Center","funder_award_id":"P30CA060553","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000914914","display_name":"Carcinogenesis Training Program","funder_award_id":"T32CA009560","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320306163","display_name":"Prostate Cancer Foundation","ror":"https://ror.org/01npwtv09"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320338485","display_name":"DOD Prostate Cancer Research Program","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3147313296.pdf","grobid_xml":"https://content.openalex.org/works/W3147313296.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1684904284","https://openalex.org/W1977090021","https://openalex.org/W1978125302","https://openalex.org/W1985003152","https://openalex.org/W1996487270","https://openalex.org/W2003307182","https://openalex.org/W2004380688","https://openalex.org/W2006594553","https://openalex.org/W2008793606","https://openalex.org/W2009109655","https://openalex.org/W2010790480","https://openalex.org/W2015132841","https://openalex.org/W2020230403","https://openalex.org/W2023396505","https://openalex.org/W2024048770","https://openalex.org/W2033478449","https://openalex.org/W2051945713","https://openalex.org/W2053116646","https://openalex.org/W2059586354","https://openalex.org/W2060608189","https://openalex.org/W2065886319","https://openalex.org/W2070678426","https://openalex.org/W2078980183","https://openalex.org/W2079298594","https://openalex.org/W2081545299","https://openalex.org/W2082015682","https://openalex.org/W2082231793","https://openalex.org/W2100630390","https://openalex.org/W2103226094","https://openalex.org/W2106969933","https://openalex.org/W2107633226","https://openalex.org/W2114698467","https://openalex.org/W2117334610","https://openalex.org/W2123106337","https://openalex.org/W2127684282","https://openalex.org/W2130410032","https://openalex.org/W2132310381","https://openalex.org/W2148121673","https://openalex.org/W2151834630","https://openalex.org/W2152974390","https://openalex.org/W2153424791","https://openalex.org/W2158610627","https://openalex.org/W2160689782","https://openalex.org/W2161112598","https://openalex.org/W2162648910","https://openalex.org/W2163458728","https://openalex.org/W2163841147","https://openalex.org/W2165894156","https://openalex.org/W2169403465","https://openalex.org/W2171439874","https://openalex.org/W2264682687","https://openalex.org/W2320983896","https://openalex.org/W2344518204","https://openalex.org/W2418751876","https://openalex.org/W2530065228","https://openalex.org/W2563170077","https://openalex.org/W2571250257","https://openalex.org/W2590871167","https://openalex.org/W2607585298","https://openalex.org/W2770240943","https://openalex.org/W2793031031","https://openalex.org/W2887294075","https://openalex.org/W2902678397","https://openalex.org/W2955039931","https://openalex.org/W2955719861","https://openalex.org/W2963332163","https://openalex.org/W2993259906"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W4297956145"],"abstract_inverted_index":{"Forkhead":[0],"box":[1],"protein":[2,54,69,129],"A1":[3],"(FOXA1)":[4],"is":[5,49,84],"essential":[6],"for":[7],"androgen-dependent":[8],"prostate":[9],"cancer":[10],"(PCa)":[11],"growth.":[12,82],"However,":[13],"how":[14],"FOXA1":[15,30,44,68,83,128],"levels":[16],"are":[17],"regulated":[18],"remains":[19],"elusive":[20],"and":[21,66,79],"its":[22],"therapeutic":[23,87,137],"targeting":[24,138],"proven":[25],"challenging.":[26],"Here,":[27],"we":[28],"report":[29],"as":[31,123],"a":[32,85,124],"nonhistone":[33],"substrate":[34],"of":[35,37,89,92,139],"enhancer":[36],"zeste":[38],"homolog":[39],"2":[40],"(EZH2),":[41],"which":[42,56,131],"methylates":[43],"at":[45],"lysine-295.":[46],"This":[47],"methylation":[48,122],"recognized":[50],"by":[51,105],"WD40":[52],"repeat":[53],"BUB3,":[55],"subsequently":[57],"recruits":[58],"ubiquitin-specific":[59],"protease":[60],"7":[61],"(USP7)":[62],"to":[63,127,135],"remove":[64],"ubiquitination":[65],"enhance":[67,136],"stability.":[70],"They":[71],"functionally":[72],"converge":[73],"in":[74,96,112],"regulating":[75],"cell":[76],"cycle":[77],"genes":[78],"promoting":[80],"PCa":[81,99,140],"major":[86],"target":[88],"the":[90],"inhibitors":[91],"EZH2":[93,106,143],"methyltransferase":[94],"activities":[95],"PCa.":[97],"FOXA1-driven":[98],"growth":[100],"can":[101],"be":[102,133],"effectively":[103],"mitigated":[104],"enzymatic":[107,142],"inhibitors,":[108],"either":[109],"alone":[110],"or":[111],"combination":[113],"with":[114],"USP7":[115],"inhibitors.":[116,144],"Together,":[117],"our":[118],"study":[119],"reports":[120],"EZH2-catalyzed":[121],"key":[125],"mechanism":[126],"stability,":[130],"may":[132],"leveraged":[134],"using":[141]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
