{"id":"https://openalex.org/W3147268564","doi":"https://doi.org/10.3390/ijms22073792","title":"Altered microRNA Transcriptome in Cultured Human Liver Cells upon Infection with Ebola Virus","display_name":"Altered microRNA Transcriptome in Cultured Human Liver Cells upon Infection with Ebola Virus","publication_year":2021,"publication_date":"2021-04-06","ids":{"openalex":"https://openalex.org/W3147268564","doi":"https://doi.org/10.3390/ijms22073792","mag":"3147268564","pmid":"https://pubmed.ncbi.nlm.nih.gov/33917562","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8038836"},"language":"en","primary_location":{"id":"doi:10.3390/ijms22073792","doi":"https://doi.org/10.3390/ijms22073792","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22073792","pdf_url":"https://www.mdpi.com/1422-0067/22/7/3792/pdf?version=1617940889","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3147268564"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/7/3792/pdf?version=1617940889","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080106827","display_name":"Idrissa Diallo","orcid":"https://orcid.org/0000-0002-6259-5850","observed_orcids":["https://orcid.org/0000-0002-6259-5850"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405256986","display_name":"Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval","ror":"https://ror.org/04rgqcd02","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256986","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Idrissa Diallo","raw_affiliation_strings":["CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada"],"raw_orcid":"https://orcid.org/0000-0002-6259-5850","affiliations":[{"raw_affiliation_string":"CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada","institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405256986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018161964","display_name":"Jeffrey Ho","orcid":"https://orcid.org/0000-0002-9983-0113","observed_orcids":["https://orcid.org/0000-0002-9983-0113"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405256986","display_name":"Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval","ror":"https://ror.org/04rgqcd02","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256986","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jeffrey Ho","raw_affiliation_strings":["CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada"],"raw_orcid":"https://orcid.org/0000-0002-9983-0113","affiliations":[{"raw_affiliation_string":"CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada","institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405256986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060257032","display_name":"Benoit Laffont","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405256986","display_name":"Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval","ror":"https://ror.org/04rgqcd02","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256986","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Benoit Laffont","raw_affiliation_strings":["CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada","institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405256986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067347461","display_name":"Jonathan Laugier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405256986","display_name":"Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval","ror":"https://ror.org/04rgqcd02","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256986","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jonathan Laugier","raw_affiliation_strings":["CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada","institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405256986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088552577","display_name":"Abderrahim Benmoussa","orcid":"https://orcid.org/0000-0002-9504-3120","observed_orcids":["https://orcid.org/0000-0002-9504-3120"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405256986","display_name":"Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval","ror":"https://ror.org/04rgqcd02","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256986","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Abderrahim Benmoussa","raw_affiliation_strings":["CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada"],"raw_orcid":"https://orcid.org/0000-0002-9504-3120","affiliations":[{"raw_affiliation_string":"CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada","institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405256986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017273896","display_name":"Marine Lambert","orcid":"https://orcid.org/0000-0002-3749-920X","observed_orcids":["https://orcid.org/0000-0002-3749-920X"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405256986","display_name":"Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval","ror":"https://ror.org/04rgqcd02","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256986","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marine Lambert","raw_affiliation_strings":["CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada"],"raw_orcid":"https://orcid.org/0000-0002-3749-920X","affiliations":[{"raw_affiliation_string":"CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada","institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405256986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104038412","display_name":"Zeinab Husseini","orcid":"https://orcid.org/0009-0006-4206-4848","observed_orcids":["https://orcid.org/0009-0006-4206-4848"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405256986","display_name":"Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval","ror":"https://ror.org/04rgqcd02","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256986","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Zeinab Husseini","raw_affiliation_strings":["CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada","institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405256986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054965432","display_name":"Geoff Soule","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177235860","display_name":"Public Health Agency of Canada","ror":"https://ror.org/023xf2a37","country_code":"CA","type":"government","lineage":["https://openalex.org/I1288894424","https://openalex.org/I177235860"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Geoff Soule","raw_affiliation_strings":["Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3B 3M9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3B 3M9, Canada","institution_ids":["https://openalex.org/I177235860"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028398799","display_name":"Robert Andrew Kozak","orcid":"https://orcid.org/0000-0002-6159-9972","observed_orcids":["https://orcid.org/0000-0002-6159-9972"]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I177235860","display_name":"Public Health Agency of Canada","ror":"https://ror.org/023xf2a37","country_code":"CA","type":"government","lineage":["https://openalex.org/I1288894424","https://openalex.org/I177235860"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert Kozak","raw_affiliation_strings":["Division of Microbiology, Department of Laboratory Medicine & Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada","Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3B 3M9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology, Department of Laboratory Medicine & Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada","institution_ids":["https://openalex.org/I1323843004"]},{"raw_affiliation_string":"Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3B 3M9, Canada","institution_ids":["https://openalex.org/I177235860"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051652706","display_name":"Gary Kobinger","orcid":"https://orcid.org/0000-0003-0612-2298","observed_orcids":["https://orcid.org/0000-0003-0612-2298"]},"institutions":[{"id":"https://openalex.org/I177235860","display_name":"Public Health Agency of Canada","ror":"https://ror.org/023xf2a37","country_code":"CA","type":"government","lineage":["https://openalex.org/I1288894424","https://openalex.org/I177235860"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405256986","display_name":"Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval","ror":"https://ror.org/04rgqcd02","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256986","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gary P. Kobinger","raw_affiliation_strings":["CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada","D\u00e9partement de Microbiologie M\u00e9dicale, Universit\u00e9 du Manitoba, Winnipeg, MB R3E 0J9, Canada","Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3B 3M9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada","institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405256986"]},{"raw_affiliation_string":"D\u00e9partement de Microbiologie M\u00e9dicale, Universit\u00e9 du Manitoba, Winnipeg, MB R3E 0J9, Canada","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3B 3M9, Canada","institution_ids":["https://openalex.org/I177235860"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064437317","display_name":"Patrick Provost","orcid":"https://orcid.org/0000-0002-6099-6562","observed_orcids":["https://orcid.org/0000-0002-6099-6562"]},"institutions":[{"id":"https://openalex.org/I4210093650","display_name":"Centre hospitalier universitaire de Qu\u00e9bec","ror":"https://ror.org/006a7pj43","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210093650","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405256986","display_name":"Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval","ror":"https://ror.org/04rgqcd02","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256986","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Patrick Provost","raw_affiliation_strings":["CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada","CHUQ Research Center/CHUL Pavilion, 2705 Blvd Laurier, Room T1-65, Quebec, QC G1V 4G2, Canada"],"raw_orcid":"https://orcid.org/0000-0002-6099-6562","affiliations":[{"raw_affiliation_string":"CHU de Qu\u00e9bec Research Center, Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Universit\u00e9 Laval, Quebec, QC G1V 4G2, Canada","institution_ids":["https://openalex.org/I43406934","https://openalex.org/I4405256986"]},{"raw_affiliation_string":"CHUQ Research Center/CHUL Pavilion, 2705 Blvd Laurier, Room T1-65, Quebec, QC G1V 4G2, Canada","institution_ids":["https://openalex.org/I4210093650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5064437317"],"corresponding_institution_ids":["https://openalex.org/I4210093650","https://openalex.org/I43406934","https://openalex.org/I4405256986"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":1.2244,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.82291788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"7","first_page":"3792","last_page":"3792"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.8560000061988831,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.8560000061988831,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.13089999556541443,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ebola-virus","display_name":"Ebola virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microrna-transcriptome","display_name":"microRNA transcriptome","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mirnome","display_name":"miRNome","score":0.7149999737739563},{"id":"https://openalex.org/keywords/huh7-cells","display_name":"Huh7 cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.5659999847412109},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.625},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.7059999704360962},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.6579999923706055},{"id":"https://openalex.org/keywords/small-rna-sequencing","display_name":"small RNA sequencing","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2777469322","wikidata":"https://www.wikidata.org/wiki/Q8064876","display_name":"Ebola virus","level":3,"score":0.8198541402816772},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7603703141212463},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7121614217758179},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6298999786376953},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5984004139900208},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5015184879302979},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.49457380175590515},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4448278248310089},{"id":"https://openalex.org/C2776430180","wikidata":"https://www.wikidata.org/wiki/Q162272","display_name":"Viral hemorrhagic fever","level":4,"score":0.4413520097732544},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.4332994222640991},{"id":"https://openalex.org/C2910344980","wikidata":"https://www.wikidata.org/wiki/Q51993","display_name":"Ebola Hemorrhagic Fever","level":4,"score":0.4177274703979492},{"id":"https://openalex.org/C2909623084","wikidata":"https://www.wikidata.org/wiki/Q5331908","display_name":"Ebolavirus","level":4,"score":0.41452455520629883},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35092389583587646},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3144558370113373},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3096555471420288},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21483051776885986},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16360026597976685}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019142","descriptor_name":"Hemorrhagic Fever, Ebola","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019142","descriptor_name":"Hemorrhagic Fever, Ebola","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029043","descriptor_name":"Ebolavirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029043","descriptor_name":"Ebolavirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms22073792","doi":"https://doi.org/10.3390/ijms22073792","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22073792","pdf_url":"https://www.mdpi.com/1422-0067/22/7/3792/pdf?version=1617940889","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:33917562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33917562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8038836","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8038836/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms22073792","doi":"https://doi.org/10.3390/ijms22073792","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22073792","pdf_url":"https://www.mdpi.com/1422-0067/22/7/3792/pdf?version=1617940889","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4871593326","display_name":"Bourses de doctorat en recherche \u2014 Acides nucl\u00e9iques","funder_award_id":"289637","funder_id":"https://openalex.org/F4320334841","funder_display_name":"Fonds de recherche du Qu\u00e9bec \u2013 Nature et technologies"},{"id":"https://openalex.org/G6455073268","display_name":"Genetic basis of human G2 checkpoint regulation","funder_award_id":"14352_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G7901198459","display_name":"Bourses de doctorat en recherche \u2014 Appareil digestif, Maladies auto-immunes","funder_award_id":"262093","funder_id":"https://openalex.org/F4320334618","funder_display_name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334618","display_name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","ror":"https://ror.org/02eqrsj93"},{"id":"https://openalex.org/F4320334841","display_name":"Fonds de recherche du Qu\u00e9bec \u2013 Nature et technologies","ror":"https://ror.org/00b9f9778"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3147268564.pdf","grobid_xml":"https://content.openalex.org/works/W3147268564.grobid-xml"},"referenced_works_count":129,"referenced_works":["https://openalex.org/W25083497","https://openalex.org/W1482198677","https://openalex.org/W1545010974","https://openalex.org/W1817123886","https://openalex.org/W1963612974","https://openalex.org/W1965909642","https://openalex.org/W1966742128","https://openalex.org/W1972689256","https://openalex.org/W1975131084","https://openalex.org/W1980005657","https://openalex.org/W1984157841","https://openalex.org/W1986196732","https://openalex.org/W2000770184","https://openalex.org/W2004791359","https://openalex.org/W2006309458","https://openalex.org/W2007151442","https://openalex.org/W2015336471","https://openalex.org/W2017003212","https://openalex.org/W2022452100","https://openalex.org/W2022675863","https://openalex.org/W2026051181","https://openalex.org/W2026570544","https://openalex.org/W2027509154","https://openalex.org/W2032019813","https://openalex.org/W2040132891","https://openalex.org/W2040622735","https://openalex.org/W2059118814","https://openalex.org/W2073524897","https://openalex.org/W2075823058","https://openalex.org/W2080118328","https://openalex.org/W2086848163","https://openalex.org/W2090144580","https://openalex.org/W2098215107","https://openalex.org/W2100021633","https://openalex.org/W2100303008","https://openalex.org/W2102286438","https://openalex.org/W2103017472","https://openalex.org/W2103795849","https://openalex.org/W2107277218","https://openalex.org/W2110295814","https://openalex.org/W2110608820","https://openalex.org/W2115102869","https://openalex.org/W2120190659","https://openalex.org/W2128048963","https://openalex.org/W2131610125","https://openalex.org/W2137627132","https://openalex.org/W2138127993","https://openalex.org/W2140913909","https://openalex.org/W2142456569","https://openalex.org/W2143110620","https://openalex.org/W2143639253","https://openalex.org/W2147495091","https://openalex.org/W2155409207","https://openalex.org/W2156631105","https://openalex.org/W2159482845","https://openalex.org/W2159793493","https://openalex.org/W2160999690","https://openalex.org/W2161081629","https://openalex.org/W2162877470","https://openalex.org/W2163335322","https://openalex.org/W2167232191","https://openalex.org/W2167551330","https://openalex.org/W2169112650","https://openalex.org/W2169336810","https://openalex.org/W2171106047","https://openalex.org/W2253819322","https://openalex.org/W2260857789","https://openalex.org/W2272476542","https://openalex.org/W2339273725","https://openalex.org/W2343186061","https://openalex.org/W2413431206","https://openalex.org/W2414786904","https://openalex.org/W2418446696","https://openalex.org/W2475077398","https://openalex.org/W2481228070","https://openalex.org/W2511385092","https://openalex.org/W2529132047","https://openalex.org/W2561721138","https://openalex.org/W2579523860","https://openalex.org/W2586352915","https://openalex.org/W2592783371","https://openalex.org/W2599269106","https://openalex.org/W2607309113","https://openalex.org/W2607397084","https://openalex.org/W2613738073","https://openalex.org/W2621436569","https://openalex.org/W2726855275","https://openalex.org/W2746006953","https://openalex.org/W2761742990","https://openalex.org/W2792642225","https://openalex.org/W2800151574","https://openalex.org/W2804757561","https://openalex.org/W2805800332","https://openalex.org/W2810625586","https://openalex.org/W2888770709","https://openalex.org/W2889882719","https://openalex.org/W2891009119","https://openalex.org/W2899176197","https://openalex.org/W2901692650","https://openalex.org/W2903624735","https://openalex.org/W2912194125","https://openalex.org/W2913184540","https://openalex.org/W2922283219","https://openalex.org/W2929022608","https://openalex.org/W2932136630","https://openalex.org/W2949149966","https://openalex.org/W2950595506","https://openalex.org/W2953010347","https://openalex.org/W2954917865","https://openalex.org/W2959550918","https://openalex.org/W2973286711","https://openalex.org/W2977996211","https://openalex.org/W2979492738","https://openalex.org/W2982984170","https://openalex.org/W2989783042","https://openalex.org/W2992141375","https://openalex.org/W3009036797","https://openalex.org/W3012320055","https://openalex.org/W3013386648","https://openalex.org/W3013757808","https://openalex.org/W3023555592","https://openalex.org/W3029717128","https://openalex.org/W3034757592","https://openalex.org/W3087149315","https://openalex.org/W4211064852","https://openalex.org/W4232026395","https://openalex.org/W4294216483","https://openalex.org/W6761160696","https://openalex.org/W6775489320"],"related_works":["https://openalex.org/W4229332595","https://openalex.org/W4393159293","https://openalex.org/W2337046103","https://openalex.org/W2805800332","https://openalex.org/W4405328874","https://openalex.org/W2475077398","https://openalex.org/W2977996211","https://openalex.org/W1609018783","https://openalex.org/W7165177186","https://openalex.org/W4289468728"],"abstract_inverted_index":{"Ebola":[0],"virus":[1,194],"(EBOV)":[2],"is":[3,31],"a":[4,24,113],"virulent":[5],"pathogen,":[6],"notorious":[7],"for":[8,17,130,139],"inducing":[9],"life-threatening":[10],"hemorrhagic":[11],"fever,":[12],"that":[13],"has":[14],"been":[15,39],"responsible":[16],"several":[18],"outbreaks":[19],"in":[20,74,135,144],"Africa":[21,142],"and":[22,76,78,101,146,161,171,188,196],"remains":[23,68],"public":[25],"health":[26],"threat.":[27],"Yet,":[28],"its":[29],"pathogenesis":[30],"still":[32],"not":[33],"completely":[34],"understood.":[35],"Although":[36],"there":[37],"have":[38,94],"numerous":[40],"studies":[41],"on":[42,51,60],"host":[43,87,197],"transcriptional":[44],"response":[45,88],"to":[46,81,89,104,152],"EBOV,":[47],"with":[48,120],"an":[49],"emphasis":[50],"the":[52,55,86,106,123,131,140,147,165,179],"clinical":[53,169],"features,":[54],"impact":[56],"of":[57,85,112,122,182],"EBOV":[58,126,186],"infection":[59,187],"post-transcriptional":[61],"regulatory":[62],"elements,":[63],"such":[64],"as":[65],"microRNAs":[66],"(miRNAs),":[67],"largely":[69],"unexplored.":[70],"MiRNAs":[71],"are":[72,79],"involved":[73],"inflammation":[75],"immunity":[77,159],"believed":[80],"be":[82],"important":[83],"modulators":[84],"viral":[90],"infection.":[91],"Here,":[92],"we":[93],"used":[95],"small":[96],"RNA":[97],"sequencing":[98],"(sRNA-Seq),":[99],"qPCR":[100],"functional":[102],"analyses":[103,174],"obtain":[105],"first":[107,132],"comparative":[108],"miRNA":[109],"transcriptome":[110],"(miRNome)":[111],"human":[114],"liver":[115,183],"cell":[116],"line":[117],"(Huh7)":[118],"infected":[119],"one":[121],"following":[124],"three":[125],"strains:":[127],"Mayinga":[128],"(responsible":[129,138],"Zaire":[133],"outbreak":[134,143],"1976),":[136],"Makona":[137],"West":[141],"2013-2016)":[145],"epizootic":[148],"Reston":[149],"(presumably":[150],"innocuous":[151],"humans).":[153],"Our":[154],"results":[155],"highlight":[156],"specific":[157],"miRNA-based":[158,193],"pathways":[160],"substantial":[162],"differences":[163],"between":[164],"strains":[166],"beyond":[167],"their":[168],"manifestation":[170],"pathogenicity.":[172],"These":[173],"shed":[175],"new":[176,190],"light":[177],"into":[178,192],"molecular":[180],"signature":[181],"cells":[184],"upon":[185],"reveal":[189],"insights":[191],"attack":[195],"defense":[198],"strategy.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-04-13T00:00:00"}