{"id":"https://openalex.org/W3147060299","doi":null,"title":"Neural Circuitry of Upper Airway Respiratory Plasticity: Identifying the Neural Circuitry Underlying Long-term Facilitation of Inspiratory Genioglossus Motor Output","display_name":"Neural Circuitry of Upper Airway Respiratory Plasticity: Identifying the Neural Circuitry Underlying Long-term Facilitation of Inspiratory Genioglossus Motor Output","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W3147060299","mag":"3147060299"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/96995","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/96995","pdf_url":"https://utoronto.scholaris.ca/bitstreams/39bb8bb0-59c3-47f0-b224-c2d22d9c3296/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/39bb8bb0-59c3-47f0-b224-c2d22d9c3296/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025329204","display_name":"Simon Lui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Simon Lui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025329204"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-plasticity","display_name":"respiratory plasticity","score":0.781000018119812},{"id":"https://openalex.org/keywords/genioglossus-muscle","display_name":"genioglossus muscle","score":0.8840000033378601},{"id":"https://openalex.org/keywords/neural-circuits","display_name":"neural circuits","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nucleus-tractus-solitarius","display_name":"nucleus tractus solitarius","score":0.9629999995231628},{"id":"https://openalex.org/keywords/locus-coeruleus","display_name":"locus coeruleus","score":1.0},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/alpha1-adrenergic-receptors","display_name":"alpha1-adrenoceptors","score":0.9520000219345093},{"id":"https://openalex.org/keywords/optogenetics","display_name":"optogenetics","score":0.8220000267028809},{"id":"https://openalex.org/keywords/neuronal-tracing","display_name":"neural tracing","score":0.9769999980926514},{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.9369999766349792},{"id":"https://openalex.org/keywords/respiratory-adaptation","display_name":"respiratory adaptation","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2778670693","wikidata":"https://www.wikidata.org/wiki/Q580326","display_name":"Genioglossus","level":3,"score":0.9094889163970947},{"id":"https://openalex.org/C1337776","wikidata":"https://www.wikidata.org/wiki/Q1941955","display_name":"Facilitation","level":2,"score":0.5904386043548584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5507487058639526},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.49674588441848755},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.49426698684692383},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.46693581342697144},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.45357975363731384},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.4207104444503784},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.35058051347732544},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2744104266166687},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.27363067865371704},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.118379145860672},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06749570369720459},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/96995","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/96995","pdf_url":"https://utoronto.scholaris.ca/bitstreams/39bb8bb0-59c3-47f0-b224-c2d22d9c3296/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:3147060299","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/96995/1/Lui_Simon_K_201906_PhD_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/96995","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/96995","pdf_url":"https://utoronto.scholaris.ca/bitstreams/39bb8bb0-59c3-47f0-b224-c2d22d9c3296/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3147060299.pdf","grobid_xml":"https://content.openalex.org/works/W3147060299.grobid-xml"},"referenced_works_count":209,"referenced_works":["https://openalex.org/W26499378","https://openalex.org/W36557223","https://openalex.org/W45657630","https://openalex.org/W70856688","https://openalex.org/W72011247","https://openalex.org/W91032893","https://openalex.org/W96550490","https://openalex.org/W106863210","https://openalex.org/W181657250","https://openalex.org/W184985917","https://openalex.org/W1496680190","https://openalex.org/W1504261214","https://openalex.org/W1535900775","https://openalex.org/W1536686934","https://openalex.org/W1536780881","https://openalex.org/W1537597456","https://openalex.org/W1560498709","https://openalex.org/W1606562251","https://openalex.org/W1658103071","https://openalex.org/W1681249975","https://openalex.org/W1750942102","https://openalex.org/W1754635640","https://openalex.org/W1788599757","https://openalex.org/W1826026795","https://openalex.org/W1853278098","https://openalex.org/W1854609517","https://openalex.org/W1942144965","https://openalex.org/W1943576895","https://openalex.org/W1963749056","https://openalex.org/W1963936141","https://openalex.org/W1966100684","https://openalex.org/W1966528871","https://openalex.org/W1966688219","https://openalex.org/W1967888272","https://openalex.org/W1969972938","https://openalex.org/W1971156703","https://openalex.org/W1971409841","https://openalex.org/W1971483865","https://openalex.org/W1973825080","https://openalex.org/W1974299769","https://openalex.org/W1975726032","https://openalex.org/W1976429090","https://openalex.org/W1977601744","https://openalex.org/W1977862375","https://openalex.org/W1982270009","https://openalex.org/W1982523698","https://openalex.org/W1982905623","https://openalex.org/W1985407755","https://openalex.org/W1987809258","https://openalex.org/W1988960741","https://openalex.org/W1994863765","https://openalex.org/W1995099697","https://openalex.org/W1996771974","https://openalex.org/W1997178402","https://openalex.org/W1997695307","https://openalex.org/W1999196447","https://openalex.org/W2000056002","https://openalex.org/W2003102216","https://openalex.org/W2004845912","https://openalex.org/W2006355149","https://openalex.org/W2006410388","https://openalex.org/W2006559782","https://openalex.org/W2006616097","https://openalex.org/W2007250963","https://openalex.org/W2008723603","https://openalex.org/W2009081954","https://openalex.org/W2009598444","https://openalex.org/W2010848825","https://openalex.org/W2012429358","https://openalex.org/W2013354666","https://openalex.org/W2014359198","https://openalex.org/W2016279110","https://openalex.org/W2018170612","https://openalex.org/W2018222414","https://openalex.org/W2018593756","https://openalex.org/W2019525615","https://openalex.org/W2026208431","https://openalex.org/W2027285489","https://openalex.org/W2027429673","https://openalex.org/W2027934187","https://openalex.org/W2028043512","https://openalex.org/W2030048548","https://openalex.org/W2030779345","https://openalex.org/W2032054534","https://openalex.org/W2032203636","https://openalex.org/W2034176987","https://openalex.org/W2038008568","https://openalex.org/W2038431342","https://openalex.org/W2042879230","https://openalex.org/W2043035384","https://openalex.org/W2045712239","https://openalex.org/W2046155193","https://openalex.org/W2046628195","https://openalex.org/W2049204174","https://openalex.org/W2050889339","https://openalex.org/W2050932531","https://openalex.org/W2053651900","https://openalex.org/W2057174409","https://openalex.org/W2058148599","https://openalex.org/W2058748246","https://openalex.org/W2058940041","https://openalex.org/W2058941115","https://openalex.org/W2059837042","https://openalex.org/W2060230744","https://openalex.org/W2060760840","https://openalex.org/W2061008935","https://openalex.org/W2062815868","https://openalex.org/W2064063251","https://openalex.org/W2064775745","https://openalex.org/W2064830340","https://openalex.org/W2070950696","https://openalex.org/W2071576115","https://openalex.org/W2074413261","https://openalex.org/W2075366948","https://openalex.org/W2076902628","https://openalex.org/W2076936216","https://openalex.org/W2077664665","https://openalex.org/W2077702100","https://openalex.org/W2077726357","https://openalex.org/W2077868571","https://openalex.org/W2079221659","https://openalex.org/W2080982887","https://openalex.org/W2081791543","https://openalex.org/W2082202033","https://openalex.org/W2082503305","https://openalex.org/W2085287004","https://openalex.org/W2087027867","https://openalex.org/W2087403493","https://openalex.org/W2087592242","https://openalex.org/W2090319528","https://openalex.org/W2093910183","https://openalex.org/W2098170217","https://openalex.org/W2098186057","https://openalex.org/W2099401565","https://openalex.org/W2103505812","https://openalex.org/W2104590670","https://openalex.org/W2105836819","https://openalex.org/W2107288483","https://openalex.org/W2108328978","https://openalex.org/W2108710130","https://openalex.org/W2108846059","https://openalex.org/W2108957007","https://openalex.org/W2112643503","https://openalex.org/W2116541930","https://openalex.org/W2117075490","https://openalex.org/W2119049654","https://openalex.org/W2121474091","https://openalex.org/W2123520472","https://openalex.org/W2124865189","https://openalex.org/W2127425975","https://openalex.org/W2130513715","https://openalex.org/W2130541746","https://openalex.org/W2130998942","https://openalex.org/W2132337218","https://openalex.org/W2133473629","https://openalex.org/W2136040856","https://openalex.org/W2137059302","https://openalex.org/W2137179442","https://openalex.org/W2137453057","https://openalex.org/W2139704316","https://openalex.org/W2142207701","https://openalex.org/W2144325042","https://openalex.org/W2145849499","https://openalex.org/W2146631034","https://openalex.org/W2146917989","https://openalex.org/W2147608198","https://openalex.org/W2149050501","https://openalex.org/W2149295320","https://openalex.org/W2149712735","https://openalex.org/W2151504418","https://openalex.org/W2151556488","https://openalex.org/W2153164067","https://openalex.org/W2153832507","https://openalex.org/W2154855755","https://openalex.org/W2156160553","https://openalex.org/W2156639158","https://openalex.org/W2160688299","https://openalex.org/W2160779028","https://openalex.org/W2163815564","https://openalex.org/W2163889059","https://openalex.org/W2164153190","https://openalex.org/W2167693963","https://openalex.org/W2168767331","https://openalex.org/W2173936670","https://openalex.org/W2175268588","https://openalex.org/W2208080011","https://openalex.org/W2255372544","https://openalex.org/W2259231394","https://openalex.org/W2275919966","https://openalex.org/W2291660862","https://openalex.org/W2303290804","https://openalex.org/W2313670466","https://openalex.org/W2319217577","https://openalex.org/W2333343699","https://openalex.org/W2337823340","https://openalex.org/W2339210156","https://openalex.org/W2357321999","https://openalex.org/W2397512165","https://openalex.org/W2413461190","https://openalex.org/W2413726107","https://openalex.org/W2476445982","https://openalex.org/W2519251045","https://openalex.org/W2559779553","https://openalex.org/W2560490590","https://openalex.org/W2588462957","https://openalex.org/W2625721407","https://openalex.org/W2783497062","https://openalex.org/W4214891130","https://openalex.org/W7095754169"],"related_works":["https://openalex.org/W2887095712","https://openalex.org/W4408385886","https://openalex.org/W3165431435","https://openalex.org/W4367848897","https://openalex.org/W2559779553","https://openalex.org/W190080977","https://openalex.org/W2259711729","https://openalex.org/W2519251045","https://openalex.org/W2142105954","https://openalex.org/W1208648815"],"abstract_inverted_index":{"The":[0],"respiratory":[1,19,63,80,92,112,126,225,238],"system":[2,219],"is":[3,46],"highly":[4],"adaptive":[5],"and":[6,27,83,115,136,155,204,232],"can":[7,33,52,186],"change":[8],"its":[9],"behaviour":[10],"to":[11,61,122,165,178,214,236],"provide":[12,230],"protective":[13],"responses":[14,32],"in":[15],"face":[16],"of":[17,24,49,79,94,125,129,168,175,192,224],"repeated":[18],"challenges.":[20],"Elucidating":[21],"the":[22,72,87,111,117,123,146,151,156,166,180,193,202,210,216,222],"role":[23],"how":[25],"neurons":[26],"neural":[28,73,88],"circuits":[29],"mediate":[30],"these":[31],"open":[34],"new":[35],"treatments":[36],"for":[37],"those":[38],"that":[39,51,75,90,103,119,161,185,220],"cannot":[40],"adapt.":[41],"Respiratory":[42],"long-term":[43],"facilitation":[44],"(LTF)":[45],"one":[47],"form":[48,78],"adaptation":[50],"increase":[53],"genioglossus":[54,96,130],"motor":[55,81,97,127,131,158,212,226],"output,":[56,98],"potentially":[57],"providing":[58],"a":[59,100,142,173,183],"means":[60],"mitigate":[62],"disorders":[64,239],"such":[65,240],"as":[66,182,241],"obstructive":[67,242],"sleep":[68,243],"apnea.":[69,244],"I":[70,84,139,170,197],"examined":[71],"circuitry":[74],"underlies":[76],"this":[77],"plasticity":[82,128],"identified:":[85],"(1)":[86],"circuit":[89,144],"mediates":[91],"LTF":[93,105,188],"inspiratory":[95],"(2)":[99],"novel":[101,233],"trigger":[102,184],"elicits":[104],"without":[106],"directly":[107],"or":[108],"indirectly":[109],"modulating":[110],"feedback":[113],"systems,":[114],"(3)":[116],"neurotransmitter(s)":[118],"are":[120,162],"essential":[121],"manifestation":[124],"output.":[132],"Using":[133],"tract-tracing,":[134],"immunohistochemical":[135],"pharmacological":[137],"approaches,":[138],"have":[140],"identified":[141,198],"tripartite":[143],"connecting":[145],"nucleus":[147],"tractus":[148],"solitarius":[149],"(NTS),":[150],"locus":[152],"coeruleus":[153],"(LC),":[154],"hypoglossal":[157,211],"nuclei":[159],"(XII)":[160],"individually":[163],"critical":[164],"elicitation":[167],"LTF.":[169],"also":[171],"employed":[172],"series":[174],"optogenetic":[176],"approaches":[177],"identify":[179],"LC":[181,194,203],"elicit":[187],"following":[189],"intermittent":[190],"stimulation":[191],"alone.":[195],"Lastly,":[196],"noradrenaline,":[199],"released":[200],"by":[201],"acting":[205],"on":[206],"\u03b11-adrenergic":[207],"receptors":[208],"at":[209],"nuclei,":[213],"be":[215],"key":[217],"neurotransmitter-receptor":[218],"gates":[221],"expression":[223],"plasticity.":[227],"These":[228],"findings":[229],"direction":[231],"therapeutic":[234],"targets":[235],"treat":[237]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2021-04-13T00:00:00"}