{"id":"https://openalex.org/W3147054576","doi":"https://doi.org/10.21203/rs.3.rs-71388/v1","title":"Analysis of Traditional Risk Factors of Atherosclerosis and Novel Risk Markers of Inflammation in Coronary Ectasia Can We Solve The Enigma ??","display_name":"Analysis of Traditional Risk Factors of Atherosclerosis and Novel Risk Markers of Inflammation in Coronary Ectasia Can We Solve The Enigma ??","publication_year":2020,"publication_date":"2020-09-15","ids":{"openalex":"https://openalex.org/W3147054576","doi":"https://doi.org/10.21203/rs.3.rs-71388/v1","mag":"3147054576"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-71388/v1","doi":"https://doi.org/10.21203/rs.3.rs-71388/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-71388/v1","pdf_url":"https://www.researchsquare.com/article/rs-71388/v1.pdf?c=1601483497000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-71388/v1.pdf?c=1601483497000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062998321","display_name":"Selvaganesh Mariappan","orcid":"https://orcid.org/0000-0003-3944-2722","observed_orcids":["https://orcid.org/0000-0003-3944-2722"]},"institutions":[{"id":"https://openalex.org/I4210104323","display_name":"Velammal Medical College Hospital and Research Institute","ror":"https://ror.org/00x9zs206","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210104323"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Selvaganesh Mariappan","raw_affiliation_strings":["Velammal Medical College Hospital and Research Institute"],"raw_orcid":"https://orcid.org/0000-0003-3944-2722","affiliations":[{"raw_affiliation_string":"Velammal Medical College Hospital and Research Institute","institution_ids":["https://openalex.org/I4210104323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032797968","display_name":"G.S. Sivakumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15664174","display_name":"Madurai Medical College","ror":"https://ror.org/05ghahk68","country_code":"IN","type":"education","lineage":["https://openalex.org/I15664174"]},{"id":"https://openalex.org/I4210104323","display_name":"Velammal Medical College Hospital and Research Institute","ror":"https://ror.org/00x9zs206","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210104323"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sivakumar G S","raw_affiliation_strings":["Madurai Medical College","Velammal Medical College Hospital and Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madurai Medical College","institution_ids":["https://openalex.org/I15664174"]},{"raw_affiliation_string":"Velammal Medical College Hospital and Research Institute","institution_ids":["https://openalex.org/I4210104323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109401910","display_name":"R R Saravanan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15664174","display_name":"Madurai Medical College","ror":"https://ror.org/05ghahk68","country_code":"IN","type":"education","lineage":["https://openalex.org/I15664174"]},{"id":"https://openalex.org/I4210104323","display_name":"Velammal Medical College Hospital and Research Institute","ror":"https://ror.org/00x9zs206","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210104323"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Saravanan R R","raw_affiliation_strings":["Madurai Medical College","Velammal Medical College Hospital and Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madurai Medical College","institution_ids":["https://openalex.org/I15664174"]},{"raw_affiliation_string":"Velammal Medical College Hospital and Research Institute","institution_ids":["https://openalex.org/I4210104323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107839792","display_name":"S. Satheeshkumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15664174","display_name":"Madurai Medical College","ror":"https://ror.org/05ghahk68","country_code":"IN","type":"education","lineage":["https://openalex.org/I15664174"]},{"id":"https://openalex.org/I4210104323","display_name":"Velammal Medical College Hospital and Research Institute","ror":"https://ror.org/00x9zs206","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210104323"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Satheeshkumar S","raw_affiliation_strings":["Madurai Medical College","Velammal Medical College Hospital and Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madurai Medical College","institution_ids":["https://openalex.org/I15664174"]},{"raw_affiliation_string":"Velammal Medical College Hospital and Research Institute","institution_ids":["https://openalex.org/I4210104323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045856993","display_name":"S.R. Veeramani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15664174","display_name":"Madurai Medical College","ror":"https://ror.org/05ghahk68","country_code":"IN","type":"education","lineage":["https://openalex.org/I15664174"]},{"id":"https://openalex.org/I4210104323","display_name":"Velammal Medical College Hospital and Research Institute","ror":"https://ror.org/00x9zs206","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210104323"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Veeramani S R","raw_affiliation_strings":["Madurai Medical College","Velammal Medical College Hospital and Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madurai Medical College","institution_ids":["https://openalex.org/I15664174"]},{"raw_affiliation_string":"Velammal Medical College Hospital and Research Institute","institution_ids":["https://openalex.org/I4210104323"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Balasubramanian S","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15664174","display_name":"Madurai Medical College","ror":"https://ror.org/05ghahk68","country_code":"IN","type":"education","lineage":["https://openalex.org/I15664174"]},{"id":"https://openalex.org/I4210104323","display_name":"Velammal Medical College Hospital and Research Institute","ror":"https://ror.org/00x9zs206","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210104323"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Balasubramanian S","raw_affiliation_strings":["Madurai Medical College","Velammal Medical College Hospital and Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madurai Medical College","institution_ids":["https://openalex.org/I15664174"]},{"raw_affiliation_string":"Velammal Medical College Hospital and Research Institute","institution_ids":["https://openalex.org/I4210104323"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066647057","display_name":"Arul A.S","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15664174","display_name":"Madurai Medical College","ror":"https://ror.org/05ghahk68","country_code":"IN","type":"education","lineage":["https://openalex.org/I15664174"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arul A.S","raw_affiliation_strings":["Madurai Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madurai Medical College","institution_ids":["https://openalex.org/I15664174"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032797968","https://openalex.org/A5045856993","https://openalex.org/A5062998321","https://openalex.org/A5107839792","https://openalex.org/A5109401910"],"corresponding_institution_ids":["https://openalex.org/I15664174","https://openalex.org/I4210104323"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12018","display_name":"Coronary Artery Anomalies","score":0.6675000190734863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12018","display_name":"Coronary Artery Anomalies","score":0.6675000190734863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.12099999934434891,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.10480000078678131,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronary-artery-ectasia","display_name":"coronary artery ectasia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/traditional-risk-factors","display_name":"traditional risk factors","score":0.574999988079071},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7940000295639038},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9940000176429749},{"id":"https://openalex.org/keywords/red-blood-cell-distribution-width","display_name":"red cell distribution width","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mean-platelet-volume","display_name":"mean platelet volume","score":0.9990000128746033},{"id":"https://openalex.org/keywords/obstructive-coronary-artery-disease","display_name":"obstructive coronary artery disease","score":0.9369999766349792},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6857796907424927},{"id":"https://openalex.org/C2779512504","wikidata":"https://www.wikidata.org/wiki/Q17084592","display_name":"Coronary artery ectasia","level":4,"score":0.6341714859008789},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4581941068172455},{"id":"https://openalex.org/C7843141","wikidata":"https://www.wikidata.org/wiki/Q1323709","display_name":"Ectasia","level":2,"score":0.4520381689071655},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29370924830436707},{"id":"https://openalex.org/C3019004856","wikidata":"https://www.wikidata.org/wiki/Q42297149","display_name":"Coronary angiography","level":3,"score":0.1282099485397339},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.04984143376350403}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-71388/v1","doi":"https://doi.org/10.21203/rs.3.rs-71388/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-71388/v1","pdf_url":"https://www.researchsquare.com/article/rs-71388/v1.pdf?c=1601483497000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-71388/v1","doi":"https://doi.org/10.21203/rs.3.rs-71388/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-71388/v1","pdf_url":"https://www.researchsquare.com/article/rs-71388/v1.pdf?c=1601483497000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3147054576.pdf","grobid_xml":"https://content.openalex.org/works/W3147054576.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1972187914","https://openalex.org/W1984643084","https://openalex.org/W1993387626","https://openalex.org/W2015029721","https://openalex.org/W2053651296","https://openalex.org/W2077714004","https://openalex.org/W2346688567","https://openalex.org/W2471763088"],"related_works":["https://openalex.org/W2141259729","https://openalex.org/W2809024265","https://openalex.org/W7014851212","https://openalex.org/W4390932468","https://openalex.org/W2161511846","https://openalex.org/W4293042549","https://openalex.org/W2979242274","https://openalex.org/W2080305414","https://openalex.org/W2899151825","https://openalex.org/W2945309958"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Coronary":[2,98,214],"artery":[3,56,61],"ectasia(CAE)":[4],"is":[5,231],"speculated":[6],"as":[7,65,240],"a":[8,48],"variant":[9],"of":[10,14,29,33,73,78,136,144,225,229,246,257],"atherosclerosis.":[11],"The":[12],"pathogenesis":[13],"CAE":[15],"remains":[16],"an":[17,127],"enigma.":[18],"Here":[19],"in":[20,37,47,51,102,142,204,218],"our":[21],"study,":[22],"we":[23],"aimed":[24],"to":[25,149,188,253],"elucidate":[26],"the":[27,104,170,183,223,241,255],"role":[28],"traditional":[30,226],"risk":[31,71,76,163,227],"factors":[32,72,164,228],"atherosclerosis":[34,74,230,239,252],"and":[35,40,58,67,75,93,133,154,173],"inflammation":[36,79,247,250],"coronary":[38,55,60],"ectasia.Methods":[39],"Results:":[41],"This":[42],"comparative":[43,94],"study":[44,105],"was":[45,96,100,139,202],"carried":[46],"tertiary":[49],"hospital":[50],"South":[52],"India.Patients":[53],"with":[54,109,130,220],"ectasia":[57,99,120,125,146,185,215],"obstructive":[59,115,155,174,189,221,235],"disease":[62],"were":[63,112,165,179],"included":[64],"cases":[66],"controls":[68],".":[69],"Traditional":[70,162],"markers":[77,178,245],"(neutrophil-lymphocyte":[80],"ratio(NLR),":[81],"red":[82],"cell":[83],"distribution":[84],"width":[85],"(RDW),":[86],"mean":[87],"platelet":[88],"volume":[89],"(MPV)":[90],")were":[91],"evaluated":[92],"analysis":[95],"done.":[97],"observed":[101,121],"5.6%(n=136)of":[103],"population.":[106],"Among":[107],"those":[108],"ectasia,112(82.4%)":[110],"patients":[111],"having":[113],"significant":[114],"CAD":[116,156,175,190,236],"(mixed":[117],"group),":[118],"isolated":[119,145],"in24":[122],"(17.6%)patients.":[123],"Isolated":[124],"had":[126],"inverse":[128],"association":[129,219],"diabetes":[131],"mellitus":[132],"male:female":[134],"ratio":[135],"(7:1).":[137],"DM":[138],"seen":[140,217],"only":[141],"25%":[143],"groups":[147,157,207],"compared":[148,187],"42.9%,":[150],"47.4%":[151],"among":[152,182,212],"mixed":[153,171],"respectively":[158],"(p":[159],"<":[160],"0.05).":[161],"not":[166,209],"significantly":[167,180],"different":[168,211],"between":[169,233],"group":[172,186,191,237],"group.":[176],"Inflammatory":[177],"higher":[181],"both":[184],"NLR:":[192],"3.98\u00b10.89,":[193],"3.58\u00b10.56,":[194],"2.82\u00b10.60":[195],"p":[196],"<0.001.":[197],"RDW:12.59\u00b10.60,":[198],"12.29\u00b10.85,12.02\u00b10.70,":[199],"p<0.005.":[200],"MPV":[201],"elevated":[203],"all":[205],"three":[206],"but":[208],"much":[210],"groups.Conclusion:":[213],"commonly":[216],"CAD,":[222],"prevalence":[224],"similar":[232],"CAE+CAD,":[234],"suggest":[238,248],"underlying":[242],"pathophysiology.":[243],"Elevated":[244],"overlying":[249],"on":[251],"be":[254],"contributor":[256],"ectasia.":[258]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2021-04-13T00:00:00"}