{"id":"https://openalex.org/W3146984436","doi":"https://doi.org/10.1182/blood.v130.suppl_1.853.853","title":"A Functional Approach to Precision Medicine Identifies Targeted Therapies for Acute Myeloid Leukemia","display_name":"A Functional Approach to Precision Medicine Identifies Targeted Therapies for Acute Myeloid Leukemia","publication_year":2017,"publication_date":"2017-12-07","ids":{"openalex":"https://openalex.org/W3146984436","doi":"https://doi.org/10.1182/blood.v130.suppl_1.853.853","mag":"3146984436"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v130.suppl_1.853.853","doi":"https://doi.org/10.1182/blood.v130.suppl_1.853.853","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v130.suppl_1.853.853","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052448809","display_name":"Shruti Bhatt","orcid":"https://orcid.org/0000-0002-2617-5082","observed_orcids":["https://orcid.org/0000-0002-2617-5082"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shruti Bhatt","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028053662","display_name":"Vineeth Kumar Murali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vineeth Kumar Murali","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, BOSTON, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, BOSTON, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086420008","display_name":"Holly Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Holly Zhu","raw_affiliation_strings":["Department of Medical oncology, Dana-Farber Cancer Institute, BOSTON, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical oncology, Dana-Farber Cancer Institute, BOSTON, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056530572","display_name":"Sophia Adamia","orcid":"https://orcid.org/0000-0001-5704-6040","observed_orcids":["https://orcid.org/0000-0001-5704-6040"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia Adamia","raw_affiliation_strings":["The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Dana-Farber Cancer Institute & HMS, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Dana-Farber Cancer Institute & HMS, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038598397","display_name":"Amanda L. Christie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda L Christie","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026688095","display_name":"David M. Weinstock","orcid":"https://orcid.org/0000-0002-8724-3907","observed_orcids":["https://orcid.org/0000-0002-8724-3907"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Weinstock","raw_affiliation_strings":["Broad Institute of Harvard and MIT, Boston, MA","Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of Harvard and MIT, Boston, MA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027260129","display_name":"Jackie S Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jackie S Garcia","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022857112","display_name":"Anthony G. Letai","orcid":"https://orcid.org/0000-0002-1993-9013","observed_orcids":["https://orcid.org/0000-0002-1993-9013"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Letai","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028053662","https://openalex.org/A5086420008"],"corresponding_institution_ids":["https://openalex.org/I4210117453"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"130","issue":"Suppl_1","first_page":"853","last_page":"853"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.9340000152587891},{"id":"https://openalex.org/keywords/mitochondrial-priming","display_name":"mitochondrial priming","score":0.7699999809265137},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8820000290870667},{"id":"https://openalex.org/keywords/smac-mimetics","display_name":"IAP antagonists","score":0.7210000157356262},{"id":"https://openalex.org/keywords/bh3-mimetics","display_name":"BH3 mimetics","score":0.7480000257492065},{"id":"https://openalex.org/keywords/relapsed-refractory-aml","display_name":"relapsed/refractory AML","score":0.8679999709129333},{"id":"https://openalex.org/keywords/drug-sensitivity-biomarkers","display_name":"drug sensitivity biomarkers","score":0.5830000042915344},{"id":"https://openalex.org/keywords/cdk9-inhibitor","display_name":"CDK9 inhibitor","score":0.6320000290870667},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9440000057220459},{"id":"https://openalex.org/keywords/jq1","display_name":"JQ1","score":0.6470000147819519},{"id":"https://openalex.org/keywords/birinapant","display_name":"birinapant","score":0.722000002861023},{"id":"https://openalex.org/keywords/cell-of-origin","display_name":"cell of origin","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5905170440673828},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.4911908805370331},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.485450804233551},{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.47613194584846497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47537222504615784},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4668833315372467},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.43576014041900635},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.43184298276901245},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.41536056995391846},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3904905915260315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35114049911499023},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33968472480773926},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.249210923910141},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22990021109580994},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12580624222755432},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10157066583633423},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v130.suppl_1.853.853","doi":"https://doi.org/10.1182/blood.v130.suppl_1.853.853","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v130.suppl_1.853.853","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4238044205","https://openalex.org/W3177570246","https://openalex.org/W4415217298","https://openalex.org/W4405038592","https://openalex.org/W4389234644","https://openalex.org/W2016398606","https://openalex.org/W2992226428","https://openalex.org/W2621779581","https://openalex.org/W4392447594","https://openalex.org/W2115272811"],"abstract_inverted_index":{"Abstract":[0],"Identification":[1],"of":[2,19,24,50,57,79,186,198,208,220,252,258,272,291,299,319,355,361,388,412,438,502,523,542,555],"genetic":[3,38,51],"heterogeneity":[4],"in":[5,229,421,463,515],"acute":[6],"myeloid":[7],"leukemia":[8],"(AML)":[9],"has":[10,27],"provided":[11],"a":[12,95,104,110,150,235,249,316,330,543,581,588,590],"unique":[13],"opportunity":[14],"for":[15,62,72,153,566,580],"the":[16,22,31,48,54,88,417,426,429,436,595],"greater":[17,312],"individualization":[18],"therapy.":[20],"However":[21],"implementation":[23],"new":[25,544],"therapies":[26,66,514],"lagged":[28],"far":[29],"behind":[30],"ability":[32,225,354,437],"to":[33,126,141,192,201,226,296,315,323,344,348,357,440,458,473,489,495,498,548,593,598],"initially":[34],"recognize":[35],"operationally":[36],"important":[37,70],"lesions.":[39],"Until":[40],"we":[41,92,157,352,434,452,518],"have":[42,470],"further":[43],"bridged":[44],"this":[45],"gap":[46],"between":[47,407],"identification":[49],"lesions":[52],"and":[53,183,195,244,265,310,373,526,539,584],"resultant":[55],"knowledge":[56],"effective":[58],"therapies,":[59],"alternative":[60],"strategies":[61],"rapidly":[63],"identifying":[64,577],"candidate":[65],"can":[67,339,511],"become":[68],"an":[69,224,289],"tool":[71,96],"precision":[73,446],"medicine.":[74],"Since":[75],"most":[76,396],"agents,":[77],"regardless":[78],"whether":[80],"\"cytotoxic\"":[81],"or":[82,172],"\"targeted\"":[83],"ultimately":[84],"function":[85],"by":[86,134],"activating":[87],"mitochondrial":[89,99,136,203,337,537],"apoptotic":[90,422],"pathway,":[91],"hypothesized":[93],"that":[94,97,116,328,336,393,415,454,553,573],"measures":[98,117],"sensitivity":[100,137,255,347],"may":[101,585],"serve":[102,586],"as":[103,321,399,450,587,589],"broadly":[105],"predictable":[106],"biomarker.":[107],"We":[108,391],"developed":[109,303,520],"dynamic":[111],"BH3":[112,143,261],"profiling":[113],"(DBP)":[114],"technique":[115],"early":[118],"death":[119,130],"signaling":[120,131],"within":[121,234],"8-16":[122],"hours":[123],"after":[124],"exposure":[125],"drugs.":[127,246],"Increased":[128],"cell":[129],"is":[132],"reflected":[133],"increased":[135,139],"(i.e.":[138],"priming)":[140],"standardized":[142],"peptides":[144],"mimicking":[145],"pro-apoptotic":[146],"proteins.":[147],"To":[148,507],"develop":[149],"personalized":[151],"therapy":[152,563,579],"AML":[154,213,301,341,379],"using":[155],"DBP,":[156],"utilized":[158],"20":[159],"independent":[160],"patient":[161,599],"derived":[162],"xenograft":[163],"(PDX)":[164],"models,":[165,381],"established":[166],"from":[167,181,287,304,325,401,484,531],"de":[168],"novo,":[169],"primary":[170],"refractory":[171],"relapsed":[173,516],"(R/R)":[174],"patients":[175,307,327],"(available":[176],"at":[177],"http://www.PRoXe.org).":[178],"Human":[179],"myeloblasts":[180],"spleen":[182],"bone":[184],"marrow":[185],"xenotransplanted":[187],"NSG":[188],"mice":[189],"were":[190,232,424],"exposed":[191],"30":[193],"targeted":[194,221,349,499],"3":[196,282],"standard":[197],"care":[199],"drugs":[200,253,320],"determine":[202],"responses.":[204,390,432],"Unsupervised":[205],"hierarchical":[206],"clustering":[207],"ex-vivo":[209,402,485],"DBP":[210,356,403,439,455,486,510],"measurements":[211,575],"across":[212,256,278,377],"PDXs":[214,231,284,302,324,342,414,427,443,464],"revealed":[215],"several":[216],"distinct":[217],"clusters.":[218],"Majority":[219],"agents":[222,500,525],"with":[223,269,428,444],"induce":[227],"priming":[228,276,293,313,338,389,423,481,538],"selective":[230],"enriched":[233],"cluster,":[236],"including":[237,260],"kinase":[238],"inhibitors,":[239],"epigenetic":[240],"modifiers,":[241],"SMAC":[242],"mimetic":[243],"chemotherapy":[245],"In":[247,568],"contrast,":[248],"discrete":[250,331],"subcluster":[251],"showed":[254,274,311,416,534],"majority":[257],"PDXs,":[259],"mimetics,":[262],"CDK9":[263],"inhibitors":[264],"HDAC":[266],"inhibitors.":[267],"Drugs":[268],"identical":[270],"mechanism":[271],"action":[273],"similar":[275],"patterns":[277],"PDXs.":[279],"Of":[280],"note,":[281],"non-myeloid":[283],"clustered":[285,308],"distinctly":[286],"AML,":[288],"indication":[290],"differential":[292],"responses":[294,314,360,405,482],"owing":[295],"their":[297,385,496],"cells":[298],"origin.":[300],"treatment":[305],"na\u00efve":[306],"adjacently":[309],"large":[317],"number":[318],"opposed":[322],"R/R":[326],"formed":[329],"cluster.":[332],"These":[333],"data":[334],"reveal":[335],"stratify":[340],"according":[343,494],"its":[345],"predicted":[346,472],"agents.":[350],"Next,":[351],"validated":[353],"predict":[358,460,512],"in-vivo":[359,431],"single":[362,524],"agent":[363],"birinapant":[364,394],"(SMAC":[365],"mimetic),":[366],"JQ-1":[367],"(BRD-4":[368],"inhibitor),":[369,372],"quizartinib":[370,461],"(FLT-3":[371],"venetoclax":[374],"(BCL-2":[375],"inhibitor)":[376],"6":[378],"PDX":[380,409,492],"prioritized":[382],"based":[383,476],"on":[384,477],"greatest":[386,418],"range":[387],"found":[392,453],"was":[395,456,487],"efficacious":[397],"nonetheless":[398],"expected":[400],"studies,":[404],"varied":[406],"different":[408,491],"models.":[410],"Myeloblasts":[411,530],"those":[413],"drug-induced":[419],"changes":[420],"indeed":[425],"highest":[430],"When":[433],"compared":[435,547],"identify":[441,594],"sensitive":[442],"additional":[445],"medicine":[447],"tools":[448],"such":[449],"genomics,":[451],"able":[457,488],"accurately":[459],"activity":[462],"expressing":[465],"WT":[466],"FLT-3,":[467],"which":[468],"would":[469],"been":[471],"be":[474,559],"unresponsive":[475],"genomic":[478],"analysis.":[479],"Collectively,":[480],"obtained":[483],"rank":[490],"models":[493,522],"sensitivities":[497],"(AUC":[501],"ROC":[503],"curve":[504],"0.8731,":[505],"p<0.005).":[506],"investigate":[508],"if":[509],"combination":[513],"settings,":[517],"first":[519],"resistant":[521],"then":[527],"repeated":[528],"DBP.":[529],"relapsing":[532],"clone":[533],"reduced":[535],"overall":[536],"lacked":[540],"acquisition":[541],"chemical":[545],"dependency":[546,565],"initial":[549],"clone.":[550],"This":[551],"suggests":[552],"targeting":[554],"pre-existing":[556],"dependencies":[557],"might":[558],"more":[560],"crucial":[561],"than":[562],"induced":[564],"AML.":[567],"summary,":[569],"our":[570],"findings":[571],"highlight":[572],"mitochondria-based":[574],"could":[576],"individualized":[578],"heterogeneous":[582],"population":[583],"powerful":[591],"biomarker":[592],"best":[596],"responders":[597],"therapies.":[600],"Disclosures":[601],"Letai:":[602],"AbbVie,":[603],"AstraZeneca,":[604],"Novartis:":[605],"Consultancy,":[606],"Research":[607],"Funding.":[608]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2021-04-13T00:00:00"}