{"id":"https://openalex.org/W3146972402","doi":null,"title":"\u03b1V\u03b28 integrin- a potential druggable target to prevent posterior capsular opacification (PCO)","display_name":"\u03b1V\u03b28 integrin- a potential druggable target to prevent posterior capsular opacification (PCO)","publication_year":2020,"publication_date":"2020-06-10","ids":{"openalex":"https://openalex.org/W3146972402","mag":"3146972402"},"language":"en","primary_location":{"id":"mag:3146972402","doi":null,"is_oa":true,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2768328","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://iovs.arvojournals.org/article.aspx?articleid=2768328","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086382918","display_name":"Mahbubul H. Shihan","orcid":"https://orcid.org/0000-0001-5190-389X","observed_orcids":["https://orcid.org/0000-0001-5190-389X"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahbubul H. Shihan","raw_affiliation_strings":["Biological Sciences, The University of Delaware, Newark, Delaware, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences, The University of Delaware, Newark, Delaware, United States","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322653","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0002-3107-4614","observed_orcids":["https://orcid.org/0000-0002-3107-4614"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":["Biological Sciences, The University of Delaware, Newark, Delaware, United States"],"raw_orcid":"https://orcid.org/0000-0002-3107-4614","affiliations":[{"raw_affiliation_string":"Biological Sciences, The University of Delaware, Newark, Delaware, United States","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044499032","display_name":"Thomas D. Arnold","orcid":"https://orcid.org/0000-0002-7310-5597","observed_orcids":["https://orcid.org/0000-0002-7310-5597"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. Arnold","raw_affiliation_strings":["Department of Pediatrics, University of California San Francisco, San Francisco, California, United States"],"raw_orcid":"https://orcid.org/0000-0002-7310-5597","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California San Francisco, San Francisco, California, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006496734","display_name":"Dean Sheppard","orcid":"https://orcid.org/0000-0002-6277-2036","observed_orcids":["https://orcid.org/0000-0002-6277-2036"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean Sheppard","raw_affiliation_strings":["Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California, United States"],"raw_orcid":"https://orcid.org/0000-0002-6277-2036","affiliations":[{"raw_affiliation_string":"Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000108853","display_name":"Amha Atakilit","orcid":"https://orcid.org/0000-0002-8586-7230","observed_orcids":["https://orcid.org/0000-0002-8586-7230"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amha Atakilit","raw_affiliation_strings":["Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California, United States"],"raw_orcid":"https://orcid.org/0000-0002-8586-7230","affiliations":[{"raw_affiliation_string":"Lung Biology Center, Department of Medicine, University of California, San Francisco, San Francisco, California, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015868340","display_name":"Nicole M. Rossi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole M. Rossi","raw_affiliation_strings":["Biological Sciences, The University of Delaware, Newark, Delaware, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences, The University of Delaware, Newark, Delaware, United States","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032365754","display_name":"Adam P. Faranda","orcid":"https://orcid.org/0000-0001-6993-8361","observed_orcids":["https://orcid.org/0000-0001-6993-8361"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Faranda","raw_affiliation_strings":["Biological Sciences, The University of Delaware, Newark, Delaware, United States"],"raw_orcid":"https://orcid.org/0000-0001-6993-8361","affiliations":[{"raw_affiliation_string":"Biological Sciences, The University of Delaware, Newark, Delaware, United States","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010301642","display_name":"Melinda K. Duncan","orcid":"https://orcid.org/0000-0003-1570-322X","observed_orcids":["https://orcid.org/0000-0003-1570-322X"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melinda K. Duncan","raw_affiliation_strings":["Biological Sciences, The University of Delaware, Newark, Delaware, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences, The University of Delaware, Newark, Delaware, United States","institution_ids":["https://openalex.org/I86501945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"61","issue":"7","first_page":"3986","last_page":"3986"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-alphavbeta8","display_name":"integrin \u03b1v\u03b28","score":0.9739999771118164},{"id":"https://openalex.org/keywords/posterior-capsule-opacification","display_name":"posterior capsule opacification","score":0.9520000219345093},{"id":"https://openalex.org/keywords/druggable-targets","display_name":"druggable targets","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cataract-surgery","display_name":"cataract surgery","score":0.6549999713897705},{"id":"https://openalex.org/keywords/lens-capsule","display_name":"lens capsule","score":0.4020000100135803},{"id":"https://openalex.org/keywords/integrin-inhibition","display_name":"integrin inhibition","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.8477833867073059},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.7043676972389221},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4634888470172882},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44891247153282166},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28387928009033203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14581751823425293},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13669762015342712},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.053727298974990845},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3146972402","doi":null,"is_oa":true,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2768328","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":{"id":"mag:3146972402","doi":null,"is_oa":true,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2768328","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3206813699","https://openalex.org/W1437333596","https://openalex.org/W1006691721","https://openalex.org/W1157581119","https://openalex.org/W2248947172","https://openalex.org/W1231578766","https://openalex.org/W3214185932","https://openalex.org/W2051770309","https://openalex.org/W2994486232","https://openalex.org/W7095417798"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-04-13T00:00:00"}