{"id":"https://openalex.org/W3146956157","doi":"https://doi.org/10.5114/aoms/135083","title":"Study on the mechanism of multi-AGC kinase AT13148 on Notch signaling pathway in glioblastoma","display_name":"Study on the mechanism of multi-AGC kinase AT13148 on Notch signaling pathway in glioblastoma","publication_year":2021,"publication_date":"2021-04-04","ids":{"openalex":"https://openalex.org/W3146956157","doi":"https://doi.org/10.5114/aoms/135083","mag":"3146956157"},"language":"en","primary_location":{"id":"doi:10.5114/aoms/135083","doi":"https://doi.org/10.5114/aoms/135083","is_oa":true,"landing_page_url":"https://doi.org/10.5114/aoms/135083","pdf_url":"https://www.archivesofmedicalscience.com/pdf-135083-63735?filename=Study on the mechanism of.pdf","source":{"id":"https://openalex.org/S30890154","display_name":"Archives of Medical Science","issn_l":"1734-1922","issn":["1734-1922","1896-9151"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320332","host_organization_name":"Termedia Publishing House","host_organization_lineage":["https://openalex.org/P4310320332"],"host_organization_lineage_names":["Termedia Publishing House"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Medical Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.archivesofmedicalscience.com/pdf-135083-63735?filename=Study on the mechanism of.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115602130","display_name":"Yanan Li","orcid":"https://orcid.org/0000-0003-4396-0557","observed_orcids":["https://orcid.org/0000-0003-4396-0557"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanan Li","raw_affiliation_strings":["Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]},{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062084611","display_name":"Guosheng Han","orcid":"https://orcid.org/0000-0002-7712-6213","observed_orcids":["https://orcid.org/0000-0002-7712-6213"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guosheng Han","raw_affiliation_strings":["Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]},{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052195725","display_name":"Weijie Min","orcid":"https://orcid.org/0000-0003-4257-3715","observed_orcids":["https://orcid.org/0000-0003-4257-3715"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijie Min","raw_affiliation_strings":["Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]},{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110516930","display_name":"Mengmeng Li","orcid":"https://orcid.org/0000-0002-6317-875X","observed_orcids":["https://orcid.org/0000-0002-6317-875X","https://orcid.org/0009-0003-8806-3427"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengmeng Li","raw_affiliation_strings":["Department of Rheumatology, Changzheng Hospital, Navy Medical University, China","Department of Rheumatology, Changzheng Hospital, Navy Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Changzheng Hospital, Navy Medical University, China","institution_ids":[]},{"raw_affiliation_string":"Department of Rheumatology, Changzheng Hospital, Navy Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025930281","display_name":"Maomao Wang","orcid":"https://orcid.org/0000-0003-0305-1834","observed_orcids":["https://orcid.org/0000-0003-0305-1834"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Maomao Wang","raw_affiliation_strings":["Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]},{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100408316","display_name":"Chao Chen","orcid":"https://orcid.org/0000-0001-8173-218X","observed_orcids":["https://orcid.org/0000-0001-8173-218X"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Chen","raw_affiliation_strings":["Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]},{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419230","display_name":"Yi Chen","orcid":"https://orcid.org/0000-0002-0528-5776","observed_orcids":["https://orcid.org/0000-0002-0528-5776"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Chen","raw_affiliation_strings":["Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]},{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034290705","display_name":"Laixing Wang","orcid":"https://orcid.org/0000-0001-6474-1754","observed_orcids":["https://orcid.org/0000-0001-6474-1754"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Laixing Wang","raw_affiliation_strings":["Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]},{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102998258","display_name":"Zhijian Yue","orcid":"https://orcid.org/0000-0002-4006-1532","observed_orcids":["https://orcid.org/0000-0002-4006-1532"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhijian Yue","raw_affiliation_strings":["Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]},{"raw_affiliation_string":"Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102998258"],"corresponding_institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"],"apc_list":{"value":1000,"currency":"EUR","value_usd":1078},"apc_paid":{"value":1000,"currency":"EUR","value_usd":1078},"fwci":0.139,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.39894311,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8769999742507935},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9850000143051147},{"id":"https://openalex.org/keywords/notch1","display_name":"Notch1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.9509999752044678},{"id":"https://openalex.org/keywords/small-molecule-kinase-inhibitors","display_name":"small-molecule kinase inhibitors","score":0.7490000128746033},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9490000009536743},{"id":"https://openalex.org/keywords/u87-cells","display_name":"U87 cells","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C128473837","wikidata":"https://www.wikidata.org/wiki/Q7863603","display_name":"U87","level":3,"score":0.8930438756942749},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.7071487903594971},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6117002964019775},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5519313216209412},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5499861836433411},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.5123165845870972},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5008304119110107},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4936021566390991},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4865190386772156},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.46973857283592224},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41452106833457947},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3692302405834198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3649751543998718},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32639220356941223},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3136047124862671},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.213473379611969},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08075720071792603},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06348133087158203}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5114/aoms/135083","doi":"https://doi.org/10.5114/aoms/135083","is_oa":true,"landing_page_url":"https://doi.org/10.5114/aoms/135083","pdf_url":"https://www.archivesofmedicalscience.com/pdf-135083-63735?filename=Study on the mechanism of.pdf","source":{"id":"https://openalex.org/S30890154","display_name":"Archives of Medical Science","issn_l":"1734-1922","issn":["1734-1922","1896-9151"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320332","host_organization_name":"Termedia Publishing House","host_organization_lineage":["https://openalex.org/P4310320332"],"host_organization_lineage_names":["Termedia Publishing House"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Medical Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5114/aoms/135083","doi":"https://doi.org/10.5114/aoms/135083","is_oa":true,"landing_page_url":"https://doi.org/10.5114/aoms/135083","pdf_url":"https://www.archivesofmedicalscience.com/pdf-135083-63735?filename=Study on the mechanism of.pdf","source":{"id":"https://openalex.org/S30890154","display_name":"Archives of Medical Science","issn_l":"1734-1922","issn":["1734-1922","1896-9151"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320332","host_organization_name":"Termedia Publishing House","host_organization_lineage":["https://openalex.org/P4310320332"],"host_organization_lineage_names":["Termedia Publishing House"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Medical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309612","display_name":"Natural Science Foundation of Shanghai","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3146956157.pdf","grobid_xml":"https://content.openalex.org/works/W3146956157.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W187258105","https://openalex.org/W929310391","https://openalex.org/W1565012938","https://openalex.org/W1575138345","https://openalex.org/W1885230865","https://openalex.org/W1995644713","https://openalex.org/W2011822602","https://openalex.org/W2083998760","https://openalex.org/W2130807572","https://openalex.org/W2215998033","https://openalex.org/W2468535583","https://openalex.org/W2473193283","https://openalex.org/W2614794838","https://openalex.org/W2755084308","https://openalex.org/W2789784221","https://openalex.org/W2791770037","https://openalex.org/W2803329568","https://openalex.org/W2803953307","https://openalex.org/W2911514323","https://openalex.org/W2914393896","https://openalex.org/W2922104671","https://openalex.org/W2923214215","https://openalex.org/W3016132436","https://openalex.org/W3024941666","https://openalex.org/W3027717499","https://openalex.org/W3048161475","https://openalex.org/W3086707353","https://openalex.org/W3098998180","https://openalex.org/W3108126332","https://openalex.org/W3152302094","https://openalex.org/W4246504168","https://openalex.org/W4286613508","https://openalex.org/W4394498362","https://openalex.org/W6827682958","https://openalex.org/W7074149878"],"related_works":["https://openalex.org/W929310391","https://openalex.org/W2103592738","https://openalex.org/W2035652406","https://openalex.org/W2965341503","https://openalex.org/W2022822197","https://openalex.org/W4324360007","https://openalex.org/W2052334769","https://openalex.org/W2166980528","https://openalex.org/W2771889891","https://openalex.org/W3086707353"],"abstract_inverted_index":{"Introduction":[0],"Glioblastoma":[1],"is":[2,11,39],"the":[3,40,87,93,96,103,141,147,154,168,179,188,198,206,223],"most":[4],"malignant":[5],"astrocytoma,":[6],"and":[7,24,46,65,78,89,95,133,135,143,149,163,183,208,227],"its":[8],"therapeutic":[9],"effect":[10],"not":[12],"ideal.":[13],"Notch":[14,36],"signaling":[15,37],"pathway":[16,38],"plays":[17],"an":[18],"important":[19],"role":[20],"in":[21,114,172,213,241],"tumor":[22],"proliferation":[23,104,199,207],"invasion.":[25],"Whether":[26],"small":[27,72,237],"molecule":[28,238],"drug":[29,74,239],"AT13148":[30,111,152,175,186,194,204,220],"can":[31,165,195],"affect":[32,222],"glioblastoma":[33,50],"by":[34],"regulating":[35],"focus":[41],"of":[42,92,105,110,121,129,146,156,161,170,181,191,200,210,225],"this":[43],"study.":[44],"Material":[45],"methods":[47],"In":[48],"vitro,":[49],"U87":[51,58,122,157,173,192,201],"cell":[52,59],"line":[53,60],"transfected":[54,61],"with":[55,62,70,126,167],"sh-ITGB1":[56,162],"(U87sh-ITGB1),":[57],"oe-ITGB1":[63,164],"(U87oe-ITGB1)":[64],"control":[66],"group":[67],"were":[68,83,112,131,137],"treated":[69],"a":[71,117,233],"molecular":[73],"AT13148.":[75],"RT-qPCR,":[76],"western-blot":[77,136],"clone":[79],"formation":[80],"ability":[81,190],"assays":[82],"used":[84,138],"to":[85,139],"detect":[86],"mRNA":[88,142],"protein":[90,144],"expression":[91,145,169,180,224],"ITGB1":[94,148,171,182,226],"key":[97],"gene":[98],"NOTCH1,":[99,228],"as":[100,102],"well":[101],"cancer":[106],"cells.":[107,123,158,174,193,202],"Therapeutic":[108],"effects":[109],"examined":[113],"vivo":[115],"using":[116],"nude":[118],"mice":[119],"model":[120],"After":[124],"treatment":[125],"AT13148,":[127],"volume":[128],"tumors":[130,212],"calculated,":[132],"RT-qPCR":[134],"evaluate":[140],"NOTCH1.":[150,184],"Results":[151],"inhibits":[153],"activity":[155],"Lentiviral":[159],"transfection":[160],"interfere":[166],"could":[176,221,231],"down-regulate":[177],"both":[178],"Moreover,":[185],"affects":[187],"cloning":[189],"also":[196,230],"inhibit":[197],"Furthermore,":[203],"inhibited":[205],"invasion":[209],"transplanted":[211],"vivo.":[214],"Conclusions":[215],"This":[216],"study":[217],"indicated":[218],"that":[219],"which":[229],"be":[232],"potential":[234,235],"anti-glioblastoma":[236],"candidate":[240],"clinic":[242],"medicine.":[243]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-04-13T00:00:00"}
