{"id":"https://openalex.org/W3146212154","doi":null,"title":"Study on ligand binding domains of human vascular endothelial growth factor receptor Flt-1 within extracellular domain and its structure analysis","display_name":"Study on ligand binding domains of human vascular endothelial growth factor receptor Flt-1 within extracellular domain and its structure analysis","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W3146212154","mag":"3146212154"},"language":"en","primary_location":{"id":"mag:3146212154","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/abstract/CBA/345902","pdf_url":null,"source":{"id":"https://openalex.org/S2911247321","display_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","issn_l":"1007-7626","issn":["1007-7626"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4324114229","host_organization_name":"Chinese Society of Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4324114229"],"host_organization_lineage_names":["Chinese Society of Biochemistry and Molecular Biology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Li Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100627833","display_name":"Zhiqing Zhang","orcid":"https://orcid.org/0000-0002-6854-8430","observed_orcids":["https://orcid.org/0000-0002-6854-8430"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhiqing Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6854-8430","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319677","display_name":"Xiaoning Wang","orcid":"https://orcid.org/0000-0003-0153-324X","observed_orcids":["https://orcid.org/0000-0003-0153-324X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoning Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109948509","display_name":"Aijun Chen","orcid":"https://orcid.org/0009-0003-6198-2861","observed_orcids":["https://orcid.org/0009-0003-6198-2861"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aijun Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-6198-2861","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039408319","display_name":"Lihong Yao","orcid":"https://orcid.org/0000-0002-3267-5980","observed_orcids":["https://orcid.org/0000-0002-3267-5980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lihong Yao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3267-5980","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030672669","display_name":"Zhongliang Jiang","orcid":"https://orcid.org/0000-0001-7822-4520","observed_orcids":["https://orcid.org/0000-0001-7822-4520"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhongliang Jiang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7822-4520","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27554777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1","first_page":"40","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flt-1","display_name":"Flt-1","score":0.9269999861717224},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor-receptor","display_name":"vascular endothelial growth factor receptor","score":0.9419999718666077},{"id":"https://openalex.org/keywords/vegf-binding","display_name":"VEGF binding","score":0.925000011920929},{"id":"https://openalex.org/keywords/ligand-binding-domain","display_name":"ligand-binding domain","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ig-like-domains","display_name":"immunoglobulin-like domains","score":0.7070000171661377},{"id":"https://openalex.org/keywords/extracellular-domain","display_name":"extracellular domain","score":0.7599999904632568},{"id":"https://openalex.org/keywords/yeast-two-hybrid","display_name":"yeast two-hybrid","score":0.7680000066757202},{"id":"https://openalex.org/keywords/vegf165","display_name":"VEGF165","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.6687853932380676},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.6685252785682678},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6282417178153992},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6067036986351013},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5379673838615417},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4989311695098877},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.49087387323379517},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.4670155644416809},{"id":"https://openalex.org/C174851938","wikidata":"https://www.wikidata.org/wiki/Q1337844","display_name":"Two-hybrid screening","level":3,"score":0.4587315618991852},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.4267025291919708},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26174628734588623},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22322407364845276},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20395129919052124},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.10053524374961853}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3146212154","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/abstract/CBA/345902","pdf_url":null,"source":{"id":"https://openalex.org/S2911247321","display_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","issn_l":"1007-7626","issn":["1007-7626"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4324114229","host_organization_name":"Chinese Society of Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4324114229"],"host_organization_lineage_names":["Chinese Society of Biochemistry and Molecular Biology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2353921836","https://openalex.org/W2363179176","https://openalex.org/W2389471872","https://openalex.org/W2126757808","https://openalex.org/W1965478715","https://openalex.org/W2372033949","https://openalex.org/W2029521699","https://openalex.org/W2053473403","https://openalex.org/W1965380392","https://openalex.org/W56534538"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,12],"detect":[3],"its":[4],"minimal":[5],"extracellular":[6],"Ig-like":[7],"domains":[8],"which":[9],"were":[10,27,49,81,87,98],"sufficient":[11],"achieve":[13],"VEGF":[14,65],"binding,":[15],"amino":[16],"acid":[17],"component":[18],"and":[19,47,58,64,79,107,138],"crystal":[20],"structure":[21],"of":[22,32,43,85],"the":[23,30,59,90,123],"first":[24],"three":[25],"loops":[26],"analyzed.":[28],"On":[29],"basis":[31],"this":[33],"analysis,":[34],"four":[35],"cDNA":[36,56],"clones":[37],"coding":[38],"truncated":[39],"Flt-1":[40,62],"mutants":[41,63],"consisting":[42],"loop2,":[44],"1-2,":[45],"2-3":[46],"1-3":[48],"amplified":[50],"by":[51,100,144],"PCR":[52],"from":[53],"human":[54],"placenta":[55],"library":[57],"interaction":[60],"between":[61],"was":[66],"investigated":[67],"with":[68],"yeast":[69,91],"two-hybrid":[70],"system.":[71],"Fusion":[72],"expressio":[73],"plasmids":[74,86],"pGAD424/Flt-1(2),":[75,76],"pGAD424/Flt-1(2-3),":[77],"pGAD424/Flt1(1-3)":[78],"pGBT9/hVEGF_(165)":[80],"constructed.":[82],"Two":[83],"kinds":[84],"cotransformed":[88],"into":[89],"reporter":[92],"strain":[93],"SFY526.":[94],"Transformants^":[95],"beta-galactosidase":[96],"activities":[97],"detected":[99],"both":[101],"filter":[102],"assay":[103,110],"for":[104,111],"qualitative":[105],"analysis":[106],"liquid":[108],"culture":[109],"quantitative":[112],"data.":[113],"The":[114],"data":[115],"presented":[116],"here":[117],"suggested":[118],"that":[119],"loop2-3":[120],"had":[121,132],"almost":[122],"same":[124],"hVEGF_(165)":[125,143],"binding":[126,136],"ability":[127,137],"as":[128],"loop1-3,":[129],"but":[130],"loop1-2":[131],"only":[133],"faint":[134],"ligand":[135],"loop2":[139],"could":[140],"not":[141],"bind":[142],"itself.":[145]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2021-04-13T00:00:00"}
