{"id":"https://openalex.org/W3146095095","doi":"https://doi.org/10.33448/rsd-v10i4.13487","title":"Efeitos delet\u00e9rios do uso cr\u00f4nico de corticoides: uma abordagem do desenvolvimento da S\u00edndrome de Cushing","display_name":"Efeitos delet\u00e9rios do uso cr\u00f4nico de corticoides: uma abordagem do desenvolvimento da S\u00edndrome de Cushing","publication_year":2021,"publication_date":"2021-04-02","ids":{"openalex":"https://openalex.org/W3146095095","doi":"https://doi.org/10.33448/rsd-v10i4.13487","mag":"3146095095"},"language":"pt","primary_location":{"id":"doi:10.33448/rsd-v10i4.13487","doi":"https://doi.org/10.33448/rsd-v10i4.13487","is_oa":true,"landing_page_url":"https://doi.org/10.33448/rsd-v10i4.13487","pdf_url":"https://rsdjournal.org/index.php/rsd/article/download/13487/12490","source":{"id":"https://openalex.org/S2739064124","display_name":"Research Society and Development","issn_l":"2525-3409","issn":["2525-3409"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312449","host_organization_name":"Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ci\u00eancias","host_organization_lineage":["https://openalex.org/P4310312449"],"host_organization_lineage_names":["Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ci\u00eancias"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research, Society and Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://rsdjournal.org/index.php/rsd/article/download/13487/12490","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111045688","display_name":"Francisco R\u00f4mulo Soares Tavares","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257498","display_name":"Faculdades Nova Esperan\u00e7a","ror":"https://ror.org/05b367g49","country_code":"BR","type":"education","lineage":["https://openalex.org/I4405257498"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Francisco R\u00f4mulo Soares Tavares","raw_affiliation_strings":["Faculdades Nova Esperan\u00e7a"],"raw_orcid":"https://orcid.org/0000-0002-6503-7117","affiliations":[{"raw_affiliation_string":"Faculdades Nova Esperan\u00e7a","institution_ids":["https://openalex.org/I4405257498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036781831","display_name":"Erivaldo Rum\u00e3o da Luz","orcid":"https://orcid.org/0000-0002-8926-1383","observed_orcids":["https://orcid.org/0000-0002-8926-1383"]},"institutions":[{"id":"https://openalex.org/I4405257498","display_name":"Faculdades Nova Esperan\u00e7a","ror":"https://ror.org/05b367g49","country_code":"BR","type":"education","lineage":["https://openalex.org/I4405257498"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Erivaldo Rum\u00e3o da Luz","raw_affiliation_strings":["Faculdades Nova Esperan\u00e7a"],"raw_orcid":"https://orcid.org/0000-0002-8926-1383","affiliations":[{"raw_affiliation_string":"Faculdades Nova Esperan\u00e7a","institution_ids":["https://openalex.org/I4405257498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062748220","display_name":"Carlos Eduardo Guedes da Silva","orcid":"https://orcid.org/0000-0003-0765-144X","observed_orcids":["https://orcid.org/0000-0003-0765-144X"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carlos Eduardo Guedes da Silva","raw_affiliation_strings":["Universidade Federal da Para\u00edba"],"raw_orcid":"https://orcid.org/0000-0003-0765-144X","affiliations":[{"raw_affiliation_string":"Universidade Federal da Para\u00edba","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064647715","display_name":"Jo\u00e3o Manoel Lima de Barros Carvalho","orcid":"https://orcid.org/0000-0001-9688-7766","observed_orcids":["https://orcid.org/0000-0001-9688-7766"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Joao Manoel  Lima de Barros Carvalho","raw_affiliation_strings":["Universidade Federal da Para\u00edba"],"raw_orcid":"https://orcid.org/0000-0001-9688-7766","affiliations":[{"raw_affiliation_string":"Universidade Federal da Para\u00edba","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039016883","display_name":"Aleson Pereira de Sousa","orcid":"https://orcid.org/0000-0002-3430-477X","observed_orcids":["https://orcid.org/0000-0002-3430-477X"]},"institutions":[{"id":"https://openalex.org/I169045520","display_name":"Universidade Federal da Para\u00edba","ror":"https://ror.org/00p9vpz11","country_code":"BR","type":"education","lineage":["https://openalex.org/I169045520"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Aleson Pereira de Sousa","raw_affiliation_strings":["Universidade Federal da Para\u00edba"],"raw_orcid":"https://orcid.org/0000-0002-3430-477X","affiliations":[{"raw_affiliation_string":"Universidade Federal da Para\u00edba","institution_ids":["https://openalex.org/I169045520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036285487","display_name":"Maria Denise Leite Ferreira","orcid":"https://orcid.org/0000-0001-8156-3443","observed_orcids":["https://orcid.org/0000-0001-8156-3443"]},"institutions":[{"id":"https://openalex.org/I4405257498","display_name":"Faculdades Nova Esperan\u00e7a","ror":"https://ror.org/05b367g49","country_code":"BR","type":"education","lineage":["https://openalex.org/I4405257498"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Denise Leite Ferreira","raw_affiliation_strings":["Faculdades Nova Esperan\u00e7a"],"raw_orcid":"https://orcid.org/0000-0002-7100-5023","affiliations":[{"raw_affiliation_string":"Faculdades Nova Esperan\u00e7a","institution_ids":["https://openalex.org/I4405257498"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5136,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.60522148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"10","issue":"4","first_page":"e12310413487","last_page":"e12310413487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.18289999663829803,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cushing-s-syndrome","display_name":"Cushing's syndrome","score":0.7929999828338623},{"id":"https://openalex.org/keywords/iatrogenic-cushing-syndrome","display_name":"iatrogenic Cushing's syndrome","score":0.9670000076293945},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8700000047683716},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.718999981880188},{"id":"https://openalex.org/keywords/glucocorticoid-pharmacokinetics","display_name":"glucocorticoid pharmacokinetics","score":0.8640000224113464},{"id":"https://openalex.org/keywords/glucocorticoid-metabolism","display_name":"glucocorticoid metabolism","score":0.8849999904632568},{"id":"https://openalex.org/keywords/glucocorticoid-withdrawal","display_name":"glucocorticoid withdrawal","score":0.8029999732971191},{"id":"https://openalex.org/keywords/adrenal-insufficiency","display_name":"adrenal insufficiency","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8644225001335144},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.35760390758514404},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.33639681339263916},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.06897342205047607}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.33448/rsd-v10i4.13487","doi":"https://doi.org/10.33448/rsd-v10i4.13487","is_oa":true,"landing_page_url":"https://doi.org/10.33448/rsd-v10i4.13487","pdf_url":"https://rsdjournal.org/index.php/rsd/article/download/13487/12490","source":{"id":"https://openalex.org/S2739064124","display_name":"Research Society and Development","issn_l":"2525-3409","issn":["2525-3409"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312449","host_organization_name":"Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ci\u00eancias","host_organization_lineage":["https://openalex.org/P4310312449"],"host_organization_lineage_names":["Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ci\u00eancias"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research, Society and Development","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.33448/rsd-v10i4.13487","doi":"https://doi.org/10.33448/rsd-v10i4.13487","is_oa":true,"landing_page_url":"https://doi.org/10.33448/rsd-v10i4.13487","pdf_url":"https://rsdjournal.org/index.php/rsd/article/download/13487/12490","source":{"id":"https://openalex.org/S2739064124","display_name":"Research Society and Development","issn_l":"2525-3409","issn":["2525-3409"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312449","host_organization_name":"Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ci\u00eancias","host_organization_lineage":["https://openalex.org/P4310312449"],"host_organization_lineage_names":["Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ci\u00eancias"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research, Society and Development","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3146095095.pdf","grobid_xml":"https://content.openalex.org/works/W3146095095.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W57329009","https://openalex.org/W1970406549","https://openalex.org/W1973211040","https://openalex.org/W1987857749","https://openalex.org/W1992240692","https://openalex.org/W2056190689","https://openalex.org/W2060789691","https://openalex.org/W2061962280","https://openalex.org/W2084712767","https://openalex.org/W2092722173","https://openalex.org/W2094359164","https://openalex.org/W2126895785","https://openalex.org/W2150725620","https://openalex.org/W2155180384","https://openalex.org/W2214733499","https://openalex.org/W2276644940","https://openalex.org/W2295871373","https://openalex.org/W2415610721","https://openalex.org/W2559407559","https://openalex.org/W2800343861","https://openalex.org/W2954976394","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4392926150","https://openalex.org/W4416323379","https://openalex.org/W4317662109","https://openalex.org/W7133131281","https://openalex.org/W3108827975","https://openalex.org/W2895371563","https://openalex.org/W2082837619","https://openalex.org/W7205005227","https://openalex.org/W4391527941","https://openalex.org/W3107229249"],"abstract_inverted_index":{"Nas":[0],"\u00faltimas":[1],"d\u00e9cadas":[2],"ocorreu":[3],"ineg\u00e1vel":[4],"avan\u00e7o":[5],"no":[6],"desenvolvimento":[7],"de":[8,15,24,80,87,107,136,157,161,166],"novos":[9],"f\u00e1rmacos,":[10],"que":[11,36,91,152],"incrementaram":[12],"a":[13,22,39,78,83,103,109,120],"qualidade":[14],"vida":[16,25],"do":[17,65,93,127,170],"paciente,":[18],"bem":[19,140],"como":[20,58,141],"estenderam":[21],"expectativa":[23],"da":[26,85,130,159],"popula\u00e7\u00e3o":[27],"mundial":[28],"\u00e0s":[29],"quais":[30],"t\u00eam":[31],"alcance.":[32],"Entretanto,":[33],"deve-se":[34],"considerar":[35],"subst\u00e2ncias":[37],"ex\u00f3genas,":[38],"n\u00edveis":[40,48],"supra":[41],"fisiol\u00f3gicos,":[42],"ou":[43],"at\u00e9":[44],"mesmo":[45],"dentro":[46],"dos":[47,62,96,115,138,150],"normais,":[49],"em":[50],"sua":[51],"maioria,":[52],"podem":[53],"causar":[54],"com":[55,119,154],"efeitos":[56,113],"delet\u00e9rios,":[57],"\u00e9":[59],"o":[60,105],"caso":[61],"corticoides,":[63],"foco":[64],"estudo":[66],"deste":[67],"trabalho.":[68],"Analisou-se":[69],"artigos":[70],"das":[71],"bases":[72],"MEDLINE,":[73],"PubMed,":[74],"Elsevier,":[75],"Nature":[76],"Review,":[77],"fim":[79],"se":[81],"explorar":[82],"evolu\u00e7\u00e3o":[84],"S\u00edndrome":[86],"Cushing":[88],"(SC)":[89],"iatrog\u00eanica,":[90],"cursa":[92],"uso":[94],"cr\u00f4nico":[95],"Glicocorticoides":[97],"(GC).":[98],"Para":[99],"tal,":[100],"foi":[101,123],"descrita":[102],"bioqu\u00edmica,":[104],"mecanismo":[106],"a\u00e7\u00e3o,":[108],"farmacocin\u00e9tica":[110],"e":[111,163],"os":[112],"metab\u00f3licos":[114],"GC.":[116],"O":[117],"paralelo":[118],"SC":[121],"iatrog\u00eanica":[122],"tra\u00e7ado":[124],"na":[125,133],"descri\u00e7\u00e3o":[126],"diagn\u00f3stico":[128],"cl\u00ednico":[129],"doen\u00e7a,":[131],"pautada":[132],"hist\u00f3ria":[134],"pr\u00e9via":[135],"corticoterapia":[137],"portadores,":[139],"foram":[142],"relatadas":[143],"as":[144],"principais":[145],"t\u00e9cnicas":[146],"recomendadas":[147],"para":[148],"desmame":[149],"GC,":[151],"cursam":[153],"menor":[155,164],"grau":[156],"recidiva":[158],"doen\u00e7a":[160],"base":[162],"risco":[165],"insufici\u00eancia":[167],"adrenal":[168],"(disfuncionalidades":[169],"eixo":[171],"Hipot\u00e1lamo-Hip\u00f3fise-Adrenal).":[172]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-04-13T00:00:00"}
