{"id":"https://openalex.org/W3145513795","doi":null,"title":"The Endothelial Barrier is not Rate-limiting to Insulin Action in the Myocardium","display_name":"The Endothelial Barrier is not Rate-limiting to Insulin Action in the Myocardium","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3145513795","mag":"3145513795"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/101122","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/101122","pdf_url":"https://utoronto.scholaris.ca/bitstreams/4e91554b-48ca-4b6e-b2e3-e6825b89d172/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/4e91554b-48ca-4b6e-b2e3-e6825b89d172/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085209184","display_name":"Rajiv Sanwal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rajiv Sanwal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5085209184"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.053300000727176666,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-action","display_name":"insulin action","score":0.6430000066757202},{"id":"https://openalex.org/keywords/myocardium","display_name":"myocardium","score":0.890999972820282},{"id":"https://openalex.org/keywords/endothelial-barrier","display_name":"endothelial barrier","score":0.9390000104904175},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.9399999976158142},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7549999952316284},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8349999785423279},{"id":"https://openalex.org/keywords/blood-flow-regulation","display_name":"blood flow regulation","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.6925485730171204},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.5874432325363159},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5569034814834595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4903450012207031},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4207971692085266},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4120532274246216},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3596819043159485},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1315048336982727},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11639449000358582},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.08427444100379944},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/101122","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/101122","pdf_url":"https://utoronto.scholaris.ca/bitstreams/4e91554b-48ca-4b6e-b2e3-e6825b89d172/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:3145513795","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/101122/1/Sanwal_Rajiv_%20_202006_MSc_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/101122","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/101122","pdf_url":"https://utoronto.scholaris.ca/bitstreams/4e91554b-48ca-4b6e-b2e3-e6825b89d172/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3878722045","display_name":null,"funder_award_id":"G-16-00013521","funder_id":"https://openalex.org/F4320307845","funder_display_name":"Heart and Stroke Foundation of Canada"}],"funders":[{"id":"https://openalex.org/F4320307845","display_name":"Heart and Stroke Foundation of Canada","ror":"https://ror.org/00qbpyp73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3145513795.pdf","grobid_xml":"https://content.openalex.org/works/W3145513795.grobid-xml"},"referenced_works_count":235,"referenced_works":["https://openalex.org/W826782111","https://openalex.org/W938248398","https://openalex.org/W1485161311","https://openalex.org/W1526128150","https://openalex.org/W1547466369","https://openalex.org/W1551443142","https://openalex.org/W1553420187","https://openalex.org/W1579096574","https://openalex.org/W1591823948","https://openalex.org/W1605041796","https://openalex.org/W1605496649","https://openalex.org/W1832995858","https://openalex.org/W1838110840","https://openalex.org/W1841050729","https://openalex.org/W1895665623","https://openalex.org/W1895996242","https://openalex.org/W1899433760","https://openalex.org/W1901437611","https://openalex.org/W1929989355","https://openalex.org/W1936651842","https://openalex.org/W1964238639","https://openalex.org/W1965263898","https://openalex.org/W1965575731","https://openalex.org/W1965580291","https://openalex.org/W1966629642","https://openalex.org/W1967723791","https://openalex.org/W1968593502","https://openalex.org/W1968878147","https://openalex.org/W1969834753","https://openalex.org/W1970285990","https://openalex.org/W1971677443","https://openalex.org/W1972142752","https://openalex.org/W1973018387","https://openalex.org/W1973409609","https://openalex.org/W1974554536","https://openalex.org/W1975236725","https://openalex.org/W1976439848","https://openalex.org/W1978030502","https://openalex.org/W1978577250","https://openalex.org/W1979834284","https://openalex.org/W1981001162","https://openalex.org/W1982471919","https://openalex.org/W1985130075","https://openalex.org/W1985750179","https://openalex.org/W1986758681","https://openalex.org/W1987967672","https://openalex.org/W1988089792","https://openalex.org/W1989762800","https://openalex.org/W1990190556","https://openalex.org/W1990644905","https://openalex.org/W1993429838","https://openalex.org/W1995150314","https://openalex.org/W1995448106","https://openalex.org/W1997460544","https://openalex.org/W1997590090","https://openalex.org/W1998355732","https://openalex.org/W1998493448","https://openalex.org/W2001069796","https://openalex.org/W2005859137","https://openalex.org/W2006062639","https://openalex.org/W2006273520","https://openalex.org/W2008603261","https://openalex.org/W2009020353","https://openalex.org/W2010763118","https://openalex.org/W2015004750","https://openalex.org/W2015016880","https://openalex.org/W2018717417","https://openalex.org/W2019862207","https://openalex.org/W2021343620","https://openalex.org/W2021403681","https://openalex.org/W2023730199","https://openalex.org/W2026550637","https://openalex.org/W2027409303","https://openalex.org/W2027469923","https://openalex.org/W2031200353","https://openalex.org/W2031259066","https://openalex.org/W2031663420","https://openalex.org/W2032925493","https://openalex.org/W2033524876","https://openalex.org/W2034626424","https://openalex.org/W2036313213","https://openalex.org/W2036832250","https://openalex.org/W2037943855","https://openalex.org/W2040814813","https://openalex.org/W2041856304","https://openalex.org/W2042006175","https://openalex.org/W2042559950","https://openalex.org/W2044376455","https://openalex.org/W2044437167","https://openalex.org/W2045405791","https://openalex.org/W2045852899","https://openalex.org/W2045956369","https://openalex.org/W2048198814","https://openalex.org/W2050989809","https://openalex.org/W2051269098","https://openalex.org/W2053127486","https://openalex.org/W2054345479","https://openalex.org/W2055216411","https://openalex.org/W2055970438","https://openalex.org/W2056064770","https://openalex.org/W2057723954","https://openalex.org/W2058172582","https://openalex.org/W2058280890","https://openalex.org/W2059369537","https://openalex.org/W2061694846","https://openalex.org/W2062613627","https://openalex.org/W2066275743","https://openalex.org/W2066639629","https://openalex.org/W2066834504","https://openalex.org/W2067349015","https://openalex.org/W2069988949","https://openalex.org/W2074466423","https://openalex.org/W2075342873","https://openalex.org/W2076186944","https://openalex.org/W2076873000","https://openalex.org/W2078920527","https://openalex.org/W2080182312","https://openalex.org/W2080348776","https://openalex.org/W2080513099","https://openalex.org/W2081275836","https://openalex.org/W2082515526","https://openalex.org/W2083138678","https://openalex.org/W2083850113","https://openalex.org/W2084697100","https://openalex.org/W2086252748","https://openalex.org/W2086279639","https://openalex.org/W2089125273","https://openalex.org/W2089582113","https://openalex.org/W2090730225","https://openalex.org/W2091171605","https://openalex.org/W2091364176","https://openalex.org/W2091499945","https://openalex.org/W2091535117","https://openalex.org/W2091638984","https://openalex.org/W2092835296","https://openalex.org/W2101286622","https://openalex.org/W2102396989","https://openalex.org/W2103831817","https://openalex.org/W2105412616","https://openalex.org/W2106466218","https://openalex.org/W2106545251","https://openalex.org/W2106560333","https://openalex.org/W2107219840","https://openalex.org/W2107287484","https://openalex.org/W2111154780","https://openalex.org/W2111833940","https://openalex.org/W2112398805","https://openalex.org/W2113447833","https://openalex.org/W2114170344","https://openalex.org/W2114416030","https://openalex.org/W2115944612","https://openalex.org/W2116479949","https://openalex.org/W2116979396","https://openalex.org/W2118038884","https://openalex.org/W2118613169","https://openalex.org/W2118688616","https://openalex.org/W2119318450","https://openalex.org/W2119380751","https://openalex.org/W2120381920","https://openalex.org/W2120852510","https://openalex.org/W2121220148","https://openalex.org/W2122898723","https://openalex.org/W2123229219","https://openalex.org/W2124517680","https://openalex.org/W2125029933","https://openalex.org/W2126281673","https://openalex.org/W2126412451","https://openalex.org/W2126700142","https://openalex.org/W2127321192","https://openalex.org/W2130595746","https://openalex.org/W2130850001","https://openalex.org/W2131515450","https://openalex.org/W2132099317","https://openalex.org/W2133930237","https://openalex.org/W2135323749","https://openalex.org/W2136229559","https://openalex.org/W2136681796","https://openalex.org/W2137035181","https://openalex.org/W2137148373","https://openalex.org/W2137521058","https://openalex.org/W2140017673","https://openalex.org/W2140538678","https://openalex.org/W2140717323","https://openalex.org/W2141244124","https://openalex.org/W2141757949","https://openalex.org/W2144827287","https://openalex.org/W2146877877","https://openalex.org/W2147176626","https://openalex.org/W2147361723","https://openalex.org/W2149098481","https://openalex.org/W2150021754","https://openalex.org/W2151869895","https://openalex.org/W2152156058","https://openalex.org/W2152252241","https://openalex.org/W2153732291","https://openalex.org/W2154284879","https://openalex.org/W2155957079","https://openalex.org/W2155993440","https://openalex.org/W2156592737","https://openalex.org/W2161803852","https://openalex.org/W2162804111","https://openalex.org/W2162897915","https://openalex.org/W2164118729","https://openalex.org/W2165252181","https://openalex.org/W2169182236","https://openalex.org/W2172260616","https://openalex.org/W2173898107","https://openalex.org/W2220777476","https://openalex.org/W2254087166","https://openalex.org/W2262241890","https://openalex.org/W2308388038","https://openalex.org/W2327640792","https://openalex.org/W2331341341","https://openalex.org/W2341717561","https://openalex.org/W2398244013","https://openalex.org/W2410681887","https://openalex.org/W2411599344","https://openalex.org/W2421023472","https://openalex.org/W2469988178","https://openalex.org/W2498756245","https://openalex.org/W2520432709","https://openalex.org/W2559894696","https://openalex.org/W2613355422","https://openalex.org/W2623056842","https://openalex.org/W2751476301","https://openalex.org/W2761168665","https://openalex.org/W2772059359","https://openalex.org/W2781760684","https://openalex.org/W2791339045","https://openalex.org/W2803379371","https://openalex.org/W2914125461","https://openalex.org/W4210343616","https://openalex.org/W4211094368","https://openalex.org/W4213464763","https://openalex.org/W4322384827"],"related_works":["https://openalex.org/W3007787728","https://openalex.org/W2801048206","https://openalex.org/W2049621798","https://openalex.org/W4200571348","https://openalex.org/W2781760684","https://openalex.org/W2106882931","https://openalex.org/W2027469923","https://openalex.org/W2349637612","https://openalex.org/W4411928200","https://openalex.org/W2043791240"],"abstract_inverted_index":{"Diabetes":[0],"is":[1,36,44,102],"characterized":[2],"by":[3],"the":[4,8,17,26,41,62,77,99,109,128],"impaired":[5],"function":[6],"of":[7,14,123,131],"pancreatic":[9],"hormone":[10],"insulin.":[11,132],"The":[12],"exit":[13],"insulin":[15,34,47,55,75,90,106,114],"from":[16],"capillaries":[18],"requires":[19],"its":[20],"passage":[21],"across":[22],"endothelial":[23,42,51,100],"cells.":[24],"Whether":[25],"endothelium":[27],"acts":[28],"as":[29],"a":[30,66],"rate-limiting":[31,45,104],"barrier":[32,43,101],"to":[33,46,76,105,112],"transport":[35,130],"controversial.We":[37],"hypothesized":[38],"that":[39,81,84,98],"if":[40],"transport,":[48],"then":[49],"increasing":[50],"permeability":[52],"will":[53],"accelerate":[54],"action":[56,91,107],"on":[57,118],"downstream":[58,119],"tissues.":[59],"To":[60],"address":[61],"question,":[63],"we":[64],"developed":[65],"murine":[67],"ex":[68],"vivo":[69],"aortic":[70],"perfusion":[71],"model":[72],"which":[73],"delivers":[74],"heart.":[78],"We":[79],"demonstrated":[80],"despite":[82],"conditions":[83],"significantly":[85],"increased":[86],"cardiac":[87],"vascular":[88],"permeability,":[89],"was":[92],"not":[93,103],"accelerated.":[94],"These":[95],"data":[96],"indicate":[97],"in":[108],"myocardium.":[110],"Efforts":[111],"decrease":[113],"resistance":[115],"should":[116],"focus":[117],"tissues":[120],"or":[121],"regulation":[122],"blood":[124],"flow":[125],"rather":[126],"than":[127],"transendothelial":[129]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-04-13T00:00:00"}
