{"id":"https://openalex.org/W3145164530","doi":"https://doi.org/10.1182/bloodadvances.2020003300","title":"Selective drug combination vulnerabilities in STAT3- and TP53-mutant malignant NK cells","display_name":"Selective drug combination vulnerabilities in STAT3- and TP53-mutant malignant NK cells","publication_year":2021,"publication_date":"2021-04-01","ids":{"openalex":"https://openalex.org/W3145164530","doi":"https://doi.org/10.1182/bloodadvances.2020003300","mag":"3145164530","pmid":"https://pubmed.ncbi.nlm.nih.gov/33792631","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8045497"},"language":"en","primary_location":{"id":"doi:10.1182/bloodadvances.2020003300","doi":"https://doi.org/10.1182/bloodadvances.2020003300","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2020003300","pdf_url":null,"source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1182/bloodadvances.2020003300","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055691523","display_name":"Elina Parri","orcid":"https://orcid.org/0000-0002-9144-5421","observed_orcids":["https://orcid.org/0000-0002-9144-5421"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Elina Parri","raw_affiliation_strings":["Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland;"],"raw_orcid":"https://orcid.org/0000-0002-9144-5421","affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland;","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061588223","display_name":"Heikki A Kuusanm\u00e4ki","orcid":"https://orcid.org/0000-0002-1903-0408","observed_orcids":["https://orcid.org/0000-0002-1903-0408"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["DK","FI"],"is_corresponding":false,"raw_author_name":"Heikki Kuusanm\u00e4ki","raw_affiliation_strings":["Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark; and","Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland;"],"raw_orcid":"https://orcid.org/0000-0002-1903-0408","affiliations":[{"raw_affiliation_string":"Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark; and","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801134892"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland;","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064674972","display_name":"Daria R. Bulanova","orcid":"https://orcid.org/0000-0002-5038-1724","observed_orcids":["https://orcid.org/0000-0002-5038-1724"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["DK","FI"],"is_corresponding":false,"raw_author_name":"Daria Bulanova","raw_affiliation_strings":["Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark; and","Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland;"],"raw_orcid":"https://orcid.org/0000-0002-5038-1724","affiliations":[{"raw_affiliation_string":"Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark; and","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801134892"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland;","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008868111","display_name":"Satu M. Mustjoki","orcid":"https://orcid.org/0000-0002-0816-8241","observed_orcids":["https://orcid.org/0000-0002-0816-8241"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Satu Mustjoki","raw_affiliation_strings":["Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland;","Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland; and","iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0002-0816-8241","affiliations":[{"raw_affiliation_string":"Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland;","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland; and","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067760174","display_name":"Krister Wennerberg","orcid":"https://orcid.org/0000-0002-1352-4220","observed_orcids":["https://orcid.org/0000-0002-1352-4220"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["DK","FI"],"is_corresponding":false,"raw_author_name":"Krister Wennerberg","raw_affiliation_strings":["Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark; and","Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland;"],"raw_orcid":"https://orcid.org/0000-0002-1352-4220","affiliations":[{"raw_affiliation_string":"Biotech Research & Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark; and","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801134892"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland;","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":0.6519,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.60747776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"5","issue":"7","first_page":"1862","last_page":"1875"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nk-cell-neoplasms","display_name":"NK-cell neoplasms","score":0.878000020980835},{"id":"https://openalex.org/keywords/ruxolitinib","display_name":"ruxolitinib","score":0.8999999761581421},{"id":"https://openalex.org/keywords/jak-inhibitors","display_name":"JAK inhibitors","score":0.7289999723434448},{"id":"https://openalex.org/keywords/drug-combination-therapy","display_name":"drug combination therapy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6909999847412109},{"id":"https://openalex.org/keywords/stat3-mutations","display_name":"STAT3 mutations","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/idasanutlin","display_name":"idasanutlin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/mdm2-inhibitors","display_name":"MDM2 inhibitors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/tipifarnib","display_name":"tipifarnib","score":0.9879999756813049},{"id":"https://openalex.org/keywords/farnesyltransferase-inhibitors","display_name":"farnesyltransferase inhibitors","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9290000200271606},{"id":"https://openalex.org/keywords/s63845","display_name":"S63845","score":0.9639999866485596},{"id":"https://openalex.org/keywords/mcl-1-inhibitors","display_name":"Mcl-1 inhibitors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/drug-sensitivity-screening","display_name":"drug sensitivity screening","score":0.7260000109672546},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6722869277000427},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5912402272224426},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.46620500087738037},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45325547456741333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3667007088661194},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29301178455352783},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28065699338912964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26325300335884094},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2508203089237213},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.17378294467926025},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14252987504005432},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1409488320350647}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1182/bloodadvances.2020003300","doi":"https://doi.org/10.1182/bloodadvances.2020003300","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2020003300","pdf_url":null,"source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8045497","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8045497","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Adv","raw_type":"Text"},{"id":"pmid:33792631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33792631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood advances","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/370fb05c-62a0-4125-a626-56d65f2d7078","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/370fb05c-62a0-4125-a626-56d65f2d7078","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Parri, E, Kuusanm\u00e4ki, H, Bulanova, D, Mustjoki, S & Wennerberg, K 2021, 'Selective drug combination vulnerabilities in STAT3- And TP53-mutant malignant NK cells', Blood advances, vol. 5, no. 7, pp. 1862-1875. https://doi.org/10.1182/BLOODADVANCES.2020003300","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:helda.helsinki.fi:10138/336325","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/336325","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1182/bloodadvances.2020003300","doi":"https://doi.org/10.1182/bloodadvances.2020003300","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2020003300","pdf_url":null,"source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3589578894","display_name":null,"funder_award_id":"NNF17CC0027852","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G7044228676","display_name":null,"funder_award_id":"NNF17CC0027852","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G855313384","display_name":"Aberrant clonal T cell proliferations in patients with hematopoietic stem cell transplantation","funder_award_id":"331256","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"}],"funders":[{"id":"https://openalex.org/F4320310078","display_name":"Blood Disease Research Foundation","ror":"https://ror.org/03we23r72"},{"id":"https://openalex.org/F4320310086","display_name":"Helsingin Yliopisto","ror":"https://ror.org/040af2s02"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320323824","display_name":"Sy\u00f6p\u00e4j\u00e4rjest\u00f6t","ror":"https://ror.org/05pgg4z49"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320328139","display_name":"Biocenter Finland","ror":"https://ror.org/03aay6c48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W76522298","https://openalex.org/W977201031","https://openalex.org/W1000149840","https://openalex.org/W1586640515","https://openalex.org/W1617495083","https://openalex.org/W1696775091","https://openalex.org/W1968707152","https://openalex.org/W1974113889","https://openalex.org/W1977198374","https://openalex.org/W1985035916","https://openalex.org/W1991077717","https://openalex.org/W1995347532","https://openalex.org/W2002783575","https://openalex.org/W2012186914","https://openalex.org/W2016682147","https://openalex.org/W2024196844","https://openalex.org/W2036386987","https://openalex.org/W2041204531","https://openalex.org/W2054787206","https://openalex.org/W2055483030","https://openalex.org/W2065942364","https://openalex.org/W2075117946","https://openalex.org/W2081504817","https://openalex.org/W2081609875","https://openalex.org/W2083329634","https://openalex.org/W2085479979","https://openalex.org/W2101515818","https://openalex.org/W2103980474","https://openalex.org/W2106391833","https://openalex.org/W2107858207","https://openalex.org/W2111411380","https://openalex.org/W2115517051","https://openalex.org/W2135109155","https://openalex.org/W2136157904","https://openalex.org/W2152526557","https://openalex.org/W2156651430","https://openalex.org/W2175452743","https://openalex.org/W2184198667","https://openalex.org/W2310716991","https://openalex.org/W2345786810","https://openalex.org/W2407061276","https://openalex.org/W2410022503","https://openalex.org/W2537909502","https://openalex.org/W2586276931","https://openalex.org/W2605336808","https://openalex.org/W2612483493","https://openalex.org/W2622400061","https://openalex.org/W2765137431","https://openalex.org/W2769496270","https://openalex.org/W2772899810","https://openalex.org/W2792211393","https://openalex.org/W2794936032","https://openalex.org/W2799754007","https://openalex.org/W2810661858","https://openalex.org/W2885043724","https://openalex.org/W2897114985","https://openalex.org/W2897855995","https://openalex.org/W2898148116","https://openalex.org/W2902633453","https://openalex.org/W2947278314","https://openalex.org/W2956213465","https://openalex.org/W2980245695","https://openalex.org/W2987669999","https://openalex.org/W2994741911","https://openalex.org/W3010256878","https://openalex.org/W3010668776","https://openalex.org/W3013405101","https://openalex.org/W3035147924","https://openalex.org/W6603128427","https://openalex.org/W6714407045"],"related_works":["https://openalex.org/W2799754007","https://openalex.org/W1974113889","https://openalex.org/W4313356078","https://openalex.org/W4283325086","https://openalex.org/W4380029345","https://openalex.org/W2792539281","https://openalex.org/W2980130884","https://openalex.org/W2752422983","https://openalex.org/W3152951713","https://openalex.org/W2016682147"],"abstract_inverted_index":{"Mature":[0],"natural":[1],"killer":[2],"(NK)":[3],"cell":[4,156,167,180],"neoplasms":[5,59,213],"are":[6,27],"rare":[7],"but":[8,185],"very":[9,21],"aggressive":[10],"types":[11],"of":[12,30,32,38,100,112,139,220,223],"cancers.":[13],"With":[14],"currently":[15],"available":[16],"treatments,":[17],"they":[18],"have":[19],"a":[20,188,198,229],"poor":[22],"prognosis":[23],"and,":[24],"as":[25],"such,":[26],"an":[28],"example":[29],"group":[31],"cancers":[33],"in":[34,78,119,152,165,228],"which":[35,224],"the":[36,62,130,144,161,174,178],"development":[37,138,219],"effective":[39],"precision":[40],"therapies":[41],"is":[42],"needed.":[43],"Using":[44],"both":[45,186],"short-":[46],"and":[47,82,133,169,214],"long-term":[48,120],"drug":[49,79,88,200,206],"sensitivity":[50,80,201],"testing,":[51],"we":[52,204],"explored":[53,118],"novel":[54],"ways":[55],"to":[56,110,191],"target":[57,210],"NK-cell":[58,76,212],"by":[60],"combining":[61],"clinically":[63],"approved":[64],"JAK":[65],"inhibitor":[66,150,163,183],"ruxolitinib":[67,104,141,158,170],"with":[68,103,143,160,172],"other":[69],"targeted":[70],"agents.":[71],"We":[72],"profiled":[73],"7":[74],"malignant":[75],"lines":[77],"screens":[81],"identified":[83,126,205],"that":[84,127,208],"these":[85,113],"exhibit":[86],"differential":[87],"sensitivities":[89],"based":[90],"on":[91],"their":[92],"genetic":[93,193],"background.":[94],"In":[95,195],"short-term":[96],"assays,":[97],"various":[98],"classes":[99],"drugs":[101],"combined":[102,142,159,171],"seemed":[105],"highly":[106],"potent.":[107],"Strikingly,":[108],"resistance":[109],"most":[111],"combinations":[114,124,207],"emerged":[115],"rapidly":[116],"when":[117],"assays.":[121],"However,":[122],"4":[123],"were":[125],"selectively":[128,209],"eradicated":[129],"cancer":[131],"cells":[132],"did":[134],"not":[135,216],"allow":[136,217],"for":[137,218],"resistance:":[140],"mouse":[145],"double-minute":[146],"2":[147],"homolog":[148],"(MDM2)":[149],"idasanutlin":[151],"STAT3-mutant,":[153],"TP53":[154],"wild-type":[155],"lines;":[157,168],"farnesyltransferase":[162],"tipifarnib":[164],"TP53-mutant":[166],"either":[173],"glucocorticoid":[175],"dexamethasone":[176],"or":[177],"myeloid":[179],"leukemia-1":[181],"(MCL-1)":[182],"S63845":[184],"without":[187],"clear":[189],"link":[190],"underlying":[192],"features.":[194],"conclusion,":[196],"using":[197],"new":[199],"screening":[202],"approach,":[203],"mature":[211],"do":[215],"resistance,":[221],"some":[222],"can":[225],"be":[226],"applied":[227],"genetically":[230],"stratified":[231],"manner.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-04-13T00:00:00"}
