{"id":"https://openalex.org/W3144933521","doi":null,"title":"Myosin VI is down-regulated by DNA damage in p53- and cell type-dependent manners","display_name":"Myosin VI is down-regulated by DNA damage in p53- and cell type-dependent manners","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W3144933521","mag":"3144933521"},"language":"en","primary_location":{"id":"mag:3144933521","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/68/9_Supplement/1745","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110028348","display_name":"Seong Jun Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seong Jun Cho","raw_affiliation_strings":["Center for Comparative Oncology, the University of California at Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Comparative Oncology, the University of California at Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002191937","display_name":"Xinbin Chen","orcid":"https://orcid.org/0000-0002-4582-6506","observed_orcids":["https://orcid.org/0000-0002-4582-6506"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinbin Chen","raw_affiliation_strings":["Center for Comparative Oncology, the University of California at Davis, Davis, CA"],"raw_orcid":"https://orcid.org/0000-0002-4582-6506","affiliations":[{"raw_affiliation_string":"Center for Comparative Oncology, the University of California at Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50253519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"68","issue":null,"first_page":"1745","last_page":"1745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myosin-vi","display_name":"myosin VI","score":0.9800000190734863},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8519999980926514},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.6890000104904175},{"id":"https://openalex.org/keywords/endosomes","display_name":"endosomes","score":0.6100000143051147},{"id":"https://openalex.org/keywords/mdm2-inhibition","display_name":"MDM2 inhibition","score":0.5329999923706055},{"id":"https://openalex.org/keywords/nutlin-3","display_name":"Nutlin-3","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cell-survival-pathways","display_name":"cell survival pathways","score":0.5440000295639038},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.8880479335784912},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5597342848777771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5419609546661377},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.5229343175888062},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.46997684240341187},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.4245398938655853},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.355180561542511},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.26887261867523193},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1957450807094574},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.1507973074913025}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3144933521","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/68/9_Supplement/1745","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2096823738","https://openalex.org/W2103586281","https://openalex.org/W7161097243","https://openalex.org/W1968220278","https://openalex.org/W2970174529","https://openalex.org/W2108179312","https://openalex.org/W2606131740","https://openalex.org/W2076452926","https://openalex.org/W1825680478","https://openalex.org/W1857008528"],"abstract_inverted_index":{"1745":[0],"Myosin":[2,33,51,66,98,135,162,184,216,245,255],"VI":[3,34,52,67,99,136,163,185,205,217,246,256],"is":[4,68,83,100,138,218,250],"an":[5,127],"unconventional":[6],"motor":[7],"protein":[8,35,137,206,259],"and":[9,24,42,72,82,104,122,166,178,193,247],"functions":[10],"in":[11,37,70,78,85,102,140,143,226,239],"a":[12,79,144,227],"variety":[13],"of":[14,26,32,97,134,148,161,170,244],"intracellular":[15],"processes":[16],"such":[17,119],"as":[18,120],"cell":[19,87],"migration,":[20],"vesicular":[21],"membrane":[22],"traffic":[23],"homeostasis":[25],"the":[27,86,94,132,149,154,159,188,237,254],"Golgi":[28,41],"complex.":[29],"The":[30],"majority":[31],"exists":[36],"cytoplasmic":[38],"organelles,":[39],"including":[40],"endosomes.":[43],"In":[44,61],"our":[45],"previous":[46],"report,":[47],"we":[48,63,91,157,213],"found":[49,64,173,202],"that":[50,65,93,174,203,215],"can":[53],"be":[54],"translocated":[55,219],"to":[56,235,252],"nucleus":[57,221],"upon":[58,222],"DNA":[59,76,116,223],"damage.":[60],"addition,":[62],"up-regulated":[69],"RKO":[71],"H1299":[73],"cells":[74,106,142],"by":[75,164],"damage":[77,117,224],"p53-dependent":[80,145],"manner":[81,146],"involved":[84],"survival":[88],"pathway.":[89],"Here,":[90],"showed":[92,214],"mRNA":[95],"level":[96,133],"decreased":[101,139],"MCF7":[103],"LNCap":[105],"treated":[107,113,125],"with":[108,114,126,209],"camptothecin":[109],"but":[110,225],"increased":[111],"when":[112],"other":[115],"agents,":[118],"doxorubicin":[121],"hydroxyurea,":[123],"or":[124,258],"Mdm-2":[128],"inhibitor":[129],"(Nutlin-3).":[130],"However,":[131],"these":[141],"regardless":[147],"agent":[150],"used.":[151],"To":[152],"determine":[153,236],"underlying":[155],"mechanism,":[156],"examine":[158],"regulation":[160],"wild-type":[165,176],"various":[167],"mutated":[168],"forms":[169],"p53.":[171],"We":[172,200],"both":[175],"p53":[177,181,191,196,210,240,249],"N-/C-terminally":[179],"truncated":[180,190],"(\u0394AD1\u0394BD)":[182],"inhibit":[183],"expression":[186],"whereas":[187],"C-terminal":[189],"(\u0394BD)":[192],"tumor-derived":[194],"mutant":[195],"(R249S)":[197],"are":[198,232],"inert.":[199],"also":[201],"myosin":[204],"physically":[207],"interacts":[208],"protein.":[211],"Moreover,":[212],"into":[220],"p53-independent":[228],"manner.":[229],"Further":[230],"studies":[231],"currently":[233],"underway":[234],"domains":[238],"responsible":[241],"for":[242],"down-regulation":[243],"whether":[248],"able":[251],"regulate":[253],"translation":[257],"stability.":[260]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2021-04-13T00:00:00"}