{"id":"https://openalex.org/W3144819964","doi":"https://doi.org/10.1109/nebc.2011.5778708","title":"Shear-induced resistance to neutrophil activation via the formyl peptide receptor","display_name":"Shear-induced resistance to neutrophil activation via the formyl peptide receptor","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W3144819964","doi":"https://doi.org/10.1109/nebc.2011.5778708","mag":"3144819964"},"language":"en","primary_location":{"id":"doi:10.1109/nebc.2011.5778708","doi":"https://doi.org/10.1109/nebc.2011.5778708","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nebc.2011.5778708","pdf_url":null,"source":{"id":"https://openalex.org/S4393916914","display_name":"IEEE Annual Northeast Bioengineering Conference (NEBEC)","issn_l":"1071-121X","issn":["1071-121X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE 37th Annual Northeast Bioengineering Conference (NEBEC)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070201038","display_name":"Michael J. Mitchell","orcid":"https://orcid.org/0000-0002-3628-2244","observed_orcids":["https://orcid.org/0000-0002-3628-2244"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.J. Mitchell","raw_affiliation_strings":["Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081005464","display_name":"Michael R. King","orcid":"https://orcid.org/0000-0002-0223-7808","observed_orcids":["https://orcid.org/0000-0002-0223-7808","https://orcid.org/0009-0006-4643-3663"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.R. King","raw_affiliation_strings":["Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.48348348,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":null,"first_page":"1","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.4636000096797943,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.4636000096797943,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.3871999979019165,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluid-shear-stress","display_name":"fluid shear stress","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neutrophil-activation","display_name":"neutrophil activation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/formyl-peptide-receptor","display_name":"formyl peptide receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/l-selectin-shedding","display_name":"L-selectin shedding","score":0.878000020980835},{"id":"https://openalex.org/keywords/beta2-integrin-activation","display_name":"\u03b22 integrin activation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/fmlp","display_name":"fMLP","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C2776731609","wikidata":"https://www.wikidata.org/wiki/Q24782993","display_name":"Formyl peptide receptor","level":4,"score":0.6174144148826599},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.6156790256500244},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5893582105636597},{"id":"https://openalex.org/C21141959","wikidata":"https://www.wikidata.org/wiki/Q657936","display_name":"Shear stress","level":2,"score":0.5536103844642639},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5037979483604431},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4575064182281494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4457274377346039},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.43975886702537537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3486594557762146},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34408649802207947},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32305842638015747},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2524421811103821},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2464560866355896},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nebc.2011.5778708","doi":"https://doi.org/10.1109/nebc.2011.5778708","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nebc.2011.5778708","pdf_url":null,"source":{"id":"https://openalex.org/S4393916914","display_name":"IEEE Annual Northeast Bioengineering Conference (NEBEC)","issn_l":"1071-121X","issn":["1071-121X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE 37th Annual Northeast Bioengineering Conference (NEBEC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1877030085","https://openalex.org/W1977986244","https://openalex.org/W2031927909","https://openalex.org/W2079096224","https://openalex.org/W2096626263","https://openalex.org/W2099675490","https://openalex.org/W2141924291","https://openalex.org/W2170499630","https://openalex.org/W2413985151"],"related_works":["https://openalex.org/W2146884456","https://openalex.org/W3174909517","https://openalex.org/W1991718644","https://openalex.org/W3137811754","https://openalex.org/W2121436531","https://openalex.org/W1877030085","https://openalex.org/W3155237269","https://openalex.org/W2090426035","https://openalex.org/W325194728","https://openalex.org/W1955099311"],"abstract_inverted_index":{"The":[0],"ability":[1],"of":[2,30,53,107,145],"activated":[3],"leukocytes":[4],"to":[5,10,19,50,61,77,92,102,112,119,127,140],"retract":[6],"pseudopods":[7],"in":[8,81,100,153],"response":[9,101],"fluid":[11,54,136],"shear":[12,55,79,121,137],"stress":[13,56,80,122],"may":[14,149,158],"be":[15,120],"a":[16,69,82,89,103,135],"critical":[17],"mechanism":[18],"downregulate":[20],"inflammation":[21],"and":[22,37,97],"maintain":[23],"stable":[24],"circulation.":[25],"By":[26],"measuring":[27],"earlier":[28],"indicators":[29],"leukocyte":[31,151],"activation":[32,62,96,113,141],"such":[33],"as":[34,161],"L-selectin":[35,98],"shedding":[36,99],"\u03b22":[38,94],"integrin":[39,95],"activation,":[40],"which":[41],"precede":[42],"morphological":[43],"changes,":[44],"we":[45],"have":[46],"found":[47],"that":[48],"exposure":[49,76],"physiological":[51],"levels":[52],"makes":[57],"neutrophils":[58,87,133],"more":[59],"resistant":[60],"via":[63,116,142],"the":[64,154],"formyl":[65],"peptide":[66],"receptor":[67,73,147],"(FPR),":[68],"chemoattractant":[70],"G-protein":[71],"coupled":[72],"(GPCR).":[74],"After":[75],"uniform":[78],"cone-and-plate":[83],"viscometer,":[84],"primary":[85],"human":[86],"showed":[88],"significant":[90],"reduction":[91],"both":[93],"0.5":[104],"nM":[105],"concentration":[106],"formyl-methionyl-leucyl-phenylalanine":[108],"(fMLP).":[109],"Neutrophil":[110],"resistance":[111,126,139],"was":[114],"shown":[115],"flow":[117],"cytometry":[118],"dose-dependent,":[123],"with":[124],"neutrophil":[125],"increasing":[128],"from":[129],"0.1-4.0":[130],"dyn/cm2.":[131],"Overall,":[132],"acquired":[134],"stress-induced":[138],"FPR.":[143],"Control":[144],"this":[146],"activity":[148],"enhance":[150],"circulation":[152],"bloodstream.":[155],"This":[156],"work":[157],"also":[159],"serve":[160],"an":[162],"example":[163],"for":[164],"other":[165],"GPCR":[166],"mechanosensing":[167],"phenomena.":[168]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2021-04-13T00:00:00"}