{"id":"https://openalex.org/W3144796306","doi":"https://doi.org/10.21037/gs-21-4","title":"The effect of inhibiting exosomes derived from adipose-derived stem cells via the TGF-\u03b21/Smad pathway on the fibrosis of keloid fibroblasts","display_name":"The effect of inhibiting exosomes derived from adipose-derived stem cells via the TGF-\u03b21/Smad pathway on the fibrosis of keloid fibroblasts","publication_year":2021,"publication_date":"2021-03-01","ids":{"openalex":"https://openalex.org/W3144796306","doi":"https://doi.org/10.21037/gs-21-4","mag":"3144796306","pmid":"https://pubmed.ncbi.nlm.nih.gov/33842249","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8033055"},"language":"en","primary_location":{"id":"doi:10.21037/gs-21-4","doi":"https://doi.org/10.21037/gs-21-4","is_oa":true,"landing_page_url":"https://doi.org/10.21037/gs-21-4","pdf_url":"https://gs.amegroups.com/article/viewFile/65503/pdf","source":{"id":"https://openalex.org/S2764374275","display_name":"Gland Surgery","issn_l":"2227-684X","issn":["2227-684X","2227-8575"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gland Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://gs.amegroups.com/article/viewFile/65503/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048556510","display_name":"Zhiyuan Wu","orcid":"https://orcid.org/0000-0001-5694-2441","observed_orcids":["https://orcid.org/0000-0001-5694-2441","https://orcid.org/0009-0002-0689-4036"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Yuan Wu","raw_affiliation_strings":["Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100635002","display_name":"Huijun Zhang","orcid":"https://orcid.org/0000-0003-1722-7511","observed_orcids":["https://orcid.org/0000-0003-1722-7511"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui-Jun Zhang","raw_affiliation_strings":["Department of Burn Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burn Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016002622","display_name":"Zhihong Zhou","orcid":"https://orcid.org/0000-0002-7886-2319","observed_orcids":["https://orcid.org/0000-0002-7886-2319"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Hong Zhou","raw_affiliation_strings":["Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000656668","display_name":"Zhanpeng Li","orcid":"https://orcid.org/0000-0003-1335-3692","observed_orcids":["https://orcid.org/0000-0003-1335-3692"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhan-Peng Li","raw_affiliation_strings":["Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014917672","display_name":"Simu Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-Mu Liao","raw_affiliation_strings":["Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091116985","display_name":"Zeyong Wu","orcid":"https://orcid.org/0009-0008-6829-5796","observed_orcids":["https://orcid.org/0009-0008-6829-5796"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ze-Yong Wu","raw_affiliation_strings":["Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088239676","display_name":"Haihua Huang","orcid":"https://orcid.org/0000-0002-2622-557X","observed_orcids":["https://orcid.org/0000-0002-2622-557X"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-Hua Huang","raw_affiliation_strings":["Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001946395","display_name":"Yu-Cang Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu-Cang Shi","raw_affiliation_strings":["Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China","institution_ids":["https://openalex.org/I176834541"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001946395"],"corresponding_institution_ids":["https://openalex.org/I176834541"],"apc_list":null,"apc_paid":null,"fwci":5.5555,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.96757466,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"3","first_page":"1046","last_page":"1056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipose-derived-stem-cell-exosomes","display_name":"adipose-derived stem cell exosomes","score":0.9300000071525574},{"id":"https://openalex.org/keywords/keloid-fibroblasts","display_name":"keloid fibroblasts","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tgf-beta1-smad3-signaling-pathway","display_name":"TGF-\u03b21/Smad3 signaling","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hypertrophic-scars","display_name":"hypertrophic scars","score":0.8489999771118164},{"id":"https://openalex.org/keywords/fibroblast-proliferation","display_name":"fibroblast proliferation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/fibroblast-migration","display_name":"fibroblast migration","score":0.9269999861717224},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.968999981880188},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9449999928474426},{"id":"https://openalex.org/keywords/exosome-therapy","display_name":"exosome therapy","score":0.5979999899864197},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.30300000309944153},{"id":"https://openalex.org/keywords/scar-reduction","display_name":"scar reduction","score":0.3100000023841858},{"id":"https://openalex.org/keywords/exosome-isolation-and-purification","display_name":"exosome isolation and purification","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C2777538232","wikidata":"https://www.wikidata.org/wiki/Q1131260","display_name":"Keloid","level":2,"score":0.7765804529190063},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6334075927734375},{"id":"https://openalex.org/C2779797417","wikidata":"https://www.wikidata.org/wiki/Q12460151","display_name":"Hydroxyproline","level":2,"score":0.5729626417160034},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.5647301077842712},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5597143173217773},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5413837432861328},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5298594832420349},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5003714561462402},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.48241695761680603},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.46166402101516724},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.4416944086551666},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43360036611557007},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40579086542129517},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39899516105651855},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.384080708026886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3067361116409302},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28018975257873535},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27767646312713623},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2150138020515442},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16009286046028137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11913496255874634},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/gs-21-4","doi":"https://doi.org/10.21037/gs-21-4","is_oa":true,"landing_page_url":"https://doi.org/10.21037/gs-21-4","pdf_url":"https://gs.amegroups.com/article/viewFile/65503/pdf","source":{"id":"https://openalex.org/S2764374275","display_name":"Gland Surgery","issn_l":"2227-684X","issn":["2227-684X","2227-8575"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gland Surgery","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8033055","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8033055","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gland Surg","raw_type":"Text"},{"id":"pmid:33842249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33842249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gland surgery","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/gs-21-4","doi":"https://doi.org/10.21037/gs-21-4","is_oa":true,"landing_page_url":"https://doi.org/10.21037/gs-21-4","pdf_url":"https://gs.amegroups.com/article/viewFile/65503/pdf","source":{"id":"https://openalex.org/S2764374275","display_name":"Gland Surgery","issn_l":"2227-684X","issn":["2227-684X","2227-8575"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gland Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308085","display_name":"Massachusetts Department of Agricultural Resources","ror":"https://ror.org/03wjj7779"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3144796306.pdf","grobid_xml":"https://content.openalex.org/works/W3144796306.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1969183806","https://openalex.org/W2007290442","https://openalex.org/W2033121392","https://openalex.org/W2043263890","https://openalex.org/W2074661784","https://openalex.org/W2086411372","https://openalex.org/W2098018562","https://openalex.org/W2110886621","https://openalex.org/W2160689761","https://openalex.org/W2256103742","https://openalex.org/W2463806122","https://openalex.org/W2484335322","https://openalex.org/W2488772485","https://openalex.org/W2519687050","https://openalex.org/W2593918601","https://openalex.org/W2604116492","https://openalex.org/W2604219658","https://openalex.org/W2604610770","https://openalex.org/W2761091945","https://openalex.org/W2770714340","https://openalex.org/W2794152344","https://openalex.org/W2810398220","https://openalex.org/W3093728330","https://openalex.org/W3113273369","https://openalex.org/W3144796306","https://openalex.org/W3186448398"],"related_works":["https://openalex.org/W4221096288","https://openalex.org/W4402552230","https://openalex.org/W4399442751","https://openalex.org/W2802732580","https://openalex.org/W3112737770","https://openalex.org/W4401652869","https://openalex.org/W4386475798","https://openalex.org/W3199205976","https://openalex.org/W4391353553","https://openalex.org/W4362692050"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"main":[2],"mechanism":[3],"of":[4,31,40,51,66,132,155,191,206,212,242,258,280,297,300,308,330,336],"keloid":[5,9,102],"formation":[6],"is":[7,13,23],"that":[8],"fibroblasts":[10],"(KFs)":[11],"apoptosis":[12,50,176,247,329],"inhibited,":[14],"leading":[15],"to":[16,59,104,150],"excessive":[17],"proliferation.":[18],"Transforming":[19],"growth":[20],"factor-\u03b21":[21],"(TGF-\u03b21)":[22],"a":[24],"key":[25],"signal":[26],"molecule":[27],"in":[28,57,145,157,194,209,233,249,288],"the":[29,38,47,63,79,84,94,152,161,172,183,204,210,221,224,234,240,246,250,256,262,271,274,289,295,306,312,322,328,334,337],"process":[30],"regulating":[32],"cell":[33,43,162,168,175],"fibrosis.":[34],"This":[35],"paper":[36],"discusses":[37],"effect":[39],"adipose-derived":[41],"stem":[42],"exosomes":[44,85],"(ADSCs-EXO)":[45],"on":[46],"proliferation":[48,154,225,323],"and":[49,53,73,83,107,121,137,203,229,261,277,286,302,311,324,326],"KFS":[52],"its":[54],"possible":[55],"mechanism,":[56],"order":[58],"provide":[60],"reference":[61],"for":[62],"clinical":[64],"intervention":[65],"hypertrophic":[67],"scar.":[68],"METHODS:":[69],"ADSCs":[70],"were":[71,89,98,126,148,264,314],"isolated":[72],"cultured":[74,99,128],"from":[75,100],"human":[76,101],"adipose":[77],"tissue,":[78],"supernatant":[80],"was":[81],"collected,":[82],"secreted":[86],"by":[87,91,177,197,215,332],"ADSCs-EXO":[88,133,243,259,309,319],"extracted":[90],"ultracentrifugation.":[92],"At":[93],"same":[95],"time,":[96],"KFs":[97,125,331],"tissue":[103],"P3":[105],"generation,":[106],"then":[108,127],"divided":[109],"into":[110],"four":[111,130],"groups:":[112],"control":[113,222,272],"group,":[114,223,273],"experimental":[115,118,122,236,252],"group":[116,119,123,147,159,196,214],"A,":[117],"B":[120],"C.":[124],"with":[129,220,239,255,270,305],"concentrations":[131],"(0,":[134],"1,":[135],"10,":[136],"100":[138],"\u00b5g/mL,":[139],"respectively).":[140],"After":[141],"24":[142],"hours,":[143],"cells":[144,156,211],"each":[146,158,195,213],"taken":[149],"detect":[151],"following:":[153],"using":[160,182],"counting":[163],"Kit":[164],"8":[165],"(CCK-8)":[166],"method,":[167,185],"migration":[169,227],"ability":[170],"via":[171],"Transwell":[173],"test,":[174],"flow":[178],"cytometry,":[179],"collagen":[180,230],"synthesis":[181,231],"hydroxyproline":[184],"messenger":[186],"ribonucleic":[187],"acid":[188],"(mRNA)":[189],"expression":[190,205,279,296,335],"fibrosis-related":[192,207],"genes":[193],"real-time":[198],"fluorescent":[199],"polymerase":[200],"chain":[201],"amplification,":[202],"proteins":[208],"western":[216],"blotting.":[217],"RESULTS:":[218],"Compared":[219],"rate,":[226,228],"levels":[232],"three":[235,251,290,298],"groups":[237,253,291],"decreased":[238,292,304],"increase":[241,257,307],"concentration,":[244,260,310],"while":[245,294],"rate":[248],"increased":[254],"differences":[263,313],"statistically":[265,315],"significant":[266,316],"(P<0.05).":[267,317],"Also,":[268],"compared":[269],"relative":[275],"mRNA":[276,301],"protein":[278,303],"alpha-smooth":[281],"muscle":[282],"actin":[283],"(\u03b1-SMA),":[284],"TGF-\u03b21,":[285],"Smad3":[287],"significantly,":[293],"kinds":[299],"CONCLUSIONS:":[318],"may":[320],"inhibit":[321],"migration,":[325],"promote":[327],"inhibiting":[333],"TGF-\u03b21/Smad":[338],"pathway.":[339]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-04-13T00:00:00"}