{"id":"https://openalex.org/W3144539588","doi":"https://doi.org/10.1177/24725552211000673","title":"A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination","display_name":"A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination","publication_year":2021,"publication_date":"2021-03-29","ids":{"openalex":"https://openalex.org/W3144539588","doi":"https://doi.org/10.1177/24725552211000673","mag":"3144539588","pmid":"https://pubmed.ncbi.nlm.nih.gov/33780296"},"language":"en","primary_location":{"id":"doi:10.1177/24725552211000673","doi":"https://doi.org/10.1177/24725552211000673","is_oa":true,"landing_page_url":"https://doi.org/10.1177/24725552211000673","pdf_url":"http://slas-discovery.org/article/S2472555222067028/pdf","source":{"id":"https://openalex.org/S4387277810","display_name":"SLAS DISCOVERY","issn_l":"2472-5552","issn":["2472-5552","2472-5560"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SLAS Discovery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://slas-discovery.org/article/S2472555222067028/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014727522","display_name":"Ellen F. Vieux","orcid":"https://orcid.org/0000-0003-3815-4366","observed_orcids":["https://orcid.org/0000-0003-3815-4366"]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen F. Vieux","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-3815-4366","affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088505736","display_name":"Roman V. Agafonov","orcid":"https://orcid.org/0000-0002-7765-899X","observed_orcids":["https://orcid.org/0000-0002-7765-899X"]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roman V. Agafonov","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lydia Emerson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lydia Emerson","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019030725","display_name":"Marta Isasa","orcid":"https://orcid.org/0009-0005-6865-9500","observed_orcids":["https://orcid.org/0009-0005-6865-9500"]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marta Isasa","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008354080","display_name":"Richard W. Deibler","orcid":"https://orcid.org/0000-0003-2226-8190","observed_orcids":["https://orcid.org/0000-0003-2226-8190"]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard W. Deibler","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008080434","display_name":"Jeffrey R. Simard","orcid":"https://orcid.org/0009-0003-6421-7663","observed_orcids":["https://orcid.org/0009-0003-6421-7663"]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey R. Simard","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016658926","display_name":"David Cocozziello","orcid":"https://orcid.org/0000-0001-5497-6031","observed_orcids":["https://orcid.org/0000-0001-5497-6031"]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Cocozziello","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003746155","display_name":"Brendon Ladd","orcid":"https://orcid.org/0009-0007-4322-0360","observed_orcids":["https://orcid.org/0009-0007-4322-0360"]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brendon Ladd","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101909024","display_name":"Linda Lee","orcid":"https://orcid.org/0000-0002-4744-7243","observed_orcids":["https://orcid.org/0000-0002-4744-7243"]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Lee","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100338828","display_name":"Heng Li","orcid":"https://orcid.org/0009-0008-7241-3927","observed_orcids":["https://orcid.org/0009-0008-7241-3927"]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heng Li","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023499622","display_name":"Stephen L. Archer","orcid":"https://orcid.org/0000-0003-1106-3202","observed_orcids":["https://orcid.org/0000-0003-1106-3202"]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Archer","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014370378","display_name":"Mark E. Fitzgerald","orcid":"https://orcid.org/0009-0001-9449-7892","observed_orcids":["https://orcid.org/0009-0001-9449-7892"]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Fitzgerald","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ryan Michael","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Michael","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017553294","display_name":"Christopher G. Nasveschuk","orcid":"https://orcid.org/0000-0003-4671-6939","observed_orcids":["https://orcid.org/0000-0003-4671-6939"]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher G. Nasveschuk","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014286955","display_name":"Eunice S. Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eunice S. Park","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gunther Kern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gunther Kern","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057196078","display_name":"David A. Proia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Proia","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014830806","display_name":"Andrew J. Phillips","orcid":"https://orcid.org/0000-0002-4625-4044","observed_orcids":["https://orcid.org/0000-0002-4625-4044"]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Phillips","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046974786","display_name":"Stewart L. Fisher","orcid":"https://orcid.org/0009-0005-5167-5213","observed_orcids":["https://orcid.org/0009-0005-5167-5213"]},"institutions":[{"id":"https://openalex.org/I4210153832","display_name":"C4 Therapeutics (United States)","ror":"https://ror.org/05334he48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153832"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stewart L. Fisher","raw_affiliation_strings":["C4 Therapeutics Inc., Watertown, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C4 Therapeutics Inc., Watertown, MA, USA","institution_ids":["https://openalex.org/I4210153832"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046974786"],"corresponding_institution_ids":["https://openalex.org/I4210153832"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":1.0188,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.73269127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"26","issue":"4","first_page":"547","last_page":"559"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/targeted-protein-degradation","display_name":"targeted protein degradation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cereblon","display_name":"cereblon","score":0.7850000262260437},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9160000085830688},{"id":"https://openalex.org/keywords/ternary-complex","display_name":"ternary complex","score":0.628000020980835},{"id":"https://openalex.org/keywords/binary-complexes","display_name":"binary complexes","score":0.640999972820282},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.5410000085830688},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7655847668647766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.597673237323761},{"id":"https://openalex.org/C74401373","wikidata":"https://www.wikidata.org/wiki/Q1829843","display_name":"Bromodomain","level":4,"score":0.5730023384094238},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.5252668261528015},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.5164785385131836},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.45465731620788574},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.4379211664199829},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4378737509250641},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.43581312894821167},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4081816077232361},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.326100617647171},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32433611154556274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26010653376579285},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.16075989603996277},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08482646942138672},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078183","descriptor_name":"Oxindoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000078183","descriptor_name":"Oxindoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000092468","descriptor_name":"Bromodomain Containing Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001681","descriptor_name":"Biological Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010797","descriptor_name":"Phthalimides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010797","descriptor_name":"Phthalimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/24725552211000673","doi":"https://doi.org/10.1177/24725552211000673","is_oa":true,"landing_page_url":"https://doi.org/10.1177/24725552211000673","pdf_url":"http://slas-discovery.org/article/S2472555222067028/pdf","source":{"id":"https://openalex.org/S4387277810","display_name":"SLAS DISCOVERY","issn_l":"2472-5552","issn":["2472-5552","2472-5560"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SLAS Discovery","raw_type":"journal-article"},{"id":"pmid:33780296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33780296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SLAS discovery : advancing life sciences R & D","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1177/24725552211000673","doi":"https://doi.org/10.1177/24725552211000673","is_oa":true,"landing_page_url":"https://doi.org/10.1177/24725552211000673","pdf_url":"http://slas-discovery.org/article/S2472555222067028/pdf","source":{"id":"https://openalex.org/S4387277810","display_name":"SLAS DISCOVERY","issn_l":"2472-5552","issn":["2472-5552","2472-5560"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SLAS Discovery","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3144539588.pdf","grobid_xml":"https://content.openalex.org/works/W3144539588.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W23768266","https://openalex.org/W1488181101","https://openalex.org/W1510153624","https://openalex.org/W1512690422","https://openalex.org/W1525055187","https://openalex.org/W1532810559","https://openalex.org/W1551702901","https://openalex.org/W1565539350","https://openalex.org/W1760694280","https://openalex.org/W1994794059","https://openalex.org/W1995596496","https://openalex.org/W1999506801","https://openalex.org/W2003939839","https://openalex.org/W2019761433","https://openalex.org/W2020983840","https://openalex.org/W2025031463","https://openalex.org/W2030770436","https://openalex.org/W2036806530","https://openalex.org/W2039778506","https://openalex.org/W2041535798","https://openalex.org/W2068455168","https://openalex.org/W2147718842","https://openalex.org/W2158824345","https://openalex.org/W2166987747","https://openalex.org/W2176682109","https://openalex.org/W2227431445","https://openalex.org/W2409568753","https://openalex.org/W2580428058","https://openalex.org/W2595729735","https://openalex.org/W2597078857","https://openalex.org/W2599180871","https://openalex.org/W2604040637","https://openalex.org/W2604744033","https://openalex.org/W2608486143","https://openalex.org/W2623602792","https://openalex.org/W2743800043","https://openalex.org/W2764246110","https://openalex.org/W2767856718","https://openalex.org/W2767966404","https://openalex.org/W2769590617","https://openalex.org/W2806672448","https://openalex.org/W2807101583","https://openalex.org/W2883182240","https://openalex.org/W2888598609","https://openalex.org/W2909353434","https://openalex.org/W2912114516","https://openalex.org/W2914587883","https://openalex.org/W2982554531","https://openalex.org/W3003178516"],"related_works":["https://openalex.org/W4391746819","https://openalex.org/W4403329684","https://openalex.org/W4387115321","https://openalex.org/W3093594852","https://openalex.org/W4210738474","https://openalex.org/W2904001172","https://openalex.org/W4413444177","https://openalex.org/W7220848377","https://openalex.org/W7172509818","https://openalex.org/W2888598609"],"abstract_inverted_index":{"Recent":[0],"advances":[1],"in":[2,37,58,90],"targeted":[3],"protein":[4],"degradation":[5,24],"have":[6],"enabled":[7],"chemical":[8],"hijacking":[9],"of":[10,20,67,118],"the":[11,50,65,91,113],"ubiquitin-proteasome":[12],"system":[13,60],"to":[14,31,47,63,80],"treat":[15],"disease.":[16],"The":[17,83],"catalytic":[18,114],"rate":[19],"cereblon":[21],"(CRBN)-dependent":[22],"bifunctional":[23],"activating":[25],"compounds":[26],"(BiDAC),":[27],"which":[28],"recruit":[29],"CRBN":[30,89],"a":[32,106],"chosen":[33],"target":[34],"protein,":[35],"resulting":[36],"its":[38],"ubiquitination":[39,72,98],"and":[40,88,96,111,115],"proteasomal":[41],"degradation,":[42],"is":[43],"an":[44,57,75],"important":[45],"parameter":[46],"consider":[48],"during":[49],"drug":[51],"discovery":[52],"process.":[53],"In":[54],"this":[55,103],"work,":[56],"vitro":[59],"was":[61],"developed":[62],"measure":[64],"kinetics":[66],"BRD4":[68],"bromodomain":[69],"1":[70],"(BD1)":[71],"by":[73],"fitting":[74],"essential":[76],"activator":[77],"kinetic":[78],"model":[79],"these":[81],"data.":[82],"affinities":[84],"between":[85],"BiDACs,":[86],"BD1,":[87],"binary":[92],"complex,":[93,95],"ternary":[94],"full":[97],"complex":[99],"were":[100],"characterized.":[101],"Together,":[102],"work":[104],"provides":[105],"new":[107],"tool":[108],"for":[109],"understanding":[110],"optimizing":[112],"thermodynamic":[116],"properties":[117],"BiDACs.":[119]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-04-13T00:00:00"}