{"id":"https://openalex.org/W3144260699","doi":"https://doi.org/10.1038/s41586-018-0381-y","title":"Ma et al. reply","display_name":"Ma et al. reply","publication_year":2018,"publication_date":"2018-08-01","ids":{"openalex":"https://openalex.org/W3144260699","doi":"https://doi.org/10.1038/s41586-018-0381-y","mag":"3144260699","pmid":"https://pubmed.ncbi.nlm.nih.gov/30089923"},"language":"en","primary_location":{"id":"doi:10.1038/s41586-018-0381-y","doi":"https://doi.org/10.1038/s41586-018-0381-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41586-018-0381-y","pdf_url":"https://www.nature.com/articles/s41586-018-0381-y.pdf","source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/s41586-018-0381-y.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hong Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Ma","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015845979","display_name":"Nuria Mart\u00ed\u2010Guti\u00e9rrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nuria Marti-Gutierrez","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100614011","display_name":"Sang-Wook Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang-Wook Park","raw_affiliation_strings":["Center for Genome Engineering, Institute for Basic Science, Daejeon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Engineering, Institute for Basic Science, Daejeon, South Korea","institution_ids":["https://openalex.org/I4210104335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045977815","display_name":"Jun Wu","orcid":"https://orcid.org/0000-0001-9863-1668","observed_orcids":["https://orcid.org/0000-0001-9863-1668"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Wu","raw_affiliation_strings":["Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA","UT Southwestern Medical Center, Molecular Biology Department, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"UT Southwestern Medical Center, Molecular Biology Department, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113531100","display_name":"Tomonari Hayama","orcid":"https://orcid.org/0000-0002-8515-4134","observed_orcids":["https://orcid.org/0000-0002-8515-4134"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomonari Hayama","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044922578","display_name":"Hayley Darby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hayley Darby","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008754311","display_name":"Crystal Van Dyken","orcid":"https://orcid.org/0000-0002-3293-9333","observed_orcids":["https://orcid.org/0000-0002-3293-9333"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal Van Dyken","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100414065","display_name":"Ying Li","orcid":"https://orcid.org/0000-0001-8321-022X","observed_orcids":["https://orcid.org/0000-0001-8321-022X"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Li","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077907423","display_name":"Amy Koski","orcid":"https://orcid.org/0000-0003-1918-528X","observed_orcids":["https://orcid.org/0000-0003-1918-528X"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Koski","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056352263","display_name":"Dan Liang","orcid":"https://orcid.org/0000-0003-2404-3075","observed_orcids":["https://orcid.org/0000-0003-2404-3075"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Liang","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089926733","display_name":"Keiichiro Suzuki","orcid":"https://orcid.org/0000-0001-5603-9105","observed_orcids":["https://orcid.org/0000-0001-5603-9105"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keiichiro Suzuki","raw_affiliation_strings":["Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067874194","display_name":"Ying Gu","orcid":"https://orcid.org/0000-0001-7822-0570","observed_orcids":["https://orcid.org/0000-0001-7822-0570"]},"institutions":[{"id":"https://openalex.org/I4210149137","display_name":"China National GeneBank","ror":"https://ror.org/03n9hr695","country_code":"CN","type":"archive","lineage":["https://openalex.org/I4210149137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Gu","raw_affiliation_strings":["BGI-Qingdao, Qingdao, China","BGI-Shenzhen, Beishan Industrial Zone, Shenzhen, China","China National GeneBank, BGI-Shenzhen, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BGI-Qingdao, Qingdao, China","institution_ids":[]},{"raw_affiliation_string":"BGI-Shenzhen, Beishan Industrial Zone, Shenzhen, China","institution_ids":[]},{"raw_affiliation_string":"China National GeneBank, BGI-Shenzhen, Shenzhen, China","institution_ids":["https://openalex.org/I4210149137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045161248","display_name":"Jianhui Gong","orcid":"https://orcid.org/0000-0002-3910-9260","observed_orcids":["https://orcid.org/0000-0002-3910-9260"]},"institutions":[{"id":"https://openalex.org/I100135526","display_name":"BGI Group (China)","ror":"https://ror.org/045pn2j94","country_code":"CN","type":"company","lineage":["https://openalex.org/I100135526"]},{"id":"https://openalex.org/I4210149137","display_name":"China National GeneBank","ror":"https://ror.org/03n9hr695","country_code":"CN","type":"archive","lineage":["https://openalex.org/I4210149137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianhui Gong","raw_affiliation_strings":["BGI-Qingdao, Qingdao, China","BGI-Shenzhen, Beishan Industrial Zone, Shenzhen, China","China National GeneBank, BGI-Shenzhen, Shenzhen, China","Shenzhen Engineering Laboratory for Innovative Molecular Diagnostics, BGI-Shenzhen, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BGI-Qingdao, Qingdao, China","institution_ids":[]},{"raw_affiliation_string":"BGI-Shenzhen, Beishan Industrial Zone, Shenzhen, China","institution_ids":[]},{"raw_affiliation_string":"China National GeneBank, BGI-Shenzhen, Shenzhen, China","institution_ids":["https://openalex.org/I4210149137"]},{"raw_affiliation_string":"Shenzhen Engineering Laboratory for Innovative Molecular Diagnostics, BGI-Shenzhen, Shenzhen, China","institution_ids":["https://openalex.org/I100135526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100451926","display_name":"Xun Xu","orcid":"https://orcid.org/0000-0002-5338-5173","observed_orcids":["https://orcid.org/0000-0002-5338-5173","https://orcid.org/0000-0003-3256-2940"]},"institutions":[{"id":"https://openalex.org/I4210149137","display_name":"China National GeneBank","ror":"https://ror.org/03n9hr695","country_code":"CN","type":"archive","lineage":["https://openalex.org/I4210149137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xun Xu","raw_affiliation_strings":["BGI-Qingdao, Qingdao, China","BGI-Shenzhen, Beishan Industrial Zone, Shenzhen, China","China National GeneBank, BGI-Shenzhen, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BGI-Qingdao, Qingdao, China","institution_ids":[]},{"raw_affiliation_string":"BGI-Shenzhen, Beishan Industrial Zone, Shenzhen, China","institution_ids":[]},{"raw_affiliation_string":"China National GeneBank, BGI-Shenzhen, Shenzhen, China","institution_ids":["https://openalex.org/I4210149137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112624277","display_name":"Riffat Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Riffat Ahmed","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037817244","display_name":"Yeonmi Lee","orcid":"https://orcid.org/0000-0003-4407-7731","observed_orcids":["https://orcid.org/0000-0003-4407-7731"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Yeonmi Lee","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","Stem Cell Center, ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Stem Cell Center, ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, South Korea","institution_ids":["https://openalex.org/I2801680663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057306920","display_name":"Eunju Kang","orcid":"https://orcid.org/0000-0002-7240-7868","observed_orcids":["https://orcid.org/0000-0002-7240-7868"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Eunju Kang","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","Stem Cell Center, ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Stem Cell Center, ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, South Korea","institution_ids":["https://openalex.org/I2801680663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061844949","display_name":"Dongmei Ji","orcid":"https://orcid.org/0000-0002-1921-1890","observed_orcids":["https://orcid.org/0000-0002-1921-1890"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Dongmei Ji","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","Center for Reproductive Medicine, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Anhui Province Key Laboratory of Reproductive Health and Genetics, Anhui Medical University, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Center for Reproductive Medicine, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Anhui Province Key Laboratory of Reproductive Health and Genetics, Anhui Medical University, Anhui, China","institution_ids":["https://openalex.org/I197869895","https://openalex.org/I4210136596"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A-Reum Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"A-Reum Park","raw_affiliation_strings":["Center for Genome Engineering, Institute for Basic Science, Daejeon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Engineering, Institute for Basic Science, Daejeon, South Korea","institution_ids":["https://openalex.org/I4210104335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083561780","display_name":"Daesik Kim","orcid":"https://orcid.org/0000-0003-0806-5979","observed_orcids":["https://orcid.org/0000-0003-0806-5979","https://orcid.org/0000-0003-0863-1539"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Daesik Kim","raw_affiliation_strings":["Department of Chemistry, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058382490","display_name":"Sang\u2010Tae Kim","orcid":"https://orcid.org/0000-0003-1645-6021","observed_orcids":["https://orcid.org/0000-0003-1645-6021","https://orcid.org/0000-0003-4847-1306"]},"institutions":[{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang-Tae Kim","raw_affiliation_strings":["Center for Genome Engineering, Institute for Basic Science, Daejeon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Engineering, Institute for Basic Science, Daejeon, South Korea","institution_ids":["https://openalex.org/I4210104335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011566295","display_name":"Stephen B. Heitner","orcid":"https://orcid.org/0000-0003-2189-1474","observed_orcids":["https://orcid.org/0000-0003-2189-1474"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B. Heitner","raw_affiliation_strings":["Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103962663","display_name":"David E. Battaglia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Battaglia","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009072113","display_name":"Sacha A. Krieg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sacha A. Krieg","raw_affiliation_strings":["Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David M. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Lee","raw_affiliation_strings":["Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103115775","display_name":"Diana H. Wu","orcid":"https://orcid.org/0009-0002-5771-2474","observed_orcids":["https://orcid.org/0009-0002-5771-2474"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana H. Wu","raw_affiliation_strings":["Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069135894","display_name":"Don P. Wolf","orcid":"https://orcid.org/0000-0001-6900-2045","observed_orcids":["https://orcid.org/0000-0001-6900-2045"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Don P. Wolf","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110803853","display_name":"Paula Amato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula Amato","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063537486","display_name":"Sanjiv Kaul","orcid":"https://orcid.org/0000-0003-0124-3920","observed_orcids":["https://orcid.org/0000-0003-0124-3920"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjiv Kaul","raw_affiliation_strings":["Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050690657","display_name":"Juan Carlos Izpis\u00faa Belmonte","orcid":"https://orcid.org/0000-0003-0557-8875","observed_orcids":["https://orcid.org/0000-0003-0557-8875"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Carlos Izpisua Belmonte","raw_affiliation_strings":["Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390285","display_name":"Jin\u2010Soo Kim","orcid":"https://orcid.org/0000-0003-4847-1306","observed_orcids":["https://orcid.org/0000-0003-4847-1306","https://orcid.org/0000-0003-0806-5979"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin-Soo Kim","raw_affiliation_strings":["Center for Genome Engineering, Institute for Basic Science, Daejeon, South Korea","Department of Chemistry, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Genome Engineering, Institute for Basic Science, Daejeon, South Korea","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Chemistry, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037802716","display_name":"Shoukhrat M. Mitalipov","orcid":"https://orcid.org/0000-0003-0937-6146","observed_orcids":["https://orcid.org/0000-0003-0937-6146"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shoukhrat Mitalipov","raw_affiliation_strings":["Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA. mitalipo@ohsu.edu","Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA. mitalipo@ohsu.edu","Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA. mitalipo@ohsu.edu","Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA. mitalipo@ohsu.edu","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA. mitalipo@ohsu.edu","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA. mitalipo@ohsu.edu","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5037802716"],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"560","issue":"7717","first_page":"E10","last_page":"E23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":null,"topics":[],"keywords":[],"concepts":[{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.2750049829483032}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41586-018-0381-y","doi":"https://doi.org/10.1038/s41586-018-0381-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41586-018-0381-y","pdf_url":"https://www.nature.com/articles/s41586-018-0381-y.pdf","source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:30089923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30089923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/165691","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/165691","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Other"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/189777","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/189777","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/s41586-018-0381-y","doi":"https://doi.org/10.1038/s41586-018-0381-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41586-018-0381-y","pdf_url":"https://www.nature.com/articles/s41586-018-0381-y.pdf","source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1393979271","display_name":null,"funder_award_id":"IBSR021-D1","funder_id":"https://openalex.org/F4320326441","funder_display_name":"Institute for Basic Science"},{"id":"https://openalex.org/G3029046815","display_name":null,"funder_award_id":"R021-D1","funder_id":"https://openalex.org/F4320326441","funder_display_name":"Institute for Basic Science"}],"funders":[{"id":"https://openalex.org/F4320309233","display_name":"Oregon Health and Science University","ror":"https://ror.org/009avj582"},{"id":"https://openalex.org/F4320309446","display_name":"Leona M. and Harry B. Helmsley Charitable Trust","ror":"https://ror.org/011x6n313"},{"id":"https://openalex.org/F4320311586","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03"},{"id":"https://openalex.org/F4320312387","display_name":"Temple University","ror":"https://ror.org/00kx1jb78"},{"id":"https://openalex.org/F4320315910","display_name":"Consorzio Interuniversitario Biotecnologie","ror":"https://ror.org/03ka4h071"},{"id":"https://openalex.org/F4320316612","display_name":"Moxie Foundation","ror":"https://ror.org/048zstp84"},{"id":"https://openalex.org/F4320320577","display_name":"La Trobe University","ror":"https://ror.org/01rxfrp27"},{"id":"https://openalex.org/F4320320978","display_name":"University of Adelaide","ror":"https://ror.org/00892tw58"},{"id":"https://openalex.org/F4320321895","display_name":"Government of Jiangxi Province","ror":"https://ror.org/02fzqav45"},{"id":"https://openalex.org/F4320323452","display_name":"Universitas Diponegoro","ror":"https://ror.org/056bjta22"},{"id":"https://openalex.org/F4320326441","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3144260699.pdf","grobid_xml":"https://content.openalex.org/works/W3144260699.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1919257374","https://openalex.org/W1987774343","https://openalex.org/W2045259542","https://openalex.org/W2058792860","https://openalex.org/W2119180969","https://openalex.org/W2141825721","https://openalex.org/W2153637799","https://openalex.org/W2154154942","https://openalex.org/W2154822693","https://openalex.org/W2168133698","https://openalex.org/W2325225354","https://openalex.org/W2618806491","https://openalex.org/W2619703893","https://openalex.org/W2740810575","https://openalex.org/W2759601393","https://openalex.org/W2794719468","https://openalex.org/W2885661865","https://openalex.org/W2952775612","https://openalex.org/W3099447321"],"related_works":["https://openalex.org/W2386167429","https://openalex.org/W2314171529","https://openalex.org/W1965188030","https://openalex.org/W2955154340","https://openalex.org/W7098375601","https://openalex.org/W3149187165","https://openalex.org/W7095514186","https://openalex.org/W4256305693","https://openalex.org/W13621520","https://openalex.org/W7097727900"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":7}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-04-13T00:00:00"}