{"id":"https://openalex.org/W3144230871","doi":"https://doi.org/10.1017/cts.2021.454","title":"73565 Defining tp53 tumor suppressor functions in zebrafish embryonal rhabdomyosarcoma","display_name":"73565 Defining tp53 tumor suppressor functions in zebrafish embryonal rhabdomyosarcoma","publication_year":2021,"publication_date":"2021-03-01","ids":{"openalex":"https://openalex.org/W3144230871","doi":"https://doi.org/10.1017/cts.2021.454","mag":"3144230871"},"language":"en","primary_location":{"id":"doi:10.1017/cts.2021.454","doi":"https://doi.org/10.1017/cts.2021.454","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2021.454","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/C30D7BC2CCA6D40BB222E8F33D4A20EB/S2059866121004544a.pdf/div-class-title-73565-defining-tp53-tumor-suppressor-functions-in-zebrafish-embryonal-rhabdomyosarcoma-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/C30D7BC2CCA6D40BB222E8F33D4A20EB/S2059866121004544a.pdf/div-class-title-73565-defining-tp53-tumor-suppressor-functions-in-zebrafish-embryonal-rhabdomyosarcoma-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053391633","display_name":"Kunal Baxi","orcid":"https://orcid.org/0000-0001-6094-6410","observed_orcids":["https://orcid.org/0000-0001-6094-6410"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kunal Baxi","raw_affiliation_strings":["University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037069094","display_name":"Jiangfei Chen","orcid":"https://orcid.org/0000-0002-0036-3771","observed_orcids":["https://orcid.org/0000-0002-0036-3771"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiangfei Chen","raw_affiliation_strings":["University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091346904","display_name":"Amanda E. Lipsitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Lipsitt","raw_affiliation_strings":["University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078253669","display_name":"Nicole Rae Hensch","orcid":"https://orcid.org/0000-0001-9946-0995","observed_orcids":["https://orcid.org/0000-0001-9946-0995"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Hensch","raw_affiliation_strings":["University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447598","display_name":"Long Wang","orcid":"https://orcid.org/0000-0003-3476-6779","observed_orcids":["https://orcid.org/0000-0003-3476-6779"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Long Wang","raw_affiliation_strings":["University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043161139","display_name":"Abhik Bandopadhyay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhik Bandopadhyay","raw_affiliation_strings":["University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071782627","display_name":"Aaron Sugalski","orcid":"https://orcid.org/0009-0007-6945-6179","observed_orcids":["https://orcid.org/0009-0007-6945-6179"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Sugalski","raw_affiliation_strings":["University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065763193","display_name":"Andrea Gilbert","orcid":"https://orcid.org/0000-0001-7687-8774","observed_orcids":["https://orcid.org/0000-0001-7687-8774"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Gilbert","raw_affiliation_strings":["University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074390982","display_name":"Eleanor Y. Chen","orcid":"https://orcid.org/0000-0003-4372-7560","observed_orcids":["https://orcid.org/0000-0003-4372-7560"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eleanor Chen","raw_affiliation_strings":["University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109173471","display_name":"Peter J. Houghton","orcid":"https://orcid.org/0000-0002-2400-8184","observed_orcids":["https://orcid.org/0000-0002-2400-8184"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Houghton","raw_affiliation_strings":["University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055519116","display_name":"Gail Elizabeth Tomlinson","orcid":"https://orcid.org/0000-0003-2579-1833","observed_orcids":["https://orcid.org/0000-0003-2579-1833"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gail Tomlinson","raw_affiliation_strings":["University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050393683","display_name":"Myron S. Ignatius","orcid":"https://orcid.org/0000-0001-6639-7707","observed_orcids":["https://orcid.org/0000-0001-6639-7707"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myron Ignatius","raw_affiliation_strings":["University of Texas Health Science Center at San Antonio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Health Science Center at San Antonio","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":{"value":1750,"currency":"USD","value_usd":1750},"apc_paid":{"value":1750,"currency":"USD","value_usd":1750},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0385367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"s1","first_page":"19","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/embryonal-rhabdomyosarcoma","display_name":"embryonal rhabdomyosarcoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/zebrafish-tumor-model","display_name":"zebrafish tumor model","score":0.7269999980926514},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.609000027179718},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.5289999842643738},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.7360000014305115},{"id":"https://openalex.org/keywords/loss-of-function","display_name":"loss of function","score":0.4699999988079071},{"id":"https://openalex.org/keywords/gain-of-function","display_name":"gain-of-function","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8990645408630371},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7073881030082703},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5853708386421204},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5829923748970032},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4664667844772339},{"id":"https://openalex.org/C2780844630","wikidata":"https://www.wikidata.org/wiki/Q1898141","display_name":"Rhabdomyosarcoma","level":3,"score":0.4460410475730896},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.4195685386657715},{"id":"https://openalex.org/C57708383","wikidata":"https://www.wikidata.org/wiki/Q260182","display_name":"Null allele","level":4,"score":0.4139046370983124},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3553411364555359},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3261873722076416},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32149600982666016},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.2576904594898224},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13576245307922363},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11329483985900879}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1017/cts.2021.454","doi":"https://doi.org/10.1017/cts.2021.454","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2021.454","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/C30D7BC2CCA6D40BB222E8F33D4A20EB/S2059866121004544a.pdf/div-class-title-73565-defining-tp53-tumor-suppressor-functions-in-zebrafish-embryonal-rhabdomyosarcoma-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8827740","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8827740","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Transl Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:746745541b8e4723853ee28927b8c2b3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/746745541b8e4723853ee28927b8c2b3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical and Translational Science, Vol 5, Pp 19-20 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1017/cts.2021.454","doi":"https://doi.org/10.1017/cts.2021.454","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2021.454","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/C30D7BC2CCA6D40BB222E8F33D4A20EB/S2059866121004544a.pdf/div-class-title-73565-defining-tp53-tumor-suppressor-functions-in-zebrafish-embryonal-rhabdomyosarcoma-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3144230871.pdf","grobid_xml":"https://content.openalex.org/works/W3144230871.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4379095348","https://openalex.org/W2889777846","https://openalex.org/W2064653829","https://openalex.org/W2113578476","https://openalex.org/W4405024508","https://openalex.org/W4252976133","https://openalex.org/W2369263270","https://openalex.org/W2746920751","https://openalex.org/W2067541661","https://openalex.org/W2064422983"],"abstract_inverted_index":{"ABSTRACT":[0],"IMPACT:":[1],"By":[2],"assessing":[3],"function":[4,56,70],"of":[5,16,19,100,114,136,157,184,189,200,288,323],"mutant":[6,20,80,160],"(patient-specific)":[7],"tp53":[8,21,69,88,131,163,195],"in":[9,37,50,62,71,82,117,175,181,219,237,244,249,252,290,301,310,340],"zebrafish":[10,83,95,215,253],"embryonal":[11],"rhabdomyosarcoma":[12],"will":[13],"inform":[14],"clinicians":[15],"the":[17,63,86,121,176,258,272,286,291,321,341],"severity":[18],"alleles.":[22],"OBJECTIVES/GOALS:":[23],"This":[24],"study":[25],"aims":[26,45],"to":[27,46,54,57,124,281,316,329],"define":[28,68,332],"loss-":[29],"and":[30,39,105,159,168,203,225,231,241,255,312,336],"gain-of-function":[31],"TP53":[32,60,218,298,334],"mutations":[33,61],"by":[34,84],"comparing":[35],"effects":[36,156,266,307],"tp53-null":[38,79],"wild-type":[40,158,190],"tumors.":[41],"In":[42],"addition,":[43],"it":[44],"generate":[47,125],"a":[48,77,98,133,197,245],"rapid":[49],"vivo":[51,311],"analysis":[52],"platform":[53],"assign":[55],"patient":[58,246,302],"specific":[59],"clinic":[64],"METHODS/STUDY":[65],"POPULATION:":[66],"To":[67],"ERMS":[72,172,201,239],"pathogenesis,":[73],"we":[74,128,154,211],"previously":[75],"generated":[76],"new":[78],"(tp53-/-)":[81],"deleting":[85],"entire":[87],"genomic":[89],"locus":[90],"using":[91,151],"TALEN":[92],"mutagenesis.":[93],"tp53-/-":[94,122,152,177,220,282],"spontaneously":[96],"develop":[97,192],"spectrum":[99],"tumors":[101,108,115,276,289,303],"including":[102],"sarcomas,":[103],"leukemia":[104],"germ":[106],"cell":[107],"(Ignatius\u2026Baxi":[109,146],"et.":[110,147],"al.,":[111,148],"eLife)":[112],"reminiscent":[113],"observed":[116,180],"Trp53-null":[118],"mice.":[119],"Using":[120],"mutants":[123],"kRASG12D-induced":[126],"ERMS,":[127,254],"discovered":[129],"that":[130,257],"is":[132,179,196,208],"potent":[134,198],"repressor":[135],"metastases":[137],"but":[138,284],"rather":[139],"surprisingly":[140],"had":[141],"no":[142],"effect":[143,205],"on":[144,164,206,268,308],"self-renewal":[145],"eLife).":[149],"Here,":[150],"zebrafish,":[153],"assessed":[155],"(patient":[161],"specific)":[162],"tumor":[165,173,229,263],"initiation,":[166],"proliferation":[167,202],"apoptosis.":[169,270],"RESULTS/ANTICIPATED":[170],"RESULTS:":[171],"initiation":[174,230,264,287],"background":[178],">":[182],"97%":[183],"animals":[185,191,221,283],"whereas":[186],"only":[187],"<40%":[188],"ERMS.":[193],"Additionally,":[194],"suppressor":[199],"its":[204],"apoptosis":[207],"minor.":[209],"Next,":[210],"expressed":[212],"either":[213],"WT":[214],"or":[216],"human":[217],"along":[222],"with":[223,247,265],"kRASG12D":[224],"both":[226],"genes":[227],"suppressed":[228,262],"growth.":[232],"We":[233],"co-expressed":[234],"TP53C176F":[235,259],"(found":[236],"two":[238],"patients)":[240],"TP53P153del":[242,273],"(identified":[243],"osteosarcoma":[248],"our":[250],"clinic)":[251],"find":[256],"allele":[260,274],"significantly":[261],"predominantly":[267],"enhanced":[269],"However,":[271],"initiated":[275],"at":[277],"similar":[278],"frequency":[279],"compared":[280],"increased":[285],"head":[292],"musculature.":[293],"DISCUSSION/SIGNIFICANCE":[294],"OF":[295],"FINDINGS:":[296],"Different":[297],"alleles":[299],"identified":[300],"have":[304],"very":[305],"different":[306],"tumorigenesis":[309],"can":[313],"respond":[314],"differently":[315],"potentially":[317],"therapeutic":[318],"compounds.":[319],"Thus,":[320],"type":[322],"precision":[324],"modeling":[325],"demonstrated":[326],"here":[327],"promises":[328],"help":[330],"further":[331],"patient-specific":[333],"biology":[335],"improve":[337],"clinical":[338],"strategies":[339],"future.":[342]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2021-04-13T00:00:00"}
