{"id":"https://openalex.org/W3143956689","doi":"https://doi.org/10.1038/s41419-021-03645-4","title":"LncRNA MALAT1 promotes gastric cancer progression via inhibiting autophagic flux and inducing fibroblast activation","display_name":"LncRNA MALAT1 promotes gastric cancer progression via inhibiting autophagic flux and inducing fibroblast activation","publication_year":2021,"publication_date":"2021-04-06","ids":{"openalex":"https://openalex.org/W3143956689","doi":"https://doi.org/10.1038/s41419-021-03645-4","mag":"3143956689","pmid":"https://pubmed.ncbi.nlm.nih.gov/33824303","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8024309"},"language":"en","primary_location":{"id":"doi:10.1038/s41419-021-03645-4","doi":"https://doi.org/10.1038/s41419-021-03645-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-021-03645-4","pdf_url":"https://www.nature.com/articles/s41419-021-03645-4.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41419-021-03645-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101532508","display_name":"Zhenqiang Wang","orcid":"https://orcid.org/0000-0002-6847-9068","observed_orcids":["https://orcid.org/0000-0002-6847-9068"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenqiang Wang","raw_affiliation_strings":["Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]},{"raw_affiliation_string":"Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064487981","display_name":"Xinjing Wang","orcid":"https://orcid.org/0009-0003-2745-7262","observed_orcids":["https://orcid.org/0009-0003-2745-7262"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinjing Wang","raw_affiliation_strings":["Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425396","display_name":"Tianqi Zhang","orcid":"https://orcid.org/0000-0003-3581-6184","observed_orcids":["https://orcid.org/0000-0003-3581-6184"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianqi Zhang","raw_affiliation_strings":["Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]},{"raw_affiliation_string":"Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087025928","display_name":"Liping Su","orcid":"https://orcid.org/0000-0003-2401-0265","observed_orcids":["https://orcid.org/0000-0003-2401-0265"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liping Su","raw_affiliation_strings":["Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]},{"raw_affiliation_string":"Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084178846","display_name":"Bingya Liu","orcid":"https://orcid.org/0000-0002-4406-3762","observed_orcids":["https://orcid.org/0000-0002-4406-3762","https://orcid.org/0000-0002-7157-5202"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingya Liu","raw_affiliation_strings":["Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China"],"raw_orcid":"https://orcid.org/0000-0002-4406-3762","affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]},{"raw_affiliation_string":"Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031420045","display_name":"Zhenggang Zhu","orcid":"https://orcid.org/0000-0003-4769-5463","observed_orcids":["https://orcid.org/0000-0003-4769-5463"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenggang Zhu","raw_affiliation_strings":["Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. zzg1954@hotmail.com","Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. zzg1954@hotmail.com","Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. zzg1954@hotmail.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]},{"raw_affiliation_string":"Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. zzg1954@hotmail.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]},{"raw_affiliation_string":"Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100369780","display_name":"Chen Li","orcid":"https://orcid.org/0000-0001-7978-4386","observed_orcids":["https://orcid.org/0000-0001-7978-4386"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chen Li","raw_affiliation_strings":["Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. leedoctor@sina.com","Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. leedoctor@sina.com","Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China"],"raw_orcid":"https://orcid.org/0000-0001-7978-4386","affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. leedoctor@sina.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]},{"raw_affiliation_string":"Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. leedoctor@sina.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]},{"raw_affiliation_string":"Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031420045","https://openalex.org/A5100369780"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"],"apc_list":{"value":4170,"currency":"USD","value_usd":4170},"apc_paid":{"value":4170,"currency":"USD","value_usd":4170},"fwci":3.4777,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.95031862,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"12","issue":"4","first_page":"368","last_page":"368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malat1","display_name":"MALAT1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9789999723434448},{"id":"https://openalex.org/keywords/gastric-cancer-progression","display_name":"gastric cancer progression","score":0.8769999742507935},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.8920000195503235},{"id":"https://openalex.org/keywords/fibroblast-activation","display_name":"fibroblast activation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.953000009059906},{"id":"https://openalex.org/keywords/hur","display_name":"HuR","score":0.9829999804496765},{"id":"https://openalex.org/keywords/akt-mtor-signaling-pathway","display_name":"Akt/mTOR signaling","score":0.9259999990463257},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.9860000014305115},{"id":"https://openalex.org/keywords/nf-kappab-nuclear-translocation","display_name":"NF-\u03baB nuclear translocation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9480000138282776},{"id":"https://openalex.org/keywords/autophagy-inhibition","display_name":"autophagy inhibition","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9149453639984131},{"id":"https://openalex.org/C2779134362","wikidata":"https://www.wikidata.org/wiki/Q18056223","display_name":"MALAT1","level":5,"score":0.9063625335693359},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6339637041091919},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5390427112579346},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5116491913795471},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5067172646522522},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.49764373898506165},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4829815924167633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.462067186832428},{"id":"https://openalex.org/C60365752","wikidata":"https://www.wikidata.org/wiki/Q5156306","display_name":"Competing endogenous RNA","level":5,"score":0.4459828734397888},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.44534486532211304},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.4392664432525635},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4191988408565521},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.41862472891807556},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4179510772228241},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39377492666244507},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28309863805770874},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.26529043912887573},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11881625652313232},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07479366660118103},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013270","descriptor_name":"Stomach","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41419-021-03645-4","doi":"https://doi.org/10.1038/s41419-021-03645-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-021-03645-4","pdf_url":"https://www.nature.com/articles/s41419-021-03645-4.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-88665/v1","doi":"https://doi.org/10.21203/rs.3.rs-88665/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-88665/v1","pdf_url":"https://www.researchsquare.com/article/rs-88665/latest.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:8024309","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8024309","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"},{"id":"pmid:33824303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33824303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:51161f7685934604b67ee4bbca64233d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/51161f7685934604b67ee4bbca64233d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death and Disease, Vol 12, Iss 4, Pp 1-17 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41419-021-03645-4","doi":"https://doi.org/10.1038/s41419-021-03645-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41419-021-03645-4","pdf_url":"https://www.nature.com/articles/s41419-021-03645-4.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1064395826","display_name":null,"funder_award_id":"YG2017MS58","funder_id":"https://openalex.org/F4320322999","funder_display_name":"Shanghai Jiao Tong University"},{"id":"https://openalex.org/G2929117699","display_name":null,"funder_award_id":"91529302","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2990797161","display_name":null,"funder_award_id":"81871904","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3573986249","display_name":null,"funder_award_id":"ZH2018QNA51","funder_id":"https://openalex.org/F4320322999","funder_display_name":"Shanghai Jiao Tong University"},{"id":"https://openalex.org/G4305347183","display_name":null,"funder_award_id":"81772518","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7535091591","display_name":null,"funder_award_id":"No. 91529302","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322942","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48"},{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3143956689.pdf","grobid_xml":"https://content.openalex.org/works/W3143956689.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1970637701","https://openalex.org/W1977841275","https://openalex.org/W1978099625","https://openalex.org/W1995547461","https://openalex.org/W2006371195","https://openalex.org/W2026938943","https://openalex.org/W2027230549","https://openalex.org/W2047533025","https://openalex.org/W2068051463","https://openalex.org/W2090786835","https://openalex.org/W2116304851","https://openalex.org/W2177243809","https://openalex.org/W2190528488","https://openalex.org/W2339703473","https://openalex.org/W2466475321","https://openalex.org/W2586907780","https://openalex.org/W2594068630","https://openalex.org/W2612730658","https://openalex.org/W2738580736","https://openalex.org/W2746563129","https://openalex.org/W2754991740","https://openalex.org/W2766770293","https://openalex.org/W2775820016","https://openalex.org/W2793957264","https://openalex.org/W2801303687","https://openalex.org/W2806112174","https://openalex.org/W2847139828","https://openalex.org/W2885889308","https://openalex.org/W2885912315","https://openalex.org/W2900750994","https://openalex.org/W2902644109","https://openalex.org/W2911557141","https://openalex.org/W2911751631","https://openalex.org/W2914267915","https://openalex.org/W2914802254","https://openalex.org/W2916733639","https://openalex.org/W2945396239","https://openalex.org/W2948787234","https://openalex.org/W2980445941","https://openalex.org/W2992097084"],"related_works":["https://openalex.org/W3134807158","https://openalex.org/W2994397802","https://openalex.org/W2770249785","https://openalex.org/W3164350598","https://openalex.org/W4404792246","https://openalex.org/W6921156587","https://openalex.org/W3194973714","https://openalex.org/W2417121586","https://openalex.org/W2604499837","https://openalex.org/W2936870695"],"abstract_inverted_index":{"Abstract":[0],"Autophagy":[1],"defection":[2],"contributes":[3],"to":[4,80,118,138],"inflammation":[5],"dysregulation,":[6],"which":[7],"plays":[8],"an":[9],"important":[10],"role":[11],"in":[12,40,48,65,92,107],"gastric":[13],"cancer":[14,98],"(GC)":[15],"progression.":[16,99],"Various":[17],"studies":[18],"have":[19],"demonstrated":[20,145],"that":[21,58,146,163],"long":[22,33],"noncoding":[23,34],"RNA":[24,35],"could":[25,44,60,77,96],"function":[26],"as":[27],"novel":[28,168],"regulators":[29],"of":[30,130],"autophagy.":[31],"Previously,":[32],"MALAT1":[36,59,76,101,162],"was":[37,154],"reported":[38],"upregulated":[39],"GC":[41,66,87,108,150,165],"cells":[42,67,88,109,151],"and":[43,89,152,170],"positively":[45],"regulate":[46],"autophagy":[47,131,157],"various":[49],"cancers.":[50],"Here,":[51],"we":[52],"for":[53,123,173],"the":[54,93,104,114,120],"first":[55],"time":[56],"found":[57],"promote":[61],"interleukin-6":[62],"(IL-6)":[63],"secretion":[64],"by":[68,75,110,156,160],"blocking":[69],"autophagic":[70,125],"flux.":[71,126],"Moreover,":[72],"IL-6":[73,140],"induced":[74],"activate":[78,119],"normal":[79],"cancer-associated":[81,90],"fibroblast":[82],"conversion.":[83],"The":[84],"interaction":[85,148],"between":[86,149],"fibroblasts":[91,153],"tumour":[94],"microenvironment":[95],"facilitate":[97],"Mechanistically,":[100],"overexpression":[102],"destabilized":[103],"PTEN":[105],"mRNA":[106],"competitively":[111],"interacting":[112],"with":[113],"RNA-binding":[115],"protein":[116],"ELAVL1":[117],"AKT/mTOR":[121],"pathway":[122],"impairing":[124],"As":[127],"a":[128],"consequence":[129],"inhibition,":[132],"SQSTM1":[133],"accumulation":[134],"promotes":[135,164],"NF-\u03baB":[136],"translocation":[137],"elevate":[139],"expression.":[141],"Overall,":[142],"these":[143],"results":[144],"intercellular":[147],"mediated":[155],"inhibition":[158],"caused":[159],"increased":[161],"progression,":[166],"providing":[167],"prevention":[169],"therapeutic":[171],"strategies":[172],"GC.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-04-13T00:00:00"}
