{"id":"https://openalex.org/W3143553418","doi":"https://doi.org/10.1111/iej.13524","title":"Potential application of immunotherapy for modulation of pulp inflammation: opportunities for vital pulp treatment","display_name":"Potential application of immunotherapy for modulation of pulp inflammation: opportunities for vital pulp treatment","publication_year":2021,"publication_date":"2021-04-02","ids":{"openalex":"https://openalex.org/W3143553418","doi":"https://doi.org/10.1111/iej.13524","mag":"3143553418","pmid":"https://pubmed.ncbi.nlm.nih.gov/33797765"},"language":"en","primary_location":{"id":"doi:10.1111/iej.13524","doi":"https://doi.org/10.1111/iej.13524","is_oa":true,"landing_page_url":"https://doi.org/10.1111/iej.13524","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iej.13524","source":{"id":"https://openalex.org/S50094856","display_name":"International Endodontic Journal","issn_l":"0143-2885","issn":["0143-2885","1365-2591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Endodontic Journal","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iej.13524","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049374669","display_name":"Shelly Arora","orcid":"https://orcid.org/0000-0002-1277-6194","observed_orcids":["https://orcid.org/0000-0002-1277-6194"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"S. Arora","raw_affiliation_strings":["Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088299148","display_name":"Paul R. Cooper","orcid":"https://orcid.org/0000-0003-1305-7287","observed_orcids":["https://orcid.org/0000-0003-1305-7287"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"P. R. Cooper","raw_affiliation_strings":["Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011907441","display_name":"Lara T. Friedlander","orcid":"https://orcid.org/0000-0002-0779-8479","observed_orcids":["https://orcid.org/0000-0002-0779-8479"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"L. T. Friedlander","raw_affiliation_strings":["Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076266085","display_name":"Shakila B. Rizwan","orcid":"https://orcid.org/0000-0001-5099-4443","observed_orcids":["https://orcid.org/0000-0001-5099-4443"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"S. Rizwan","raw_affiliation_strings":["School of Pharmacy, University of Otago, Dunedin, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019861812","display_name":"Benedict Seo","orcid":"https://orcid.org/0000-0002-5887-2448","observed_orcids":["https://orcid.org/0000-0002-5887-2448"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"B. Seo","raw_affiliation_strings":["Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010211927","display_name":"Alison Mary Rich","orcid":"https://orcid.org/0000-0001-8096-4245","observed_orcids":["https://orcid.org/0000-0001-8096-4245"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"A. M. Rich","raw_affiliation_strings":["Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075072832","display_name":"Haizal Mohd Hussaini","orcid":"https://orcid.org/0000-0002-5005-5224","observed_orcids":["https://orcid.org/0000-0002-5005-5224"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"H. M. Hussaini","raw_affiliation_strings":["Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand"],"raw_orcid":"https://orcid.org/0000-0002-5005-5224","affiliations":[{"raw_affiliation_string":"Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand","institution_ids":["https://openalex.org/I80281795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075072832"],"corresponding_institution_ids":["https://openalex.org/I80281795"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":1.8922,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.87921847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"54","issue":"8","first_page":"1263","last_page":"1274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10113","display_name":"Dental materials and restorations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9369999766349792},{"id":"https://openalex.org/keywords/vital-pulp-therapy","display_name":"vital pulp therapy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/pulpitis","display_name":"pulpitis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/irreversible-pulpitis","display_name":"irreversible pulpitis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/anti-cytokine-therapy","display_name":"anti-cytokine therapy","score":0.921999990940094},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9430000185966492},{"id":"https://openalex.org/keywords/dental-caries","display_name":"dental caries","score":0.6549999713897705},{"id":"https://openalex.org/keywords/pulp-healing","display_name":"pulp healing","score":0.781000018119812},{"id":"https://openalex.org/keywords/chronic-inflammatory-diseases","display_name":"chronic inflammatory diseases","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.578000009059906},{"id":"https://openalex.org/keywords/interleukins","display_name":"interleukins","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7427141666412354},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6927921772003174},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.689257800579071},{"id":"https://openalex.org/C2779700951","wikidata":"https://www.wikidata.org/wiki/Q932843","display_name":"Pulpitis","level":3,"score":0.6862889528274536},{"id":"https://openalex.org/C188442228","wikidata":"https://www.wikidata.org/wiki/Q48286","display_name":"Pulp (tooth)","level":2,"score":0.6751035451889038},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6642143130302429},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6053454875946045},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4850460886955261},{"id":"https://openalex.org/C2908727407","wikidata":"https://www.wikidata.org/wiki/Q948056","display_name":"Dentine hypersensitivity","level":2,"score":0.4339365065097809},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.423194944858551},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.23761513829231262}],"mesh":[{"descriptor_ui":"D003782","descriptor_name":"Dental Pulp","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003789","descriptor_name":"Dental Pulp Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011671","descriptor_name":"Pulpitis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/iej.13524","doi":"https://doi.org/10.1111/iej.13524","is_oa":true,"landing_page_url":"https://doi.org/10.1111/iej.13524","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iej.13524","source":{"id":"https://openalex.org/S50094856","display_name":"International Endodontic Journal","issn_l":"0143-2885","issn":["0143-2885","1365-2591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Endodontic Journal","raw_type":"journal-article"},{"id":"pmid:33797765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33797765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International endodontic journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/iej.13524","doi":"https://doi.org/10.1111/iej.13524","is_oa":true,"landing_page_url":"https://doi.org/10.1111/iej.13524","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/iej.13524","source":{"id":"https://openalex.org/S50094856","display_name":"International Endodontic Journal","issn_l":"0143-2885","issn":["0143-2885","1365-2591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Endodontic Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3143553418.pdf","grobid_xml":"https://content.openalex.org/works/W3143553418.grobid-xml"},"referenced_works_count":118,"referenced_works":["https://openalex.org/W91258909","https://openalex.org/W1491588541","https://openalex.org/W1617041404","https://openalex.org/W1661544713","https://openalex.org/W1822749802","https://openalex.org/W1844444168","https://openalex.org/W1955721074","https://openalex.org/W1964249139","https://openalex.org/W1968893079","https://openalex.org/W1975174220","https://openalex.org/W1976560499","https://openalex.org/W1977578894","https://openalex.org/W1977884267","https://openalex.org/W1981499371","https://openalex.org/W1981762158","https://openalex.org/W1986097146","https://openalex.org/W1986439877","https://openalex.org/W1990493775","https://openalex.org/W1992073381","https://openalex.org/W1995344305","https://openalex.org/W1995379504","https://openalex.org/W1997664980","https://openalex.org/W1997834526","https://openalex.org/W1998230178","https://openalex.org/W2000083699","https://openalex.org/W2002890481","https://openalex.org/W2004150448","https://openalex.org/W2009923660","https://openalex.org/W2010897203","https://openalex.org/W2012950781","https://openalex.org/W2013322085","https://openalex.org/W2016300251","https://openalex.org/W2021746597","https://openalex.org/W2023138404","https://openalex.org/W2023447919","https://openalex.org/W2024073000","https://openalex.org/W2028013493","https://openalex.org/W2029946781","https://openalex.org/W2030522563","https://openalex.org/W2035259864","https://openalex.org/W2035406121","https://openalex.org/W2038636068","https://openalex.org/W2053654922","https://openalex.org/W2054345935","https://openalex.org/W2055942727","https://openalex.org/W2064610856","https://openalex.org/W2079366348","https://openalex.org/W2082668399","https://openalex.org/W2087905758","https://openalex.org/W2093949724","https://openalex.org/W2100941609","https://openalex.org/W2107137298","https://openalex.org/W2107235439","https://openalex.org/W2111913995","https://openalex.org/W2115867185","https://openalex.org/W2117494977","https://openalex.org/W2121785002","https://openalex.org/W2122262666","https://openalex.org/W2126894693","https://openalex.org/W2133484311","https://openalex.org/W2133662619","https://openalex.org/W2140033444","https://openalex.org/W2142273705","https://openalex.org/W2142563401","https://openalex.org/W2146366178","https://openalex.org/W2148770916","https://openalex.org/W2149404153","https://openalex.org/W2154515402","https://openalex.org/W2157204844","https://openalex.org/W2158732030","https://openalex.org/W2168535055","https://openalex.org/W2180349132","https://openalex.org/W2279102027","https://openalex.org/W2312929775","https://openalex.org/W2332236125","https://openalex.org/W2360365987","https://openalex.org/W2396885039","https://openalex.org/W2408593291","https://openalex.org/W2432418760","https://openalex.org/W2502274362","https://openalex.org/W2548799826","https://openalex.org/W2561062294","https://openalex.org/W2563946227","https://openalex.org/W2747242946","https://openalex.org/W2750544356","https://openalex.org/W2767478133","https://openalex.org/W2778416039","https://openalex.org/W2785867880","https://openalex.org/W2797152839","https://openalex.org/W2891364404","https://openalex.org/W2914669715","https://openalex.org/W2915541941","https://openalex.org/W2920392315","https://openalex.org/W2921280804","https://openalex.org/W2934362744","https://openalex.org/W2938774134","https://openalex.org/W2939819363","https://openalex.org/W2953258114","https://openalex.org/W2957938761","https://openalex.org/W2972157551","https://openalex.org/W2973219767","https://openalex.org/W2997029751","https://openalex.org/W2999584823","https://openalex.org/W2999958881","https://openalex.org/W3000721519","https://openalex.org/W3001788572","https://openalex.org/W3020522844","https://openalex.org/W3083356684","https://openalex.org/W3087107467","https://openalex.org/W3087149834","https://openalex.org/W4211246989","https://openalex.org/W4232879750","https://openalex.org/W4240337585","https://openalex.org/W4241398143","https://openalex.org/W4249670569","https://openalex.org/W4250957873","https://openalex.org/W4252528216","https://openalex.org/W4252848326"],"related_works":["https://openalex.org/W7216336558","https://openalex.org/W7166550921","https://openalex.org/W4402363886","https://openalex.org/W7198488677","https://openalex.org/W2982158018","https://openalex.org/W2409290229","https://openalex.org/W3203012453","https://openalex.org/W4392558151","https://openalex.org/W4210360372","https://openalex.org/W3209148643"],"abstract_inverted_index":{"Caries":[0],"results":[1],"in":[2,104,163,176,188,233],"the":[3,13,30,33,58,164,186,189,223],"demineralization":[4],"and":[5,9,11,29,45,55,57,85,89,98,108,125,142,151,195,197,210,216],"destruction":[6],"of":[7,32,35,39,71,137,145,166,178,225],"enamel":[8],"dentine,":[10],"as":[12,120],"disease":[14],"progresses,":[15],"irreversible":[16,105],"pulpitis":[17],"can":[18,102],"occur.":[19],"Vital":[20],"pulp":[21,27,67,106,179,209],"therapy":[22],"(VPT)":[23],"is":[24,47,171],"directed":[25],"towards":[26],"preservation":[28],"prevention":[31],"progression":[34],"inflammation.":[36,180],"The":[37,65],"outcomes":[38,232],"VPT":[40],"are":[41,128,219],"not":[42],"always":[43],"predictable,":[44],"there":[46],"often":[48],"a":[49,62,91,109],"poor":[50],"correlation":[51],"between":[52,191],"clinical":[53,217],"signs":[54],"symptoms,":[56],"events":[59],"occurring":[60],"at":[61],"molecular":[63],"level.":[64],"inflamed":[66,208],"expresses":[68],"increased":[69,143],"levels":[70,141],"cytokines,":[72],"including":[73],"tumour":[74],"necrosis":[75],"factor":[76],"(TNF)-\u03b1,":[77],"interleukin":[78],"(IL)-1\u03b1,":[79],"IL-1\u03b2,":[80],"IL-4,":[81],"IL-6,":[82],"IL-8,":[83],"IL-17":[84],"IL-23,":[86],"which":[87],"recruit":[88],"drive":[90],"complex":[92],"cellular":[93],"immune":[94,134,146],"response.":[95],"Chronic":[96],"inflammation":[97],"sustained":[99],"cytokine":[100,140],"release":[101],"result":[103],"damage":[107],"decreased":[110],"capacity":[111],"for":[112],"tissue":[113,153],"healing.":[114,212],"Other":[115],"chronic":[116,192],"inflammatory":[117,122,193],"diseases,":[118,168],"such":[119],"psoriasis,":[121],"bowel":[123],"diseases":[124,194],"rheumatoid":[126],"arthritis,":[127],"also":[129],"characterized":[130],"by":[131],"an":[132,207],"dysregulated":[133],"response":[135],"composed":[136],"relatively":[138],"high":[139],"numbers":[144],"cells":[147],"along":[148],"with":[149],"microbial":[150],"hard-soft":[152],"destructive":[154],"pathologies.":[155],"Whilst":[156],"anti-cytokine":[157,200],"therapies":[158,201],"have":[159],"been":[160],"successfully":[161],"applied":[162,204],"treatment":[165],"these":[167,226],"this":[169],"approach":[170],"yet":[172],"to":[173,205,221,228],"be":[174,203],"attempted":[175],"cases":[177],"This":[181],"review":[182],"therefore":[183],"focuses":[184],"on":[185],"similarities":[187],"aetiology":[190],"pulpitis,":[196],"explores":[198],"how":[199],"could":[202],"manage":[206],"facilitate":[211],"Further":[213],"proof-of-concept":[214],"studies":[215],"trials":[218],"justified":[220],"determine":[222],"effectiveness":[224],"treatments":[227],"enable":[229],"more":[230],"predictable":[231],"VPT.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-04-13T00:00:00"}