{"id":"https://openalex.org/W3143323338","doi":"https://doi.org/10.11620/ijob.2021.46.1.15","title":"Alpha-lipoic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced cell injury by inhibiting autophagy and apoptosis","display_name":"Alpha-lipoic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced cell injury by inhibiting autophagy and apoptosis","publication_year":2021,"publication_date":"2021-03-31","ids":{"openalex":"https://openalex.org/W3143323338","doi":"https://doi.org/10.11620/ijob.2021.46.1.15","mag":"3143323338"},"language":"en","primary_location":{"id":"doi:10.11620/ijob.2021.46.1.15","doi":"https://doi.org/10.11620/ijob.2021.46.1.15","is_oa":true,"landing_page_url":"https://doi.org/10.11620/ijob.2021.46.1.15","pdf_url":null,"source":{"id":"https://openalex.org/S2764563534","display_name":"International Journal of Oral Biology","issn_l":"1226-7155","issn":["1226-7155","2287-6618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-candidate"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oral Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W3143323338"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.11620/ijob.2021.46.1.15","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045918855","display_name":"Kyeong\u2010Rok Kang","orcid":"https://orcid.org/0000-0003-1369-3865","observed_orcids":["https://orcid.org/0000-0003-1369-3865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyeong-Rok Kang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780339","display_name":"Jae\u2010Sung Kim","orcid":"https://orcid.org/0000-0002-3584-6351","observed_orcids":["https://orcid.org/0000-0002-3584-6351"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jae-Sung Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101856156","display_name":"Tae\u2010Hyeon Kim","orcid":"https://orcid.org/0000-0002-6232-3476","observed_orcids":["https://orcid.org/0000-0002-6232-3476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tae-Hyeon Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016265175","display_name":"Jeong-Yeon Seo","orcid":"https://orcid.org/0000-0002-9290-364X","observed_orcids":["https://orcid.org/0000-0002-9290-364X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeong-Yeon Seo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064059046","display_name":"HyangI Lim","orcid":"https://orcid.org/0000-0002-2728-4205","observed_orcids":["https://orcid.org/0000-0002-2728-4205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HyangI Lim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108046716","display_name":"Jong-Hyun Park","orcid":"https://orcid.org/0000-0003-1320-0207","observed_orcids":["https://orcid.org/0000-0003-1320-0207"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jong-Hyun Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102093312","display_name":"Kwang Yeol Yang","orcid":"https://orcid.org/0000-0002-8320-3027","observed_orcids":["https://orcid.org/0000-0002-8320-3027"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kwang Yeol Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054985810","display_name":"Sun\u2010Kyoung Yu","orcid":"https://orcid.org/0000-0003-0801-1663","observed_orcids":["https://orcid.org/0000-0003-0801-1663"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sun-Kyoung Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046710765","display_name":"Heung\u2010Joong Kim","orcid":"https://orcid.org/0000-0003-1636-3669","observed_orcids":["https://orcid.org/0000-0003-1636-3669"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heung-Joong Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048160692","display_name":"Chun Sung Kim","orcid":"https://orcid.org/0000-0001-8612-3420","observed_orcids":["https://orcid.org/0000-0001-8612-3420"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chun Sung Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089704428","display_name":"Hong Sung Chun","orcid":"https://orcid.org/0000-0003-4174-0139","observed_orcids":["https://orcid.org/0000-0003-4174-0139"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Sung Chun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"1","first_page":"15","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.7773000001907349,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.7773000001907349,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.14970000088214874,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.05090000107884407,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-lipoic-acid","display_name":"alpha-lipoic acid","score":1.0},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8610000014305115},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9940000176429749},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":1.0},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8859999775886536},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.7850000262260437},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9359999895095825},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.7950000166893005},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lc3","display_name":"LC3","score":0.8169999718666077},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8949999809265137},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.9819999933242798}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8786535263061523},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7265788912773132},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.6441195011138916},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6024894714355469},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5619224905967712},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4807131588459015},{"id":"https://openalex.org/C2910140794","wikidata":"https://www.wikidata.org/wiki/Q312229","display_name":"Alpha-Lipoic Acid","level":3,"score":0.45149514079093933},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42705416679382324},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40839359164237976},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2698204517364502},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2627132534980774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24613037705421448},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24410197138786316},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.20129770040512085},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1852300763130188}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.11620/ijob.2021.46.1.15","doi":"https://doi.org/10.11620/ijob.2021.46.1.15","is_oa":true,"landing_page_url":"https://doi.org/10.11620/ijob.2021.46.1.15","pdf_url":null,"source":{"id":"https://openalex.org/S2764563534","display_name":"International Journal of Oral Biology","issn_l":"1226-7155","issn":["1226-7155","2287-6618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-candidate"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oral Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.11620/ijob.2021.46.1.15","doi":"https://doi.org/10.11620/ijob.2021.46.1.15","is_oa":true,"landing_page_url":"https://doi.org/10.11620/ijob.2021.46.1.15","pdf_url":null,"source":{"id":"https://openalex.org/S2764563534","display_name":"International Journal of Oral Biology","issn_l":"1226-7155","issn":["1226-7155","2287-6618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-candidate"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oral Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2937745825","https://openalex.org/W1472932264","https://openalex.org/W3030719855","https://openalex.org/W2522004728","https://openalex.org/W1991020561","https://openalex.org/W2028464299","https://openalex.org/W2796185288","https://openalex.org/W7160529952","https://openalex.org/W2604202267","https://openalex.org/W2135723126"],"abstract_inverted_index":{"Alpha-lipoic":[0],"acid":[1],"(ALA)":[2],"is":[3],"a":[4],"naturally":[5],"occurring":[6],"antioxidant":[7,118],"and":[8,16,48,86,98,106,108,127,156],"has":[9],"been":[10],"previously":[11],"used":[12],"to":[13,40],"treat":[14],"diabetes":[15],"cardiovascular":[17],"disease.":[18],"However,":[19],"the":[20,42,54,66,114,117,123],"autophagy":[21,47,129,155],"effects":[22],"of":[23,36,44,116,125],"ALA":[24,45,91,101,112,134,143],"against":[25,50,149],"oxidative":[26,51],"stress-induced":[27],"dopaminergic":[28,57,146],"neuronal":[29,58,147],"cell":[30,59,77,99,137,151],"injury":[31,152],"remain":[32],"unclear.":[33],"The":[34],"aim":[35],"this":[37],"study":[38],"was":[39,131],"investigate":[41],"role":[43],"in":[46,53,135],"apoptosis":[49],"stress":[52],"SH-SY5Y":[55,63],"human":[56,145],"line.":[60],"We":[61],"examined":[62],"phenotypes":[64],"using":[65],"3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium":[67],"bromide":[68],"assay":[69],"(cell":[70],"viability/proliferation),":[71],"4\u2032,6-diamidino-2-phenylindole":[72],"dihydrochloride":[73],"nuclear":[74],"staining,":[75],"Live/Dead":[76],"assay,":[78,84],"cellular":[79],"reactive":[80],"oxygen":[81],"species":[82],"(ROS)":[83],"immunoblotting,":[85],"immunocytochemistry.":[87],"Our":[88],"data":[89,141],"showed":[90],"attenuated":[92],"hydrogen":[93],"peroxide":[94],"(H2O2)-induced":[95],"ROS":[96],"generation":[97],"death.":[100],"effectively":[102],"suppressed":[103],"Bax":[104],"up-regulation":[105],"Bcl-2":[107],"BclxL":[109],"down-regulation.":[110],"Furthermore,":[111],"increased":[113],"expression":[115,124],"enzyme,":[119],"heme":[120],"oxygenase-1.":[121],"Moreover,":[122],"Beclin-1":[126],"LC-3":[128],"biomarkers":[130],"decreased":[132],"by":[133,153],"our":[136],"model.":[138],"Combined,":[139],"these":[140],"suggest":[142],"protects":[144],"cells":[148],"H2O2-induced":[150],"inhibiting":[154],"apoptosis.":[157]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-04-13T00:00:00"}