{"id":"https://openalex.org/W3142872005","doi":null,"title":"MATRIZ EXTRACELULAR DESCELULARIZADA CEREBRAL COMO MODELO IN VITRO DE DIFERENCIACI\u00d3N CELULAR","display_name":"MATRIZ EXTRACELULAR DESCELULARIZADA CEREBRAL COMO MODELO IN VITRO DE DIFERENCIACI\u00d3N CELULAR","publication_year":2016,"publication_date":"2016-10-01","ids":{"openalex":"https://openalex.org/W3142872005","mag":"3142872005"},"language":"es","primary_location":{"id":"mag:3142872005","doi":null,"is_oa":false,"landing_page_url":"http://repo.ulatina.edu.pa/handle/123456789/21","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070651104","display_name":"Sebasti\u00e1n Valerio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sebasti\u00e1n Valerio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030652733","display_name":"Didio Alberto Ortiz","orcid":"https://orcid.org/0000-0002-6392-8434","observed_orcids":["https://orcid.org/0000-0002-6392-8434"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Didio Ortiz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6392-8434","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025532303","display_name":"Carly Morgan","orcid":"https://orcid.org/0000-0002-4852-5135","observed_orcids":["https://orcid.org/0000-0002-4852-5135"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carly Morgan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4852-5135","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064016136","display_name":"Diego Reginensi","orcid":"https://orcid.org/0000-0002-7709-1663","observed_orcids":["https://orcid.org/0000-0002-7709-1663"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diego Reginensi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7709-1663","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073695665","display_name":"Rolando A. Gittens","orcid":"https://orcid.org/0000-0002-0286-3956","observed_orcids":["https://orcid.org/0000-0002-0286-3956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rolando A. Gittens","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0286-3956","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44373397,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-extracellular-matrix","display_name":"brain extracellular matrix","score":0.7519999742507935},{"id":"https://openalex.org/keywords/porcine-brain","display_name":"porcine brain","score":0.7680000066757202},{"id":"https://openalex.org/keywords/biomimetic-biomaterials","display_name":"biomimetic biomaterials","score":0.6690000295639038},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.7919999957084656},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.972000002861023},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/surface-nanotopography","display_name":"surface nanotopography","score":0.7179999947547913},{"id":"https://openalex.org/keywords/protein-adsorption","display_name":"protein adsorption","score":0.7409999966621399},{"id":"https://openalex.org/keywords/maldi-tof-mass-spectrometry","display_name":"MALDI-TOF mass spectrometry","score":0.6970000267028809},{"id":"https://openalex.org/keywords/brain-injury-model","display_name":"brain injury model","score":0.4779999852180481},{"id":"https://openalex.org/keywords/cellular-microenvironment","display_name":"cell microenvironment","score":0.46399998664855957},{"id":"https://openalex.org/keywords/biomaterial-characterization","display_name":"biomaterial characterization","score":0.5910000205039978},{"id":"https://openalex.org/keywords/poly-d-lysine","display_name":"poly-D-lysine","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.714553952217102},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.487824946641922}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3142872005","doi":null,"is_oa":false,"landing_page_url":"http://repo.ulatina.edu.pa/handle/123456789/21","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3178482505","https://openalex.org/W7120845722","https://openalex.org/W6939918472","https://openalex.org/W7018325303","https://openalex.org/W3008414802","https://openalex.org/W2948536597","https://openalex.org/W7065067753","https://openalex.org/W2599008437","https://openalex.org/W2810540554","https://openalex.org/W6999748642"],"abstract_inverted_index":{"Los":[0],"mecanismos":[1],"celulares":[2,17],"de":[3,15,22,46,57,63,68,84,101,115,130,134,140,146,150,152,168,172,182,187,192,219,267,277,303,314,337],"proliferacion,":[4,72],"migracion":[5],"y":[6,18,34,75,97,111,148,238,256,325],"diferenciacion":[7,195,227,279],"son":[8,28,163],"procesos":[9,27],"gobernados":[10],"sinergicamente":[11],"entre":[12],"los":[13,19],"complejos":[14],"anclaje":[16],"diversos":[20],"componentes":[21],"la":[23,121,141,169,194,202,220,226,232,265,268,286,292,342],"matriz":[24,54,221,269,293,343],"extracelular.":[25],"Dichos":[26],"especificos":[29],"para":[30,212],"cada":[31],"tipo":[32],"celular":[33,70,157,166,204,234,280,288],"varian":[35],"segun":[36],"el":[37,40,61,214,311,335],"microambiente":[38],"en":[39,53,79,180,225,241,247,281,317,321,329,341,347,359],"que":[41,162,174,179,231,250,264],"se":[42,89,118],"encuentran.":[43],"Nuestro":[44],"grupo":[45],"investigacion":[47],"ha":[48,90,119,251],"desarrollado":[49],"un":[50,177,208,330,338],"biomaterial":[51,93,124,249],"basado":[52,340],"extracelular":[55,222,270,294,344],"descelularizado":[56],"cerebro":[58],"porcino,":[59],"con":[60],"objetivo":[62],"realizar":[64],"estudios":[65,318],"in":[66,82,217,319,332],"vitro":[67,218],"dinamica":[69],"(p.e":[71,185,244],"migracion,":[73],"diferenciacion)":[74],"su":[76,326],"futura":[77],"aplicacion":[78],"modelos":[80],"animales":[81],"vivo":[83],"lesion":[85],"cerebral.\r\nA":[86],"nivel":[87],"experimental,":[88],"caracterizado":[91],"nuestro":[92,248,315],"mediante":[94,128,254,334],"herramientas":[95],"moleculares":[96],"celulares,":[98],"incluyendo:":[99],"analisis":[100,129,139,149],"DNA":[102],"(Quant-ITTM":[103],"PicoGreen\u00ae,":[104],"Invitrogen),":[105],"composicion":[106],"proteica":[107],"(BCA":[108,136],"Assay":[109,137],"PierceTM)":[110],"ultraestructura":[112],"(microscopia":[113,144],"electronica":[114,145],"barrido).":[116],"Luego,":[117],"estudiado":[120],"adhesion":[122],"del":[123,350],"a":[125,176,196,291],"diversas":[126],"superficies":[127],"fluorescencia":[131],"(FM1-43),":[132],"adsorcion":[133],"proteinas":[135],"PierceTM),":[138],"nanotopografia":[142],"superficial":[143],"barrido)":[147],"senal":[151],"analitos":[153],"proteicos":[154],"(MALDI-TOF).\r\nComo":[155],"modelo":[156,209,331],"utilizamos":[158],"las":[159],"celulas":[160,322],"PC12":[161,205,235,289],"una":[164,355],"linea":[165,203,233,287],"obtenida":[167],"glandula":[170],"adrenal":[171],"rata,":[173],"corresponde":[175],"feocromacitoma":[178],"presencia":[181],"factores":[183],"neurales":[184,324],"Factor":[186],"Crecimiento":[188],"Neuronal)":[189],"es":[190,301],"capaz":[191,276,302],"promover":[193],"fenotipo":[197],"tipo-neuronal.":[198],"De":[199],"esta":[200],"forma,":[201],"resulta":[206],"ser":[207],"unidireccional":[210],"interesante":[211],"probar":[213],"potencial":[215,312],"biomimetico":[216],"descelularizada":[223,271,295,345],"cerebral":[224,296,346],"celular.\r\nComo":[228],"resultado,":[229],"obtuvimos":[230],"adhieren,":[236],"proliferan":[237],"migran":[239],"tanto":[240],"sustratos":[242],"tradicionales":[243],"Poli-D-Lisina),":[245],"como":[246,273,298,354],"sido":[252],"analizado":[253],"inmunofluorescencia":[255],"microcopia":[257],"electronica,":[258],"no":[259,261],"obstante,":[260],"hemos":[262],"observado":[263],"topografia":[266],"cerebral,":[272],"sustrato,":[274],"sea":[275],"inducir":[278,304],"este":[282],"linaje":[283],"celular.":[284],"Interesantemente,":[285],"frente":[290],"(MECd),":[297],"factor":[299],"soluble,":[300],"fenotipos":[305],"neuronales.":[306],"Nuestras":[307],"proyecciones":[308],"buscan":[309],"investigar":[310],"diferenciador":[313],"biomaterial,":[316],"vitro,":[320],"madres":[323],"posible":[327],"aplicacion,":[328],"vivo,":[333],"desarrollo":[336],"hidrogel":[339],"lesiones":[348],"traumaticas":[349],"sistema":[351],"nervioso":[352],"central,":[353],"nueva":[356],"terapia":[357],"vanguardista":[358],"medicina":[360],"regenerativa.":[361]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2021-04-13T00:00:00"}
