{"id":"https://openalex.org/W3142844368","doi":null,"title":"E cacy and Safety of Flurbiprofen Axetil for Clinical Analgesic E ect: A Meta-analysis","display_name":"E cacy and Safety of Flurbiprofen Axetil for Clinical Analgesic E ect: A Meta-analysis","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W3142844368","mag":"3142844368"},"language":"en","primary_location":{"id":"mag:3142844368","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZZXZ201112015.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764588682","display_name":"Zhongguo xunzheng yixue zazhi","issn_l":"1672-2531","issn":["1672-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4320800639","host_organization_name":"Sichuan University School of Medicine","host_organization_lineage":["https://openalex.org/P4320800639"],"host_organization_lineage_names":["Sichuan University School of Medicine"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo xunzheng yixue zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100943096","display_name":"Ling Pei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ling Pei","raw_affiliation_strings":["Department of Anesthesiology,the First A liated Hospital,China Medical University,Shenyang 110001,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology,the First A liated Hospital,China Medical University,Shenyang 110001,China","institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100943096"],"corresponding_institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55901639,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.03909999877214432,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flurbiprofen-axetil","display_name":"flurbiprofen axetil","score":0.9890000224113464},{"id":"https://openalex.org/keywords/propofol-injection-pain","display_name":"propofol injection pain","score":0.9670000076293945},{"id":"https://openalex.org/keywords/preemptive-analgesia","display_name":"preemptive analgesia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/general-anesthesia","display_name":"general anesthesia","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibitors","display_name":"cyclooxygenase inhibitors","score":0.8980000019073486},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.8259999752044678},{"id":"https://openalex.org/keywords/analgesic-efficacy","display_name":"analgesic efficacy","score":0.8059999942779541},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.9039999842643738},{"id":"https://openalex.org/keywords/visual-analog-scale","display_name":"visual analogue scale","score":0.628000020980835},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.44999998807907104},{"id":"https://openalex.org/keywords/postoperative-nausea-and-vomiting","display_name":"postoperative nausea and vomiting","score":0.5249999761581421},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.3070000112056732},{"id":"https://openalex.org/keywords/postoperative-shivering","display_name":"postoperative shivering","score":0.3499999940395355},{"id":"https://openalex.org/keywords/postoperative-hypothermia","display_name":"postoperative hypothermia","score":0.5249999761581421},{"id":"https://openalex.org/keywords/postoperative-delirium","display_name":"postoperative delirium","score":0.4690000116825104},{"id":"https://openalex.org/keywords/postoperative-confusion","display_name":"postoperative confusion","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8905481100082397},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7405404448509216},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.7349351644515991},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.589974045753479},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5821389555931091},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5318975448608398},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.5280046463012695},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5267659425735474},{"id":"https://openalex.org/C2781000538","wikidata":"https://www.wikidata.org/wiki/Q419890","display_name":"Flurbiprofen","level":2,"score":0.4303535521030426},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28357774019241333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15031057596206665},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3142844368","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZZXZ201112015.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764588682","display_name":"Zhongguo xunzheng yixue zazhi","issn_l":"1672-2531","issn":["1672-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4320800639","host_organization_name":"Sichuan University School of Medicine","host_organization_lineage":["https://openalex.org/P4320800639"],"host_organization_lineage_names":["Sichuan University School of Medicine"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo xunzheng yixue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2166860228","https://openalex.org/W2460149583","https://openalex.org/W2350909243","https://openalex.org/W2389867858","https://openalex.org/W2360549902","https://openalex.org/W2380933519","https://openalex.org/W2353646115","https://openalex.org/W2386276358","https://openalex.org/W3115630931","https://openalex.org/W2386628182"],"abstract_inverted_index":{"Objective":[0],"To":[1],"evaluate":[2],"the":[3,61,67,73,106,112,120,146,151,185,201,209,212,238,244,267,278,296,299],"e":[4,314],"cacy":[5],"and":[6,18,29,46,66,122,171,264,318],"safety":[7],"of":[8,60,86,95,155,196,211,214,233,298],"COX":[9],"inhibitor":[10],"urbiprofen":[11,39,180,204],"axetil":[12,40,109,181,205,241,271,282,293],"in":[13,41,125,141,194,231,261],"relieving":[14,142],"propofol":[15,43,101,113,279],"injection":[16,44,102,114,280],"pain":[17,45,124,144,289,304],"preemptive":[19,47],"analgesia":[20,48],"a":[21,49],"er":[22,50],"general":[23,51],"anesthesia.Methods":[24],"Databases":[25],"such":[26],"as":[27],"PubMed,CBM,Springer,Ovid,CNKI":[28],"ISI":[30],"were":[31,69,92,135,188,225,255],"searched":[32],"to":[33,56,72,117,129,132,161,165,169,175,220,250,311],"identify":[34],"randomized":[35],"controlled":[36],"trials(RCTs)":[37],"about":[38],"reliev-ing":[42],"anesthesia":[52],"published":[53],"from":[54],"2000":[55],"2010.e":[57],"meth-odological":[58],"quality":[59],"included":[62],"RCTs":[63,88,308],"was":[64,77,177,182,206,222],"assessed":[65],"data":[68],"extracted":[70],"according":[71],"Cochrane":[74],"Handbook":[75],"5.0.1.Meta-analysis":[76],"performed":[78],"by":[79],"using":[80],"RevMan":[81],"4.2.10":[82],"software.Results":[83],"A":[84],"total":[85],"15":[87],"involving":[89],"1?425":[90],"patients":[91],"included.e":[93],"results":[94],"meta-analyses":[96],"showed":[97],"that:":[98],"a)":[99],"Relieving":[100],"pain:":[103],"Compared":[104],"with":[105],"placebo":[107],"group,urbiprofen":[108],"could":[110,242],"prevent":[111,275],"pain(RR=3.13,95%CI":[115],"1.08":[116],"9.11,P=0.04),and":[118],"relieve":[119,277,287,302],"moderate":[121],"severe":[123],"injecting":[126],"propofol(RR=0.57,95%CI":[127],"0.40":[128],"0.81,P=0.002;RR=0.14,95%CI":[130],"0.05":[131],"0.34,P0.000?1,respectively),but":[133],"there":[134,187,224,254],"no":[136,189,226,256],"signi":[137,190,227,257,273],"cant":[138,191,228,258],"di":[139,192,229,259],"erences":[140,193,230,260],"mild":[143],"between":[145,200,237],"two":[147,202,239,268],"groups;b)":[148],"Preemptive":[149],"analgesia:":[150],"visual":[152],"analog":[153],"scale(VAS)":[154],"post-operation":[156,197,215,234],"at":[157,198,208,216,235,290,295,305],"2-hour(WMD=":[158],"\u20132.25,95%CI":[159],"\u20134.20":[160],"\u20130.29,P=0.02),4-hour(WMD=":[162],"\u20131.99,95%CI":[163],"\u20133.19":[164],"\u20130.79,P=0.001),8-hour(WMD=":[166],"\u20131.39,95%CI":[167],"\u20131.86":[168],"\u20130.93,P0.000?01)":[170],"12-hour(WMD=":[172,217],"\u20132.70,95%CI":[173],"\u20134.73":[174],"\u20130.68,P=0.009)":[176],"decreased":[178],"when":[179],"injected":[183,207,283,294],"before":[184,284],"operation,but":[186],"VAS":[195,232],"48-hour":[199],"groups.When":[203],"end":[210,297],"operation,VAS":[213],"\u20130.94,95%CI":[218],"\u20131.73":[219],"\u20130.16,P=0.02)":[221],"decreased,but":[223],"24-hour":[236],"groups;urbiprofen":[240],"lessen":[243],"need":[245],"for":[246],"opioid":[247],"analgesics(RR=0.47,95%CI":[248],"0.27":[249],"0.82,P=0.008);and":[251],"c)":[252],"Safety:":[253],"postoperative":[262],"nausea,vomit":[263,317],"somnolence":[265],"be-tween":[266],"groups.Conclusion":[269],"Flurbiprofen":[270],"can":[272,286,301],"cantly":[274],"or":[276],"pain;urbiprofen":[281],"operation":[285,300],"post-operative":[288,303],"2-,4-,8-and":[291],"12-hour;urbiprofen":[292],"12-hour.Yet":[306],"more":[307],"are":[309],"required":[310],"discuss":[312],"its":[313],"ects":[315],"on":[316],"somnolence.":[319]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2021-04-13T00:00:00"}
