{"id":"https://openalex.org/W3142548396","doi":null,"title":"Ultrasensitive DNA sequencing using liquid biopsies enables precision medicine","display_name":"Ultrasensitive DNA sequencing using liquid biopsies enables precision medicine","publication_year":2021,"publication_date":"2021-03-18","ids":{"openalex":"https://openalex.org/W3142548396","mag":"3142548396"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/67332","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2077/67332","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052474293","display_name":"Gustav Johansson","orcid":"https://orcid.org/0000-0002-3992-3318","observed_orcids":["https://orcid.org/0000-0002-3992-3318"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gustav Johansson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3992-3318","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052474293"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cell-free-tumor-dna","display_name":"cell-free tumor DNA","score":0.8019999861717224},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.7950000166893005},{"id":"https://openalex.org/keywords/unique-molecular-identifiers","display_name":"unique molecular identifiers","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gastrointestinal-stromal-tumor","display_name":"gastrointestinal stromal tumor","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tumor-monitoring","display_name":"cancer monitoring","score":0.5910000205039978},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6600000262260437},{"id":"https://openalex.org/keywords/relapse-detection","display_name":"relapse detection","score":0.6679999828338623},{"id":"https://openalex.org/keywords/immune-repertoire-sequencing","display_name":"immune repertoire sequencing","score":0.8059999942779541},{"id":"https://openalex.org/keywords/t-cell-clonality","display_name":"T cell clonality","score":0.9089999794960022},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.8840000033378601},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.6000000238418579},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.6316666007041931},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5328807234764099},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.5100148916244507},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.490804523229599},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.4876629114151001},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37873080372810364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34518760442733765},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24478906393051147},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1091301441192627}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/67332","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2077/67332","pdf_url":null,"source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:3142548396","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/handle/2077/67332","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W25562819","https://openalex.org/W1590537765","https://openalex.org/W1749324649","https://openalex.org/W1893868216","https://openalex.org/W1967867591","https://openalex.org/W1981491302","https://openalex.org/W1983466841","https://openalex.org/W2006762876","https://openalex.org/W2008189289","https://openalex.org/W2013972020","https://openalex.org/W2015438948","https://openalex.org/W2020094108","https://openalex.org/W2021429824","https://openalex.org/W2038814052","https://openalex.org/W2039512961","https://openalex.org/W2051241958","https://openalex.org/W2053067769","https://openalex.org/W2057470956","https://openalex.org/W2059864409","https://openalex.org/W2070059866","https://openalex.org/W2102862705","https://openalex.org/W2107726313","https://openalex.org/W2116922255","https://openalex.org/W2117692326","https://openalex.org/W2123232650","https://openalex.org/W2125665528","https://openalex.org/W2139511378","https://openalex.org/W2141688036","https://openalex.org/W2141993327","https://openalex.org/W2151984951","https://openalex.org/W2154131040","https://openalex.org/W2164421236","https://openalex.org/W2205667543","https://openalex.org/W2206684187","https://openalex.org/W2323851578","https://openalex.org/W2327217129","https://openalex.org/W2490393521","https://openalex.org/W2492693765","https://openalex.org/W2513507045","https://openalex.org/W2514365970","https://openalex.org/W2529299484","https://openalex.org/W2560717039","https://openalex.org/W2593493913","https://openalex.org/W2613978126","https://openalex.org/W2671261300","https://openalex.org/W2724321582","https://openalex.org/W2730259699","https://openalex.org/W2752126733","https://openalex.org/W2764195238","https://openalex.org/W2765860936","https://openalex.org/W2783674487","https://openalex.org/W2790358412","https://openalex.org/W2793773213","https://openalex.org/W2796153844","https://openalex.org/W2797540610","https://openalex.org/W2802964883","https://openalex.org/W2883645764","https://openalex.org/W2887179222","https://openalex.org/W2887694233","https://openalex.org/W2894265806","https://openalex.org/W2894513321","https://openalex.org/W2912214830","https://openalex.org/W2917516523","https://openalex.org/W2921918064","https://openalex.org/W2940469730","https://openalex.org/W2945564879","https://openalex.org/W2947989913","https://openalex.org/W2952901975","https://openalex.org/W2954530517","https://openalex.org/W2955806433","https://openalex.org/W2985336022","https://openalex.org/W3003373436","https://openalex.org/W3005322731","https://openalex.org/W3017406972","https://openalex.org/W3020301997","https://openalex.org/W3032348033","https://openalex.org/W3044470192","https://openalex.org/W3081499876","https://openalex.org/W3110953136","https://openalex.org/W3122927608"],"related_works":["https://openalex.org/W7217280638","https://openalex.org/W7218291760","https://openalex.org/W3035948879","https://openalex.org/W2915827996","https://openalex.org/W2161332321","https://openalex.org/W7164651140","https://openalex.org/W2741405900","https://openalex.org/W2981078321","https://openalex.org/W4364856319","https://openalex.org/W6983116315"],"abstract_inverted_index":{"Liquid":[0],"biopsies":[1,19,58,310],"are":[2],"minimally":[3],"invasive":[4],"and":[5,47,74,99,104,125,136,145,176,196,212,225,255,258,264,273,291,323,340,354,358],"allow":[6],"repetitive":[7],"sampling":[8],"of":[9,13,52,86,101,134,139,151,169,173,239,296,326,329,335,342,360],"body":[10],"fluids.":[11],"Analysis":[12,51],"cell-free":[14,35,185],"tumor":[15,44,186,194],"DNA":[16,36,55,81,187,238,280],"in":[17,29,56,77,107,217,285,314,317],"liquid":[18,33,57,309,344],"can":[20,59,205,259],"be":[21,60,206,260,312],"used":[22],"as":[23],"a":[24,162,223,251],"biomarker":[25],"for":[26,351],"cancer.":[27],"However,":[28,68],"most":[30],"clinically":[31],"relevant":[32],"biopsies,":[34],"is":[37,48,248],"present":[38],"at":[39],"low":[40],"concentrations,":[41],"contains":[42],"minute":[43],"allele":[45],"frequencies,":[46],"highly":[49],"fragmented.":[50],"immune":[53,65,227,294],"cell":[54,66,197],"profiled":[61],"to":[62,90,160,165,208,231,262,282],"examine":[63],"the":[64,97,132,149,167,237,293,318,324,338],"repertoire.":[67],"this":[69,87,333],"application":[70],"requires":[71],"unbiased":[72],"quantification":[73,100],"accurate":[75],"sequencing":[76,93,115,229,281],"an":[78,113],"incredibly":[79],"diverse":[80,327],"background.":[82],"The":[83],"overall":[84],"aim":[85],"thesis":[88],"was":[89],"develop":[91],"ultrasensitive":[92,114,226,279,343],"approaches":[94],"that":[95,122,131,202,245,277,303,307],"enable":[96],"detection":[98],"individual":[102],"molecules":[103],"single":[105],"cells":[106],"these":[108],"applications.":[109],"We":[110,154,301],"applied":[111,207,261],"SiMSen-Seq,":[112],"strategy":[116],"based":[117],"on":[118],"unique":[119],"molecular":[120],"identifiers":[121],"enables":[123],"error-free":[124],"quantitative":[126],"sequencing.":[127],"First,":[128],"we":[129,221,243,269],"showed":[130],"amounts":[133],"plasma":[135],"DNA,":[137,171],"number":[138],"targeted":[140,224],"somatic":[141],"variants,":[142],"assay":[143],"length,":[144],"target":[146],"sequences":[147],"affect":[148],"sensitivity":[150],"ctDNA":[152],"analysis.":[153],"developed":[155,222,270],"multiple":[156],"quality":[157,359],"control":[158],"steps":[159],"evaluate":[161],"preanalytical":[163],"workflow":[164],"analyze":[166],"amount":[168],"amplifiable":[170],"degree":[172],"cellular":[174],"contamination,":[175],"enzymatic":[177],"inhibition.":[178],"In":[179,267],"patients":[180,286,353],"with":[181,189,287],"gastrointestinal":[182,288],"stromal":[183,289],"tumors,":[184],"correlated":[188],"risk":[190],"classification,":[191],"treatment":[192,210],"response,":[193],"size,":[195],"proliferation.":[198],"Our":[199],"data":[200],"indicate":[201],"our":[203,246],"method":[204,230],"monitoring":[209],"efficacy":[211],"identifying":[213],"relapse":[214],"early,":[215],"especially":[216],"high-risk":[218],"patients.":[219],"Finally,":[220],"repertoire":[228,295],"profile":[232,292],"T-cell":[233],"clonality.":[234],"By":[235],"studying":[236],"\u03b3\u03b4":[240,297],"T":[241,298],"cells,":[242,299],"demonstrated":[244],"approach":[247],"characterized":[249],"by":[250],"wide":[252],"dynamic":[253],"range":[254],"high":[256],"reproducibility":[257],"enriched":[263],"non-enriched":[265],"cells.":[266],"conclusion,":[268],"two":[271],"flexible":[272],"simple":[274],"liquid-biopsy":[275],"applications":[276,306],"use":[278,325],"monitor":[283],"cancer":[284],"tumors":[290],"respectively.":[300],"expect":[302],"several":[304],"diagnostic":[305],"utilize":[308],"will":[311,331,347],"implemented":[313],"clinical":[315],"routines":[316],"future.":[319],"Further":[320],"technology":[321],"development":[322,339],"types":[328],"analytes":[330],"advance":[332],"field":[334],"research.":[336],"Ultimately,":[337],"implementation":[341],"biopsy-based":[345],"analysis":[346],"facilitate":[348],"precision":[349],"medicine":[350],"more":[352],"improve":[355],"their":[356],"survival":[357],"life.":[361]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2021-04-13T00:00:00"}
