{"id":"https://openalex.org/W3142226166","doi":"https://doi.org/10.14740/jh140w","title":"High-Resolution Analysis of Chromosomal Alterations in Adult Acute Lymphoblastic Leukemia","display_name":"High-Resolution Analysis of Chromosomal Alterations in Adult Acute Lymphoblastic Leukemia","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W3142226166","doi":"https://doi.org/10.14740/jh140w","mag":"3142226166"},"language":"en","primary_location":{"id":"doi:10.14740/jh140w","doi":"https://doi.org/10.14740/jh140w","is_oa":true,"landing_page_url":"https://doi.org/10.14740/jh140w","pdf_url":"https://www.thejh.org/index.php/jh/article/download/140/116","source":{"id":"https://openalex.org/S4210202061","display_name":"Journal of Hematology","issn_l":"1927-1212","issn":["1927-1212","1927-1220"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4328135221","host_organization_name":"Elmer Press Inc.","host_organization_lineage":["https://openalex.org/P4328135221"],"host_organization_lineage_names":["Elmer Press Inc."],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.thejh.org/index.php/jh/article/download/140/116","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yuen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yuen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2123,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54228406,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":"3","first_page":"65","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adult-acute-lymphoblastic-leukemia","display_name":"adult acute lymphoblastic leukemia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9929999709129333},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.7829999923706055},{"id":"https://openalex.org/keywords/gene-deletion","display_name":"gene deletion","score":0.8500000238418579},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9039999842643738},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9570000171661377}],"concepts":[{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.8143829107284546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6772770881652832},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.45167675614356995},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34403011202812195},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3238884210586548},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2819451689720154}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.14740/jh140w","doi":"https://doi.org/10.14740/jh140w","is_oa":true,"landing_page_url":"https://doi.org/10.14740/jh140w","pdf_url":"https://www.thejh.org/index.php/jh/article/download/140/116","source":{"id":"https://openalex.org/S4210202061","display_name":"Journal of Hematology","issn_l":"1927-1212","issn":["1927-1212","1927-1220"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4328135221","host_organization_name":"Elmer Press Inc.","host_organization_lineage":["https://openalex.org/P4328135221"],"host_organization_lineage_names":["Elmer Press Inc."],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology","raw_type":"journal-article"},{"id":"mag:2058773828","doi":null,"is_oa":false,"landing_page_url":"https://www.thejh.org/index.php/jh/article/view/140/115","pdf_url":null,"source":{"id":"https://openalex.org/S4210202061","display_name":"Journal of Hematology","issn_l":"1927-1212","issn":["1927-1212","1927-1220"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4328135221","host_organization_name":"Elmer Press Inc.","host_organization_lineage":["https://openalex.org/P4328135221"],"host_organization_lineage_names":["Elmer Press Inc."],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of hematology","raw_type":null}],"best_oa_location":{"id":"doi:10.14740/jh140w","doi":"https://doi.org/10.14740/jh140w","is_oa":true,"landing_page_url":"https://doi.org/10.14740/jh140w","pdf_url":"https://www.thejh.org/index.php/jh/article/download/140/116","source":{"id":"https://openalex.org/S4210202061","display_name":"Journal of Hematology","issn_l":"1927-1212","issn":["1927-1212","1927-1220"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4328135221","host_organization_name":"Elmer Press Inc.","host_organization_lineage":["https://openalex.org/P4328135221"],"host_organization_lineage_names":["Elmer Press Inc."],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9598000049591064}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320328177","display_name":"Kementerian Kesihatan Malaysia","ror":"https://ror.org/05ddxe180"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3142226166.pdf","grobid_xml":"https://content.openalex.org/works/W3142226166.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W187237976","https://openalex.org/W191574092","https://openalex.org/W200461798","https://openalex.org/W1482882106","https://openalex.org/W1483687177","https://openalex.org/W1506183674","https://openalex.org/W1506630651","https://openalex.org/W1900681261","https://openalex.org/W1916214535","https://openalex.org/W1971019321","https://openalex.org/W1976021347","https://openalex.org/W1976135633","https://openalex.org/W1980115344","https://openalex.org/W1990493664","https://openalex.org/W1994880679","https://openalex.org/W1997603717","https://openalex.org/W2002941125","https://openalex.org/W2004426203","https://openalex.org/W2023773505","https://openalex.org/W2049461277","https://openalex.org/W2051440417","https://openalex.org/W2061185078","https://openalex.org/W2067354565","https://openalex.org/W2077089071","https://openalex.org/W2085848567","https://openalex.org/W2101129521","https://openalex.org/W2107621463","https://openalex.org/W2111507070","https://openalex.org/W2115111607","https://openalex.org/W2130880972","https://openalex.org/W2137083371","https://openalex.org/W2165055731","https://openalex.org/W2167624541","https://openalex.org/W2168656234","https://openalex.org/W2312531325","https://openalex.org/W7036961695"],"related_works":["https://openalex.org/W2597912211","https://openalex.org/W1662848829","https://openalex.org/W2411446618","https://openalex.org/W2580819343","https://openalex.org/W2074581933","https://openalex.org/W2062661073","https://openalex.org/W2905245339","https://openalex.org/W2563359267","https://openalex.org/W2341757872","https://openalex.org/W2554491655"],"abstract_inverted_index":{"Background:":[0],"Chromosomal":[1],"alterations":[2,19,44,157],"occur":[3],"frequently":[4,155],"in":[5,45,158,187],"acute":[6],"lymphoblastic":[7],"leukemia":[8],"(ALL),":[9],"affecting":[10],"either":[11],"the":[12,112,115,153],"chromosome":[13,96,145,150,197],"number":[14,77],"or":[15],"structural":[16],"changes.":[17],"These":[18,161,180],"can":[20],"lead":[21],"to":[22,38,185],"inactivation":[23],"of":[24,30,34,60,80,144,149],"tumor":[25],"suppressor":[26],"genes":[27,165,182],"and/or":[28,41],"activation":[29],"oncogenes.":[31],"The":[32,90,190],"objective":[33],"this":[35,159],"study":[36],"was":[37],"identify":[39],"recurrent":[40],"novel":[42],"chromosomal":[43,162],"adult":[46,61,188],"ALL":[47,62],"using":[48,68],"single":[49],"nucleotide":[50],"polymorphism":[51],"(SNP)":[52],"array":[53],"analysis.":[54],"Methods:":[55],"We":[56],"studied":[57],"41":[58],"cases":[59],"compared":[63],"with":[64],"healthy":[65],"normal":[66],"controls":[67],"SNP":[69],"array.":[70],"Results:":[71],"Our":[72],"analysis":[73],"revealed":[74],"43":[75],"copy":[76],"variant":[78],"regions,":[79],"which":[81],"44%":[82],"were":[83,87,94,119,152],"amplifications":[84,93],"and":[85,108,139,147,177,192],"56%":[86],"deletions":[88,118],".":[89,179],"most":[91,116,154],"common":[92,117],"on":[95,121],"regions":[97,163],"8p23.1":[98,146],"(71%),":[99],"1q44":[100],"(66%),":[101],"1q23.3":[102],"(54%),":[103,105,136],"11q23.3":[104],"12p13.33":[106],"(54%)":[107],"8q24.21":[109],"(51%).":[110,141],"On":[111],"other":[113],"hand,":[114],"identified":[120],"chromosomes":[122],"1p31.1":[123,151],"(76%),":[124],"3q26.1":[125],"(68%),":[126],"11p11.12":[127],"(63%),":[128],"4q12":[129],"(59%),":[130,132],"19p13.2":[131],"7q11.21":[133,137],"(56%),":[134],"Xp22.33":[135],"(51%)":[138],"19p13.11":[140],"Conclusions:":[142],"Amplification":[143],"deletion":[148],"found":[156],"study.":[160],"contain":[164],"such":[166],"as":[167],"SPAG11B":[168],",":[169,171,173,175],"DEFB104A":[170],"DEFB105A":[172],"DEFB107A":[174],"DEFB106A":[176],"SPAG11A":[178],"potential":[181],"may":[183],"contribute":[184],"leukemogenesis":[186],"ALL.":[189],"cytogenetic":[191],"molecular":[193],"mechanisms":[194],"underlying":[195],"these":[196],"changes":[198],"deserve":[199],"further":[200],"investigations.":[201],"J":[202],"Hematol.":[203],"2014;3(3):65-71":[204],"doi:":[205],"http://dx.doi.org/10.14740/jh140w":[206]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2021-04-13T00:00:00"}