{"id":"https://openalex.org/W3142210554","doi":"https://doi.org/10.1530/erc-20-0435","title":"Molecular alterations in H\u00fcrthle cell nodules and preoperative cancer risk","display_name":"Molecular alterations in H\u00fcrthle cell nodules and preoperative cancer risk","publication_year":2021,"publication_date":"2021-04-01","ids":{"openalex":"https://openalex.org/W3142210554","doi":"https://doi.org/10.1530/erc-20-0435","mag":"3142210554","pmid":"https://pubmed.ncbi.nlm.nih.gov/33792557"},"language":"en","primary_location":{"id":"doi:10.1530/erc-20-0435","doi":"https://doi.org/10.1530/erc-20-0435","is_oa":false,"landing_page_url":"https://doi.org/10.1530/erc-20-0435","pdf_url":null,"source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036258478","display_name":"William R Doerfler","orcid":"https://orcid.org/0000-0003-2439-6786","observed_orcids":["https://orcid.org/0000-0003-2439-6786"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R Doerfler","raw_affiliation_strings":["1Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055025342","display_name":"Alyaksandr V. Nikitski","orcid":"https://orcid.org/0000-0001-6486-667X","observed_orcids":["https://orcid.org/0000-0001-6486-667X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alyaksandr V Nikitski","raw_affiliation_strings":["2Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037107538","display_name":"Elena M. Morariu","orcid":"https://orcid.org/0000-0002-8753-5280","observed_orcids":["https://orcid.org/0000-0002-8753-5280"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena M Morariu","raw_affiliation_strings":["1Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010884267","display_name":"N. Paul Ohori","orcid":"https://orcid.org/0000-0002-3280-0534","observed_orcids":["https://orcid.org/0000-0002-3280-0534"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Paul Ohori","raw_affiliation_strings":["2Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073112024","display_name":"Simion I. Chiosea","orcid":"https://orcid.org/0000-0002-5766-8779","observed_orcids":["https://orcid.org/0000-0002-5766-8779"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simion I Chiosea","raw_affiliation_strings":["2Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael S Landau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S Landau","raw_affiliation_strings":["2Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036048186","display_name":"Marina N. Nikiforova","orcid":"https://orcid.org/0000-0001-9976-9378","observed_orcids":["https://orcid.org/0000-0001-9976-9378"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina N Nikiforova","raw_affiliation_strings":["2Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020353829","display_name":"Yuri E. Nikiforov","orcid":"https://orcid.org/0000-0002-2239-1095","observed_orcids":["https://orcid.org/0000-0002-2239-1095"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuri E Nikiforov","raw_affiliation_strings":["2Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology, University of Pittsburgh, Pittsburgh, Pennysylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058901105","display_name":"Linwah Yip","orcid":"https://orcid.org/0000-0002-2449-3685","observed_orcids":["https://orcid.org/0000-0002-2449-3685"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linwah Yip","raw_affiliation_strings":["3Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, Pennysylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, Pennysylvania, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038649407","display_name":"Pooja Manroa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pooja Manroa","raw_affiliation_strings":["1Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA","4Division of Endocrinology, University of Texas Medical Branch, Galveston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, Pennysylvania, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"4Division of Endocrinology, University of Texas Medical Branch, Galveston, Texas, USA","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.9863,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.9750642,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"28","issue":"5","first_page":"301","last_page":"309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12631","display_name":"Head and Neck Anomalies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hurthle-cell-carcinoma","display_name":"H\u00fcrthle cell carcinoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hurthle-cell-adenoma","display_name":"Hurthle cell adenoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dna-copy-number-alterations","display_name":"DNA copy number alterations","score":0.9319999814033508},{"id":"https://openalex.org/keywords/tert-mutation","display_name":"TERT mutation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/thyroseq-v3","display_name":"ThyroSeq v3","score":0.8889999985694885},{"id":"https://openalex.org/keywords/fine-needle-aspiration","display_name":"fine-needle aspiration","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nodule-size","display_name":"nodule size","score":0.9769999980926514}],"concepts":[{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6230626702308655},{"id":"https://openalex.org/C2776731575","wikidata":"https://www.wikidata.org/wiki/Q2916245","display_name":"Nodule (geology)","level":2,"score":0.6135974526405334},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5980031490325928},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5858202576637268},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5366095900535583},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5209056735038757},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.4487537145614624},{"id":"https://openalex.org/C2779022025","wikidata":"https://www.wikidata.org/wiki/Q53829","display_name":"Thyroid nodules","level":3,"score":0.41979336738586426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37172824144363403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25158482789993286},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D016606","descriptor_name":"Thyroid Nodule","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016606","descriptor_name":"Thyroid Nodule","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016606","descriptor_name":"Thyroid Nodule","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D018249","descriptor_name":"Adenoma, Oxyphilic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024862","descriptor_name":"Oxyphil Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024862","descriptor_name":"Oxyphil Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D044963","descriptor_name":"Biopsy, Fine-Needle","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1530/erc-20-0435","doi":"https://doi.org/10.1530/erc-20-0435","is_oa":false,"landing_page_url":"https://doi.org/10.1530/erc-20-0435","pdf_url":null,"source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},{"id":"pmid:33792557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33792557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-related cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1953215899","https://openalex.org/W2010114289","https://openalex.org/W2027313318","https://openalex.org/W2031820449","https://openalex.org/W2127581464","https://openalex.org/W2146970646","https://openalex.org/W2296729886","https://openalex.org/W2552226163","https://openalex.org/W2603963723","https://openalex.org/W2766712571","https://openalex.org/W2804198114","https://openalex.org/W2904207453","https://openalex.org/W2922023474","https://openalex.org/W2965861570","https://openalex.org/W2967501594","https://openalex.org/W3042773898"],"related_works":["https://openalex.org/W3021136425","https://openalex.org/W4385514944","https://openalex.org/W4220892518","https://openalex.org/W3092211304","https://openalex.org/W2053238849","https://openalex.org/W2884633350","https://openalex.org/W2899362816","https://openalex.org/W2161814467","https://openalex.org/W2031820449","https://openalex.org/W2914572023"],"abstract_inverted_index":{"H\u00fcrthle":[0,32,37],"cell":[1,33,38],"carcinoma":[2],"(HCC)":[3],"is":[4,242],"a":[5],"distinct":[6],"type":[7,23],"of":[8,20,100,105,144,183,202,209,221,232],"thyroid":[9,248],"cancer":[10,83,166,222],"genetically":[11],"characterized":[12],"by":[13,190],"DNA":[14],"copy":[15],"number":[16],"alterations":[17],"(CNA),":[18],"typically":[19],"genome":[21],"haploidization":[22],"(GH-type).":[24],"However,":[25],"whether":[26],"CNA":[27,69,90,123,207,226],"also":[28,211],"occurs":[29],"in":[30,46,85,103,108,113,134,213,223,234,244,247],"benign":[31],"adenomas":[34],"(HCA)":[35],"or":[36,146],"hyperplastic":[39],"nodules":[40,224],"(HCHN),":[41],"and":[42,64,70,80,91,107,124,158,168,219,239],"have":[43],"diagnostic":[44],"impact":[45],"fine-needle":[47],"aspiration":[48],"(FNA)":[49],"samples,":[50],"remains":[51],"unknown.":[52],"To":[53],"address":[54],"these":[55],"questions,":[56],"we":[57],"(1)":[58],"analyzed":[59],"26":[60],"HCC,":[61,137],"24":[62,135],"HCA,":[63,110,214],"8":[65],"HCHN":[66],"tissues":[67],"for":[68],"other":[71,237],"mutations":[72,238],"using":[73],"ThyroSeq":[74],"v3":[75],"(TSv3)":[76],"next-generation":[77],"sequencing":[78],"panel,":[79],"(2)":[81],"determined":[82],"rate":[84,167],"111":[86,149],"FNA":[87,150],"samples":[88],"with":[89,118,140,152,176,216,225,228,236],"known":[92],"surgical":[93],"outcome.":[94],"We":[95],"identified":[96],"CNA,":[97,153,178,233],"more":[98],"often":[99],"the":[101,187,200],"GH-type,":[102],"81%":[104],"HCC":[106,117,210],"38%":[109],"but":[111],"not":[112],"HCHN.":[114],"Among":[115,148],"four":[116],"distant":[119],"metastasis,":[120],"all":[121,139],"had":[122],"three":[125],"TERT":[126],"mutations.":[127],"Overall,":[128],"positive":[129],"TSv3":[130],"results":[131,201],"were":[132,156],"obtained":[133],"(92%)":[136],"including":[138],"ATA":[141],"high":[142],"risk":[143],"recurrence":[145],"metastasis.":[147],"cases":[151,175],"38":[154],"(34%)":[155],"malignant":[157],"73":[159],"(66%)":[160],"benign.":[161],"A":[162],"significant":[163],"correlation":[164],"between":[165],"nodule":[169,184,229,240],"size":[170,185],"was":[171],"observed,":[172],"particularly":[173],"among":[174],"GH-type":[177],"where":[179],"every":[180],"additional":[181],"centimeter":[182],"increased":[186],"malignancy":[188,246],"odds":[189],"1.9":[191],"(95%":[192],"CI":[193],"1.3-2.7;":[194],"P":[195],"=":[196],"0.001).":[197],"In":[198],"summary,":[199],"this":[203],"study":[204],"demonstrate":[205],"that":[206],"characteristic":[208],"occur":[212],"although":[215],"lower":[217],"frequency,":[218],"probability":[220],"increases":[227],"size.":[230],"Detection":[231],"conjunction":[235],"size,":[241],"helpful":[243],"predicting":[245],"nodules.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-04-13T00:00:00"}
