{"id":"https://openalex.org/W3141497538","doi":null,"title":"Gene Therapy for Parkinson's Disease","display_name":"Gene Therapy for Parkinson's Disease","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W3141497538","mag":"3141497538"},"language":"en","primary_location":{"id":"pmh:oai:commons.pacificu.edu:pa-1298","doi":null,"is_oa":false,"landing_page_url":"https://commons.pacificu.edu/pa/280","pdf_url":null,"source":{"id":"https://openalex.org/S4377196976","display_name":"CommonKnowledge Research Repository (Pacific University Oregon)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108541056","host_organization_name":"Pacific University Oregon","host_organization_lineage":["https://openalex.org/I108541056"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"School of Physician Assistant Studies","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kari Andersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149261","display_name":"Pacific University","ror":"https://ror.org/059z5w858","country_code":"US","type":"education","lineage":["https://openalex.org/I4210149261"]},{"id":"https://openalex.org/I4400573277","display_name":"Pacific University","ror":"https://ror.org/05p9z4t69","country_code":"IN","type":"education","lineage":["https://openalex.org/I4400573277"]}],"countries":["IN","US"],"is_corresponding":true,"raw_author_name":"Kari Andersen","raw_affiliation_strings":["Pacific University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific University","institution_ids":["https://openalex.org/I4210149261","https://openalex.org/I4400573277"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210149261","https://openalex.org/I4400573277"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.45559999346733093,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.45559999346733093,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.42969998717308044,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.06870000064373016,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9779999852180481},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":1.0},{"id":"https://openalex.org/keywords/adeno-associated-virus-2","display_name":"adeno-associated virus type 2","score":0.8420000076293945},{"id":"https://openalex.org/keywords/neurturin","display_name":"neurturin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/glutamic-acid-decarboxylase","display_name":"glutamic acid decarboxylase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/subthalamic-nucleus","display_name":"subthalamic nucleus","score":0.8009999990463257},{"id":"https://openalex.org/keywords/putamen","display_name":"putamen","score":0.8539999723434448},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.8619999885559082},{"id":"https://openalex.org/keywords/dopamine-replacement-therapy","display_name":"dopamine replacement therapy","score":0.8579999804496765},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7300000190734863},{"id":"https://openalex.org/keywords/sham-surgery","display_name":"sham surgery","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5609533786773682},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5578107237815857},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.5074772238731384},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4629477262496948},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.46186619997024536},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.44353312253952026},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.42421072721481323},{"id":"https://openalex.org/C2777603835","wikidata":"https://www.wikidata.org/wiki/Q22679857","display_name":"Neurturin","level":5,"score":0.4210549592971802},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.38337188959121704},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3676207661628723},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2817055583000183},{"id":"https://openalex.org/C185856081","wikidata":"https://www.wikidata.org/wiki/Q14916286","display_name":"Glial cell line-derived neurotrophic factor","level":4,"score":0.27317219972610474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24514341354370117},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.18131065368652344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1142631471157074},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08356282114982605},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:commons.pacificu.edu:pa-1298","doi":null,"is_oa":false,"landing_page_url":"https://commons.pacificu.edu/pa/280","pdf_url":null,"source":{"id":"https://openalex.org/S4377196976","display_name":"CommonKnowledge Research Repository (Pacific University Oregon)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108541056","host_organization_name":"Pacific University Oregon","host_organization_lineage":["https://openalex.org/I108541056"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"School of Physician Assistant Studies","raw_type":"text"},{"id":"mag:3141497538","doi":null,"is_oa":false,"landing_page_url":"https://commons.pacificu.edu/pa/280/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W15418036","https://openalex.org/W1966343782","https://openalex.org/W1970914521","https://openalex.org/W1971258758","https://openalex.org/W1972747973","https://openalex.org/W1977314903","https://openalex.org/W1982014300","https://openalex.org/W1989720524","https://openalex.org/W1991208841","https://openalex.org/W1993408885","https://openalex.org/W1999694937","https://openalex.org/W2000355331","https://openalex.org/W2005029096","https://openalex.org/W2009681413","https://openalex.org/W2014850190","https://openalex.org/W2017568864","https://openalex.org/W2025522522","https://openalex.org/W2031740174","https://openalex.org/W2039583977","https://openalex.org/W2040934666","https://openalex.org/W2047000182","https://openalex.org/W2054810445","https://openalex.org/W2055459938","https://openalex.org/W2064996887","https://openalex.org/W2070415473","https://openalex.org/W2082859312","https://openalex.org/W2084380893","https://openalex.org/W2087262420","https://openalex.org/W2089925020","https://openalex.org/W2106900546","https://openalex.org/W2108724455","https://openalex.org/W2111837903","https://openalex.org/W2117065100","https://openalex.org/W2122085123","https://openalex.org/W2135907949","https://openalex.org/W2145954079","https://openalex.org/W2149476088","https://openalex.org/W2149522871","https://openalex.org/W2149731696","https://openalex.org/W2152657141","https://openalex.org/W2154352878","https://openalex.org/W2155284188","https://openalex.org/W2156733045","https://openalex.org/W2161558564","https://openalex.org/W2161634584","https://openalex.org/W2395092221","https://openalex.org/W2972597017"],"related_works":["https://openalex.org/W1993782286","https://openalex.org/W4399019293","https://openalex.org/W7213562395","https://openalex.org/W4415719656","https://openalex.org/W7082497952","https://openalex.org/W2089925020","https://openalex.org/W4323312729","https://openalex.org/W4415945685","https://openalex.org/W4415600703","https://openalex.org/W4412596355"],"abstract_inverted_index":{"Background:":[0],"Parkinson\u2019s":[1,112,225],"disease":[2,73,113,226],"(PD)":[3],"is":[4],"a":[5,84,218],"neurodegenerative":[6],"disorder":[7],"of":[8,15,38,45,59,99,234],"unknown":[9],"cause.":[10],"The":[11,126],"characteristic":[12],"motor":[13,60],"impairments":[14],"PD":[16],"including":[17],"resting":[18],"tremor,":[19],"rigidity,":[20],"slowed":[21],"movement,":[22],"decreased":[23],"dexterity,":[24],"small":[25],"handwriting,":[26],"flexed":[27],"posture,":[28],"gait":[29],"disorder,":[30],"and":[31,70,103,111,116,136,150,165,232],"imbalance":[32],"predominantly":[33],"arise":[34],"from":[35],"the":[36,41,46,50,106,131,148,155,181,199,228],"loss":[37],"neurons":[39],"in":[40,95,114,154,180,198,227],"substantia":[42],"nigra":[43],"region":[44],"midbrain":[47],"that":[48],"produce":[49],"neurotransmitter":[51],"dopamine.":[52],"Dopamine":[53],"replacement":[54],"therapy":[55,82,110,213,236],"provides":[56],"temporary":[57],"relief":[58],"symptoms,":[61],"but":[62],"chronic":[63],"use":[64],"leads":[65],"to":[66,123,130,186,204,216],"serious":[67],"side":[68],"effects":[69],"cannot":[71],"prevent":[72],"progression.":[74],"This":[75,208],"systematic":[76,209],"review":[77,210],"will":[78],"focus":[79],"upon":[80],"gene":[81,109,212,235],"as":[83,118,120],"possible":[85],"treatment":[86,219],"for":[87,169,221],"PD.\\nMethods:":[88],"An":[89],"exhaustive":[90],"literature":[91],"search":[92,107,127],"was":[93,128,183,202],"conducted":[94],"Medline,":[96],"CINAHL,":[97],"Web":[98],"Science,":[100],"Google":[101],"Scholar,":[102],"EBMRmultifile,":[104],"using":[105],"terms":[108,121],"combination":[115],"alone":[117],"well":[119],"known":[122],"be":[124,217],"synonymous.":[125],"limited":[129],"English":[132],"language,":[133],"clinical":[134],"trials":[135,164],"double-blind,":[137,161],"randomized,":[138,162],"controlled":[139,163],"trials.":[140],"\\nResults:":[141],"Two":[142],"studies":[143,159],"were":[144,160],"reviewed":[145],"based":[146],"on":[147],"inclusion":[149],"exclusion":[151],"criteria":[152],"delineated":[153],"methods":[156],"section.":[157],"Both":[158],"utilized":[166],"sham":[167,187,205],"surgery":[168],"comparison.":[170],"Marks":[171],"et":[172,190],"al":[173,191],"showed":[174,192],"adeno-associated":[175],"type-2":[176],"vector":[177],"(AAV2)-neurturin":[178],"delivery":[179,197],"putamen":[182],"not":[184],"superior":[185,203],"surgery.":[188,206],"LeWitt":[189],"AAV2-glutamic":[193],"acid":[194],"decarboxylase":[195],"(GAD)":[196],"subthalamic":[200],"nucleus":[201],"\\nConclusion:":[207],"shows":[211],"may":[214],"prove":[215],"option":[220],"patients":[222],"with":[223],"advanced":[224],"future.":[229],"More":[230],"research":[231],"development":[233],"are":[237],"needed.":[238]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-04-13T00:00:00"}
