{"id":"https://openalex.org/W3141480656","doi":"https://doi.org/10.1111/febs.15836","title":"Inhibition of the DNA damage response to activate immune responses toward tumors","display_name":"Inhibition of the DNA damage response to activate immune responses toward tumors","publication_year":2021,"publication_date":"2021-04-02","ids":{"openalex":"https://openalex.org/W3141480656","doi":"https://doi.org/10.1111/febs.15836","mag":"3141480656","pmid":"https://pubmed.ncbi.nlm.nih.gov/33811455"},"language":"en","primary_location":{"id":"doi:10.1111/febs.15836","doi":"https://doi.org/10.1111/febs.15836","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.15836","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.15836","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.15836","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086761700","display_name":"Sheetal Sharma","orcid":"https://orcid.org/0000-0003-1818-7355","observed_orcids":["https://orcid.org/0000-0003-1818-7355"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sheetal Sharma","raw_affiliation_strings":["Department of Experimental Medicine and Biotechnology Post\u2010graduate Institute of Medical Research & Education Chandigarh India"],"raw_orcid":"https://orcid.org/0000-0003-1818-7355","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biotechnology Post\u2010graduate Institute of Medical Research & Education Chandigarh India","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011566232","display_name":"Mrinal Srivastava","orcid":"https://orcid.org/0000-0002-5539-265X","observed_orcids":["https://orcid.org/0000-0002-5539-265X"]},"institutions":[{"id":"https://openalex.org/I11947397","display_name":"Tata Institute of Fundamental Research","ror":"https://ror.org/03ht1xw27","country_code":"IN","type":"education","lineage":["https://openalex.org/I11947397","https://openalex.org/I2799351866","https://openalex.org/I3149292468"]},{"id":"https://openalex.org/I4210112849","display_name":"TIFR Centre for Interdisciplinary Sciences","ror":"https://ror.org/01dagn361","country_code":"IN","type":"facility","lineage":["https://openalex.org/I11947397","https://openalex.org/I2799351866","https://openalex.org/I3149292468","https://openalex.org/I4210112849"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Mrinal Srivastava","raw_affiliation_strings":["TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research (TIFR) Hyderabad, India"],"raw_orcid":"https://orcid.org/0000-0002-5539-265X","affiliations":[{"raw_affiliation_string":"TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research (TIFR) Hyderabad, India","institution_ids":["https://openalex.org/I11947397","https://openalex.org/I4210112849"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011566232","https://openalex.org/A5086761700"],"corresponding_institution_ids":["https://openalex.org/I11947397","https://openalex.org/I4210112849","https://openalex.org/I45294948"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"288","issue":"15","first_page":"4503","last_page":"4506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.10080000013113022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.09059999883174896,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9340000152587891},{"id":"https://openalex.org/keywords/ddr-inhibitors","display_name":"DDR inhibitors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.7049999833106995},{"id":"https://openalex.org/keywords/dna-damaging-agents","display_name":"DNA-damaging agents","score":0.7490000128746033},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.9259999990463257},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.729577362537384},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7048831582069397},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.561237096786499},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46152961254119873},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3781800866127014},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37795719504356384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34281277656555176},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22093775868415833}],"mesh":[{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/febs.15836","doi":"https://doi.org/10.1111/febs.15836","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.15836","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.15836","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:33811455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33811455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/febs.15836","doi":"https://doi.org/10.1111/febs.15836","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.15836","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.15836","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3141480656.pdf","grobid_xml":"https://content.openalex.org/works/W3141480656.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1969824361","https://openalex.org/W2083147016","https://openalex.org/W2084188360","https://openalex.org/W2116054786","https://openalex.org/W2119864130","https://openalex.org/W2135660738","https://openalex.org/W2594870910","https://openalex.org/W2625452721","https://openalex.org/W2733154631","https://openalex.org/W2738136165","https://openalex.org/W2751370630","https://openalex.org/W2795875233","https://openalex.org/W2977255036","https://openalex.org/W3126592381","https://openalex.org/W3130960912","https://openalex.org/W4254055122"],"related_works":["https://openalex.org/W3007587622","https://openalex.org/W4416949542","https://openalex.org/W6887896603","https://openalex.org/W4205380847","https://openalex.org/W4362464930","https://openalex.org/W1648266957","https://openalex.org/W3034952448","https://openalex.org/W7171504668","https://openalex.org/W3170416681","https://openalex.org/W7214129059"],"abstract_inverted_index":{"Cancer":[0],"immunotherapy":[1],"represents":[2],"a":[3,37,49],"very":[4],"encouraging":[5],"mode":[6],"of":[7,26,72],"treatment":[8],"for":[9,69],"cancer":[10],"where":[11],"one's":[12],"immune":[13,43,57],"system":[14],"is":[15],"utilized":[16],"to":[17,39],"eliminate":[18],"tumor":[19],"cells.":[20],"Wayne":[21],"et":[22],"al.":[23],"explore":[24],"inhibition":[25],"DNA":[27],"damage":[28],"response":[29,58],"(DDR)":[30],"pathways":[31],"with":[32,42],"small":[33],"molecule":[34],"inhibitors":[35,61],"as":[36],"means":[38],"prime":[40],"cells":[41],"response.":[44],"These":[45],"findings":[46],"suggest":[47],"that":[48],"one-size-fits-all":[50],"approach":[51],"cannot":[52],"be":[53],"used":[54],"when":[55],"harnessing":[56],"via":[59],"DDR":[60],"and":[62],"genotoxic":[63],"agents,":[64],"which":[65],"are":[66],"required":[67],"ultimately":[68],"the":[70],"success":[71],"immunotherapy.":[73],"Comment":[74],"on:":[75],"https://doi.org/10.1111/febs.15747.":[76]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-04-13T00:00:00"}