{"id":"https://openalex.org/W3141193558","doi":"https://doi.org/10.1177/09603271211002886","title":"Therapeutic effects of myocardin-related transcription factor A (MRTF-A) knockout on experimental mice with nonalcoholic steatohepatitis induced by high-fat diet","display_name":"Therapeutic effects of myocardin-related transcription factor A (MRTF-A) knockout on experimental mice with nonalcoholic steatohepatitis induced by high-fat diet","publication_year":2021,"publication_date":"2021-03-29","ids":{"openalex":"https://openalex.org/W3141193558","doi":"https://doi.org/10.1177/09603271211002886","mag":"3141193558","pmid":"https://pubmed.ncbi.nlm.nih.gov/33779332"},"language":"en","primary_location":{"id":"doi:10.1177/09603271211002886","doi":"https://doi.org/10.1177/09603271211002886","is_oa":false,"landing_page_url":"https://doi.org/10.1177/09603271211002886","pdf_url":null,"source":{"id":"https://openalex.org/S147701277","display_name":"Human & Experimental Toxicology","issn_l":"0960-3271","issn":["0960-3271","1477-0903"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human & Experimental Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100780610","display_name":"Lei Zhang","orcid":"https://orcid.org/0000-0002-3918-9926","observed_orcids":["https://orcid.org/0000-0002-3918-9926"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zhang","raw_affiliation_strings":["Department of Infectious Diseases, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China"],"raw_orcid":"https://orcid.org/0000-0002-3918-9926","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hua-Long Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua-Long Li","raw_affiliation_strings":["Department of Infectious Diseases, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036344178","display_name":"Dingding Zhang","orcid":"https://orcid.org/0000-0002-5234-752X","observed_orcids":["https://orcid.org/0000-0002-5234-752X"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ding-Ding Zhang","raw_affiliation_strings":["Department of Infectious Diseases, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004197910","display_name":"Xiao-Chun Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao-Chun Cui","raw_affiliation_strings":["Bone and Joint Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone and Joint Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China","institution_ids":["https://openalex.org/I134841294"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004197910"],"corresponding_institution_ids":["https://openalex.org/I134841294"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.7043,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.65286713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"40","issue":"10","first_page":"1634","last_page":"1645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrtf-a","display_name":"MRTF-A","score":0.9539999961853027},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":1.0},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9539999961853027},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/liver-macrophages","display_name":"hepatic macrophages","score":0.8270000219345093},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.7429999709129333},{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.925000011920929},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/ccr2","display_name":"CCR2","score":0.6520000100135803},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.890999972820282},{"id":"https://openalex.org/keywords/tgf-beta1-smad3-signaling-pathway","display_name":"TGF-\u03b21/Smad3 signaling","score":0.8450000286102295},{"id":"https://openalex.org/keywords/col1a2","display_name":"COL1A2","score":0.6809999942779541},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.6940000057220459},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6785795092582703},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6435253620147705},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.6104919910430908},{"id":"https://openalex.org/C2779770810","wikidata":"https://www.wikidata.org/wiki/Q23069155","display_name":"Sirius Red","level":3,"score":0.5632193684577942},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5511019229888916},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.5004923343658447},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.49333515763282776},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.47385600209236145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4534008204936981},{"id":"https://openalex.org/C2776460901","wikidata":"https://www.wikidata.org/wiki/Q21109693","display_name":"CD68","level":3,"score":0.4154006242752075},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.41448867321014404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32397595047950745},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3227333426475525},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21776559948921204},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08065882325172424},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07462504506111145},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/09603271211002886","doi":"https://doi.org/10.1177/09603271211002886","is_oa":false,"landing_page_url":"https://doi.org/10.1177/09603271211002886","pdf_url":null,"source":{"id":"https://openalex.org/S147701277","display_name":"Human & Experimental Toxicology","issn_l":"0960-3271","issn":["0960-3271","1477-0903"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human & Experimental Toxicology","raw_type":"journal-article"},{"id":"pmid:33779332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33779332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human & experimental toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W2032727505","https://openalex.org/W2040160735","https://openalex.org/W2088433407","https://openalex.org/W2096243841","https://openalex.org/W2103996457","https://openalex.org/W2106549878","https://openalex.org/W2113262559","https://openalex.org/W2126489810","https://openalex.org/W2132705463","https://openalex.org/W2139602514","https://openalex.org/W2146434832","https://openalex.org/W2146692092","https://openalex.org/W2152363670","https://openalex.org/W2615304118","https://openalex.org/W2768610925","https://openalex.org/W2802217048","https://openalex.org/W2803755458","https://openalex.org/W2809390483","https://openalex.org/W2901776842","https://openalex.org/W2907318946","https://openalex.org/W2909391947","https://openalex.org/W2945335310","https://openalex.org/W2976107635","https://openalex.org/W2981766010","https://openalex.org/W2993542255","https://openalex.org/W3000385169","https://openalex.org/W3009723993","https://openalex.org/W3012674174","https://openalex.org/W3014006594","https://openalex.org/W3023036454","https://openalex.org/W3023677765","https://openalex.org/W3025559183","https://openalex.org/W3037666066","https://openalex.org/W3042810354","https://openalex.org/W3049282620","https://openalex.org/W3081322823","https://openalex.org/W3082706973","https://openalex.org/W3091295206","https://openalex.org/W3106724836","https://openalex.org/W3110951553","https://openalex.org/W3117332695","https://openalex.org/W3120199583"],"related_works":["https://openalex.org/W3010241471","https://openalex.org/W3112776982","https://openalex.org/W3044298824","https://openalex.org/W2000541661","https://openalex.org/W2065880243","https://openalex.org/W3101939097","https://openalex.org/W4409139545","https://openalex.org/W2995961563","https://openalex.org/W2765446062","https://openalex.org/W2992807639"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"explore":[2],"the":[3,153,182],"effects":[4],"of":[5,142,155,165,186,195,232],"myocardin-related":[6],"transcription":[7],"factor":[8],"A":[9],"(MRTF-A)":[10],"knockout":[11,219],"on":[12],"mice":[13,39,91,127,149,168,208],"with":[14,86,114,120,151,171,198],"nonalcoholic":[15],"steatohepatitis":[16],"(NASH)":[17],"induced":[18],"by":[19,134],"high-fat":[20],"diet":[21,25],"(HFD).":[22],"Methods:":[23],"Normal-fat":[24],"(NFD)":[26],"or":[27],"HFD":[28,89,96,201,206],"was":[29,46],"fed":[30,150],"to":[31],"MRTF-A-knockout":[32],"(MRTF-A":[33],"\u2212/\u2212":[34,94,126,167,204],")":[35],"and":[36,50,61,66,81,109,139,146,159,227,230],"wild-type":[37],"(WT)":[38],"for":[40,243],"16":[41],"weeks.":[42],"Liver":[43],"histopathological":[44],"status":[45],"observed":[47,183],"using":[48],"Hematoxylin":[49],"Eosin":[51],"(HE)":[52],"staining,":[53,57,60],"Oil":[54],"Red":[55,59],"O":[56],"Sirius":[58],"Immunohistochemical":[62],"staining.":[63],"The":[64],"mRNA":[65],"protein":[67],"levels":[68],"in":[69,92,100,130,162,175,214,235],"liver":[70,107,115,163,215,233],"tissues":[71,164,234],"were":[72,98,128,209],"measured":[73],"through":[74],"quantitative":[75],"reverse":[76],"transcription-polymerase":[77],"chain":[78],"reaction":[79],"(qRT-PCR)":[80],"Western":[82],"blot.":[83],"Results:":[84],"Compared":[85,197],"WT":[87,122,172,199],"+":[88,95,200,205],"group,":[90,202],"MRTF-A":[93,125,166,203,218],"group":[97,207],"decreased":[99,135,193,210],"body":[101],"weight,":[102],"blood":[103],"glucose,":[104],"plasma":[105],"insulin,":[106],"TG":[108],"NAFLD":[110],"activity":[111],"score":[112],"(NAS),":[113],"function":[116],"recovery.":[117],"Besides,":[118,174],"compared":[119,170],"HFD-fed":[121,124,180],"mice,":[123,181,236],"improved":[129],"hepatic":[131,176],"fibrosis,":[132],"accompanied":[133],"collagen":[136],"content":[137],"(%)":[138],"down-regulated":[140,223],"expressions":[141],"\u03b1-SMA,":[143],"COL1A2,":[144],"TGF\u03b21,":[145],"SMAD3.":[147],"In":[148],"HFD,":[152],"expression":[154,185,194],"MCP-1,":[156,189],"CCR2,":[157],"F4/80":[158],"CD68":[160],"declined":[161],"as":[169,190,192],"mice.":[173],"macrophages":[177],"isolated":[178],"from":[179],"increased":[184],"TNF-\u03b1,":[187],"IL-1\u03b2,":[188],"well":[191],"CCR2.":[196],"regarding":[211],"NF-\u03baB":[212,224],"p65":[213,225],"tissues.":[216],"Conclusion:":[217],"reduced":[220],"macrophage":[221],"infiltration,":[222],"expression,":[226],"ameliorated":[228],"inflammation":[229],"fibrosis":[231],"thereby":[237],"becoming":[238],"a":[239],"potential":[240],"therapeutic":[241],"target":[242],"NASH":[244],"treatment.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-04-13T00:00:00"}