{"id":"https://openalex.org/W3140623213","doi":"https://doi.org/10.1080/13816810.2021.1904420","title":"Correlation of the intronic LOXL1 polymorphism rs11638944 with pseudoexfoliation syndrome and glaucoma in a Greek population","display_name":"Correlation of the intronic LOXL1 polymorphism rs11638944 with pseudoexfoliation syndrome and glaucoma in a Greek population","publication_year":2021,"publication_date":"2021-04-01","ids":{"openalex":"https://openalex.org/W3140623213","doi":"https://doi.org/10.1080/13816810.2021.1904420","mag":"3140623213","pmid":"https://pubmed.ncbi.nlm.nih.gov/33792495"},"language":"en","primary_location":{"id":"doi:10.1080/13816810.2021.1904420","doi":"https://doi.org/10.1080/13816810.2021.1904420","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13816810.2021.1904420","pdf_url":null,"source":{"id":"https://openalex.org/S12713009","display_name":"Ophthalmic Genetics","issn_l":"1381-6810","issn":["1381-6810","1744-5094"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmic Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088778140","display_name":"Maria-Kyriaki Papadopoulou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Maria-Kyriaki Papadopoulou","raw_affiliation_strings":["Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens","Department of Clinical Biochemistry and Molecular Diagnostics, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Department of Clinical Biochemistry and Molecular Diagnostics, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020123731","display_name":"Irini Chatziralli","orcid":"https://orcid.org/0000-0001-8523-1024","observed_orcids":["https://orcid.org/0000-0001-8523-1024"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Irini Chatziralli","raw_affiliation_strings":["Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens","2nd Department of Ophthalmology, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"2nd Department of Ophthalmology, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089070652","display_name":"Konstantina Tzika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantina Tzika","raw_affiliation_strings":["Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens","Department of Clinical Biochemistry and Molecular Diagnostics, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Department of Clinical Biochemistry and Molecular Diagnostics, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088201067","display_name":"Dimitrios Chiras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141877","display_name":"University Hospital of Ioannina","ror":"https://ror.org/03zww1h73","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141877"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Chiras","raw_affiliation_strings":["University Hospital of Ioannina","Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital of Ioannina","institution_ids":["https://openalex.org/I4210141877"]},{"raw_affiliation_string":"Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I4210141877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038851855","display_name":"George Kitsos","orcid":"https://orcid.org/0000-0001-8041-5190","observed_orcids":["https://orcid.org/0000-0001-8041-5190"]},"institutions":[{"id":"https://openalex.org/I4210141877","display_name":"University Hospital of Ioannina","ror":"https://ror.org/03zww1h73","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141877"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"George Kitsos","raw_affiliation_strings":["University Hospital of Ioannina","Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital of Ioannina","institution_ids":["https://openalex.org/I4210141877"]},{"raw_affiliation_string":"Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I4210141877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031768538","display_name":"Christos \u039aroupis","orcid":"https://orcid.org/0000-0002-5876-2599","observed_orcids":["https://orcid.org/0000-0002-5876-2599","https://orcid.org/0000-0002-5162-1304"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Christos Kroupis","raw_affiliation_strings":["Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens","Department of Clinical Biochemistry and Molecular Diagnostics, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Department of Clinical Biochemistry and Molecular Diagnostics, Attikon General University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020123731"],"corresponding_institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"],"apc_list":null,"apc_paid":null,"fwci":0.2121,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.425575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"42","issue":"4","first_page":"405","last_page":"411"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/loxl1","display_name":"LOXL1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/intronic-polymorphism","display_name":"intronic polymorphism","score":0.8849999904632568},{"id":"https://openalex.org/keywords/pseudoexfoliation-syndrome","display_name":"pseudoexfoliation syndrome","score":0.984000027179718},{"id":"https://openalex.org/keywords/pseudoexfoliation-glaucoma","display_name":"pseudoexfoliation glaucoma","score":1.0},{"id":"https://openalex.org/keywords/primary-open-angle-glaucoma","display_name":"primary open-angle glaucoma","score":0.8889999985694885},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.6510000228881836},{"id":"https://openalex.org/keywords/genotyping-methods","display_name":"genotyping methods","score":0.5410000085830688},{"id":"https://openalex.org/keywords/pcr-rflp","display_name":"PCR-RFLP","score":0.7739999890327454},{"id":"https://openalex.org/keywords/protective-alleles","display_name":"protective alleles","score":0.7950000166893005},{"id":"https://openalex.org/keywords/greek-population","display_name":"Greek population","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.8086609840393066},{"id":"https://openalex.org/C2779541357","wikidata":"https://www.wikidata.org/wiki/Q3824795","display_name":"Pseudoexfoliation syndrome","level":3,"score":0.6907442808151245},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.648444414138794},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5904487371444702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5833155512809753},{"id":"https://openalex.org/C84133368","wikidata":"https://www.wikidata.org/wiki/Q6813768","display_name":"Melting curve analysis","level":4,"score":0.5551031827926636},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5157694816589355},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.49607476592063904},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.47892531752586365},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4732787311077118},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4680559039115906},{"id":"https://openalex.org/C168007829","wikidata":"https://www.wikidata.org/wiki/Q857299","display_name":"Restriction fragment length polymorphism","level":4,"score":0.4187338352203369},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.2935577630996704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19129076600074768},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1259484887123108},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072776","descriptor_name":"Slit Lamp Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000594","descriptor_name":"Amino Acid Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006115","descriptor_name":"Greece","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014065","descriptor_name":"Tonometry, Ocular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017889","descriptor_name":"Exfoliation Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017889","descriptor_name":"Exfoliation Syndrome","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D017889","descriptor_name":"Exfoliation Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/13816810.2021.1904420","doi":"https://doi.org/10.1080/13816810.2021.1904420","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13816810.2021.1904420","pdf_url":null,"source":{"id":"https://openalex.org/S12713009","display_name":"Ophthalmic Genetics","issn_l":"1381-6810","issn":["1381-6810","1744-5094"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmic Genetics","raw_type":"journal-article"},{"id":"pmid:33792495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33792495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmic genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W183460740","https://openalex.org/W1611315021","https://openalex.org/W1914374322","https://openalex.org/W1976421669","https://openalex.org/W1978372306","https://openalex.org/W1985564676","https://openalex.org/W1990378159","https://openalex.org/W1996103258","https://openalex.org/W2003838710","https://openalex.org/W2018412721","https://openalex.org/W2019002861","https://openalex.org/W2031288220","https://openalex.org/W2034742711","https://openalex.org/W2055170582","https://openalex.org/W2081393706","https://openalex.org/W2089792780","https://openalex.org/W2090091671","https://openalex.org/W2093030458","https://openalex.org/W2100113746","https://openalex.org/W2115717891","https://openalex.org/W2116379013","https://openalex.org/W2118094114","https://openalex.org/W2132848405","https://openalex.org/W2141813032","https://openalex.org/W2148977592","https://openalex.org/W2154903822","https://openalex.org/W2161957190","https://openalex.org/W2167653641","https://openalex.org/W2320447672","https://openalex.org/W2320976765","https://openalex.org/W2326621723","https://openalex.org/W2620042124","https://openalex.org/W2777376269","https://openalex.org/W2793592840","https://openalex.org/W2811459875","https://openalex.org/W2892360626","https://openalex.org/W2899308387","https://openalex.org/W2981835568","https://openalex.org/W3006630598","https://openalex.org/W3008905349","https://openalex.org/W3139602705","https://openalex.org/W4211012086"],"related_works":["https://openalex.org/W3139602705","https://openalex.org/W2128036779","https://openalex.org/W2031288220","https://openalex.org/W3008905349","https://openalex.org/W2128722399","https://openalex.org/W2892360626","https://openalex.org/W2320692419","https://openalex.org/W2272006205","https://openalex.org/W2046697568","https://openalex.org/W2132209169"],"abstract_inverted_index":{"Background":[0],"The":[1,131,172],"purpose":[2],"of":[3,11,34,113,117],"this":[4],"study":[5],"is":[6,204,240],"the":[7,32,83,96,126,147,197,201,233,237,260],"development":[8],"and":[9,14,31,42,50,66,77,91,102,150,265],"validation":[10],"a":[12,19,47,88,107,114,268],"novel":[13],"robust":[15],"genotyping":[16,143],"method":[17,110,149],"for":[18,100,111,160,166,196,206,232,242,259],"new":[20],"lysyl":[21],"oxidase-like":[22],"1":[23],"(LOXL1)":[24],"intronic":[25,84,261],"polymorphism":[26,263],"(rs11638944,":[27],"C":[28,161,202,238],">":[29],"G)":[30],"investigation":[33],"its":[35],"potential":[36],"association":[37,256],"with":[38,125,146,153,208,244],"pseudoexfoliation":[39,43],"syndrome":[40],"(PXS)":[41],"glaucoma":[44,63],"(PXG)":[45],"in":[46,79,95,142,179,186,191,222,227,267],"Greek":[48,269],"population.Material":[49],"methods":[51],"242":[52],"DNA":[53,128,151],"samples":[54],"from":[55,184,220],"49":[56],"PXS,":[57],"64":[58],"PXG,":[59],"50":[60],"primary":[61],"open-angle":[62],"(POAG)":[64],"patients":[65,193,229],"79":[67],"healthy":[68,187,223],"age-matched":[69],"controls":[70,188,224],"were":[71,75,174],"analyzed.":[72],"Novel":[73],"methodologies":[74],"developed":[76],"optimized,":[78],"order":[80],"to":[81,189,225],"genotype":[82],"LOXL1":[85,262],"polymorphism:":[86],"a)":[87],"real-time":[89,132],"qPCR":[90,133],"melting":[92],"curve":[93],"analysis":[94,104,112],"Light":[97],"Cycler":[98],"platform":[99],"rapid":[101],"cost-effective":[103],"and,":[105],"b)":[106],"conventional":[108],"PCR-RFLP":[109,148],"small":[115],"number":[116],"samples.":[118],"In":[119],"selected":[120],"samples,":[121],"validity":[122],"was":[123,135,194,230,257],"checked":[124],"reference":[127],"Sequencing":[129],"method.Results":[130],"methodology":[134],"reliable,":[136],"demonstrating":[137],"good":[138,154],"efficiency,":[139],"reproducibility,":[140],"accuracy":[141],"(100%":[144],"concordance":[145],"Sequencing),":[152],"allele":[155,203,239],"discrimination":[156],"(Tm":[157],"=":[158,164,170,210,246],"53.26\u00b0C":[159],"allele,":[162,168],"Tm":[163],"61.83\u00b0C":[165],"G":[167],"\u0394Tm":[169],"8.57\u00b0C).":[171],"results":[173],"characterized":[175],"by":[176],"Hardy\u2013Weinberg":[177],"equilibrium":[178],"all":[180],"groups.":[181],"An":[182],"increase":[183,219],"18%":[185,221],"61%":[190],"PXS":[192,207],"detected":[195,231],"G/G":[198,234],"homozygote":[199,235],"thus,":[200,236],"protective":[205,241],"OR":[209,245],"0.22":[211],"(95%CI:":[212,248],"0.11\u20130.42,":[213],"p":[214,250],"<":[215,251],".0001).":[216],"Moreover,":[217],"an":[218],"70%":[226],"PXG":[228,243],"0.13":[247],"0.06\u20130.25,":[249],".0001).Conclusions":[252],"A":[253],"statistically":[254],"significant":[255],"verified":[258],"rs11638944":[264],"PXS/PXG":[266],"population.":[270]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-04-13T00:00:00"}