{"id":"https://openalex.org/W3139560086","doi":"https://doi.org/10.1080/07391102.2021.1905556","title":"Insilicoinquest reveals the efficacy of Cannabis in the treatment of post-Covid-19 related neurodegeneration","display_name":"Insilicoinquest reveals the efficacy of Cannabis in the treatment of post-Covid-19 related neurodegeneration","publication_year":2021,"publication_date":"2021-04-02","ids":{"openalex":"https://openalex.org/W3139560086","doi":"https://doi.org/10.1080/07391102.2021.1905556","mag":"3139560086","pmid":"https://pubmed.ncbi.nlm.nih.gov/33810774"},"language":"en","primary_location":{"id":"doi:10.1080/07391102.2021.1905556","doi":"https://doi.org/10.1080/07391102.2021.1905556","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07391102.2021.1905556","pdf_url":null,"source":{"id":"https://openalex.org/S178711970","display_name":"Journal of Biomolecular Structure and Dynamics","issn_l":"0739-1102","issn":["0739-1102","1538-0254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular Structure and Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076494122","display_name":"Indrani Sarkar","orcid":"https://orcid.org/0000-0002-5829-4510","observed_orcids":["https://orcid.org/0000-0002-5829-4510"]},"institutions":[{"id":"https://openalex.org/I56090587","display_name":"North Bengal University","ror":"https://ror.org/039w8qr24","country_code":"IN","type":"education","lineage":["https://openalex.org/I56090587"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Indrani Sarkar","raw_affiliation_strings":["Bioinformatics Facility, Department of Botany, University of North Bengal, Siliguri, India"],"raw_orcid":"https://orcid.org/0000-0002-5829-4510","affiliations":[{"raw_affiliation_string":"Bioinformatics Facility, Department of Botany, University of North Bengal, Siliguri, India","institution_ids":["https://openalex.org/I56090587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110794576","display_name":"Gargi Sen","orcid":"https://orcid.org/0000-0002-9711-9141","observed_orcids":["https://orcid.org/0000-0002-9711-9141","https://orcid.org/0000-0002-7929-1634"]},"institutions":[{"id":"https://openalex.org/I56090587","display_name":"North Bengal University","ror":"https://ror.org/039w8qr24","country_code":"IN","type":"education","lineage":["https://openalex.org/I56090587"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gargi Sen","raw_affiliation_strings":["Bioinformatics Facility, Department of Botany, University of North Bengal, Siliguri, India","Department of Tea Science, University of North Bengal, Siliguri, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Facility, Department of Botany, University of North Bengal, Siliguri, India","institution_ids":["https://openalex.org/I56090587"]},{"raw_affiliation_string":"Department of Tea Science, University of North Bengal, Siliguri, India","institution_ids":["https://openalex.org/I56090587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018673629","display_name":"Malay Bhattacharya","orcid":"https://orcid.org/0000-0002-4066-2979","observed_orcids":["https://orcid.org/0000-0002-4066-2979"]},"institutions":[{"id":"https://openalex.org/I56090587","display_name":"North Bengal University","ror":"https://ror.org/039w8qr24","country_code":"IN","type":"education","lineage":["https://openalex.org/I56090587"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Malay Bhattacharya","raw_affiliation_strings":["Department of Tea Science, University of North Bengal, Siliguri, India"],"raw_orcid":"https://orcid.org/0000-0002-4066-2979","affiliations":[{"raw_affiliation_string":"Department of Tea Science, University of North Bengal, Siliguri, India","institution_ids":["https://openalex.org/I56090587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007476350","display_name":"Subires Bhattacharyya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56090587","display_name":"North Bengal University","ror":"https://ror.org/039w8qr24","country_code":"IN","type":"education","lineage":["https://openalex.org/I56090587"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subires Bhattacharyya","raw_affiliation_strings":["Biswa Bangla Genome Centre, University of North Bengal, Siliguri, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biswa Bangla Genome Centre, University of North Bengal, Siliguri, India","institution_ids":["https://openalex.org/I56090587"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073827394","display_name":"Arnab Sen","orcid":"https://orcid.org/0000-0002-2079-5117","observed_orcids":["https://orcid.org/0000-0002-2079-5117"]},"institutions":[{"id":"https://openalex.org/I56090587","display_name":"North Bengal University","ror":"https://ror.org/039w8qr24","country_code":"IN","type":"education","lineage":["https://openalex.org/I56090587"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Arnab Sen","raw_affiliation_strings":["Bioinformatics Facility, Department of Botany, University of North Bengal, Siliguri, India","Biswa Bangla Genome Centre, University of North Bengal, Siliguri, India"],"raw_orcid":"https://orcid.org/0000-0002-2079-5117","affiliations":[{"raw_affiliation_string":"Bioinformatics Facility, Department of Botany, University of North Bengal, Siliguri, India","institution_ids":["https://openalex.org/I56090587"]},{"raw_affiliation_string":"Biswa Bangla Genome Centre, University of North Bengal, Siliguri, India","institution_ids":["https://openalex.org/I56090587"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073827394"],"corresponding_institution_ids":["https://openalex.org/I56090587"],"apc_list":null,"apc_paid":null,"fwci":2.0689,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.85273191,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"40","issue":"17","first_page":"8030","last_page":"8039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.49559998512268066,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.49559998512268066,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.28540000319480896,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.1590999960899353,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-haulers","display_name":"long-haulers","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cannabis","display_name":"cannabis","score":0.75},{"id":"https://openalex.org/keywords/cannabidiol","display_name":"cannabidiol","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ace2","display_name":"ACE2","score":0.8690000176429749},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tmprss2","display_name":"TMPRSS2","score":0.8299999833106995},{"id":"https://openalex.org/keywords/neuropilin-1","display_name":"neuropilin-1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7110000252723694},{"id":"https://openalex.org/keywords/protein-ligand-binding","display_name":"protein-ligand binding","score":0.6639999747276306},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.517338216304779},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5106330513954163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49969005584716797},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.4904138743877411},{"id":"https://openalex.org/C2777056318","wikidata":"https://www.wikidata.org/wiki/Q79817","display_name":"Cannabis","level":2,"score":0.455588161945343},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.42679259181022644},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3589881658554077},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3536742925643921},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34491801261901855},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33944669365882874},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28854697942733765},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.26770007610321045},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.23902779817581177},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1441953182220459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13388746976852417},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.11764901876449585}],"mesh":[{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002185","descriptor_name":"Cannabidiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002188","descriptor_name":"Cannabis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063386","descriptor_name":"Cannabinoid Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/07391102.2021.1905556","doi":"https://doi.org/10.1080/07391102.2021.1905556","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07391102.2021.1905556","pdf_url":null,"source":{"id":"https://openalex.org/S178711970","display_name":"Journal of Biomolecular Structure and Dynamics","issn_l":"0739-1102","issn":["0739-1102","1538-0254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular Structure and Dynamics","raw_type":"journal-article"},{"id":"pmid:33810774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33810774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomolecular structure & dynamics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W2008059340","https://openalex.org/W2057765792","https://openalex.org/W2078903760","https://openalex.org/W2134967712","https://openalex.org/W2158470315","https://openalex.org/W2160544821","https://openalex.org/W2190320061","https://openalex.org/W2569107931","https://openalex.org/W2593436234","https://openalex.org/W3009946390","https://openalex.org/W3012454642","https://openalex.org/W3014850166","https://openalex.org/W3015321334","https://openalex.org/W3015706105","https://openalex.org/W3016626550","https://openalex.org/W3023774360","https://openalex.org/W3024835017","https://openalex.org/W3025110670","https://openalex.org/W3026207066","https://openalex.org/W3036486867","https://openalex.org/W3036763837","https://openalex.org/W3038753733","https://openalex.org/W3042094126","https://openalex.org/W3044555078","https://openalex.org/W3047669224","https://openalex.org/W3081388769","https://openalex.org/W3085760048","https://openalex.org/W3092680125","https://openalex.org/W3095689911","https://openalex.org/W3097067972","https://openalex.org/W3105370246","https://openalex.org/W3107143983","https://openalex.org/W3109194389","https://openalex.org/W3125919088"],"related_works":["https://openalex.org/W4390458996","https://openalex.org/W4386328774","https://openalex.org/W4380666745","https://openalex.org/W4393950739","https://openalex.org/W4317722120","https://openalex.org/W4405992556","https://openalex.org/W3132366281","https://openalex.org/W4383101219","https://openalex.org/W3114676741","https://openalex.org/W4224995918"],"abstract_inverted_index":{"Coronavirus":[0],"(SARS-CoV-2),":[1],"the":[2,6,13,20,40,45,55,112,141],"causative":[3],"agent":[4],"of":[5,19,48,78],"Covid-19":[7,38,136],"pandemic":[8],"has":[9,22],"proved":[10],"itself":[11],"as":[12,72,89,154,201],"deadliest":[14],"pathogen.":[15],"A":[16],"major":[17],"portion":[18],"population":[21],"become":[23],"susceptible":[24],"to":[25,33,105,109,132,176],"this":[26,95,101,148],"strain.":[27],"Scientists":[28],"are":[29,70,81,87,129],"pushing":[30],"their":[31],"limits":[32],"formulate":[34],"a":[35,107],"vaccine":[36],"against":[37,94,206],"with":[39,84,111],"least":[41],"side":[42],"effects.":[43],"Although":[44],"recent":[46],"discoveries":[47],"vaccines":[49],"have":[50],"shown":[51],"some":[52],"relief":[53],"from":[54,172],"covid":[56],"infection":[57],"rate,":[58],"however,":[59],"physical":[60],"fatigue,":[61],"mental":[62],"abnormalities,":[63],"inflammation":[64],"and":[65,91,126,138,161,168,185],"other":[66],"multiple":[67],"organ":[68],"damages":[69],"arising":[71],"post-Covid":[73,113,142,177,207],"symptoms.":[74,114],"The":[75,158],"long-term":[76],"effects":[77],"these":[79],"symptoms":[80,86,178,194],"massive.":[82],"Patients":[83],"such":[85],"known":[88,153],"long-haulers":[90],"treatment":[92,195],"strategy":[93,108],"condition":[96],"is":[97,150],"still":[98],"unknown.":[99],"In":[100],"study,":[102],"we":[103,198],"tried":[104],"explore":[106],"deal":[110],"We":[115],"targeted":[116],"three":[117],"human":[118],"proteins":[119,137,184],"namely":[120],"ACE2,":[121],"Interleukin-6,":[122],"Transmembrane":[123],"serine":[124],"protease":[125],"NRP1":[127],"which":[128,188],"already":[130],"reported":[131],"be":[133,190],"damaged":[134],"via":[135],"upregulated":[139],"in":[140,147,156,192],"stage.":[143],"Our":[144],"target":[145],"plant":[146,205],"study":[149],"Cannabis":[151,173,200],"(popularly":[152],"\u2018Ganja\u2019":[155],"India).":[157],"molecular":[159],"docking":[160],"simulation":[162],"studies":[163],"revealed":[164],"that":[165],"Cannabidiol":[166],"(CBD)":[167],"Cannabivarin":[169],"(CVN)":[170],"obtained":[171],"can":[174,189],"bind":[175],"related":[179],"central":[180],"nervous":[181],"system":[182],"(CNS)":[183],"downregulate":[186],"them":[187],"beneficial":[191],"post-covid":[193],"strategy.":[196],"Thus":[197],"propose":[199],"an":[202],"important":[203],"therapeutic":[204],"symptoms.Communicated":[208],"by":[209],"Ramaswamy":[210],"H.":[211],"Sarma":[212]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-04-13T00:00:00"}
