{"id":"https://openalex.org/W3139533609","doi":null,"title":"[TREATMENT OF HOMOZYGOTES OF FAMILIAL HYPERCHOLESTEROLEMIA: RECOMMENDATIONS OF THE ISRAELI SOCIETY OF ATHEROSCLEROSIS].","display_name":"[TREATMENT OF HOMOZYGOTES OF FAMILIAL HYPERCHOLESTEROLEMIA: RECOMMENDATIONS OF THE ISRAELI SOCIETY OF ATHEROSCLEROSIS].","publication_year":2021,"publication_date":"2021-03-01","ids":{"openalex":"https://openalex.org/W3139533609","mag":"3139533609","pmid":"https://pubmed.ncbi.nlm.nih.gov/33749180"},"language":"en","primary_location":{"id":"pmid:33749180","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33749180","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Harefuah","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109109030","display_name":"Hofit Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hofit Cohen","raw_affiliation_strings":["The Bert W. Strassburger Lipid Center, the Chaim Sheba Medical Center, Tel-Hashomer, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Bert W. Strassburger Lipid Center, the Chaim Sheba Medical Center, Tel-Hashomer, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010326841","display_name":"Ronen Y. Durst","orcid":"https://orcid.org/0000-0003-3559-1050","observed_orcids":["https://orcid.org/0000-0003-3559-1050"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ronen Durst","raw_affiliation_strings":["Center for Prevention and Treatment of Atherosclerosis, Hadassah Hebrew University Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Prevention and Treatment of Atherosclerosis, Hadassah Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042944403","display_name":"Avishay Elis","orcid":"https://orcid.org/0000-0001-7924-3088","observed_orcids":["https://orcid.org/0000-0001-7924-3088"]},"institutions":[{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Avishay Elis","raw_affiliation_strings":["Department of Internal Medicine, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel","institution_ids":["https://openalex.org/I2800389475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113601109","display_name":"Dov Gavish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717019","display_name":"Wolfson Medical Center","ror":"https://ror.org/04ayype77","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800717019"]},{"id":"https://openalex.org/I2801962034","display_name":"Shaare Zedek Medical Center","ror":"https://ror.org/04d0szq68","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801962034"]},{"id":"https://openalex.org/I2802879425","display_name":"Bikur Cholim Hospital","ror":"https://ror.org/03zpnb459","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2802879425"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dov Gavish","raw_affiliation_strings":["Cardiovascular Research Center, Edith Wolfson Medical Center, Holon, Israel","Cardio-Metabolic Clinic, Shaare Zedek Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center, Edith Wolfson Medical Center, Holon, Israel","institution_ids":["https://openalex.org/I2800717019"]},{"raw_affiliation_string":"Cardio-Metabolic Clinic, Shaare Zedek Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2801962034","https://openalex.org/I2802879425"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108384994","display_name":"Daniel Schurr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Daniel Schurr","raw_affiliation_strings":["Center for Prevention and Treatment of Atherosclerosis, Hadassah Hebrew University Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Prevention and Treatment of Atherosclerosis, Hadassah Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04811803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"160","issue":"3","first_page":"170","last_page":"174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homozygous-familial-hypercholesterolemia","display_name":"homozygous familial hypercholesterolemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.6330000162124634},{"id":"https://openalex.org/keywords/ldl-cholesterol-lowering","display_name":"LDL cholesterol lowering","score":0.7379999756813049},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.8149999976158142},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.6850000023841858},{"id":"https://openalex.org/keywords/ezetimibe","display_name":"ezetimibe","score":1.0},{"id":"https://openalex.org/keywords/pcsk9-inhibitors","display_name":"PCSK9 inhibitors","score":0.9940000176429749},{"id":"https://openalex.org/keywords/evolocumab","display_name":"evolocumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ldl-apheresis","display_name":"LDL apheresis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/lomitapide","display_name":"lomitapide","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mtp-inhibitors","display_name":"MTP inhibitors","score":0.6589999794960022},{"id":"https://openalex.org/keywords/family-screening","display_name":"family screening","score":0.8220000267028809},{"id":"https://openalex.org/keywords/genetic-diagnosis","display_name":"genetic diagnosis","score":0.6620000004768372},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.5220000147819519},{"id":"https://openalex.org/keywords/treatment-guidelines","display_name":"treatment guidelines","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.9066078662872314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8919690847396851},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.6372979879379272},{"id":"https://openalex.org/C2778114629","wikidata":"https://www.wikidata.org/wiki/Q15623825","display_name":"Evolocumab","level":5,"score":0.5916017889976501},{"id":"https://openalex.org/C13028836","wikidata":"https://www.wikidata.org/wiki/Q21122998","display_name":"Microsomal triglyceride transfer protein","level":5,"score":0.5642440915107727},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4998352527618408},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49125856161117554},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.47725316882133484},{"id":"https://openalex.org/C12125453","wikidata":"https://www.wikidata.org/wiki/Q5156837","display_name":"Compound heterozygosity","level":4,"score":0.46887922286987305},{"id":"https://openalex.org/C2778751355","wikidata":"https://www.wikidata.org/wiki/Q1797967","display_name":"LDL apheresis","level":4,"score":0.41114574670791626},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.36364424228668213},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.34615179896354675},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.33423131704330444},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.21046602725982666},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13547727465629578},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.07818105816841125},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2780745583","wikidata":"https://www.wikidata.org/wiki/Q1316030","display_name":"Apolipoprotein A1","level":4,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000071449","descriptor_name":"Proprotein Convertase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006938","descriptor_name":"Hyperlipoproteinemia Type II","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:33749180","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33749180","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Harefuah","raw_type":"Journal Article"},{"id":"mag:3139533609","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/MED/33749180","pdf_url":null,"source":{"id":"https://openalex.org/S109185276","display_name":"Harefuah","issn_l":"0017-7768","issn":["0017-7768"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","ki-jl-1","medline","poland-20"],"host_organization":"https://openalex.org/P4310319206","host_organization_name":"Israel Medical Association","host_organization_lineage":["https://openalex.org/P4310319206"],"host_organization_lineage_names":["Israel Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Harefuah","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3153394895","https://openalex.org/W2540308544","https://openalex.org/W4394858987","https://openalex.org/W1618479134","https://openalex.org/W2165791625","https://openalex.org/W2041710164","https://openalex.org/W2979626658","https://openalex.org/W2894417323","https://openalex.org/W2888362397","https://openalex.org/W7011845902"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Familial":[1],"hypercholesterolemia":[2],"(FH)":[3],"is":[4,28,44,53,71,84,93,146,159,181,185],"an":[5,77],"autosomal":[6],"dominant":[7],"genetic":[8,106],"disorder":[9],"caused":[10],"by":[11,125],"mutations":[12],"affecting":[13],"the":[14,17,21,24,32,37,66,91,110,126,199,202],"function":[15],"of":[16,34,40,49,65,115,175,177,201],"LDL":[18,168,179],"receptor.":[19],"In":[20],"Israeli":[22],"population,":[23],"carrier":[25],"heterozygote":[26],"state":[27],"quite":[29],"common,":[30],"with":[31,99,166],"prevalence":[33,39],"1:250,":[35],"and":[36,60,80,112,131,150],"estimated":[38],"homozygote":[41],"(hoFH)":[42],"patients":[43,52,98],"1:500,000.":[45],"The":[46,63,143,171],"life":[47],"span":[48],"untreated":[50],"hoFH":[51,70,100,165],"significantly":[54],"shortened":[55],"due":[56],"to":[57,101,108,197],"premature":[58],"atherosclerosis":[59],"cardiovascular":[61],"mortality.":[62],"basis":[64],"appropriate":[67],"treatment":[68,145],"for":[69,118,164],"aggressive":[72],"lipid":[73],"lowering":[74,87],"therapy":[75],"from":[76],"early":[78],"age":[79],"therefore,":[81],"our":[82],"approach":[83],"intensive":[85],"LDL-C":[86,135,182],"as":[88,90,123,133],"soon":[89],"diagnosis":[92,111],"made.":[94],"We":[95],"recommend":[96,105],"referring":[97],"lipid-specialist":[102],"clinics":[103],".We":[104],"evaluation":[107],"confirm":[109],"cascade":[113],"screening":[114],"family":[116],"members":[117],"heterozygosity.":[119],"Lipid":[120],"goals":[121],"are":[122,141],"recommended":[124],"European":[127],"Atherosclerosis":[128],"Society.":[129],"Aggressive":[130],"low":[132],"possible":[134],"targets":[136],"(at":[137],"least":[138],"50%":[139],"reduction)":[140],"recommended.":[142],"initial":[144],"high-dose":[147],"potent":[148],"statin":[149],"additional":[151,162],"ezetimibe10":[152],"mg":[153],"daily.":[154],"PCSK9":[155],"inhibitor":[156,192],"-":[157],"Evolocumab":[158],"a":[160,186],"novel":[161],"option":[163],"residual":[167],"receptor":[169],"activity.":[170],"most":[172],"effective":[173],"method":[174],"reduction":[176],"plasma":[178],"levels":[180],"apheresis.":[183],"Lomitapide":[184],"microsomal":[187],"triglyceride":[188],"transfer":[189],"protein":[190],"(MTP)":[191],"that":[193],"should":[194],"be":[195],"added":[196],"reduce":[198],"frequency":[200],"apheresis":[203],"procedures.":[204]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-29T00:00:00"}
