{"id":"https://openalex.org/W3139532858","doi":"https://doi.org/10.36076/ppj.2012/15/495","title":"The Effect of Helicobacter Pylori Eradication on Migraine: A Randomized, Double Blind, Controlled Trial","display_name":"The Effect of Helicobacter Pylori Eradication on Migraine: A Randomized, Double Blind, Controlled Trial","publication_year":2012,"publication_date":"2012-12-14","ids":{"openalex":"https://openalex.org/W3139532858","doi":"https://doi.org/10.36076/ppj.2012/15/495","mag":"3139532858","pmid":"https://pubmed.ncbi.nlm.nih.gov/23159967"},"language":"en","primary_location":{"id":"doi:10.36076/ppj.2012/15/495","doi":"https://doi.org/10.36076/ppj.2012/15/495","is_oa":false,"landing_page_url":"https://doi.org/10.36076/ppj.2012/15/495","pdf_url":null,"source":{"id":"https://openalex.org/S193700400","display_name":"Pain Physician","issn_l":"1533-3159","issn":["1533-3159","2150-1149"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316371","host_organization_name":"American Society of Interventional Pain Physicians","host_organization_lineage":["https://openalex.org/P4310316371"],"host_organization_lineage_names":["American Society of Interventional Pain Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain Physician","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068654443","display_name":"Nader Zarinfar","orcid":"https://orcid.org/0000-0002-3098-1706","observed_orcids":["https://orcid.org/0000-0002-3098-1706"]},"institutions":[{"id":"https://openalex.org/I133903919","display_name":"Arak University of Medical Sciences","ror":"https://ror.org/056mgfb42","country_code":"IR","type":"education","lineage":["https://openalex.org/I133903919"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Nader Zarinfar","raw_affiliation_strings":["Arak University of Medical Sciences, Arak, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arak University of Medical Sciences, Arak, Iran","institution_ids":["https://openalex.org/I133903919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068654443"],"corresponding_institution_ids":["https://openalex.org/I133903919"],"apc_list":null,"apc_paid":null,"fwci":2.5918,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.89418861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"6;15","issue":"6;12","first_page":"495","last_page":"498"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.10819999873638153,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.9369999766349792},{"id":"https://openalex.org/keywords/helicobacter-pylori-eradication","display_name":"Helicobacter pylori eradication","score":0.8870000243186951},{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.9409999847412109},{"id":"https://openalex.org/keywords/migraine-disability","display_name":"migraine disability","score":0.6700000166893005},{"id":"https://openalex.org/keywords/midas-questionnaire","display_name":"MIDAS questionnaire","score":0.9409999847412109},{"id":"https://openalex.org/keywords/headache-management","display_name":"headache treatment","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9384765625},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.8684360980987549},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6742465496063232},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.6439352035522461},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6204785704612732},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5749803185462952},{"id":"https://openalex.org/C100480397","wikidata":"https://www.wikidata.org/wiki/Q7836899","display_name":"Treatment and control groups","level":2,"score":0.5246665477752686},{"id":"https://openalex.org/C2991744798","wikidata":"https://www.wikidata.org/wiki/Q608510","display_name":"Double blind","level":4,"score":0.5018975734710693},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4888555407524109},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4508195221424103},{"id":"https://openalex.org/C2780564907","wikidata":"https://www.wikidata.org/wiki/Q6844299","display_name":"Migraine treatment","level":3,"score":0.4192531704902649},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0647973120212555},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D009853","descriptor_name":"Omeprazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017291","descriptor_name":"Clarithromycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.36076/ppj.2012/15/495","doi":"https://doi.org/10.36076/ppj.2012/15/495","is_oa":false,"landing_page_url":"https://doi.org/10.36076/ppj.2012/15/495","pdf_url":null,"source":{"id":"https://openalex.org/S193700400","display_name":"Pain Physician","issn_l":"1533-3159","issn":["1533-3159","2150-1149"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316371","host_organization_name":"American Society of Interventional Pain Physicians","host_organization_lineage":["https://openalex.org/P4310316371"],"host_organization_lineage_names":["American Society of Interventional Pain Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain Physician","raw_type":"journal-article"},{"id":"pmid:23159967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23159967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain physician","raw_type":"Journal Article"},{"id":"mag:127184826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23159967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W36307229","https://openalex.org/W47609614","https://openalex.org/W340321310","https://openalex.org/W1517769147","https://openalex.org/W2048688678","https://openalex.org/W2055949171","https://openalex.org/W2070951197","https://openalex.org/W2073160193","https://openalex.org/W2083855899","https://openalex.org/W2091378434","https://openalex.org/W2119534551","https://openalex.org/W2137762446","https://openalex.org/W2156341109","https://openalex.org/W2160662378","https://openalex.org/W2165252946","https://openalex.org/W2344410750","https://openalex.org/W4256139547","https://openalex.org/W7125695608"],"related_works":["https://openalex.org/W2336549853","https://openalex.org/W2087161947","https://openalex.org/W47609614","https://openalex.org/W4288083431","https://openalex.org/W4248264063","https://openalex.org/W2558671616","https://openalex.org/W2264130041","https://openalex.org/W36307229","https://openalex.org/W7018764307","https://openalex.org/W2357625781"],"abstract_inverted_index":{"BACKGROUND:":[0],"Recent":[1],"studies":[2],"have":[3,251],"shown":[4],"a":[5,56,68,76,166,252],"positive":[6],"correlation":[7],"between":[8,131,191],"Helicobacter":[9],"pylori":[10,23,82,248,264],"(H.":[11],"pylori)infection":[12],"and":[13,63,67,75,90,97,100,122,135,152,194],"migraine":[14,26,61,73,256,270],"headache.":[15,27,257],"OBJECTIVE:":[16],"To":[17],"study":[18],"the":[19,46,94,104,117,155,158,162,173,192,200,221,224,231,260,267],"impact":[20],"of":[21,80,119,157,262,269],"H.":[22,81,247,263],"eradication":[24,65,83,249],"on":[25,255],"STUDY":[28],"DESIGN:":[29],"Double":[30],"blind,":[31],"randomized,":[32],"controlled":[33],"clinical":[34,150],"trial.":[35],"SETTING:":[36],"Sixty-four":[37],"patients":[38,49,134,138,160,171],"diagnosed":[39],"with":[40,139,197],"migraine-type":[41],"headache":[42,271],"were":[43,50,87],"included":[44],"in":[45,78,93,103,161,172,223,230,266],"study.":[47],"The":[48,107],"randomly":[51],"allocated":[52],"into":[53],"2":[54],"groups:":[55],"treatment":[57,62,74,95,132,163,193,203,232,265],"group":[58,70,96,133,137,164,175,233],"that":[59,71,220],"received":[60,72],"H.pylori":[64],"treatment,":[66],"control":[69,105,136,174,195],"placebo":[77],"place":[79],"treatment.":[84,124],"METHODS:":[85],"There":[86,126,186],"25":[88],"women":[89,99],"7":[91],"men":[92,102],"22":[98],"10":[101],"group.":[106],"MIDAS":[108,168,225],"(Migraine":[109],"Disability":[110],"Assessment)":[111],"questionnaire":[112],"was":[113,127,187,227],"used":[114],"to":[115,141,170,199],"assess":[116],"severity":[118],"symptoms,":[120],"before":[121],"after":[123,202],"RESULT:":[125],"no":[128,188],"significant":[129,189],"difference":[130,190],"respect":[140,198],"age":[142],"(44.6":[143],"\u00b1":[144,148,177,181,205,209],"8.8":[145],"vs.":[146,179,207],"43.8":[147],"13.8),":[149],"symptoms":[151],"signs.":[153],"In":[154],"beginning":[156],"study,":[159],"had":[165],"higher":[167],"compared":[169],"(28.87":[176],"6.18":[178],"25.43":[180],"7.13,":[182],"P":[183,211,239],"<":[184],"0.05).":[185,241],"groups,":[196],"MIDAS,":[201],"(20.09":[204],"1.14":[206],"20.00":[208],"1.150,":[210],"=":[212,240],"0.5).":[213],"General":[214],"linear":[215],"model,":[216],"repeated":[217],"measures":[218],"demonstrated":[219],"reduction":[222],"score":[226],"more":[228],"prominent":[229],"(Mean":[234],"Square":[235],"164.25,":[236],"F:":[237],"2.02,":[238],"LIMITATIONS:":[242],"Short-term":[243],"follow":[244],"up.":[245],"CONCLUSION:":[246],"may":[250],"beneficial":[253],"role":[254],"This":[258],"shows":[259],"significance":[261],"management":[268],"among":[272],"Iranian":[273],"patients.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2021-03-29T00:00:00"}