{"id":"https://openalex.org/W3139418756","doi":"https://doi.org/10.1155/2021/6661828","title":"miR-22-3p/PGC1\u03b2 Suppresses Breast Cancer Cell Tumorigenesis via PPAR\u03b3","display_name":"miR-22-3p/PGC1\u03b2 Suppresses Breast Cancer Cell Tumorigenesis via PPAR\u03b3","publication_year":2021,"publication_date":"2021-03-12","ids":{"openalex":"https://openalex.org/W3139418756","doi":"https://doi.org/10.1155/2021/6661828","mag":"3139418756","pmid":"https://pubmed.ncbi.nlm.nih.gov/33777130","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7981180"},"language":"en","primary_location":{"id":"doi:10.1155/2021/6661828","doi":"https://doi.org/10.1155/2021/6661828","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/6661828","pdf_url":"https://downloads.hindawi.com/journals/ppar/2021/6661828.pdf","source":{"id":"https://openalex.org/S71649485","display_name":"PPAR Research","issn_l":"1687-4757","issn":["1687-4757","1687-4765"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PPAR Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/ppar/2021/6661828.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101673663","display_name":"Xuehui Wang","orcid":"https://orcid.org/0000-0001-8997-5303","observed_orcids":["https://orcid.org/0000-0001-8997-5303","https://orcid.org/0000-0001-7505-3316"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuehui Wang","raw_affiliation_strings":["Department of Thyroid and Breast Surgery, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai 200072, China","Nanjing Medical University, Nanjing 211166, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid and Breast Surgery, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai 200072, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]},{"raw_affiliation_string":"Nanjing Medical University, Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059179814","display_name":"Zhilu Yao","orcid":"https://orcid.org/0009-0008-6941-7441","observed_orcids":["https://orcid.org/0009-0008-6941-7441"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhilu Yao","raw_affiliation_strings":["Department of Thyroid and Breast Surgery, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai 200072, China","Nanjing Medical University, Nanjing 211166, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid and Breast Surgery, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai 200072, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]},{"raw_affiliation_string":"Nanjing Medical University, Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101811389","display_name":"Lin Fang","orcid":"https://orcid.org/0000-0003-2418-3617","observed_orcids":["https://orcid.org/0000-0003-2418-3617"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Fang","raw_affiliation_strings":["Department of Thyroid and Breast Surgery, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai 200072, China","Nanjing Medical University, Nanjing 211166, China"],"raw_orcid":"https://orcid.org/0000-0003-2418-3617","affiliations":[{"raw_affiliation_string":"Department of Thyroid and Breast Surgery, Shanghai Tenth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai 200072, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]},{"raw_affiliation_string":"Nanjing Medical University, Nanjing 211166, China","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101811389"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741","https://openalex.org/I83519826"],"apc_list":{"value":1630,"currency":"USD","value_usd":1630},"apc_paid":{"value":1630,"currency":"USD","value_usd":1630},"fwci":1.8056,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.85433522,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"2021","issue":null,"first_page":"1","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-22-3p","display_name":"miR-22-3p","score":1.0},{"id":"https://openalex.org/keywords/pgc-1beta","display_name":"PGC-1\u03b2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ppargamma-signaling-pathway","display_name":"PPAR\u03b3 signaling pathway","score":0.8159999847412109},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.847000002861023},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.722000002861023},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.8485238552093506},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7378969788551331},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6246077418327332},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5869527459144592},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5491745471954346},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5282285213470459},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5106549859046936},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.4951695501804352},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.46315115690231323},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.41162562370300293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4097694158554077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37576642632484436},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3275378346443176},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32265082001686096},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17849186062812805},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11156776547431946}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2021/6661828","doi":"https://doi.org/10.1155/2021/6661828","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/6661828","pdf_url":"https://downloads.hindawi.com/journals/ppar/2021/6661828.pdf","source":{"id":"https://openalex.org/S71649485","display_name":"PPAR Research","issn_l":"1687-4757","issn":["1687-4757","1687-4765"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PPAR Research","raw_type":"journal-article"},{"id":"pmid:33777130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33777130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PPAR research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7981180","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7981180/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PPAR Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4c89f2ca3ede44f99cdf31f638ddab1f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4c89f2ca3ede44f99cdf31f638ddab1f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PPAR Research, Vol 2021 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2021/6661828","doi":"https://doi.org/10.1155/2021/6661828","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/6661828","pdf_url":"https://downloads.hindawi.com/journals/ppar/2021/6661828.pdf","source":{"id":"https://openalex.org/S71649485","display_name":"PPAR Research","issn_l":"1687-4757","issn":["1687-4757","1687-4765"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PPAR Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2007456281","display_name":null,"funder_award_id":"No. 82073204","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3457212136","display_name":null,"funder_award_id":"82073204","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3139418756.pdf","grobid_xml":"https://content.openalex.org/works/W3139418756.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1963823440","https://openalex.org/W1964170925","https://openalex.org/W1964876127","https://openalex.org/W1995574334","https://openalex.org/W2015858554","https://openalex.org/W2024162065","https://openalex.org/W2034131665","https://openalex.org/W2124098526","https://openalex.org/W2124359549","https://openalex.org/W2142712029","https://openalex.org/W2145968349","https://openalex.org/W2147609336","https://openalex.org/W2162153815","https://openalex.org/W2176077264","https://openalex.org/W2534069516","https://openalex.org/W2570618306","https://openalex.org/W2614596316","https://openalex.org/W2752131577","https://openalex.org/W2761806140","https://openalex.org/W2791869502","https://openalex.org/W2804658037","https://openalex.org/W2892305751","https://openalex.org/W2938163061","https://openalex.org/W2938415695","https://openalex.org/W2946104530","https://openalex.org/W2966817473","https://openalex.org/W3020804057","https://openalex.org/W3023299375","https://openalex.org/W3048809627","https://openalex.org/W3086196372","https://openalex.org/W3087994600","https://openalex.org/W3089579250","https://openalex.org/W3091830828","https://openalex.org/W3119158007"],"related_works":["https://openalex.org/W3185263676","https://openalex.org/W3211130521","https://openalex.org/W7128084999","https://openalex.org/W4200170562","https://openalex.org/W3022630151","https://openalex.org/W2990468416","https://openalex.org/W2913316254","https://openalex.org/W2542658396","https://openalex.org/W4404081997","https://openalex.org/W4200396769"],"abstract_inverted_index":{"In":[0,56],"this":[1],"study,":[2],"we":[3],"found":[4],"that":[5],"miR-22-3p":[6,20,37,43],"expression":[7],"was":[8],"decreased":[9],"in":[10,29,32,54],"breast":[11],"cancer":[12],"(BC)":[13],"cell":[14,61],"lines":[15],"and":[16,24,31,48,71],"tissues.":[17],"Overexpression":[18],"of":[19,26,36],"inhibited":[21],"the":[22,39,51],"proliferation":[23],"migration":[25],"BC":[27,60],"cells":[28],"vitro":[30],"vivo,":[33],"while":[34],"depletion":[35],"exhibited":[38],"opposite":[40],"effect.":[41],"Importantly,":[42],"could":[44],"directly":[45],"target":[46],"PGC1\u03b2":[47],"finally":[49],"regulate":[50],"PPAR\u03b3":[52],"pathway":[53],"BC.":[55],"conclusion,":[57],"miR-22-3p/PGC1\u03b2":[58],"suppresses":[59],"tumorigenesis":[62],"via":[63],"PPAR\u03b3,":[64],"which":[65],"may":[66],"become":[67],"a":[68],"potential":[69],"biomarker":[70],"therapeutic":[72],"target.":[73]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-29T00:00:00"}
