{"id":"https://openalex.org/W3139260627","doi":"https://doi.org/10.1038/s41598-021-85534-6","title":"Extracellular vesicles from human airway basal cells respond to cigarette smoke extract and affect vascular endothelial cells","display_name":"Extracellular vesicles from human airway basal cells respond to cigarette smoke extract and affect vascular endothelial cells","publication_year":2021,"publication_date":"2021-03-17","ids":{"openalex":"https://openalex.org/W3139260627","doi":"https://doi.org/10.1038/s41598-021-85534-6","mag":"3139260627","pmid":"https://pubmed.ncbi.nlm.nih.gov/33731767","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7969738"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-021-85534-6","doi":"https://doi.org/10.1038/s41598-021-85534-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-85534-6","pdf_url":"https://www.nature.com/articles/s41598-021-85534-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-021-85534-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075739031","display_name":"Ashish Saxena","orcid":"https://orcid.org/0000-0003-3353-129X","observed_orcids":["https://orcid.org/0000-0003-3353-129X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ashish Saxena","raw_affiliation_strings":["Department of Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ahs9018@med.cornell.edu","Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY, USA. ahs9018@med.cornell.edu","Department of Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ahs9018@med.cornell.edu","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY, USA. ahs9018@med.cornell.edu","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071115670","display_name":"Matthew S. Walters","orcid":"https://orcid.org/0000-0003-0010-8444","observed_orcids":["https://orcid.org/0000-0003-0010-8444"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew S. Walters","raw_affiliation_strings":["Department of Genetic Medicine, Weill Cornell Medicine, New York, NY, USA","Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091269790","display_name":"Jae-Hung Shieh","orcid":"https://orcid.org/0000-0001-6179-2847","observed_orcids":["https://orcid.org/0000-0001-6179-2847"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jae-Hung Shieh","raw_affiliation_strings":["Department of Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA","Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062806347","display_name":"Lingbo Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling-Bo Shen","raw_affiliation_strings":["Cell Therapy and Cell Engineering Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA","Department of Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Therapy and Cell Engineering Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112248308","display_name":"Kazunori Gomi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazunori Gomi","raw_affiliation_strings":["Department of Genetic Medicine, Weill Cornell Medicine, New York, NY, USA","Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009311007","display_name":"Robert J. Downey","orcid":"https://orcid.org/0000-0001-5715-9731","observed_orcids":["https://orcid.org/0000-0001-5715-9731"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Downey","raw_affiliation_strings":["Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064433832","display_name":"Ronald G. Crystal","orcid":"https://orcid.org/0000-0001-6177-6839","observed_orcids":["https://orcid.org/0000-0001-6177-6839"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald G. Crystal","raw_affiliation_strings":["Department of Genetic Medicine, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110863459","display_name":"Malcolm A.S. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malcolm A. S. Moore","raw_affiliation_strings":["Department of Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075739031"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I4387153466"],"apc_list":{"value":1990,"currency":"USD","value_usd":1990},"apc_paid":{"value":1990,"currency":"USD","value_usd":1990},"fwci":1.2552,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.78312041,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"6104","last_page":"6104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.9620000123977661},{"id":"https://openalex.org/keywords/airway-basal-cells","display_name":"airway basal cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cigarette-smoke-extract","display_name":"cigarette smoke extract","score":0.972000002861023},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8539999723434448},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.8309999704360962},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.968999981880188},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.800000011920929},{"id":"https://openalex.org/keywords/endothelial-cell-survival","display_name":"endothelial cell survival","score":0.8090000152587891},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7739999890327454},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8529999852180481},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.6620000004768372},{"id":"https://openalex.org/keywords/airway-epithelium","display_name":"airway epithelium","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7633712887763977},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.6133328676223755},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.5946542620658875},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.578082799911499},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5455822348594666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5453311204910278},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.5281493663787842},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4756440818309784},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43667343258857727},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.4192831218242645},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.3618462085723877},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.24192482233047485},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.21605417132377625},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.1838112771511078},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12319913506507874},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0877406895160675},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06515201926231384},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.060295164585113525},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014028","descriptor_name":"Tobacco Smoke Pollution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D062789","descriptor_name":"Tobacco Products","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-021-85534-6","doi":"https://doi.org/10.1038/s41598-021-85534-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-85534-6","pdf_url":"https://www.nature.com/articles/s41598-021-85534-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7969738","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7969738","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:33731767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33731767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:92449e126f694f7d8e77c16977597922","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/92449e126f694f7d8e77c16977597922","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-021-85534-6","doi":"https://doi.org/10.1038/s41598-021-85534-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-021-85534-6","pdf_url":"https://www.nature.com/articles/s41598-021-85534-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4103979886","display_name":"Overlapping Airway Basal Cell Transcriptome Reprogramming in COPD and Lung Cancer","funder_award_id":"R01HL107882","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000867119","display_name":"Clinical and Translational Science Center","funder_award_id":"UL1TR002384","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3139260627.pdf","grobid_xml":"https://content.openalex.org/works/W3139260627.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1923975596","https://openalex.org/W1980969801","https://openalex.org/W1999590973","https://openalex.org/W2000626895","https://openalex.org/W2001920766","https://openalex.org/W2004653956","https://openalex.org/W2007946604","https://openalex.org/W2022751366","https://openalex.org/W2069774245","https://openalex.org/W2070307875","https://openalex.org/W2084601974","https://openalex.org/W2101716045","https://openalex.org/W2108057472","https://openalex.org/W2108877784","https://openalex.org/W2125851698","https://openalex.org/W2125981106","https://openalex.org/W2130318026","https://openalex.org/W2136782621","https://openalex.org/W2139817277","https://openalex.org/W2167963839","https://openalex.org/W2169894204","https://openalex.org/W2170935967","https://openalex.org/W2193861601","https://openalex.org/W2311113928","https://openalex.org/W2322031379","https://openalex.org/W2486397717","https://openalex.org/W2514059345","https://openalex.org/W2561834398","https://openalex.org/W2597800033","https://openalex.org/W2608932173","https://openalex.org/W2776824478","https://openalex.org/W2802757599","https://openalex.org/W2802868810","https://openalex.org/W2803347918","https://openalex.org/W2901127498","https://openalex.org/W2904802348","https://openalex.org/W2925579059","https://openalex.org/W2951017561"],"related_works":["https://openalex.org/W2001920766","https://openalex.org/W2151107334","https://openalex.org/W2322949811","https://openalex.org/W2609301549","https://openalex.org/W2559831888","https://openalex.org/W2921428193","https://openalex.org/W4396502402","https://openalex.org/W2171869761","https://openalex.org/W2933695982","https://openalex.org/W2419072572"],"abstract_inverted_index":{"The":[0,177],"human":[1,50,90],"airway":[2,51,91,124,167,211],"epithelium":[3],"lining":[4],"the":[5,31,129,153,163,171,188],"bronchial":[6],"tree":[7],"contains":[8],"basal":[9,52,92,125,168,212],"cells":[10,25,93,109,121,133,169,209],"that":[11,24,44,58,70,88,117,135,158],"proliferate,":[12],"differentiate,":[13],"and":[14,35,56,134,142,170,185,199],"communicate":[15],"with":[16],"other":[17,36,82],"components":[18],"of":[19,33,75,119,131,194,207],"their":[20,59],"microenvironment.":[21],"One":[22],"method":[23],"use":[26],"for":[27],"intercellular":[28,164],"communication":[29],"involves":[30,139],"secretion":[32,60],"exosomes":[34],"extracellular":[37],"vesicles":[38],"(EVs).":[39],"We":[40,84],"isolated":[41],"exosome-enriched":[42,123],"EVs":[43,76,127,159],"were":[45],"produced":[46],"from":[47],"an":[48],"immortalized":[49],"cell":[53,126,213],"line":[54],"(BCi-NS1.1)":[55],"found":[57],"is":[61],"increased":[62,192],"by":[63,149],"exposure":[64,118,206],"to":[65,81,122,187,210],"cigarette":[66],"smoke":[67],"extract,":[68],"suggesting":[69],"this":[71,136],"stress":[72],"stimulates":[73],"release":[74],"which":[77,101,173],"could":[78],"affect":[79],"signaling":[80,105,165,179],"cells.":[83],"have":[85],"previously":[86,175],"shown":[87],"primary":[89],"secrete":[94],"vascular":[95],"endothelial":[96,108,120,208],"growth":[97],"factor":[98],"A":[99],"(VEGFA)":[100],"can":[102],"activate":[103],"MAPK":[104,201],"cascades":[106],"in":[107,146,152,162],"via":[110],"VEGF":[111],"receptor-2":[112],"(VEGFR2).":[113],"Here,":[114],"we":[115,174],"show":[116],"promotes":[128],"survival":[130],"these":[132],"effect":[137],"also":[138],"VEGFR2":[140],"activation":[141],"is,":[143],"at":[144],"least":[145],"part,":[147],"mediated":[148],"VEGFA":[150],"present":[151],"EVs.":[154,214],"These":[155],"observations":[156],"demonstrate":[157],"are":[160],"involved":[161,181],"between":[166],"endothelium":[172],"reported.":[176],"downstream":[178],"pathways":[180],"may":[182],"be":[183],"distinct":[184],"specific":[186],"EVs,":[189],"however,":[190],"as":[191],"phosphorylation":[193],"Akt,":[195],"STAT3,":[196],"p44/42":[197],"MAPK,":[198],"p38":[200],"was":[202],"not":[203],"seen":[204],"following":[205]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-29T00:00:00"}