{"id":"https://openalex.org/W3138975854","doi":"https://doi.org/10.3238/arztebl.m2021.0164","title":"Adults Born Preterm: Long-Term Health Risks of Former Very Low Birth Weight Infants","display_name":"Adults Born Preterm: Long-Term Health Risks of Former Very Low Birth Weight Infants","publication_year":2021,"publication_date":"2021-07-27","ids":{"openalex":"https://openalex.org/W3138975854","doi":"https://doi.org/10.3238/arztebl.m2021.0164","mag":"3138975854","pmid":"https://pubmed.ncbi.nlm.nih.gov/33734986","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8503949"},"language":"en","primary_location":{"id":"doi:10.3238/arztebl.m2021.0164","doi":"https://doi.org/10.3238/arztebl.m2021.0164","is_oa":false,"landing_page_url":"https://doi.org/10.3238/arztebl.m2021.0164","pdf_url":null,"source":{"id":"https://openalex.org/S40230991","display_name":"Deutsches \u00c4rzteblatt international","issn_l":"1866-0452","issn":["1866-0452"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313962","host_organization_name":"Deutscher \u00c4rzte-Verlag","host_organization_lineage":["https://openalex.org/P4310313962"],"host_organization_lineage_names":["Deutscher \u00c4rzte-Verlag"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Deutsches \u00c4rzteblatt international","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8503949","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055249823","display_name":"Dominique Singer","orcid":"https://orcid.org/0000-0002-7081-6123","observed_orcids":["https://orcid.org/0000-0002-7081-6123"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominique Singer","raw_affiliation_strings":["University Medical Center Hamburg-Eppendorf UKE, Division of Neonatology and Pediatric IntensiveCare Medicine, Department of Pediatrics and Adolescent Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Medical Center Hamburg-Eppendorf UKE, Division of Neonatology and Pediatric IntensiveCare Medicine, Department of Pediatrics and Adolescent Medicine","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072262024","display_name":"Luise Pauline Thiede","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luise Pauline Thiede","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030839727","display_name":"Anna Perez","orcid":"https://orcid.org/0000-0002-8488-3300","observed_orcids":["https://orcid.org/0000-0002-8488-3300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Perez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7595,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.95730003,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"118","issue":"31-32","first_page":"521","last_page":"527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.8047000169754028,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.8047000169754028,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.18700000643730164,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/very-low-birth-weight-infants","display_name":"very low birth weight infants","score":0.8180000185966492},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.9179999828338623},{"id":"https://openalex.org/keywords/long-term-health-effects","display_name":"long-term health effects","score":0.8550000190734863},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.7670000195503235},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.828000009059906},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6010000109672546},{"id":"https://openalex.org/keywords/neurocognitive-impairment","display_name":"neurocognitive impairment","score":0.9020000100135803},{"id":"https://openalex.org/keywords/reproductive-outcomes","display_name":"reproductive outcomes","score":0.5109999775886536},{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.8140000104904175},{"id":"https://openalex.org/keywords/psychosocial-outcomes","display_name":"psychosocial outcomes","score":0.8140000104904175},{"id":"https://openalex.org/keywords/personalized-prevention","display_name":"personalized prevention","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8955010175704956},{"id":"https://openalex.org/C2779083892","wikidata":"https://www.wikidata.org/wiki/Q6692979","display_name":"Low birth weight","level":3,"score":0.6033210158348083},{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.6008488535881042},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5513911247253418},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.5343035459518433},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4556286036968231},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3472396433353424},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2150479555130005},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.13235247135162354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047928","descriptor_name":"Premature Birth","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3238/arztebl.m2021.0164","doi":"https://doi.org/10.3238/arztebl.m2021.0164","is_oa":false,"landing_page_url":"https://doi.org/10.3238/arztebl.m2021.0164","pdf_url":null,"source":{"id":"https://openalex.org/S40230991","display_name":"Deutsches \u00c4rzteblatt international","issn_l":"1866-0452","issn":["1866-0452"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313962","host_organization_name":"Deutscher \u00c4rzte-Verlag","host_organization_lineage":["https://openalex.org/P4310313962"],"host_organization_lineage_names":["Deutscher \u00c4rzte-Verlag"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Deutsches \u00c4rzteblatt international","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8503949","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8503949","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dtsch Arztebl Int","raw_type":"Text"},{"id":"pmid:33734986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33734986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Deutsches Arzteblatt international","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8503949","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8503949","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dtsch Arztebl Int","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W120027482","https://openalex.org/W1701596890","https://openalex.org/W1771794856","https://openalex.org/W1859302639","https://openalex.org/W1960771228","https://openalex.org/W1973097196","https://openalex.org/W1975755498","https://openalex.org/W1979939649","https://openalex.org/W1980938313","https://openalex.org/W1992001119","https://openalex.org/W1996637726","https://openalex.org/W1996783786","https://openalex.org/W2000193800","https://openalex.org/W2005461405","https://openalex.org/W2010593051","https://openalex.org/W2027986310","https://openalex.org/W2032093297","https://openalex.org/W2063096978","https://openalex.org/W2064396942","https://openalex.org/W2071043712","https://openalex.org/W2072999822","https://openalex.org/W2090523671","https://openalex.org/W2094517267","https://openalex.org/W2098474777","https://openalex.org/W2105009603","https://openalex.org/W2110361553","https://openalex.org/W2110902903","https://openalex.org/W2113820034","https://openalex.org/W2121349530","https://openalex.org/W2121734518","https://openalex.org/W2130765416","https://openalex.org/W2134716189","https://openalex.org/W2140674849","https://openalex.org/W2143847855","https://openalex.org/W2159140433","https://openalex.org/W2163413113","https://openalex.org/W2164560186","https://openalex.org/W2168145248","https://openalex.org/W2168233902","https://openalex.org/W2168972047","https://openalex.org/W2179360554","https://openalex.org/W2183337241","https://openalex.org/W2286904530","https://openalex.org/W2288876040","https://openalex.org/W2292895269","https://openalex.org/W2308510141","https://openalex.org/W2311988401","https://openalex.org/W2386170543","https://openalex.org/W2399262309","https://openalex.org/W2415776181","https://openalex.org/W2469859534","https://openalex.org/W2510158158","https://openalex.org/W2514232413","https://openalex.org/W2515705541","https://openalex.org/W2517677111","https://openalex.org/W2552783467","https://openalex.org/W2587852293","https://openalex.org/W2594273274","https://openalex.org/W2595103610","https://openalex.org/W2605921691","https://openalex.org/W2606756155","https://openalex.org/W2609231744","https://openalex.org/W2648496024","https://openalex.org/W2735944743","https://openalex.org/W2752900046","https://openalex.org/W2768105036","https://openalex.org/W2780221042","https://openalex.org/W2793031799","https://openalex.org/W2801245355","https://openalex.org/W2885878352","https://openalex.org/W2888882389","https://openalex.org/W2891676034","https://openalex.org/W2895921683","https://openalex.org/W2895995729","https://openalex.org/W2897330014","https://openalex.org/W2898130513","https://openalex.org/W2905314137","https://openalex.org/W2923852139","https://openalex.org/W2937152732","https://openalex.org/W2942751913","https://openalex.org/W2942801104","https://openalex.org/W2944783061","https://openalex.org/W2948046110","https://openalex.org/W2948206476","https://openalex.org/W2961726814","https://openalex.org/W2961946900","https://openalex.org/W2993116545","https://openalex.org/W2995564330","https://openalex.org/W3109165134"],"related_works":["https://openalex.org/W3084269468","https://openalex.org/W2605921691","https://openalex.org/W3002242860","https://openalex.org/W6995925386","https://openalex.org/W2944150795","https://openalex.org/W4387052632","https://openalex.org/W2511319282","https://openalex.org/W4389523025","https://openalex.org/W4241351105","https://openalex.org/W2898777580"],"abstract_inverted_index":{"BACKGROUND:":[0],"Advances":[1],"in":[2,46,120,173,226],"neonatology":[3],"now":[4],"enable":[5],"increasing":[6],"numbers":[7],"of":[8,38,105,143,168,199,214],"very":[9,39],"low":[10,40,174],"birth":[11,41],"weight":[12,42],"neonates":[13],"(<1500":[14],"g)":[15],"to":[16,180,205],"survive":[17],"into":[18],"early":[19],"adulthood":[20,47,227],"and":[21,67,90,102,125,153],"beyond.":[22],"What":[23],"are":[24,54,118,171],"the":[25,36,57,72,100,112,115,178,196],"implications":[26],"for":[27,80,159,182,212],"their":[28],"long-term":[29,69],"care?":[30],"METHODS:":[31],"Selective":[32],"literature":[33],"search":[34],"on":[35,56],"outcome":[37],"neo":[43],"-":[44],"nates":[45],"(\"adults":[48],"born":[49,163],"preterm\").":[50],"RESULTS:":[51],"Robust":[52],"data":[53],"available":[55],"pulmonary,":[58],"metabolic,":[59],"cardiovascular,":[60],"renal,":[61],"neurocognitive,":[62],"sensory-visual,":[63],"social-emotional,":[64],"mental,":[65],"reproductive,":[66],"musculoskeletal":[68],"risks.":[70],"On":[71,111],"somatic":[73,152],"level,":[74,114],"elevated":[75,141],"rates":[76],"have":[77,139],"been":[78],"documented":[79],"asthma":[81],"(odds":[82],"Ratio":[83],"[OR]":[84],"2.37),":[85],"diabetes":[86],"mellitus":[87],"(OR":[88,123],"1.54),":[89],"chronic":[91],"renal":[92],"disease":[93],"(hazard":[94],"ratio":[95],"[HR]":[96],"3.01),":[97],"along":[98],"with":[99,150,186,207],"cardiovascular":[101],"cerebrovascular":[103],"sequelae":[104],"a":[106,126],"tendency":[107],"toward":[108],"arterial":[109],"hypertension.":[110],"psychosocial":[113,154],"main":[116],"findings":[117],"deficits":[119,184],"romantic":[121],"partnerships":[122],"0.72)":[124],"lower":[127],"reproduction":[128],"rate":[129],"(relative":[130],"risk":[131,142,148],"[RR]":[132],"male/female":[133],"0.24/0.33).":[134],"The":[135],"affected":[136],"women":[137],"also":[138],"an":[140],"preterm":[144],"delivery.":[145],"CONCLUSION:":[146],"A":[147,202],"profile":[149],"both":[151],"aspects":[155],"can":[156],"be":[157],"discerned":[158],"adults":[160,189],"who":[161],"were":[162],"prematurely,":[164],"even":[165],"if":[166],"some":[167],"these":[169],"risks":[170],"present":[172],"absolute":[175],"numbers.":[176],"As":[177],"ability":[179],"compensate":[181],"latent":[183],"declines":[185],"age,":[187],"such":[188],"may":[190],"suffer":[191],"from":[192,220],"\"premature":[193],"aging":[194],"as":[195,228],"late":[197],"price":[198],"premature":[200],"birth.\"":[201],"holistic":[203],"approach":[204],"care":[206],"personalized":[208],"prevention":[209],"strategies-":[210],"which":[211],"most":[213],"them":[215],"was":[216],"discontinued":[217],"at":[218],"discharge":[219],"pediatric":[221],"followup-":[222],"therefore":[223],"seems":[224],"appropriate":[225],"well.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-03-29T00:00:00"}
