{"id":"https://openalex.org/W3138900072","doi":"https://doi.org/10.4149/neo_2021_201116n1229","title":"Cytidine deaminase 435C>T polymorphism relates to gemcitabine-platinum efficacy and hematological toxicity in Chinese non-small-cell lung cancer patients","display_name":"Cytidine deaminase 435C>T polymorphism relates to gemcitabine-platinum efficacy and hematological toxicity in Chinese non-small-cell lung cancer patients","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3138900072","doi":"https://doi.org/10.4149/neo_2021_201116n1229","mag":"3138900072","pmid":"https://pubmed.ncbi.nlm.nih.gov/33724861"},"language":"en","primary_location":{"id":"doi:10.4149/neo_2021_201116n1229","doi":"https://doi.org/10.4149/neo_2021_201116n1229","is_oa":false,"landing_page_url":"https://doi.org/10.4149/neo_2021_201116n1229","pdf_url":null,"source":{"id":"https://openalex.org/S52683455","display_name":"Neoplasma","issn_l":"0028-2685","issn":["0028-2685","1338-4317"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310314442","host_organization_name":"AEPress","host_organization_lineage":["https://openalex.org/P4310314442"],"host_organization_lineage_names":["AEPress"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103239253","display_name":"Lili Hu","orcid":"https://orcid.org/0000-0003-1082-0451","observed_orcids":["https://orcid.org/0000-0003-1082-0451"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lili Hu","raw_affiliation_strings":["Department of Pharmacy, The Affiliated Hospital of Xuzhou Medical University; Clinical College, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The Affiliated Hospital of Xuzhou Medical University; Clinical College, Xuzhou Medical University, Xuzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xintong Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xintong Mao","raw_affiliation_strings":["College of Pharmacy, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101806228","display_name":"Chao Gao","orcid":"https://orcid.org/0000-0002-2068-6586","observed_orcids":["https://orcid.org/0000-0002-2068-6586"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Gao","raw_affiliation_strings":["Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064176957","display_name":"Yinhai Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinhai Xu","raw_affiliation_strings":["Department of Medical Laboratory, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100675585","display_name":"Chenglin Li","orcid":"https://orcid.org/0000-0002-8781-3789","observed_orcids":["https://orcid.org/0000-0002-8781-3789"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenglin Li","raw_affiliation_strings":["Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical University, Xuzhou, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453525","display_name":"Tao Wang","orcid":"https://orcid.org/0000-0002-4355-149X","observed_orcids":["https://orcid.org/0000-0002-4355-149X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Wang","raw_affiliation_strings":["Department of Pharmacy, The Affiliated Hospital of Xuzhou Medical University; Clinical College, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The Affiliated Hospital of Xuzhou Medical University; Clinical College, Xuzhou Medical University, Xuzhou, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067891086","display_name":"Dongmei Lv","orcid":"https://orcid.org/0000-0001-6165-4049","observed_orcids":["https://orcid.org/0000-0001-6165-4049"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dongmei Lv","raw_affiliation_strings":["Department of Pharmacy, The Affiliated Hospital of Xuzhou Medical University; Clinical College, Xuzhou Medical University, Xuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The Affiliated Hospital of Xuzhou Medical University; Clinical College, Xuzhou Medical University, Xuzhou, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067891086"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7984,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.7040621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"68","issue":"03","first_page":"638","last_page":"644"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.4961000084877014,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.4961000084877014,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.459199994802475,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.02710000053048134,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytidine-deaminase","display_name":"cytidine deaminase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.8799999952316284},{"id":"https://openalex.org/keywords/platinum-based-chemotherapy","display_name":"platinum-based chemotherapy","score":0.7699999809265137},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/leukopenia","display_name":"leukopenia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.7409999966621399},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6549999713897705},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.8622991442680359},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6933336853981018},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6552799940109253},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6208270788192749},{"id":"https://openalex.org/C2780873365","wikidata":"https://www.wikidata.org/wiki/Q496812","display_name":"Leukopenia","level":3,"score":0.5998349785804749},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5937620401382446},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5664699077606201},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47747206687927246},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.32824552059173584}],"mesh":[{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010984","descriptor_name":"Platinum","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4149/neo_2021_201116n1229","doi":"https://doi.org/10.4149/neo_2021_201116n1229","is_oa":false,"landing_page_url":"https://doi.org/10.4149/neo_2021_201116n1229","pdf_url":null,"source":{"id":"https://openalex.org/S52683455","display_name":"Neoplasma","issn_l":"0028-2685","issn":["0028-2685","1338-4317"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310314442","host_organization_name":"AEPress","host_organization_lineage":["https://openalex.org/P4310314442"],"host_organization_lineage_names":["AEPress"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"journal-article"},{"id":"pmid:33724861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33724861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W777350815","https://openalex.org/W1837502540","https://openalex.org/W1967326783","https://openalex.org/W1967428096","https://openalex.org/W1969875775","https://openalex.org/W1978350956","https://openalex.org/W1981347210","https://openalex.org/W1990615874","https://openalex.org/W2007629457","https://openalex.org/W2019607817","https://openalex.org/W2050119069","https://openalex.org/W2053039983","https://openalex.org/W2065028774","https://openalex.org/W2096442753","https://openalex.org/W2099977816","https://openalex.org/W2103374204","https://openalex.org/W2117278104","https://openalex.org/W2118246132","https://openalex.org/W2134086590","https://openalex.org/W2145238269","https://openalex.org/W2152263917","https://openalex.org/W2155096329","https://openalex.org/W2156576546","https://openalex.org/W2159701687","https://openalex.org/W2164193797","https://openalex.org/W2236121837","https://openalex.org/W2272984102","https://openalex.org/W2312132282","https://openalex.org/W2782354676","https://openalex.org/W2789662105","https://openalex.org/W2804524416","https://openalex.org/W2972363927","https://openalex.org/W2999417355"],"related_works":["https://openalex.org/W2561789646","https://openalex.org/W3157978852","https://openalex.org/W1981347210","https://openalex.org/W2317457289","https://openalex.org/W2152263917","https://openalex.org/W2979789063","https://openalex.org/W2065028774","https://openalex.org/W2104265571","https://openalex.org/W1967428096","https://openalex.org/W2028998203"],"abstract_inverted_index":{"CDA":[0,67,102,117,160,171],"435C>T":[1,68,172],"is":[2,10,139,186],"reported":[3],"as":[4],"a":[5,126],"functional":[6],"SNP":[7],"but":[8,130,189],"there":[9,138],"no":[11,140],"relevant":[12],"research":[13],"on":[14],"the":[15,90,96,152,159,170,175,181,200],"efficacy/hematological":[16],"toxicity":[17,146],"of":[18,62,147,154],"gemcitabine-platinum":[19,58],"treatment":[20],"in":[21,142,151,174,178],"Chinese":[22,176],"non-small-cell":[23],"lung":[24],"cancer":[25],"(NSCLC)":[26],"patients.":[27,202],"In":[28],"this":[29],"study,":[30],"63":[31],"patients":[32,49,149,179],"who":[33],"received":[34],"radical":[35],"resection":[36],"(stage":[37,45],"IB":[38],"or":[39,47,119],"IIIA)":[40],"and":[41,53,75,81,92,162],"100":[42,155],"advanced":[43],"NSCLC":[44],"IIIB":[46],"IV)":[48],"have":[50,70,85,98,110,164],"been":[51,71,86,99],"collected,":[52],"all":[54],"were":[55],"treated":[56],"with":[57,125,180],"regimens":[59],"from":[60,196],"February":[61,65],"2017":[63],"to":[64,88,134,194],"2019.":[66],"polymorphisms":[69],"detected":[72],"by":[73],"PCR":[74],"direct":[76],"sequencing.":[77],"CT":[78],"scan":[79],"results":[80],"blood":[82],"routine":[83],"examinations":[84],"collected":[87],"evaluate":[89],"efficacy":[91,128],"hematological":[93,197],"toxicity.":[94],"Then":[95],"relationships":[97],"analyzed":[100],"about":[101],"435C>T.":[103],"We":[104],"found":[105],"that":[106],"T":[107,183],"allele":[108],"carriers":[109],"better":[111,127],"therapy":[112],"response":[113],"(p<0.05).":[114,136,168],"Patients":[115],"carrying":[116],"435C/T":[118,161],"T/T":[120,163],"genotypes":[121],"are":[122,131,191],"statistically":[123],"associated":[124],"(p<0.05)":[129],"more":[132,187,192],"prone":[133,193],"leukopenia":[135],"Although":[137],"difference":[141],"grade":[143],"III-IV":[144],"hematologic":[145],"163":[148],"(p>0.05),":[150],"case":[153],"stage":[156],"IIIB-IV":[157],"patients,":[158],"an":[165],"increased":[166],"risk":[167],"Regarding":[169],"polymorphism":[173],"population,":[177],"mutant":[182],"allele,":[184],"gemcitabine":[185],"effective,":[188],"they":[190],"suffering":[195],"toxicity,":[198],"especially":[199],"late-stage":[201]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2021-03-29T00:00:00"}
