{"id":"https://openalex.org/W3138700959","doi":"https://doi.org/10.3389/fcimb.2021.574067","title":"Dengue Virus Non-Structural Protein 5 as a Versatile, Multi-Functional Effector in Host\u2013Pathogen Interactions","display_name":"Dengue Virus Non-Structural Protein 5 as a Versatile, Multi-Functional Effector in Host\u2013Pathogen Interactions","publication_year":2021,"publication_date":"2021-03-18","ids":{"openalex":"https://openalex.org/W3138700959","doi":"https://doi.org/10.3389/fcimb.2021.574067","mag":"3138700959","pmid":"https://pubmed.ncbi.nlm.nih.gov/33816326","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8015806"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2021.574067","doi":"https://doi.org/10.3389/fcimb.2021.574067","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2021.574067","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcimb.2021.574067/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcimb.2021.574067/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070810883","display_name":"Priya Bhatnagar","orcid":"https://orcid.org/0000-0002-9412-9811","observed_orcids":["https://orcid.org/0000-0002-9412-9811"]},"institutions":[{"id":"https://openalex.org/I118315836","display_name":"TERI University","ror":"https://ror.org/03rh3e906","country_code":"IN","type":"education","lineage":["https://openalex.org/I118315836"]},{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Priya Bhatnagar","raw_affiliation_strings":["Department of Biotechnology, TERI School of Advanced Studies, New Delhi, India","ICGEB-Emory Vaccine Centre, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, TERI School of Advanced Studies, New Delhi, India","institution_ids":["https://openalex.org/I118315836"]},{"raw_affiliation_string":"ICGEB-Emory Vaccine Centre, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005498936","display_name":"Gopinathan Pillai Sreekanth","orcid":"https://orcid.org/0000-0002-0278-8642","observed_orcids":["https://orcid.org/0000-0002-0278-8642"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gopinathan Pillai Sreekanth","raw_affiliation_strings":["ICGEB-Emory Vaccine Centre, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICGEB-Emory Vaccine Centre, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087887010","display_name":"Kaja Murali\u2010Krishna","orcid":"https://orcid.org/0000-0002-6275-1710","observed_orcids":["https://orcid.org/0000-0002-6275-1710"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Kaja Murali-Krishna","raw_affiliation_strings":["Department of Paediatrics and Emory Vaccine Centre, Emory University School of Medicine, Atlanta, GA, United States","ICGEB-Emory Vaccine Centre, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics and Emory Vaccine Centre, Emory University School of Medicine, Atlanta, GA, United States","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"ICGEB-Emory Vaccine Centre, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013327224","display_name":"Anmol Chandele","orcid":"https://orcid.org/0000-0002-5702-7170","observed_orcids":["https://orcid.org/0000-0002-5702-7170"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Anmol Chandele","raw_affiliation_strings":["ICGEB-Emory Vaccine Centre, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICGEB-Emory Vaccine Centre, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021909871","display_name":"Ramakrishnan Sitaraman","orcid":"https://orcid.org/0000-0002-4577-4224","observed_orcids":["https://orcid.org/0000-0002-4577-4224"]},"institutions":[{"id":"https://openalex.org/I118315836","display_name":"TERI University","ror":"https://ror.org/03rh3e906","country_code":"IN","type":"education","lineage":["https://openalex.org/I118315836"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ramakrishnan Sitaraman","raw_affiliation_strings":["Department of Biotechnology, TERI School of Advanced Studies, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, TERI School of Advanced Studies, New Delhi, India","institution_ids":["https://openalex.org/I118315836"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013327224","https://openalex.org/A5021909871"],"corresponding_institution_ids":["https://openalex.org/I118315836","https://openalex.org/I4210142124"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.2397,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.76733201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"11","issue":null,"first_page":"574067","last_page":"574067"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dengue-virus","display_name":"dengue virus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ns5-protein","display_name":"NS5 protein","score":0.7390000224113464},{"id":"https://openalex.org/keywords/rna-dependent-rna-polymerase","display_name":"RNA-dependent RNA polymerase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/rna-methyltransferase","display_name":"RNA methyltransferase","score":0.9620000123977661},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.8270000219345093},{"id":"https://openalex.org/keywords/protein-interactors","display_name":"protein interactors","score":0.7329999804496765},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.9559999704360962},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.9160000085830688},{"id":"https://openalex.org/keywords/innate-immune-evasion","display_name":"innate immune evasion","score":0.7419999837875366},{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.6610000133514404},{"id":"https://openalex.org/keywords/dengue-virus-serotypes","display_name":"dengue serotypes","score":0.7739999890327454},{"id":"https://openalex.org/keywords/viral-rna-replication","display_name":"viral RNA replication","score":0.5239999890327454},{"id":"https://openalex.org/keywords/viral-polyprotein-processing","display_name":"viral polyprotein processing","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.7715696096420288},{"id":"https://openalex.org/C132379496","wikidata":"https://www.wikidata.org/wiki/Q83141645","display_name":"NS3","level":4,"score":0.7096878290176392},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7079523801803589},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.6069453954696655},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5987783074378967},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5631830096244812},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5061582922935486},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.48601728677749634},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4273460805416107},{"id":"https://openalex.org/C2780568436","wikidata":"https://www.wikidata.org/wiki/Q1165479","display_name":"Flavivirus","level":3,"score":0.4127275347709656},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.41132885217666626},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3989441990852356},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3214387893676758},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26008981466293335},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2526160776615143},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.18432492017745972},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.15599748492240906}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fcimb.2021.574067","doi":"https://doi.org/10.3389/fcimb.2021.574067","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2021.574067","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcimb.2021.574067/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},{"id":"pmid:33816326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33816326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular and infection microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8015806","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8015806/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Infect Microbiol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b37a5c584c214a2aae376d0147bd8f89","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b37a5c584c214a2aae376d0147bd8f89","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2021.574067","doi":"https://doi.org/10.3389/fcimb.2021.574067","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2021.574067","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcimb.2021.574067/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2085443018","display_name":null,"funder_award_id":"BT/NBM0099/02/18","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G6769228622","display_name":null,"funder_award_id":"BT/NBM0099/02/18","funder_id":"https://openalex.org/F4320336200","funder_display_name":"Biotechnology Industry Research Assistance Council"},{"id":"https://openalex.org/G873615465","display_name":null,"funder_award_id":"BT/PR30260/MED/15/194/2018","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"}],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320336200","display_name":"Biotechnology Industry Research Assistance Council","ror":"https://ror.org/05qr7ed45"},{"id":"https://openalex.org/F4320337407","display_name":"Division of Human Resource Development","ror":"https://ror.org/03mamvh39"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3138700959.pdf","grobid_xml":"https://content.openalex.org/works/W3138700959.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W5034282","https://openalex.org/W95601165","https://openalex.org/W410370780","https://openalex.org/W1715451660","https://openalex.org/W1968774761","https://openalex.org/W1973587186","https://openalex.org/W1975050610","https://openalex.org/W1983907306","https://openalex.org/W1987011260","https://openalex.org/W1992770138","https://openalex.org/W2013519130","https://openalex.org/W2031277784","https://openalex.org/W2040231819","https://openalex.org/W2042479028","https://openalex.org/W2045179297","https://openalex.org/W2050975040","https://openalex.org/W2051355772","https://openalex.org/W2058031315","https://openalex.org/W2062693912","https://openalex.org/W2077122919","https://openalex.org/W2081810122","https://openalex.org/W2083720374","https://openalex.org/W2101643828","https://openalex.org/W2102025023","https://openalex.org/W2109788141","https://openalex.org/W2111738929","https://openalex.org/W2113500493","https://openalex.org/W2120423686","https://openalex.org/W2121780828","https://openalex.org/W2126573043","https://openalex.org/W2130090902","https://openalex.org/W2131222241","https://openalex.org/W2143482423","https://openalex.org/W2145259841","https://openalex.org/W2153833484","https://openalex.org/W2249486403","https://openalex.org/W2281975422","https://openalex.org/W2322022606","https://openalex.org/W2340452337","https://openalex.org/W2464834014","https://openalex.org/W2489494699","https://openalex.org/W2504782965","https://openalex.org/W2516001222","https://openalex.org/W2529745498","https://openalex.org/W2554758214","https://openalex.org/W2608233928","https://openalex.org/W2748813793","https://openalex.org/W2756464106","https://openalex.org/W2766967608","https://openalex.org/W2768886517","https://openalex.org/W2785260734","https://openalex.org/W2883372641","https://openalex.org/W2886348268","https://openalex.org/W2892030934","https://openalex.org/W2904824676","https://openalex.org/W2911665238","https://openalex.org/W2920070818","https://openalex.org/W2944745527","https://openalex.org/W2946173685","https://openalex.org/W2951376956","https://openalex.org/W2970491619","https://openalex.org/W2984246112","https://openalex.org/W3027802024","https://openalex.org/W3048948192"],"related_works":["https://openalex.org/W4376255337","https://openalex.org/W4211130397","https://openalex.org/W4319869605","https://openalex.org/W2784613026","https://openalex.org/W2608233928","https://openalex.org/W2013519130","https://openalex.org/W4225403909","https://openalex.org/W4391657891","https://openalex.org/W1929382588","https://openalex.org/W4367319313"],"abstract_inverted_index":{"Dengue":[0],"is":[1,51,67],"emerging":[2],"as":[3,46,75,114,142,177],"one":[4],"of":[5,12,18,42,70,132,174,194],"the":[6,19,68,71,84,95,105,117,139,156,171,195,201,207],"most":[7,151],"prevalent":[8],"mosquito-borne":[9],"viral":[10,55,85,96],"diseases":[11],"humans.":[13],"The":[14,150],"11kb":[15],"RNA":[16,79,86,89,99],"genome":[17,97],"dengue":[20,175],"virus":[21,176],"encodes":[22],"three":[23],"structural":[24],"proteins":[25,32,112],"(envelope,":[26],"pre-membrane,":[27],"capsid)":[28],"and":[29,39,56,87,134,146,155,165,184,206,209],"seven":[30],"non-structural":[31,72],"(NS1,":[33],"NS2A,":[34],"NS2B,":[35],"NS3,":[36],"NS4A,":[37],"NS4B,":[38],"NS5),":[40],"all":[41],"which":[43,198],"are":[44,162],"translated":[45],"a":[47],"single":[48],"polyprotein":[49,102],"that":[50,82,93],"subsequently":[52],"cleaved":[53],"by":[54,98,144,197],"host":[57,141],"cellular":[58],"proteases":[59],"at":[60],"specific":[61,172],"sites.":[62],"Non-structural":[63],"protein":[64,153],"5":[65],"(NS5)":[66],"largest":[69],"proteins,":[73],"functioning":[74],"both":[76],"an":[77,88,191],"RNA-dependent":[78],"polymerase":[80],"(RdRp)":[81],"replicates":[83],"methyltransferase":[90],"enzyme":[91],"(MTase)":[92],"protects":[94],"capping,":[100],"facilitating":[101],"translation.":[103],"Within":[104],"human":[106,140],"host,":[107],"NS5":[108,136,199],"interacts":[109],"with":[110,122,170],"several":[111],"such":[113],"those":[115],"in":[116,138,161,204,213],"JAK-STAT":[118],"pathway,":[119],"thereby":[120],"interfering":[121],"anti-viral":[123],"interferon":[124],"signalling.":[125],"This":[126,179],"mini-review":[127],"presents":[128],"annotated,":[129],"consolidated":[130],"lists":[131],"known":[133],"potential":[135],"interactors":[137,154],"determined":[143],"experimental":[145],"computational":[147],"approaches":[148],"respectively.":[149],"significant":[152],"biological":[157],"pathways":[158],"they":[159],"participate":[160],"also":[163],"highlighted":[164],"their":[166],"implications":[167],"discussed,":[168],"along":[169],"serotype":[173],"appropriate.":[178],"information":[180],"can":[181],"potentially":[182],"stimulate":[183],"inform":[185],"further":[186],"research":[187],"efforts":[188],"towards":[189],"providing":[190],"integrative":[192],"understanding":[193],"mechanisms":[196],"manipulates":[200],"human-virus":[202],"interface":[203],"general":[205],"innate":[208],"adaptive":[210],"immune":[211],"responses":[212],"particular.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-29T00:00:00"}
